<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:fe6d37a5-97b2-481d-9d22-5da5f3801323,g:56acf6c3-3221-47c4-ae18-83c2b35479d2-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CondensedConsolidatedStatementsofIncomeLoss" xlink:type="simple" xlink:href="jazz-20220930.xsd#CondensedConsolidatedStatementsofIncomeLoss"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CondensedConsolidatedStatementsofIncomeLoss" xlink:type="extended" id="ia07bdb14e82b41a5b6f9354a36e69404_CondensedConsolidatedStatementsofIncomeLoss">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_e4d97130-8a87-40b3-b5d8-8456d972a3aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_RevenuesAbstract_e4d97130-8a87-40b3-b5d8-8456d972a3aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a52f6959-1e62-406b-b6a6-961ab242b515" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_e4d97130-8a87-40b3-b5d8-8456d972a3aa" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_a52f6959-1e62-406b-b6a6-961ab242b515" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment_1984b62f-c3e2-4af0-98fa-69ded1805dc2" xlink:href="jazz-20220930.xsd#jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment_1984b62f-c3e2-4af0-98fa-69ded1805dc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_5b024065-60bb-4c37-856e-0ded52c88e94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_5b024065-60bb-4c37-856e-0ded52c88e94" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_d0bfa0e7-46c3-4d45-95d2-7d6150bd32d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_d0bfa0e7-46c3-4d45-95d2-7d6150bd32d1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_29dd7107-d19f-40bb-899c-79d118eff1db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_29dd7107-d19f-40bb-899c-79d118eff1db" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_e08ba316-0911-42a2-8c34-ffd2fb872ecc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_e08ba316-0911-42a2-8c34-ffd2fb872ecc" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_3ac1d52c-314d-4440-af5c-23d03c4efb43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_us-gaap_AssetImpairmentCharges_3ac1d52c-314d-4440-af5c-23d03c4efb43" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_13c63f95-cc1b-42cd-be9c-d94c69c50326" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_b95d1008-10e7-44cd-96d3-b290e1ec71a4" xlink:to="loc_us-gaap_CostsAndExpenses_13c63f95-cc1b-42cd-be9c-d94c69c50326" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_3bd70082-91de-4181-a282-cccf796d7581" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_OperatingIncomeLoss_3bd70082-91de-4181-a282-cccf796d7581" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_b47e2e6e-ba51-49a4-972d-1d69786efa99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_b47e2e6e-ba51-49a4-972d-1d69786efa99" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_d0d5367f-2af4-4f4e-ae6e-ad809175481d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_d0d5367f-2af4-4f4e-ae6e-ad809175481d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_c00c425a-2606-4a4d-96f4-31c56c2811bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_c00c425a-2606-4a4d-96f4-31c56c2811bf" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_fab7df1b-194f-46a1-9660-df2effcd16b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_fab7df1b-194f-46a1-9660-df2effcd16b3" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_74802808-3f63-4b0b-96a2-5695a6071fea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_74802808-3f63-4b0b-96a2-5695a6071fea" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b3a24291-0c18-40c8-82f5-917d2aa3f2f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_NetIncomeLoss_b3a24291-0c18-40c8-82f5-917d2aa3f2f1" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_EarningsLossPerOrdinaryShareAbstract_8cef9138-8c53-4f5c-ae66-e5dd0638bfcf" xlink:href="jazz-20220930.xsd#jazz_EarningsLossPerOrdinaryShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_jazz_EarningsLossPerOrdinaryShareAbstract_8cef9138-8c53-4f5c-ae66-e5dd0638bfcf" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_46ecc81f-a4cf-4300-a683-748612b46e69" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_EarningsLossPerOrdinaryShareAbstract_8cef9138-8c53-4f5c-ae66-e5dd0638bfcf" xlink:to="loc_us-gaap_EarningsPerShareBasic_46ecc81f-a4cf-4300-a683-748612b46e69" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_e5a037b0-a0f0-4b46-ab04-950d1916540b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_EarningsLossPerOrdinaryShareAbstract_8cef9138-8c53-4f5c-ae66-e5dd0638bfcf" xlink:to="loc_us-gaap_EarningsPerShareDiluted_e5a037b0-a0f0-4b46-ab04-950d1916540b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_efe9d950-9459-4690-a3f7-8a1f0887a1c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_efe9d950-9459-4690-a3f7-8a1f0887a1c8" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_63dccc93-741d-499c-90a4-85272e94597d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_63dccc93-741d-499c-90a4-85272e94597d" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_3baec149-74fd-46d8-bf53-dbae94088785" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_efae6c5e-4772-4dee-b30c-00a35167c83f" xlink:to="loc_us-gaap_StatementTable_3baec149-74fd-46d8-bf53-dbae94088785" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_35947a5d-c0b7-432f-b37c-cdb01b3de183" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_3baec149-74fd-46d8-bf53-dbae94088785" xlink:to="loc_srt_ProductOrServiceAxis_35947a5d-c0b7-432f-b37c-cdb01b3de183" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_35947a5d-c0b7-432f-b37c-cdb01b3de183_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_35947a5d-c0b7-432f-b37c-cdb01b3de183" xlink:to="loc_srt_ProductsAndServicesDomain_35947a5d-c0b7-432f-b37c-cdb01b3de183_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_bd879cb6-38b0-4f17-8e40-982f1d1744f3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_35947a5d-c0b7-432f-b37c-cdb01b3de183" xlink:to="loc_srt_ProductsAndServicesDomain_bd879cb6-38b0-4f17-8e40-982f1d1744f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_cbc7b001-bed6-4150-9f53-f72701cd897e" xlink:href="jazz-20220930.xsd#jazz_ProductAndServicesProductSalesNetOfDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_bd879cb6-38b0-4f17-8e40-982f1d1744f3" xlink:to="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_cbc7b001-bed6-4150-9f53-f72701cd897e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_79c71d56-2614-419b-bd00-0359d01d7666" xlink:href="jazz-20220930.xsd#jazz_ProductAndServicesRoyaltiesAndContractRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_bd879cb6-38b0-4f17-8e40-982f1d1744f3" xlink:to="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_79c71d56-2614-419b-bd00-0359d01d7666" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CondensedConsolidatedStatementsofShareholdersEquity" xlink:type="simple" xlink:href="jazz-20220930.xsd#CondensedConsolidatedStatementsofShareholdersEquity"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CondensedConsolidatedStatementsofShareholdersEquity" xlink:type="extended" id="icbc61c347423453796595f14d76e5bbc_CondensedConsolidatedStatementsofShareholdersEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_abbcfdb5-64de-43af-8e71-733662f40493" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_abbcfdb5-64de-43af-8e71-733662f40493" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_7f59ee34-a6fb-4dda-8bc3-74d3b13011bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_SharesOutstanding_7f59ee34-a6fb-4dda-8bc3-74d3b13011bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_b8cd6547-b2f0-4d7f-a5d6-b3601ccfcc21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockholdersEquity_b8cd6547-b2f0-4d7f-a5d6-b3601ccfcc21" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_fd0c797e-be2c-498e-9820-18135a4e17fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_fd0c797e-be2c-498e-9820-18135a4e17fc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_c1d9ebe1-054f-4c44-96f4-ea4f4e9a99e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_c1d9ebe1-054f-4c44-96f4-ea4f4e9a99e0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_6582820e-0316-48ab-a068-8976cfd51e32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_6582820e-0316-48ab-a068-8976cfd51e32" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_9b05dce0-2498-410c-91a5-451f166cb879" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_9b05dce0-2498-410c-91a5-451f166cb879" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_fd47abd5-a0e7-4c19-9356-eb2264c11393" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_fd47abd5-a0e7-4c19-9356-eb2264c11393" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_7e32af4a-4040-410b-af91-ba366bc9cbb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_7e32af4a-4040-410b-af91-ba366bc9cbb5" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_5e47ade0-9fcc-4675-9e28-dd163832dcc7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_5e47ade0-9fcc-4675-9e28-dd163832dcc7" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_5499de5b-ea50-48ef-b33c-1c6f4c368918" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_5499de5b-ea50-48ef-b33c-1c6f4c368918" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_1e5b5974-c693-4058-b076-eb40b2af4c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_1e5b5974-c693-4058-b076-eb40b2af4c1a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_ac326b12-680c-4be7-b297-d6210feffc63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_ac326b12-680c-4be7-b297-d6210feffc63" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_48de76f2-21df-4346-9753-8f686923d987" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_48de76f2-21df-4346-9753-8f686923d987" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2a115004-be48-40e0-ba63-f547d71359e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_2a115004-be48-40e0-ba63-f547d71359e0" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9f6bc988-fc11-41e8-9873-75e4590d1e3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_5c2f49e6-bbc6-4fef-8d12-3a4b7e970911" xlink:to="loc_us-gaap_NetIncomeLoss_9f6bc988-fc11-41e8-9873-75e4590d1e3c" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_9ccc7d42-be24-4620-9919-7645a415d342" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_15605ef3-0450-4c82-9889-5d7d16601776" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdateExtensibleList_5459d716-fb86-434f-9d7d-cbe0e4614423" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingStandardsUpdateExtensibleList"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_abbcfdb5-64de-43af-8e71-733662f40493" xlink:to="loc_us-gaap_AccountingStandardsUpdateExtensibleList_5459d716-fb86-434f-9d7d-cbe0e4614423" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_1e157df4-f887-4c41-a014-fbdda905e4a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_abbcfdb5-64de-43af-8e71-733662f40493" xlink:to="loc_us-gaap_StatementTable_1e157df4-f887-4c41-a014-fbdda905e4a9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_983758d7-616f-474b-9b33-9dfa85fcd5b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_1e157df4-f887-4c41-a014-fbdda905e4a9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_983758d7-616f-474b-9b33-9dfa85fcd5b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_983758d7-616f-474b-9b33-9dfa85fcd5b2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_983758d7-616f-474b-9b33-9dfa85fcd5b2" xlink:to="loc_us-gaap_EquityComponentDomain_983758d7-616f-474b-9b33-9dfa85fcd5b2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_983758d7-616f-474b-9b33-9dfa85fcd5b2" xlink:to="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_be01b2cc-ddd7-43c9-8336-d43b96dad02f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:to="loc_us-gaap_CommonStockMember_be01b2cc-ddd7-43c9-8336-d43b96dad02f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_EuroDeferredSharesMember_5da69407-a443-4e01-94bd-576cd047dcd5" xlink:href="jazz-20220930.xsd#jazz_EuroDeferredSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:to="loc_jazz_EuroDeferredSharesMember_5da69407-a443-4e01-94bd-576cd047dcd5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CapitalRedemptionReserveMember_d9b9ea9c-40de-4045-9c89-3934631ccc6e" xlink:href="jazz-20220930.xsd#jazz_CapitalRedemptionReserveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:to="loc_jazz_CapitalRedemptionReserveMember_d9b9ea9c-40de-4045-9c89-3934631ccc6e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_a2995b71-4eda-4724-bf04-4441382ab223" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_a2995b71-4eda-4724-bf04-4441382ab223" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_cff449c4-c3a9-491d-b58e-82ded3555400" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_cff449c4-c3a9-491d-b58e-82ded3555400" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_04cdca54-a523-4152-b408-6a44387e60ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_3dafc0de-a257-4be1-9322-578328818f3c" xlink:to="loc_us-gaap_RetainedEarningsMember_04cdca54-a523-4152-b408-6a44387e60ac" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_68cb6d99-4f36-4104-a0e2-6361bd8e913d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_1e157df4-f887-4c41-a014-fbdda905e4a9" xlink:to="loc_us-gaap_AwardTypeAxis_68cb6d99-4f36-4104-a0e2-6361bd8e913d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_68cb6d99-4f36-4104-a0e2-6361bd8e913d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_68cb6d99-4f36-4104-a0e2-6361bd8e913d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_68cb6d99-4f36-4104-a0e2-6361bd8e913d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a6b44360-de6b-4410-b4ea-d2e6848032db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_68cb6d99-4f36-4104-a0e2-6361bd8e913d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a6b44360-de6b-4410-b4ea-d2e6848032db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_4e8d555c-8029-41f4-9ca6-d2cab464614e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a6b44360-de6b-4410-b4ea-d2e6848032db" xlink:to="loc_us-gaap_EmployeeStockOptionMember_4e8d555c-8029-41f4-9ca6-d2cab464614e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_69d22a98-6193-428a-aa2d-5df693344688" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_1e157df4-f887-4c41-a014-fbdda905e4a9" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_69d22a98-6193-428a-aa2d-5df693344688" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_69d22a98-6193-428a-aa2d-5df693344688_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_69d22a98-6193-428a-aa2d-5df693344688" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_69d22a98-6193-428a-aa2d-5df693344688_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_a3f0057f-171c-4658-bf43-127f8d4f6e6a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_69d22a98-6193-428a-aa2d-5df693344688" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_a3f0057f-171c-4658-bf43-127f8d4f6e6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_f8a29df9-4dc5-4770-97c2-cb1e6051191e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_a3f0057f-171c-4658-bf43-127f8d4f6e6a" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_f8a29df9-4dc5-4770-97c2-cb1e6051191e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails" xlink:type="extended" id="i1b47054c0ae44c1c976fc190a4ab9de7_TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_43c801ab-a389-4759-90a1-2e5a32698a81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NumberOfCountriesProductApprovedAndCommercialized_b9a7ffbb-8356-4050-86c5-3ec77f1cdcac" xlink:href="jazz-20220930.xsd#jazz_NumberOfCountriesProductApprovedAndCommercialized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_43c801ab-a389-4759-90a1-2e5a32698a81" xlink:to="loc_jazz_NumberOfCountriesProductApprovedAndCommercialized_b9a7ffbb-8356-4050-86c5-3ec77f1cdcac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_41e7f3ed-5930-4bf5-b805-fb080cc7c2a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_43c801ab-a389-4759-90a1-2e5a32698a81" xlink:to="loc_us-gaap_NumberOfOperatingSegments_41e7f3ed-5930-4bf5-b805-fb080cc7c2a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_b13fae9a-ce4b-43d9-b827-a02c5cdcb696" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_43c801ab-a389-4759-90a1-2e5a32698a81" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_b13fae9a-ce4b-43d9-b827-a02c5cdcb696" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_43e7088a-6c2b-49c9-b589-1a99c6909523" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b13fae9a-ce4b-43d9-b827-a02c5cdcb696" xlink:to="loc_srt_ProductOrServiceAxis_43e7088a-6c2b-49c9-b589-1a99c6909523" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_43e7088a-6c2b-49c9-b589-1a99c6909523_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_43e7088a-6c2b-49c9-b589-1a99c6909523" xlink:to="loc_srt_ProductsAndServicesDomain_43e7088a-6c2b-49c9-b589-1a99c6909523_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_1f66cd5c-a278-434c-ac17-842753e39124" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_43e7088a-6c2b-49c9-b589-1a99c6909523" xlink:to="loc_srt_ProductsAndServicesDomain_1f66cd5c-a278-434c-ac17-842753e39124" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SativexMember_866129eb-8b54-4b47-8561-681a447307ee" xlink:href="jazz-20220930.xsd#jazz_SativexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_1f66cd5c-a278-434c-ac17-842753e39124" xlink:to="loc_jazz_SativexMember_866129eb-8b54-4b47-8561-681a447307ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_e5e4f7f1-09ee-41d3-8691-2c03da176bba" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_b13fae9a-ce4b-43d9-b827-a02c5cdcb696" xlink:to="loc_srt_StatementGeographicalAxis_e5e4f7f1-09ee-41d3-8691-2c03da176bba" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_e5e4f7f1-09ee-41d3-8691-2c03da176bba_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_e5e4f7f1-09ee-41d3-8691-2c03da176bba" xlink:to="loc_srt_SegmentGeographicalDomain_e5e4f7f1-09ee-41d3-8691-2c03da176bba_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_deb447ea-8acb-419b-928d-c1141c8f853b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_e5e4f7f1-09ee-41d3-8691-2c03da176bba" xlink:to="loc_srt_SegmentGeographicalDomain_deb447ea-8acb-419b-928d-c1141c8f853b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OutsideUnitedStatesMember_f156f3e1-deb7-417e-bbd5-c846e439fd7f" xlink:href="jazz-20220930.xsd#jazz_OutsideUnitedStatesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_deb447ea-8acb-419b-928d-c1141c8f853b" xlink:to="loc_jazz_OutsideUnitedStatesMember_f156f3e1-deb7-417e-bbd5-c846e439fd7f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesAdoptionofNewAccountingStandardsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesAdoptionofNewAccountingStandardsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesAdoptionofNewAccountingStandardsDetails" xlink:type="extended" id="ic71acebc16f9424d93658e7e5fd645a3_TheCompanyandSummaryofSignificantAccountingPoliciesAdoptionofNewAccountingStandardsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_5d7f103a-e1ef-481b-abde-fee22c4f0c80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_5d7f103a-e1ef-481b-abde-fee22c4f0c80" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_26ba82c2-7f6e-47fb-8e2e-879b6a9e3dab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_26ba82c2-7f6e-47fb-8e2e-879b6a9e3dab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_910e6476-db88-4a17-ae0d-53171c1cca4c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_910e6476-db88-4a17-ae0d-53171c1cca4c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b7764c15-a7be-43b8-83be-4e0101cb47ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_b7764c15-a7be-43b8-83be-4e0101cb47ec" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_3b6649e1-64e7-4f4d-ae10-da46700147ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_3b6649e1-64e7-4f4d-ae10-da46700147ed" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_242f6d38-ca27-4641-9fca-d0048682caa5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_InterestExpense_242f6d38-ca27-4641-9fca-d0048682caa5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_2b72ad7f-8dbe-4630-8981-e7cdf757e319" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_EarningsPerShareBasic_2b72ad7f-8dbe-4630-8981-e7cdf757e319" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_4e896e7a-3820-4407-ae95-47307e07fa3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_EarningsPerShareDiluted_4e896e7a-3820-4407-ae95-47307e07fa3f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_4808e999-ae16-425a-8867-f7aef62d167c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_ea1ebaa6-ae30-42c1-a716-f47df4af3c09" xlink:to="loc_us-gaap_ConcentrationRiskTable_4808e999-ae16-425a-8867-f7aef62d167c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_32369110-9f02-4eb1-9fc9-e570e459dc73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_4808e999-ae16-425a-8867-f7aef62d167c" xlink:to="loc_us-gaap_DebtInstrumentAxis_32369110-9f02-4eb1-9fc9-e570e459dc73" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_32369110-9f02-4eb1-9fc9-e570e459dc73_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_32369110-9f02-4eb1-9fc9-e570e459dc73" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_32369110-9f02-4eb1-9fc9-e570e459dc73_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_862408d1-04e6-418c-afd8-7bc16fbbc481" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_32369110-9f02-4eb1-9fc9-e570e459dc73" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_862408d1-04e6-418c-afd8-7bc16fbbc481" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_243022dd-5292-4137-b257-2260b970b7f4" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_862408d1-04e6-418c-afd8-7bc16fbbc481" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_243022dd-5292-4137-b257-2260b970b7f4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_4c177c6b-b2dc-4793-aedd-ff7e97b486b7" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_862408d1-04e6-418c-afd8-7bc16fbbc481" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_4c177c6b-b2dc-4793-aedd-ff7e97b486b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_3b79792b-a0f0-4b12-8833-0a5539443354" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_4808e999-ae16-425a-8867-f7aef62d167c" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_3b79792b-a0f0-4b12-8833-0a5539443354" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_3b79792b-a0f0-4b12-8833-0a5539443354_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3b79792b-a0f0-4b12-8833-0a5539443354" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_3b79792b-a0f0-4b12-8833-0a5539443354_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f3b821d1-e0be-4d5f-8b7b-971c90f0c14b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_3b79792b-a0f0-4b12-8833-0a5539443354" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f3b821d1-e0be-4d5f-8b7b-971c90f0c14b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_8b40e9a7-d87e-4310-b60c-9a84f329cc8a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f3b821d1-e0be-4d5f-8b7b-971c90f0c14b" xlink:to="loc_us-gaap_ConvertibleDebtMember_8b40e9a7-d87e-4310-b60c-9a84f329cc8a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9feeda88-b33e-47b1-b2bb-83b3c35ce667" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_4808e999-ae16-425a-8867-f7aef62d167c" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9feeda88-b33e-47b1-b2bb-83b3c35ce667" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_9feeda88-b33e-47b1-b2bb-83b3c35ce667_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9feeda88-b33e-47b1-b2bb-83b3c35ce667" xlink:to="loc_us-gaap_TypeOfAdoptionMember_9feeda88-b33e-47b1-b2bb-83b3c35ce667_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_02683c5d-1b9b-4f6b-b711-ade7a3d31462" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9feeda88-b33e-47b1-b2bb-83b3c35ce667" xlink:to="loc_us-gaap_TypeOfAdoptionMember_02683c5d-1b9b-4f6b-b711-ade7a3d31462" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate202006Member_04682e7a-7504-4991-813a-ac8fb9d68b30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingStandardsUpdate202006Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_02683c5d-1b9b-4f6b-b711-ade7a3d31462" xlink:to="loc_us-gaap_AccountingStandardsUpdate202006Member_04682e7a-7504-4991-813a-ac8fb9d68b30" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_c32667a1-64a3-410b-8b83-2e832b8c8308" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_4808e999-ae16-425a-8867-f7aef62d167c" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_c32667a1-64a3-410b-8b83-2e832b8c8308" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_c32667a1-64a3-410b-8b83-2e832b8c8308_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_c32667a1-64a3-410b-8b83-2e832b8c8308" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_c32667a1-64a3-410b-8b83-2e832b8c8308_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_adb60305-d8bf-4cb3-9f77-d8059bdfc060" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionAxis_c32667a1-64a3-410b-8b83-2e832b8c8308" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_adb60305-d8bf-4cb3-9f77-d8059bdfc060" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_fafac248-8ae7-4170-a344-f2d581f841e6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_adb60305-d8bf-4cb3-9f77-d8059bdfc060" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_fafac248-8ae7-4170-a344-f2d581f841e6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustedBalanceMember_4ebe45be-0584-4917-b436-00ba4075202c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustedBalanceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_CumulativeEffectPeriodOfAdoptionDomain_adb60305-d8bf-4cb3-9f77-d8059bdfc060" xlink:to="loc_srt_CumulativeEffectPeriodOfAdoptionAdjustedBalanceMember_4ebe45be-0584-4917-b436-00ba4075202c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesSignificantRisksandUncertaintiesDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesSignificantRisksandUncertaintiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesSignificantRisksandUncertaintiesDetails" xlink:type="extended" id="ic0fe1b055a2247d49c9a208a17190a4c_TheCompanyandSummaryofSignificantAccountingPoliciesSignificantRisksandUncertaintiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_735ef425-37b9-4e7c-aec1-99a276312d6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_a2488c53-f109-4d6a-821c-98b630309613" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_735ef425-37b9-4e7c-aec1-99a276312d6e" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_a2488c53-f109-4d6a-821c-98b630309613" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e1799359-4fa8-4f2d-9a79-e6a6295d0747" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_735ef425-37b9-4e7c-aec1-99a276312d6e" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e1799359-4fa8-4f2d-9a79-e6a6295d0747" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_53ef5353-b2d5-4ec6-8d17-059b34fd54d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_e1799359-4fa8-4f2d-9a79-e6a6295d0747" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_53ef5353-b2d5-4ec6-8d17-059b34fd54d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_53ef5353-b2d5-4ec6-8d17-059b34fd54d8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_53ef5353-b2d5-4ec6-8d17-059b34fd54d8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_53ef5353-b2d5-4ec6-8d17-059b34fd54d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_806a5d4b-90bb-4ec0-ad8f-4624ca6b052e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_53ef5353-b2d5-4ec6-8d17-059b34fd54d8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_806a5d4b-90bb-4ec0-ad8f-4624ca6b052e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWPharmaceuticalsPlcMember_4d0f36e6-d3a4-4616-a9f7-b7fbf46a6434" xlink:href="jazz-20220930.xsd#jazz_GWPharmaceuticalsPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_806a5d4b-90bb-4ec0-ad8f-4624ca6b052e" xlink:to="loc_jazz_GWPharmaceuticalsPlcMember_4d0f36e6-d3a4-4616-a9f7-b7fbf46a6434" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails" xlink:type="extended" id="if3378cba701d4a63878113b83d1d2908_TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_9c6fd791-afb2-4e8c-89cb-899ec87e59ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_1ee015ea-6f7b-46e1-a97d-dc49a2bf2795" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_9c6fd791-afb2-4e8c-89cb-899ec87e59ab" xlink:to="loc_us-gaap_DerivativeNotionalAmount_1ee015ea-6f7b-46e1-a97d-dc49a2bf2795" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_9fa1d14c-23fe-4e41-b372-bf187e0b35c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_9c6fd791-afb2-4e8c-89cb-899ec87e59ab" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_9fa1d14c-23fe-4e41-b372-bf187e0b35c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_127bf637-683f-4b1c-8996-05304f490350" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_9c6fd791-afb2-4e8c-89cb-899ec87e59ab" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_127bf637-683f-4b1c-8996-05304f490350" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_9c6fd791-afb2-4e8c-89cb-899ec87e59ab" xlink:to="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b204f354-b07c-4b8d-9bc2-e46c2da14828" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b204f354-b07c-4b8d-9bc2-e46c2da14828" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b204f354-b07c-4b8d-9bc2-e46c2da14828_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b204f354-b07c-4b8d-9bc2-e46c2da14828" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b204f354-b07c-4b8d-9bc2-e46c2da14828_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_1cf649cb-1adc-4426-9f93-cc82a17f8dcc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b204f354-b07c-4b8d-9bc2-e46c2da14828" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_1cf649cb-1adc-4426-9f93-cc82a17f8dcc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_c81efe12-fc2d-4b3f-9323-ba7783ce933f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_1cf649cb-1adc-4426-9f93-cc82a17f8dcc" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_c81efe12-fc2d-4b3f-9323-ba7783ce933f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_81a3e463-d02b-4582-9be6-82b2a88f32a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:to="loc_us-gaap_HedgingDesignationAxis_81a3e463-d02b-4582-9be6-82b2a88f32a0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_81a3e463-d02b-4582-9be6-82b2a88f32a0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_81a3e463-d02b-4582-9be6-82b2a88f32a0" xlink:to="loc_us-gaap_HedgingDesignationDomain_81a3e463-d02b-4582-9be6-82b2a88f32a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_9538c4f9-b741-4cc4-bf02-84a91cbe72d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_81a3e463-d02b-4582-9be6-82b2a88f32a0" xlink:to="loc_us-gaap_HedgingDesignationDomain_9538c4f9-b741-4cc4-bf02-84a91cbe72d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_db692880-0fe7-42d4-ab74-3adcbcc112d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_9538c4f9-b741-4cc4-bf02-84a91cbe72d2" xlink:to="loc_us-gaap_NondesignatedMember_db692880-0fe7-42d4-ab74-3adcbcc112d2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_4503ebf7-fac0-43d0-8c21-c4095fa8039d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_4503ebf7-fac0-43d0-8c21-c4095fa8039d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_4503ebf7-fac0-43d0-8c21-c4095fa8039d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_4503ebf7-fac0-43d0-8c21-c4095fa8039d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_4503ebf7-fac0-43d0-8c21-c4095fa8039d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_2ebc810d-4b34-42e3-a8f4-bbd5b6361aa9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_4503ebf7-fac0-43d0-8c21-c4095fa8039d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_2ebc810d-4b34-42e3-a8f4-bbd5b6361aa9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_1d2df1d7-38d8-4267-9b58-0cc3c3e281b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_2ebc810d-4b34-42e3-a8f4-bbd5b6361aa9" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_1d2df1d7-38d8-4267-9b58-0cc3c3e281b9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_4b8033b0-20d9-4c4d-9212-9f26fa400d99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_4b8033b0-20d9-4c4d-9212-9f26fa400d99" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_4b8033b0-20d9-4c4d-9212-9f26fa400d99_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_4b8033b0-20d9-4c4d-9212-9f26fa400d99" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_4b8033b0-20d9-4c4d-9212-9f26fa400d99_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_61f2eb47-fbfb-40b8-aa8f-bee94bc428ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_4b8033b0-20d9-4c4d-9212-9f26fa400d99" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_61f2eb47-fbfb-40b8-aa8f-bee94bc428ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_0d3472d5-548e-4ddb-8538-bfb753639709" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_61f2eb47-fbfb-40b8-aa8f-bee94bc428ea" xlink:to="loc_us-gaap_AccountsReceivableMember_0d3472d5-548e-4ddb-8538-bfb753639709" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_196e5010-4d76-4129-8ea5-303f13bddf3d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_b43ad33f-c1c0-4fa6-a6db-7c2aba378924" xlink:to="loc_srt_MajorCustomersAxis_196e5010-4d76-4129-8ea5-303f13bddf3d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_196e5010-4d76-4129-8ea5-303f13bddf3d_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_196e5010-4d76-4129-8ea5-303f13bddf3d" xlink:to="loc_srt_NameOfMajorCustomerDomain_196e5010-4d76-4129-8ea5-303f13bddf3d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_a12876eb-9fe7-43b9-b4f0-b5df9a4cb67f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_196e5010-4d76-4129-8ea5-303f13bddf3d" xlink:to="loc_srt_NameOfMajorCustomerDomain_a12876eb-9fe7-43b9-b4f0-b5df9a4cb67f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ThreeCustomersMember_b657bbd1-253f-4f47-892e-1bc135d54d85" xlink:href="jazz-20220930.xsd#jazz_ThreeCustomersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_a12876eb-9fe7-43b9-b4f0-b5df9a4cb67f" xlink:to="loc_jazz_ThreeCustomersMember_b657bbd1-253f-4f47-892e-1bc135d54d85" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExpressScriptsMember_30c4b78d-d4fe-4e7c-8971-b7ff09c725d0" xlink:href="jazz-20220930.xsd#jazz_ExpressScriptsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ThreeCustomersMember_b657bbd1-253f-4f47-892e-1bc135d54d85" xlink:to="loc_jazz_ExpressScriptsMember_30c4b78d-d4fe-4e7c-8971-b7ff09c725d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CardinalHealthIncMember_f55685c6-4c41-4c5b-b598-9887ba9f8d80" xlink:href="jazz-20220930.xsd#jazz_CardinalHealthIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ThreeCustomersMember_b657bbd1-253f-4f47-892e-1bc135d54d85" xlink:to="loc_jazz_CardinalHealthIncMember_f55685c6-4c41-4c5b-b598-9887ba9f8d80" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_McKessonCorporationMember_f7488c01-2c99-4668-83bc-185e26ac6422" xlink:href="jazz-20220930.xsd#jazz_McKessonCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ThreeCustomersMember_b657bbd1-253f-4f47-892e-1bc135d54d85" xlink:to="loc_jazz_McKessonCorporationMember_f7488c01-2c99-4668-83bc-185e26ac6422" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DispositionandLicenseAgreementsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DispositionandLicenseAgreementsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DispositionandLicenseAgreementsDetails" xlink:type="extended" id="ia619caef479949c498713868e33ab2ed_DispositionandLicenseAgreementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_c1022ec4-c0a4-4cae-9590-0a567ee384e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_DisposalGroupNotDiscontinuedOperationUpfrontPaymentReceived_e7d95580-81fe-42f3-8089-d191c283d701" xlink:href="jazz-20220930.xsd#jazz_DisposalGroupNotDiscontinuedOperationUpfrontPaymentReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_c1022ec4-c0a4-4cae-9590-0a567ee384e4" xlink:to="loc_jazz_DisposalGroupNotDiscontinuedOperationUpfrontPaymentReceived_e7d95580-81fe-42f3-8089-d191c283d701" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_e5eb0bda-4d4a-4d63-8534-a76cf980e68c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_c1022ec4-c0a4-4cae-9590-0a567ee384e4" xlink:to="loc_us-gaap_DisposalGroupNotDiscontinuedOperationGainLossOnDisposal_e5eb0bda-4d4a-4d63-8534-a76cf980e68c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_b6ca84b4-6a8f-4228-85a4-a3a786985bb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_c1022ec4-c0a4-4cae-9590-0a567ee384e4" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_b6ca84b4-6a8f-4228-85a4-a3a786985bb1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_2251941c-b052-4507-9140-704437793c04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_c1022ec4-c0a4-4cae-9590-0a567ee384e4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_2251941c-b052-4507-9140-704437793c04" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_ddde3348-38d5-457a-8efc-dde9e3768d9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_c1022ec4-c0a4-4cae-9590-0a567ee384e4" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_ddde3348-38d5-457a-8efc-dde9e3768d9f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_03120bfd-0de2-4d55-911b-9a7a7d2d6892" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_ddde3348-38d5-457a-8efc-dde9e3768d9f" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_03120bfd-0de2-4d55-911b-9a7a7d2d6892" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_03120bfd-0de2-4d55-911b-9a7a7d2d6892_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_03120bfd-0de2-4d55-911b-9a7a7d2d6892" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_03120bfd-0de2-4d55-911b-9a7a7d2d6892_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_a56f2f26-6788-464c-8de0-29b6d84e160f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_03120bfd-0de2-4d55-911b-9a7a7d2d6892" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_a56f2f26-6788-464c-8de0-29b6d84e160f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SunosiMember_cbaea619-3059-4869-b75c-6de4ee7f7678" xlink:href="jazz-20220930.xsd#jazz_SunosiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_a56f2f26-6788-464c-8de0-29b6d84e160f" xlink:to="loc_jazz_SunosiMember_cbaea619-3059-4869-b75c-6de4ee7f7678" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_310fadfc-e1d4-4a7d-a822-36f8b080b6f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_ddde3348-38d5-457a-8efc-dde9e3768d9f" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_310fadfc-e1d4-4a7d-a822-36f8b080b6f7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_310fadfc-e1d4-4a7d-a822-36f8b080b6f7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_310fadfc-e1d4-4a7d-a822-36f8b080b6f7" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_310fadfc-e1d4-4a7d-a822-36f8b080b6f7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_3b1f09da-8f07-48d1-b180-156aece87fba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_310fadfc-e1d4-4a7d-a822-36f8b080b6f7" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_3b1f09da-8f07-48d1-b180-156aece87fba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_da46b895-7ebf-4b27-8702-05d8f32908b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_3b1f09da-8f07-48d1-b180-156aece87fba" xlink:to="loc_us-gaap_DisposalGroupHeldforsaleNotDiscontinuedOperationsMember_da46b895-7ebf-4b27-8702-05d8f32908b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_360ba5dc-4b7a-4cd2-ba3a-a79221a37a12" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_ddde3348-38d5-457a-8efc-dde9e3768d9f" xlink:to="loc_srt_CounterpartyNameAxis_360ba5dc-4b7a-4cd2-ba3a-a79221a37a12" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_360ba5dc-4b7a-4cd2-ba3a-a79221a37a12_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_360ba5dc-4b7a-4cd2-ba3a-a79221a37a12" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_360ba5dc-4b7a-4cd2-ba3a-a79221a37a12_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ea1e6555-f02b-4392-8423-9b49fdc46f4f" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_360ba5dc-4b7a-4cd2-ba3a-a79221a37a12" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ea1e6555-f02b-4392-8423-9b49fdc46f4f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_AxsomeMember_60b80c88-2794-44c3-8180-078aea2f0237" xlink:href="jazz-20220930.xsd#jazz_AxsomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ea1e6555-f02b-4392-8423-9b49fdc46f4f" xlink:to="loc_jazz_AxsomeMember_60b80c88-2794-44c3-8180-078aea2f0237" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_WerewolfMember_41836f92-5a4f-4bf1-8a1f-0c92f04507ec" xlink:href="jazz-20220930.xsd#jazz_WerewolfMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ea1e6555-f02b-4392-8423-9b49fdc46f4f" xlink:to="loc_jazz_WerewolfMember_41836f92-5a4f-4bf1-8a1f-0c92f04507ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SumitomoMember_8f7cea44-acff-4dae-8734-6c0e742282a5" xlink:href="jazz-20220930.xsd#jazz_SumitomoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_ea1e6555-f02b-4392-8423-9b49fdc46f4f" xlink:to="loc_jazz_SumitomoMember_8f7cea44-acff-4dae-8734-6c0e742282a5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_4eb1c4f8-d4c5-4b74-a61f-0743f7500bf3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_ddde3348-38d5-457a-8efc-dde9e3768d9f" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_4eb1c4f8-d4c5-4b74-a61f-0743f7500bf3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_4eb1c4f8-d4c5-4b74-a61f-0743f7500bf3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_4eb1c4f8-d4c5-4b74-a61f-0743f7500bf3" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_4eb1c4f8-d4c5-4b74-a61f-0743f7500bf3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_f7563a1c-5010-4af9-9d44-849ab99a8660" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_4eb1c4f8-d4c5-4b74-a61f-0743f7500bf3" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_f7563a1c-5010-4af9-9d44-849ab99a8660" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_UpfrontPaymentsMember_cf1d46ef-2a7a-4aff-96a5-ef826f7e3a27" xlink:href="jazz-20220930.xsd#jazz_UpfrontPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_f7563a1c-5010-4af9-9d44-849ab99a8660" xlink:to="loc_jazz_UpfrontPaymentsMember_cf1d46ef-2a7a-4aff-96a5-ef826f7e3a27" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PotentialMilestonePaymentMember_8620b648-4f92-459a-be86-82efe316d1f9" xlink:href="jazz-20220930.xsd#jazz_PotentialMilestonePaymentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_f7563a1c-5010-4af9-9d44-849ab99a8660" xlink:to="loc_jazz_PotentialMilestonePaymentMember_8620b648-4f92-459a-be86-82efe316d1f9" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails" xlink:type="extended" id="ifcbd403d73d942d6827aaa9c8a06c57f_CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_dbc67b06-880f-4829-ab16-6b8df3f99428" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_dbc67b06-880f-4829-ab16-6b8df3f99428" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_98d911a8-3750-4415-b203-464a50b5c2d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_98d911a8-3750-4415-b203-464a50b5c2d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d162a0b5-1a9a-4860-a690-846b599bbc3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_d162a0b5-1a9a-4860-a690-846b599bbc3c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ad342ce7-cd59-4b2f-a219-e028ce72d19a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ad342ce7-cd59-4b2f-a219-e028ce72d19a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_00af25ec-d7ff-4886-a302-aa9af062dfcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_00af25ec-d7ff-4886-a302-aa9af062dfcb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Investments_309cf6bc-141e-4d85-ba90-dc4a4d0cd65f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Investments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_Investments_309cf6bc-141e-4d85-ba90-dc4a4d0cd65f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8caf5353-37be-4c65-9aa4-bc8e573f2ab7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_f1b014f1-b257-4919-9a6b-f7229bc03945" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8caf5353-37be-4c65-9aa4-bc8e573f2ab7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_3117efb3-a9f0-4354-88eb-781d4b2491a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_8caf5353-37be-4c65-9aa4-bc8e573f2ab7" xlink:to="loc_us-gaap_FinancialInstrumentAxis_3117efb3-a9f0-4354-88eb-781d4b2491a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3117efb3-a9f0-4354-88eb-781d4b2491a9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_3117efb3-a9f0-4354-88eb-781d4b2491a9" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3117efb3-a9f0-4354-88eb-781d4b2491a9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_350f4c7a-04a2-4090-8614-8d8caf870a98" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_3117efb3-a9f0-4354-88eb-781d4b2491a9" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_350f4c7a-04a2-4090-8614-8d8caf870a98" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashMember_8bd14d4c-0c7a-4671-97c4-ef4ae4b1fb3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_350f4c7a-04a2-4090-8614-8d8caf870a98" xlink:to="loc_us-gaap_CashMember_8bd14d4c-0c7a-4671-97c4-ef4ae4b1fb3d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_c2bfa775-9db1-4354-bd48-84c43f3f1f7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_350f4c7a-04a2-4090-8614-8d8caf870a98" xlink:to="loc_us-gaap_BankTimeDepositsMember_c2bfa775-9db1-4354-bd48-84c43f3f1f7e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_e9ec18f5-4383-4efc-8d24-9d156e2f6566" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_350f4c7a-04a2-4090-8614-8d8caf870a98" xlink:to="loc_us-gaap_MoneyMarketFundsMember_e9ec18f5-4383-4efc-8d24-9d156e2f6566" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended" id="ia94572b77dbe4186b6e7e21525083e95_FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2068efd5-77a5-4afc-a648-befd7deb1d7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_3d4e28a0-8522-4fa3-a09b-bd86a27a192b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2068efd5-77a5-4afc-a648-befd7deb1d7a" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_3d4e28a0-8522-4fa3-a09b-bd86a27a192b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_36d09f81-f9b7-44fc-acdb-f38d533489bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_3d4e28a0-8522-4fa3-a09b-bd86a27a192b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_36d09f81-f9b7-44fc-acdb-f38d533489bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_00147eff-ee5f-410d-a6ae-72d89f67bf60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_36d09f81-f9b7-44fc-acdb-f38d533489bd" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_00147eff-ee5f-410d-a6ae-72d89f67bf60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_779b4d5a-4b2d-46d1-9a42-3c71d01f6c3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_3d4e28a0-8522-4fa3-a09b-bd86a27a192b" xlink:to="loc_us-gaap_DerivativeAssets_779b4d5a-4b2d-46d1-9a42-3c71d01f6c3f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_6a61957c-14c0-4079-913b-48b17dfbbbef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_3d4e28a0-8522-4fa3-a09b-bd86a27a192b" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_6a61957c-14c0-4079-913b-48b17dfbbbef" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_4c044084-320b-4273-91e5-d6aaee767e46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2068efd5-77a5-4afc-a648-befd7deb1d7a" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_4c044084-320b-4273-91e5-d6aaee767e46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_916a1665-914d-496d-ab20-aa9419bb74dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_4c044084-320b-4273-91e5-d6aaee767e46" xlink:to="loc_us-gaap_DerivativeLiabilities_916a1665-914d-496d-ab20-aa9419bb74dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_cd7c1840-2e6d-4929-84b1-8a5b59af0b5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_4c044084-320b-4273-91e5-d6aaee767e46" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_cd7c1840-2e6d-4929-84b1-8a5b59af0b5c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_ec99f63e-4616-4195-9e6d-43164a100d95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2068efd5-77a5-4afc-a648-befd7deb1d7a" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_ec99f63e-4616-4195-9e6d-43164a100d95" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0755c18c-5e0a-42cb-84e6-8146e2c368b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_ec99f63e-4616-4195-9e6d-43164a100d95" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0755c18c-5e0a-42cb-84e6-8146e2c368b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_0755c18c-5e0a-42cb-84e6-8146e2c368b9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0755c18c-5e0a-42cb-84e6-8146e2c368b9" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_0755c18c-5e0a-42cb-84e6-8146e2c368b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_ed8f65fa-2d6a-43d6-82ec-1c5b531b33c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_0755c18c-5e0a-42cb-84e6-8146e2c368b9" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_ed8f65fa-2d6a-43d6-82ec-1c5b531b33c6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_4e1f23d5-2329-4345-ad99-55e79d10af01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_ed8f65fa-2d6a-43d6-82ec-1c5b531b33c6" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_4e1f23d5-2329-4345-ad99-55e79d10af01" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_cc476f8b-43b4-47f1-9f60-65220ceef248" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_ec99f63e-4616-4195-9e6d-43164a100d95" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_cc476f8b-43b4-47f1-9f60-65220ceef248" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cc476f8b-43b4-47f1-9f60-65220ceef248_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_cc476f8b-43b4-47f1-9f60-65220ceef248" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_cc476f8b-43b4-47f1-9f60-65220ceef248_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b5b91c42-729c-441f-9aab-8e9af7bfbc60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_cc476f8b-43b4-47f1-9f60-65220ceef248" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b5b91c42-729c-441f-9aab-8e9af7bfbc60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_b507cc86-3704-42e4-94c8-f63f9b2f621a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b5b91c42-729c-441f-9aab-8e9af7bfbc60" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_b507cc86-3704-42e4-94c8-f63f9b2f621a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_83ef385c-3513-4840-baf9-97ec004abf6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_b5b91c42-729c-441f-9aab-8e9af7bfbc60" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_83ef385c-3513-4840-baf9-97ec004abf6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_97a67020-ffab-40c0-8ea2-15af6922e045" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_ec99f63e-4616-4195-9e6d-43164a100d95" xlink:to="loc_us-gaap_FinancialInstrumentAxis_97a67020-ffab-40c0-8ea2-15af6922e045" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_97a67020-ffab-40c0-8ea2-15af6922e045_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_97a67020-ffab-40c0-8ea2-15af6922e045" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_97a67020-ffab-40c0-8ea2-15af6922e045_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_86d7db43-6c29-42a4-84cf-9fa639339c85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_97a67020-ffab-40c0-8ea2-15af6922e045" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_86d7db43-6c29-42a4-84cf-9fa639339c85" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_1a0a326f-5db7-46cc-b367-4f27f171c7ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_86d7db43-6c29-42a4-84cf-9fa639339c85" xlink:to="loc_us-gaap_MoneyMarketFundsMember_1a0a326f-5db7-46cc-b367-4f27f171c7ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_fb85a6ba-016f-4abd-8f8b-417d3e9170cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_86d7db43-6c29-42a4-84cf-9fa639339c85" xlink:to="loc_us-gaap_BankTimeDepositsMember_fb85a6ba-016f-4abd-8f8b-417d3e9170cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_29516c12-c301-476e-856b-88754c6db47b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_86d7db43-6c29-42a4-84cf-9fa639339c85" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_29516c12-c301-476e-856b-88754c6db47b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_f4159bd8-877c-4544-9691-b6a3a06c2beb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_86d7db43-6c29-42a4-84cf-9fa639339c85" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_f4159bd8-877c-4544-9691-b6a3a06c2beb" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#FairValueMeasurementNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="extended" id="i8481aa9107f84371a402484bc0375164_FairValueMeasurementNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_8eb63ae5-45ef-4ee6-af28-abf74d48d430" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_8eb63ae5-45ef-4ee6-af28-abf74d48d430" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_830b5650-80d0-4f60-837c-07f38f23d9d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_830b5650-80d0-4f60-837c-07f38f23d9d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_62bdd3cf-938e-4eb6-a329-9f0efa3b181e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_DebtInstrumentTerm_62bdd3cf-938e-4eb6-a329-9f0efa3b181e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_88c95b53-4230-433c-8c4d-98194355b7c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_88c95b53-4230-433c-8c4d-98194355b7c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_17b296f3-5b0f-4fcc-b713-0c5fe9e0eb75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_17b296f3-5b0f-4fcc-b713-0c5fe9e0eb75" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableFairValueDisclosure_d430cf82-70dc-4c8b-bbee-80cceee4305f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesPayableFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_NotesPayableFairValueDisclosure_d430cf82-70dc-4c8b-bbee-80cceee4305f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LinesOfCreditFairValueDisclosure_4cd74def-e41f-4671-92c7-22f55c29d8b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LinesOfCreditFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_LinesOfCreditFairValueDisclosure_4cd74def-e41f-4671-92c7-22f55c29d8b9" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_490a1144-9933-4b39-ae30-9b125d7399d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_cb00ea1c-49be-429f-8c76-90570070337c" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_490a1144-9933-4b39-ae30-9b125d7399d3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_aba5b689-158a-4ce7-8e16-ec8e5db5db75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_490a1144-9933-4b39-ae30-9b125d7399d3" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_aba5b689-158a-4ce7-8e16-ec8e5db5db75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_aba5b689-158a-4ce7-8e16-ec8e5db5db75_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_aba5b689-158a-4ce7-8e16-ec8e5db5db75" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_aba5b689-158a-4ce7-8e16-ec8e5db5db75_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8da12761-2024-4350-abf5-62ecca223377" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_aba5b689-158a-4ce7-8e16-ec8e5db5db75" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8da12761-2024-4350-abf5-62ecca223377" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_96cfa7e1-288c-4fe5-b6cf-41781bd58847" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8da12761-2024-4350-abf5-62ecca223377" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_96cfa7e1-288c-4fe5-b6cf-41781bd58847" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_34787d47-813e-43e2-b53d-f57675cda667" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_490a1144-9933-4b39-ae30-9b125d7399d3" xlink:to="loc_us-gaap_DebtInstrumentAxis_34787d47-813e-43e2-b53d-f57675cda667" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_34787d47-813e-43e2-b53d-f57675cda667_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_34787d47-813e-43e2-b53d-f57675cda667" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_34787d47-813e-43e2-b53d-f57675cda667_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_23a586ea-27f9-4ada-b200-4d77580e2304" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_34787d47-813e-43e2-b53d-f57675cda667" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_23a586ea-27f9-4ada-b200-4d77580e2304" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember_cece302c-44b7-4e22-9d71-836831cbc194" xlink:href="jazz-20220930.xsd#jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_23a586ea-27f9-4ada-b200-4d77580e2304" xlink:to="loc_jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember_cece302c-44b7-4e22-9d71-836831cbc194" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_095317d3-e825-48e9-bc22-5c22ac2bffc5" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_23a586ea-27f9-4ada-b200-4d77580e2304" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_095317d3-e825-48e9-bc22-5c22ac2bffc5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_a3a36ebd-0220-4872-ba69-f2a6e53d2d3c" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_23a586ea-27f9-4ada-b200-4d77580e2304" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_a3a36ebd-0220-4872-ba69-f2a6e53d2d3c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorNotesDue2029Member_880e0b14-da2d-486b-90eb-f344346d52b8" xlink:href="jazz-20220930.xsd#jazz_SeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_23a586ea-27f9-4ada-b200-4d77580e2304" xlink:to="loc_jazz_SeniorNotesDue2029Member_880e0b14-da2d-486b-90eb-f344346d52b8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_18331d68-aede-4e21-89c4-adf75f539b5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_490a1144-9933-4b39-ae30-9b125d7399d3" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_18331d68-aede-4e21-89c4-adf75f539b5a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_18331d68-aede-4e21-89c4-adf75f539b5a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_18331d68-aede-4e21-89c4-adf75f539b5a" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_18331d68-aede-4e21-89c4-adf75f539b5a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4f17db8b-e657-410f-88c2-441b7cc65687" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_18331d68-aede-4e21-89c4-adf75f539b5a" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4f17db8b-e657-410f-88c2-441b7cc65687" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredDebtMember_c791b1e0-63f5-4286-b431-946fb025646e" xlink:href="jazz-20220930.xsd#jazz_SeniorSecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4f17db8b-e657-410f-88c2-441b7cc65687" xlink:to="loc_jazz_SeniorSecuredDebtMember_c791b1e0-63f5-4286-b431-946fb025646e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_58683c11-6c14-4193-ae81-b7c9c192b6a3" xlink:href="jazz-20220930.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4f17db8b-e657-410f-88c2-441b7cc65687" xlink:to="loc_jazz_TermLoanMember_58683c11-6c14-4193-ae81-b7c9c192b6a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_9b0c50ed-7c1c-49de-abb9-692d1b2bb6b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4f17db8b-e657-410f-88c2-441b7cc65687" xlink:to="loc_us-gaap_ConvertibleDebtMember_9b0c50ed-7c1c-49de-abb9-692d1b2bb6b0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_87205aed-90d0-4c8f-b98b-ce371483be38" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_490a1144-9933-4b39-ae30-9b125d7399d3" xlink:to="loc_dei_LegalEntityAxis_87205aed-90d0-4c8f-b98b-ce371483be38" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_87205aed-90d0-4c8f-b98b-ce371483be38_default" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_87205aed-90d0-4c8f-b98b-ce371483be38" xlink:to="loc_dei_EntityDomain_87205aed-90d0-4c8f-b98b-ce371483be38_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_e0891bec-6e4d-4929-9d1a-ab76fce4011b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_87205aed-90d0-4c8f-b98b-ce371483be38" xlink:to="loc_dei_EntityDomain_e0891bec-6e4d-4929-9d1a-ab76fce4011b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_JazzSecuritiesDesignatedActivityCompanyMember_826e224c-6bf0-4521-80fd-b3dd29b96742" xlink:href="jazz-20220930.xsd#jazz_JazzSecuritiesDesignatedActivityCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_e0891bec-6e4d-4929-9d1a-ab76fce4011b" xlink:to="loc_jazz_JazzSecuritiesDesignatedActivityCompanyMember_826e224c-6bf0-4521-80fd-b3dd29b96742" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DerivativeInstrumentsandHedgingActivitiesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" xlink:type="extended" id="i3479db22c682413ba696c959aa1d35da_DerivativeInstrumentsandHedgingActivitiesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_36b06262-d2ca-4b4e-b5ce-c6037855cd65" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_8ddd771a-bc39-4f6c-947b-3f525454c87e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_36b06262-d2ca-4b4e-b5ce-c6037855cd65" xlink:to="loc_us-gaap_DebtInstrumentTerm_8ddd771a-bc39-4f6c-947b-3f525454c87e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_f3b9e8eb-5630-4bea-a9cd-cd63cac1446f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_36b06262-d2ca-4b4e-b5ce-c6037855cd65" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_f3b9e8eb-5630-4bea-a9cd-cd63cac1446f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_5312503d-bef6-4a1d-94e3-d40729cfd69b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_36b06262-d2ca-4b4e-b5ce-c6037855cd65" xlink:to="loc_us-gaap_DerivativeNotionalAmount_5312503d-bef6-4a1d-94e3-d40729cfd69b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_dececa82-a419-4cb1-9ea3-0a5bc3ac10e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_36b06262-d2ca-4b4e-b5ce-c6037855cd65" xlink:to="loc_us-gaap_DerivativeTable_dececa82-a419-4cb1-9ea3-0a5bc3ac10e6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_0578733e-a9f4-4a41-ba39-4181eeca3d75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_dececa82-a419-4cb1-9ea3-0a5bc3ac10e6" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_0578733e-a9f4-4a41-ba39-4181eeca3d75" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_0578733e-a9f4-4a41-ba39-4181eeca3d75_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0578733e-a9f4-4a41-ba39-4181eeca3d75" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_0578733e-a9f4-4a41-ba39-4181eeca3d75_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_a0e374a3-2f9f-4ce7-9ca8-7ad7bf7ca37f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_0578733e-a9f4-4a41-ba39-4181eeca3d75" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_a0e374a3-2f9f-4ce7-9ca8-7ad7bf7ca37f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_99ab6929-07f6-47ba-bbd3-28a6ea273b16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_a0e374a3-2f9f-4ce7-9ca8-7ad7bf7ca37f" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_99ab6929-07f6-47ba-bbd3-28a6ea273b16" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_26d3d4e6-6d86-40dd-b39e-69a91db0d7d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_dececa82-a419-4cb1-9ea3-0a5bc3ac10e6" xlink:to="loc_us-gaap_HedgingDesignationAxis_26d3d4e6-6d86-40dd-b39e-69a91db0d7d0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_26d3d4e6-6d86-40dd-b39e-69a91db0d7d0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_26d3d4e6-6d86-40dd-b39e-69a91db0d7d0" xlink:to="loc_us-gaap_HedgingDesignationDomain_26d3d4e6-6d86-40dd-b39e-69a91db0d7d0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_297fdb4e-dc17-4b17-a898-7ab0446c999b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_26d3d4e6-6d86-40dd-b39e-69a91db0d7d0" xlink:to="loc_us-gaap_HedgingDesignationDomain_297fdb4e-dc17-4b17-a898-7ab0446c999b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_7855b5d0-12c1-40e8-8374-3d1b0a66ba6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_297fdb4e-dc17-4b17-a898-7ab0446c999b" xlink:to="loc_us-gaap_NondesignatedMember_7855b5d0-12c1-40e8-8374-3d1b0a66ba6d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_b3de36d9-31a2-4006-a7ea-20a076433439" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_dececa82-a419-4cb1-9ea3-0a5bc3ac10e6" xlink:to="loc_us-gaap_DebtInstrumentAxis_b3de36d9-31a2-4006-a7ea-20a076433439" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_b3de36d9-31a2-4006-a7ea-20a076433439_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_b3de36d9-31a2-4006-a7ea-20a076433439" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_b3de36d9-31a2-4006-a7ea-20a076433439_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1a75f14e-42ee-48e8-a1e3-f357d2dfcc79" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_b3de36d9-31a2-4006-a7ea-20a076433439" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1a75f14e-42ee-48e8-a1e3-f357d2dfcc79" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TwoThousandTwentyOneCreditAgreementEuroTermLoanMember_3a02f507-b054-4c84-a168-d1ee5a7336c5" xlink:href="jazz-20220930.xsd#jazz_TwoThousandTwentyOneCreditAgreementEuroTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_1a75f14e-42ee-48e8-a1e3-f357d2dfcc79" xlink:to="loc_jazz_TwoThousandTwentyOneCreditAgreementEuroTermLoanMember_3a02f507-b054-4c84-a168-d1ee5a7336c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_49fedd3b-d696-4b25-a3b0-c407b6e6426c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_dececa82-a419-4cb1-9ea3-0a5bc3ac10e6" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_49fedd3b-d696-4b25-a3b0-c407b6e6426c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_49fedd3b-d696-4b25-a3b0-c407b6e6426c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_49fedd3b-d696-4b25-a3b0-c407b6e6426c" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_49fedd3b-d696-4b25-a3b0-c407b6e6426c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_d5b8336c-dadb-4e3e-ba9f-4a287fe201a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_49fedd3b-d696-4b25-a3b0-c407b6e6426c" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_d5b8336c-dadb-4e3e-ba9f-4a287fe201a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_3cf16c88-1939-4c9d-94b8-32a7b86f93d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_d5b8336c-dadb-4e3e-ba9f-4a287fe201a5" xlink:to="loc_us-gaap_LineOfCreditMember_3cf16c88-1939-4c9d-94b8-32a7b86f93d3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesCrossCurrencyLossDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DerivativeInstrumentsandHedgingActivitiesCrossCurrencyLossDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesCrossCurrencyLossDerivativeInstrumentsDetails" xlink:type="extended" id="i1e8a2bfd8c8240a7862140aeaeb3eb77_DerivativeInstrumentsandHedgingActivitiesCrossCurrencyLossDerivativeInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7d08a65f-b643-4987-a9ca-9cb1d040c531" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossFinancialLiabilityFairValueOptionAfterTaxAndReclassificationAdjustment_fc983d44-5f9c-4779-af0d-904606fcb689" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossFinancialLiabilityFairValueOptionAfterTaxAndReclassificationAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7d08a65f-b643-4987-a9ca-9cb1d040c531" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossFinancialLiabilityFairValueOptionAfterTaxAndReclassificationAdjustment_fc983d44-5f9c-4779-af0d-904606fcb689" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_0dbf620a-d72b-4f02-9481-fef5f23e8545" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7d08a65f-b643-4987-a9ca-9cb1d040c531" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_0dbf620a-d72b-4f02-9481-fef5f23e8545" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings_317f804e-4eb2-49f9-b66f-d5a44fe182c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7d08a65f-b643-4987-a9ca-9cb1d040c531" xlink:to="loc_us-gaap_GainLossOnFairValueHedgesRecognizedInEarnings_317f804e-4eb2-49f9-b66f-d5a44fe182c7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_c6e3fc87-f170-4da3-9320-37a46ff396eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_7d08a65f-b643-4987-a9ca-9cb1d040c531" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_c6e3fc87-f170-4da3-9320-37a46ff396eb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_b8913822-4831-422d-bca4-dc5c2343fd4c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_c6e3fc87-f170-4da3-9320-37a46ff396eb" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_b8913822-4831-422d-bca4-dc5c2343fd4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b8913822-4831-422d-bca4-dc5c2343fd4c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b8913822-4831-422d-bca4-dc5c2343fd4c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b8913822-4831-422d-bca4-dc5c2343fd4c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_99d88321-963b-48b5-bed6-21e4996dd655" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_b8913822-4831-422d-bca4-dc5c2343fd4c" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_99d88321-963b-48b5-bed6-21e4996dd655" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_274f430e-e00c-43bb-934b-5c3746924d0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_99d88321-963b-48b5-bed6-21e4996dd655" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_274f430e-e00c-43bb-934b-5c3746924d0e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_bc1ac673-a29a-42e3-a2e0-ae0838e68773" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_c6e3fc87-f170-4da3-9320-37a46ff396eb" xlink:to="loc_us-gaap_HedgingDesignationAxis_bc1ac673-a29a-42e3-a2e0-ae0838e68773" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_bc1ac673-a29a-42e3-a2e0-ae0838e68773_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_bc1ac673-a29a-42e3-a2e0-ae0838e68773" xlink:to="loc_us-gaap_HedgingDesignationDomain_bc1ac673-a29a-42e3-a2e0-ae0838e68773_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_0454d715-02b6-41f2-a45c-f08368db309c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_bc1ac673-a29a-42e3-a2e0-ae0838e68773" xlink:to="loc_us-gaap_HedgingDesignationDomain_0454d715-02b6-41f2-a45c-f08368db309c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_a2ac19dc-c73a-4c35-b213-bd1e77b46588" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_0454d715-02b6-41f2-a45c-f08368db309c" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_a2ac19dc-c73a-4c35-b213-bd1e77b46588" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails" xlink:type="extended" id="i3a3c83b762684c3abd040f9ca2f2fe87_DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_e17e7795-c8c7-4a22-aef5-823058d8f689" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_48c5e861-df90-4194-a896-21674eca6157" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_e17e7795-c8c7-4a22-aef5-823058d8f689" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_48c5e861-df90-4194-a896-21674eca6157" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_5fe72820-f334-457a-8017-4fe8ad0cf8f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_e17e7795-c8c7-4a22-aef5-823058d8f689" xlink:to="loc_us-gaap_DerivativeTable_5fe72820-f334-457a-8017-4fe8ad0cf8f5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_66fcb890-62d9-49f2-891c-b7daba9499f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_5fe72820-f334-457a-8017-4fe8ad0cf8f5" xlink:to="loc_us-gaap_HedgingDesignationAxis_66fcb890-62d9-49f2-891c-b7daba9499f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_66fcb890-62d9-49f2-891c-b7daba9499f7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_66fcb890-62d9-49f2-891c-b7daba9499f7" xlink:to="loc_us-gaap_HedgingDesignationDomain_66fcb890-62d9-49f2-891c-b7daba9499f7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_1566cf3d-0beb-4765-96fc-6d9244717923" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_66fcb890-62d9-49f2-891c-b7daba9499f7" xlink:to="loc_us-gaap_HedgingDesignationDomain_1566cf3d-0beb-4765-96fc-6d9244717923" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_3eb9de54-930b-48e8-b830-71627592354a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_1566cf3d-0beb-4765-96fc-6d9244717923" xlink:to="loc_us-gaap_NondesignatedMember_3eb9de54-930b-48e8-b830-71627592354a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_cab75613-26ae-4582-8585-cb4331670ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_5fe72820-f334-457a-8017-4fe8ad0cf8f5" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_cab75613-26ae-4582-8585-cb4331670ba9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_cab75613-26ae-4582-8585-cb4331670ba9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_cab75613-26ae-4582-8585-cb4331670ba9" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_cab75613-26ae-4582-8585-cb4331670ba9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_e9db2ab4-13f0-49b5-8b5e-9df51e5c7683" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_cab75613-26ae-4582-8585-cb4331670ba9" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_e9db2ab4-13f0-49b5-8b5e-9df51e5c7683" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_81b8eb76-c573-45e2-8fc0-418ec3654bbf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_e9db2ab4-13f0-49b5-8b5e-9df51e5c7683" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_81b8eb76-c573-45e2-8fc0-418ec3654bbf" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesGainLossonDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DerivativeInstrumentsandHedgingActivitiesGainLossonDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesGainLossonDerivativeInstrumentsDetails" xlink:type="extended" id="iab1fd74b3f014661894b9df260d08407_DerivativeInstrumentsandHedgingActivitiesGainLossonDerivativeInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_0d51d941-0a15-47be-bbdc-5e60a6e6f54f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_86a9d92a-577a-41d3-bde8-9b777b8a22f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_0d51d941-0a15-47be-bbdc-5e60a6e6f54f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_86a9d92a-577a-41d3-bde8-9b777b8a22f4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_21ac5129-5ee4-45a0-95e3-be75516b6c57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_0d51d941-0a15-47be-bbdc-5e60a6e6f54f" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_21ac5129-5ee4-45a0-95e3-be75516b6c57" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_be0af84e-6c73-4773-9e0a-2605c13123d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_0d51d941-0a15-47be-bbdc-5e60a6e6f54f" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_be0af84e-6c73-4773-9e0a-2605c13123d1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_20c857e5-db2a-43ca-bc89-194b4f3e4011" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_be0af84e-6c73-4773-9e0a-2605c13123d1" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_20c857e5-db2a-43ca-bc89-194b4f3e4011" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_20c857e5-db2a-43ca-bc89-194b4f3e4011_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_20c857e5-db2a-43ca-bc89-194b4f3e4011" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_20c857e5-db2a-43ca-bc89-194b4f3e4011_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_79008da6-16ff-422c-a1fa-91ceaafd103f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_20c857e5-db2a-43ca-bc89-194b4f3e4011" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_79008da6-16ff-422c-a1fa-91ceaafd103f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_7eb0b801-b633-4380-9eff-bcb204a8d137" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_79008da6-16ff-422c-a1fa-91ceaafd103f" xlink:to="loc_us-gaap_InterestRateContractMember_7eb0b801-b633-4380-9eff-bcb204a8d137" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7d68f83c-a7da-4805-bb92-835503cde456" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_be0af84e-6c73-4773-9e0a-2605c13123d1" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7d68f83c-a7da-4805-bb92-835503cde456" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_7d68f83c-a7da-4805-bb92-835503cde456_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7d68f83c-a7da-4805-bb92-835503cde456" xlink:to="loc_us-gaap_HedgingRelationshipDomain_7d68f83c-a7da-4805-bb92-835503cde456_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_1fb69ba5-2602-422d-b7cb-8e359e83a430" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_7d68f83c-a7da-4805-bb92-835503cde456" xlink:to="loc_us-gaap_HedgingRelationshipDomain_1fb69ba5-2602-422d-b7cb-8e359e83a430" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_5ea4f0c1-9117-4121-9fc6-ed5abd76ad00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_1fb69ba5-2602-422d-b7cb-8e359e83a430" xlink:to="loc_us-gaap_CashFlowHedgingMember_5ea4f0c1-9117-4121-9fc6-ed5abd76ad00" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails" xlink:type="extended" id="i96c3622ab27c4c37be252edf7f165609_DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_b631062c-e5cf-4d17-bb86-2b229667ec6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_2b215c04-8fbd-4fee-8f70-114c5d22d054" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_b631062c-e5cf-4d17-bb86-2b229667ec6f" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_2b215c04-8fbd-4fee-8f70-114c5d22d054" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_f81220be-d9f3-4f54-913d-e004cf7338ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_b631062c-e5cf-4d17-bb86-2b229667ec6f" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_f81220be-d9f3-4f54-913d-e004cf7338ce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_099a7fe9-cf69-4036-9a39-3966bafe6374" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_b631062c-e5cf-4d17-bb86-2b229667ec6f" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_099a7fe9-cf69-4036-9a39-3966bafe6374" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_de513db2-edcd-4c65-9570-f18827c8dc37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_099a7fe9-cf69-4036-9a39-3966bafe6374" xlink:to="loc_us-gaap_HedgingDesignationAxis_de513db2-edcd-4c65-9570-f18827c8dc37" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_de513db2-edcd-4c65-9570-f18827c8dc37_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_de513db2-edcd-4c65-9570-f18827c8dc37" xlink:to="loc_us-gaap_HedgingDesignationDomain_de513db2-edcd-4c65-9570-f18827c8dc37_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_519aefdc-9fd2-4119-99da-dd1ec9c08b95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_de513db2-edcd-4c65-9570-f18827c8dc37" xlink:to="loc_us-gaap_HedgingDesignationDomain_519aefdc-9fd2-4119-99da-dd1ec9c08b95" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_02e4aee0-06e5-48eb-ba2e-997cbf58e13a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_519aefdc-9fd2-4119-99da-dd1ec9c08b95" xlink:to="loc_us-gaap_NondesignatedMember_02e4aee0-06e5-48eb-ba2e-997cbf58e13a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_8e009e22-2c1d-49dd-a08d-8444b8148f5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_519aefdc-9fd2-4119-99da-dd1ec9c08b95" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_8e009e22-2c1d-49dd-a08d-8444b8148f5e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_54fb532f-c1df-4f18-afd4-d1377c7a5a5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_099a7fe9-cf69-4036-9a39-3966bafe6374" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_54fb532f-c1df-4f18-afd4-d1377c7a5a5f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_54fb532f-c1df-4f18-afd4-d1377c7a5a5f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_54fb532f-c1df-4f18-afd4-d1377c7a5a5f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_54fb532f-c1df-4f18-afd4-d1377c7a5a5f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_beaa63da-5a48-4ad7-941d-8cc43aa432bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_54fb532f-c1df-4f18-afd4-d1377c7a5a5f" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_beaa63da-5a48-4ad7-941d-8cc43aa432bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_790af744-a5a7-4d56-8939-9858f36eec1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_beaa63da-5a48-4ad7-941d-8cc43aa432bc" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_790af744-a5a7-4d56-8939-9858f36eec1f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CrossCurrencyInterestRateContractMember_18301d8a-5ea8-4077-8921-d6fea1e46140" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_beaa63da-5a48-4ad7-941d-8cc43aa432bc" xlink:to="loc_us-gaap_CrossCurrencyInterestRateContractMember_18301d8a-5ea8-4077-8921-d6fea1e46140" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_5c657659-f21e-450f-a408-1eccbd467909" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_099a7fe9-cf69-4036-9a39-3966bafe6374" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_5c657659-f21e-450f-a408-1eccbd467909" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_5c657659-f21e-450f-a408-1eccbd467909_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_5c657659-f21e-450f-a408-1eccbd467909" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_5c657659-f21e-450f-a408-1eccbd467909_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_fa07ff89-16e3-4686-8340-88b1531fc832" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_5c657659-f21e-450f-a408-1eccbd467909" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_fa07ff89-16e3-4686-8340-88b1531fc832" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentAssetsMember_c935709a-4172-426c-8d84-5bba80f804aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_fa07ff89-16e3-4686-8340-88b1531fc832" xlink:to="loc_us-gaap_OtherCurrentAssetsMember_c935709a-4172-426c-8d84-5bba80f804aa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_66303f78-a744-49a6-8b98-00f5a4c7680f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_fa07ff89-16e3-4686-8340-88b1531fc832" xlink:to="loc_us-gaap_AccruedLiabilitiesMember_66303f78-a744-49a6-8b98-00f5a4c7680f" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails" xlink:type="extended" id="ifd6338edfabf47f48b1105f2d4d62d6e_DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsLineItems_a2d95070-9a5e-4571-b171-ed9982f425cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OffsettingAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsAbstract_009e233d-f964-466d-878f-a88746434331" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_a2d95070-9a5e-4571-b171-ed9982f425cd" xlink:to="loc_us-gaap_DerivativeAssetsAbstract_009e233d-f964-466d-878f-a88746434331" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_d08f842c-4d62-43af-ab1f-caceb26a8822" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_009e233d-f964-466d-878f-a88746434331" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_d08f842c-4d62-43af-ab1f-caceb26a8822" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossLiability_85b59567-adcc-4a56-b3b7-5998630b653e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetFairValueGrossLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_009e233d-f964-466d-878f-a88746434331" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossLiability_85b59567-adcc-4a56-b3b7-5998630b653e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_c366068e-ab1d-4dc0-a45d-03ae53c27543" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_009e233d-f964-466d-878f-a88746434331" xlink:to="loc_us-gaap_DerivativeAssets_c366068e-ab1d-4dc0-a45d-03ae53c27543" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_871c8ddb-18f3-451f-ada4-0faba40fbac1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_a2d95070-9a5e-4571-b171-ed9982f425cd" xlink:to="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_871c8ddb-18f3-451f-ada4-0faba40fbac1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_f8c3d9f4-dc9c-4b94-93d1-fec46f67c829" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralObligationToReturnSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_871c8ddb-18f3-451f-ada4-0faba40fbac1" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_f8c3d9f4-dc9c-4b94-93d1-fec46f67c829" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_ce61c134-3e68-47f0-b607-9484d6623888" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_871c8ddb-18f3-451f-ada4-0faba40fbac1" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_ce61c134-3e68-47f0-b607-9484d6623888" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_a1465b30-734e-4711-a56e-4e036b029508" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_871c8ddb-18f3-451f-ada4-0faba40fbac1" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_a1465b30-734e-4711-a56e-4e036b029508" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsTable_3648f9ce-5629-42b8-8530-7bfb204fe1ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OffsettingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_a2d95070-9a5e-4571-b171-ed9982f425cd" xlink:to="loc_us-gaap_OffsettingAssetsTable_3648f9ce-5629-42b8-8530-7bfb204fe1ef" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_3a977c70-2cee-4939-bfaa-fb5e5568ed86" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingAssetsTable_3648f9ce-5629-42b8-8530-7bfb204fe1ef" xlink:to="loc_srt_StatementScenarioAxis_3a977c70-2cee-4939-bfaa-fb5e5568ed86" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_3a977c70-2cee-4939-bfaa-fb5e5568ed86_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_3a977c70-2cee-4939-bfaa-fb5e5568ed86" xlink:to="loc_srt_ScenarioUnspecifiedDomain_3a977c70-2cee-4939-bfaa-fb5e5568ed86_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_b30f9792-da48-48f8-8ead-064dd03bf8e5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_3a977c70-2cee-4939-bfaa-fb5e5568ed86" xlink:to="loc_srt_ScenarioUnspecifiedDomain_b30f9792-da48-48f8-8ead-064dd03bf8e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProFormaMember_da0cdaea-3805-415e-8614-49805e4ee5e6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProFormaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_b30f9792-da48-48f8-8ead-064dd03bf8e5" xlink:to="loc_srt_ProFormaMember_da0cdaea-3805-415e-8614-49805e4ee5e6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesLineItems_66cd6935-78bb-4e35-afad-286326d29ea9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OffsettingLiabilitiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesAbstract_058d5d12-b59d-4a72-b6c4-c4d8b3679040" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_66cd6935-78bb-4e35-afad-286326d29ea9" xlink:to="loc_us-gaap_DerivativeLiabilitiesAbstract_058d5d12-b59d-4a72-b6c4-c4d8b3679040" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_5321d0c3-fba6-4b19-ba25-3115f894434c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_058d5d12-b59d-4a72-b6c4-c4d8b3679040" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_5321d0c3-fba6-4b19-ba25-3115f894434c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_fc909dd7-e717-4d6f-8bea-cd4cfedbe2e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityFairValueGrossAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_058d5d12-b59d-4a72-b6c4-c4d8b3679040" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_fc909dd7-e717-4d6f-8bea-cd4cfedbe2e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_2eb67f42-57ba-4e1b-b72c-d05b9fde66d7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_058d5d12-b59d-4a72-b6c4-c4d8b3679040" xlink:to="loc_us-gaap_DerivativeLiabilities_2eb67f42-57ba-4e1b-b72c-d05b9fde66d7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_4b89d122-f7e5-4786-b36c-33e5738e4f9a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_66cd6935-78bb-4e35-afad-286326d29ea9" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_4b89d122-f7e5-4786-b36c-33e5738e4f9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_98311031-0a9e-4d1b-95ab-3964874c35b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralRightToReclaimSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_4b89d122-f7e5-4786-b36c-33e5738e4f9a" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_98311031-0a9e-4d1b-95ab-3964874c35b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_30474fbb-57e8-4f37-b063-fe502d6ef040" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_4b89d122-f7e5-4786-b36c-33e5738e4f9a" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_30474fbb-57e8-4f37-b063-fe502d6ef040" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_1426dc76-35d1-4f9e-97a1-dcd40f43f35c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_4b89d122-f7e5-4786-b36c-33e5738e4f9a" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_1426dc76-35d1-4f9e-97a1-dcd40f43f35c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesTable_5cc73044-19c7-4517-815b-f25fd5a52729" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OffsettingLiabilitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_66cd6935-78bb-4e35-afad-286326d29ea9" xlink:to="loc_us-gaap_OffsettingLiabilitiesTable_5cc73044-19c7-4517-815b-f25fd5a52729" xlink:type="arc" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_00eb502c-ac0d-426b-8a2e-6c6d0cb2f941" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingLiabilitiesTable_5cc73044-19c7-4517-815b-f25fd5a52729" xlink:to="loc_srt_StatementScenarioAxis_00eb502c-ac0d-426b-8a2e-6c6d0cb2f941" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_00eb502c-ac0d-426b-8a2e-6c6d0cb2f941_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_e12fd3ee-49d9-47de-80ce-dee30f86e407" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProFormaMember_1fd09425-e5ad-45aa-a5ea-2bff38fa6e44" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProFormaMember"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/InventoriesComponentsofInventoriesDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#InventoriesComponentsofInventoriesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/InventoriesComponentsofInventoriesDetails" xlink:type="extended" id="i7bb025b790a34bb2a1aac01a59ce6ae5_InventoriesComponentsofInventoriesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_9a36de7b-e322-4410-b917-19b03918a23e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_9a36de7b-e322-4410-b917-19b03918a23e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_db89c1c0-6514-4e93-8ba5-f969452bfa63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_db89c1c0-6514-4e93-8ba5-f969452bfa63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_aff7ed46-686c-40f3-bb96-5bb57d64a4f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_aff7ed46-686c-40f3-bb96-5bb57d64a4f0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_3db98c78-e43a-4141-ada4-ccd9ebb4fca1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:to="loc_us-gaap_InventoryNet_3db98c78-e43a-4141-ada4-ccd9ebb4fca1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InventoryStepUpValue_4447610a-7d77-41da-8edc-a7b11355b8f3" xlink:href="jazz-20220930.xsd#jazz_InventoryStepUpValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:to="loc_jazz_InventoryStepUpValue_4447610a-7d77-41da-8edc-a7b11355b8f3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_772f4386-cad4-485b-98df-808e60e92194" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryCurrentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_InventoryLineItems_fb343599-6d8f-45ab-b19f-ad7c88bc99ec" xlink:to="loc_us-gaap_InventoryCurrentTable_772f4386-cad4-485b-98df-808e60e92194" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_576470ca-62c3-41d9-9f8c-d425c04f51b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_InventoryCurrentTable_772f4386-cad4-485b-98df-808e60e92194" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_576470ca-62c3-41d9-9f8c-d425c04f51b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_576470ca-62c3-41d9-9f8c-d425c04f51b3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_576470ca-62c3-41d9-9f8c-d425c04f51b3" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_576470ca-62c3-41d9-9f8c-d425c04f51b3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38cead63-d9f2-4816-ac07-aacad3acc1b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_576470ca-62c3-41d9-9f8c-d425c04f51b3" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38cead63-d9f2-4816-ac07-aacad3acc1b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWPharmaceuticalsPlcMember_92b05658-1305-4059-ac66-9a942a061a7e" xlink:href="jazz-20220930.xsd#jazz_GWPharmaceuticalsPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_38cead63-d9f2-4816-ac07-aacad3acc1b9" xlink:to="loc_jazz_GWPharmaceuticalsPlcMember_92b05658-1305-4059-ac66-9a942a061a7e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails" xlink:type="extended" id="i88ad723a394f4be8a6b60ce17abd798a_GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d14d9af2-540d-45c4-a61b-68304d50cef7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_4efe684d-0861-4ca9-bf26-68d7f43f92f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d14d9af2-540d-45c4-a61b-68304d50cef7" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_4efe684d-0861-4ca9-bf26-68d7f43f92f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_f1c5af23-9600-4ca7-aa93-5388b21a5887" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d14d9af2-540d-45c4-a61b-68304d50cef7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_f1c5af23-9600-4ca7-aa93-5388b21a5887" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_039276e3-5271-46c8-b14b-0f386af3b16c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d14d9af2-540d-45c4-a61b-68304d50cef7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_039276e3-5271-46c8-b14b-0f386af3b16c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_94214ef9-81ec-4cdf-9e0e-ff4459b37823" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d14d9af2-540d-45c4-a61b-68304d50cef7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_94214ef9-81ec-4cdf-9e0e-ff4459b37823" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_47b2a051-6de1-4d7b-92ec-4cd1c383c122" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_d14d9af2-540d-45c4-a61b-68304d50cef7" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_47b2a051-6de1-4d7b-92ec-4cd1c383c122" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_05a9d09e-d41a-4eab-b38b-1863d27169b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_47b2a051-6de1-4d7b-92ec-4cd1c383c122" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_05a9d09e-d41a-4eab-b38b-1863d27169b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_05a9d09e-d41a-4eab-b38b-1863d27169b9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_05a9d09e-d41a-4eab-b38b-1863d27169b9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_05a9d09e-d41a-4eab-b38b-1863d27169b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bb74e487-c962-45aa-b191-bc5ff29217f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_05a9d09e-d41a-4eab-b38b-1863d27169b9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bb74e487-c962-45aa-b191-bc5ff29217f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_a0faea71-beb4-4c81-a00c-905a9d425706" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bb74e487-c962-45aa-b191-bc5ff29217f2" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_a0faea71-beb4-4c81-a00c-905a9d425706" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ManufacturingContractsMember_8dbc8ba8-adf0-42ca-8e50-ec5006020500" xlink:href="jazz-20220930.xsd#jazz_ManufacturingContractsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bb74e487-c962-45aa-b191-bc5ff29217f2" xlink:to="loc_jazz_ManufacturingContractsMember_8dbc8ba8-adf0-42ca-8e50-ec5006020500" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_c9da43b3-f5b9-4dff-91ca-eb7e4ec36d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_bb74e487-c962-45aa-b191-bc5ff29217f2" xlink:to="loc_us-gaap_TrademarksMember_c9da43b3-f5b9-4dff-91ca-eb7e4ec36d3d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b6b961d1-06a9-482a-9283-186b8c93f0a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_a4ba6b52-4c58-4d68-b907-c73ed9528b0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b6b961d1-06a9-482a-9283-186b8c93f0a7" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_a4ba6b52-4c58-4d68-b907-c73ed9528b0e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_6c0a628f-aa3e-45cb-afae-a9e7988bca7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b6b961d1-06a9-482a-9283-186b8c93f0a7" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_6c0a628f-aa3e-45cb-afae-a9e7988bca7d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_f9a2386c-6b66-476d-8ef7-1b695d8e73ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b6b961d1-06a9-482a-9283-186b8c93f0a7" xlink:to="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_f9a2386c-6b66-476d-8ef7-1b695d8e73ea" xlink:type="arc" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_f64a8dec-36bd-45b8-94e4-8d4cf157341d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_f9a2386c-6b66-476d-8ef7-1b695d8e73ea" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_f64a8dec-36bd-45b8-94e4-8d4cf157341d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f64a8dec-36bd-45b8-94e4-8d4cf157341d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_f64a8dec-36bd-45b8-94e4-8d4cf157341d" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f64a8dec-36bd-45b8-94e4-8d4cf157341d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_0ee707ae-4e49-4949-b008-a8ace03a6ee4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_f64a8dec-36bd-45b8-94e4-8d4cf157341d" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_0ee707ae-4e49-4949-b008-a8ace03a6ee4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InProcessResearchAndDevelopmentMember_019456e0-4fa5-451a-8e8c-87ce06c9d16a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InProcessResearchAndDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_0ee707ae-4e49-4949-b008-a8ace03a6ee4" xlink:to="loc_us-gaap_InProcessResearchAndDevelopmentMember_019456e0-4fa5-451a-8e8c-87ce06c9d16a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CertainBalanceSheetItemsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#CertainBalanceSheetItemsPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CertainBalanceSheetItemsPropertyandEquipmentDetails" xlink:type="extended" id="i8cb4f65a113546bb99933cabf148a2ea_CertainBalanceSheetItemsPropertyandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_b304dd1a-2bd9-4abf-a7ae-2dea1dbcd52e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_b5edf9ee-71d1-443e-8103-9e66806f0597" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_b304dd1a-2bd9-4abf-a7ae-2dea1dbcd52e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_b5edf9ee-71d1-443e-8103-9e66806f0597" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_4113da83-1270-4d45-ad92-c49b0462bf22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_b304dd1a-2bd9-4abf-a7ae-2dea1dbcd52e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_4113da83-1270-4d45-ad92-c49b0462bf22" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0909e8a5-5b7d-4e1a-8b51-af4bdc0a8142" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_b304dd1a-2bd9-4abf-a7ae-2dea1dbcd52e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_0909e8a5-5b7d-4e1a-8b51-af4bdc0a8142" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_fb6b2277-3ec7-4c67-b881-7cd37d37153e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_b304dd1a-2bd9-4abf-a7ae-2dea1dbcd52e" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_fb6b2277-3ec7-4c67-b881-7cd37d37153e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_69074ce5-3ad4-4ab3-b0c3-d15f6c4ac5d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_fb6b2277-3ec7-4c67-b881-7cd37d37153e" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_69074ce5-3ad4-4ab3-b0c3-d15f6c4ac5d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_69074ce5-3ad4-4ab3-b0c3-d15f6c4ac5d1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_69074ce5-3ad4-4ab3-b0c3-d15f6c4ac5d1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_69074ce5-3ad4-4ab3-b0c3-d15f6c4ac5d1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_69074ce5-3ad4-4ab3-b0c3-d15f6c4ac5d1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_04057150-a334-4352-9fd9-2a3144261841" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_04057150-a334-4352-9fd9-2a3144261841" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_044d7240-9696-46e0-8153-16d5d5d931ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_ConstructionInProgressMember_044d7240-9696-46e0-8153-16d5d5d931ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandAndBuildingMember_c6acfe7e-cc1f-41ae-91f2-fd34d13dfbdb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LandAndBuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_LandAndBuildingMember_c6acfe7e-cc1f-41ae-91f2-fd34d13dfbdb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_21d55bd0-e8d5-47f7-bcfb-72fab15dba1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_21d55bd0-e8d5-47f7-bcfb-72fab15dba1f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_a1c5b602-a404-4bba-b538-0c8161a6d505" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_a1c5b602-a404-4bba-b538-0c8161a6d505" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_ba2ca52e-d6b4-4fcd-8cbb-1e4106677e07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_ComputerEquipmentMember_ba2ca52e-d6b4-4fcd-8cbb-1e4106677e07" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_f74f0cd0-bc21-414a-be7c-6e6bebd04b71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b4211e51-5af5-40ab-bc47-5106d2f3d1a6" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_f74f0cd0-bc21-414a-be7c-6e6bebd04b71" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtScheduleofLongtermDebtDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DebtScheduleofLongtermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtScheduleofLongtermDebtDetails" xlink:type="extended" id="ie04a0d3aaa934ac78a628bb68d8f76b2_DebtScheduleofLongtermDebtDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_810264a6-3caa-44b5-ba6e-8ee3250bc1fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_810264a6-3caa-44b5-ba6e-8ee3250bc1fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_4e7664e7-c580-4d58-a118-89bab1499db1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_4e7664e7-c580-4d58-a118-89bab1499db1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_a6801517-32a8-4525-b09d-7f99820c0226" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_a6801517-32a8-4525-b09d-7f99820c0226" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_fd253c1b-9d86-4330-bebb-606736d2e404" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_LongTermDebt_fd253c1b-9d86-4330-bebb-606736d2e404" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_773f0f2a-c2cc-477b-9227-4b5399fdabea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_LongTermDebtCurrent_773f0f2a-c2cc-477b-9227-4b5399fdabea" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_2863ec72-242f-48c0-96cd-0dfa7ab5a966" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_2863ec72-242f-48c0-96cd-0dfa7ab5a966" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_6ece94cb-55aa-414d-aedc-5e9a005671f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_DebtInstrumentTerm_6ece94cb-55aa-414d-aedc-5e9a005671f7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_23341057-a7db-428c-88fe-dc1855729f34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_23341057-a7db-428c-88fe-dc1855729f34" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_ddf39f39-5246-4899-9c3d-e0d5c836385c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_ddf39f39-5246-4899-9c3d-e0d5c836385c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_e570e5c3-9d9d-44e7-ba4f-b06452712a36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_b352f750-99d6-497a-b128-8124bc4d5739" xlink:to="loc_us-gaap_DebtInstrumentTable_e570e5c3-9d9d-44e7-ba4f-b06452712a36" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_33606861-a82a-4356-86cc-ada62d2f7b99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e570e5c3-9d9d-44e7-ba4f-b06452712a36" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_33606861-a82a-4356-86cc-ada62d2f7b99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_33606861-a82a-4356-86cc-ada62d2f7b99_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_33606861-a82a-4356-86cc-ada62d2f7b99" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_33606861-a82a-4356-86cc-ada62d2f7b99_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_de24d2f5-4677-4348-97ba-ce1b6a96f013" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_33606861-a82a-4356-86cc-ada62d2f7b99" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_de24d2f5-4677-4348-97ba-ce1b6a96f013" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_19082e36-965f-495a-97fa-92c81bc919ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_de24d2f5-4677-4348-97ba-ce1b6a96f013" xlink:to="loc_us-gaap_ConvertibleDebtMember_19082e36-965f-495a-97fa-92c81bc919ab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_38d2aafd-5c01-495c-8fad-ac88f41851e1" xlink:href="jazz-20220930.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_de24d2f5-4677-4348-97ba-ce1b6a96f013" xlink:to="loc_jazz_TermLoanMember_38d2aafd-5c01-495c-8fad-ac88f41851e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_77f9c97e-617a-4700-af96-90b370067450" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_de24d2f5-4677-4348-97ba-ce1b6a96f013" xlink:to="loc_us-gaap_LineOfCreditMember_77f9c97e-617a-4700-af96-90b370067450" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_1392cd58-6d75-417c-815e-186d81182784" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e570e5c3-9d9d-44e7-ba4f-b06452712a36" xlink:to="loc_us-gaap_DebtInstrumentAxis_1392cd58-6d75-417c-815e-186d81182784" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_1392cd58-6d75-417c-815e-186d81182784_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_1392cd58-6d75-417c-815e-186d81182784" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_1392cd58-6d75-417c-815e-186d81182784_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_1392cd58-6d75-417c-815e-186d81182784" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_32a8c2e0-4623-4b16-bca4-a18b41840460" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_32a8c2e0-4623-4b16-bca4-a18b41840460" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_4b3de2ad-ee0a-42be-b13e-1a93c09241e9" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_4b3de2ad-ee0a-42be-b13e-1a93c09241e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorNotesDue2029Member_eb9bcf81-bf17-4652-b3c8-4c86a0baf6fd" xlink:href="jazz-20220930.xsd#jazz_SeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:to="loc_jazz_SeniorNotesDue2029Member_eb9bcf81-bf17-4652-b3c8-4c86a0baf6fd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TwoThousandTwentyOneCreditAgreementRevolvingCreditFacilityMember_7088b4cc-5ebe-4791-b7a4-2c3b91e0ed0c" xlink:href="jazz-20220930.xsd#jazz_TwoThousandTwentyOneCreditAgreementRevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:to="loc_jazz_TwoThousandTwentyOneCreditAgreementRevolvingCreditFacilityMember_7088b4cc-5ebe-4791-b7a4-2c3b91e0ed0c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember_8d424e60-a758-43e5-b2b9-b5b49a023e1d" xlink:href="jazz-20220930.xsd#jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_c0494090-762b-4553-850d-4b891eeab088" xlink:to="loc_jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember_8d424e60-a758-43e5-b2b9-b5b49a023e1d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_84bb05c7-0cb8-48ac-8461-b63f7055f128" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_e570e5c3-9d9d-44e7-ba4f-b06452712a36" xlink:to="loc_us-gaap_CreditFacilityAxis_84bb05c7-0cb8-48ac-8461-b63f7055f128" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_84bb05c7-0cb8-48ac-8461-b63f7055f128_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_84bb05c7-0cb8-48ac-8461-b63f7055f128" xlink:to="loc_us-gaap_CreditFacilityDomain_84bb05c7-0cb8-48ac-8461-b63f7055f128_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_10d96cbd-ab83-45aa-9548-7fb72f012c13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_84bb05c7-0cb8-48ac-8461-b63f7055f128" xlink:to="loc_us-gaap_CreditFacilityDomain_10d96cbd-ab83-45aa-9548-7fb72f012c13" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_17b183b4-9309-42bf-a127-9933ca7b672d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_10d96cbd-ab83-45aa-9548-7fb72f012c13" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_17b183b4-9309-42bf-a127-9933ca7b672d" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtExchangeableSeniorNotesDue2026NarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DebtExchangeableSeniorNotesDue2026NarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtExchangeableSeniorNotesDue2026NarrativeDetails" xlink:type="extended" id="i94f855488de848428b8ae6f227b0b806_DebtExchangeableSeniorNotesDue2026NarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_bf269ced-2cd7-4ec8-a3b7-0a06cb99696b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_bf269ced-2cd7-4ec8-a3b7-0a06cb99696b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_a3c9906b-a54d-430d-bd17-c73faf99fab8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_a3c9906b-a54d-430d-bd17-c73faf99fab8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_62359bcf-a040-4572-94b6-d1208c121b06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_62359bcf-a040-4572-94b6-d1208c121b06" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_aabee523-e45d-4e48-90f0-132c72cd94c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_aabee523-e45d-4e48-90f0-132c72cd94c1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_496eff56-1f32-44a9-9cb2-2c3e954e084d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_496eff56-1f32-44a9-9cb2-2c3e954e084d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_44e9e4f4-a624-46c7-b9f7-1694bd8ba05e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_44e9e4f4-a624-46c7-b9f7-1694bd8ba05e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_97d75202-2a99-4db1-affc-7c2fcf329d62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_97d75202-2a99-4db1-affc-7c2fcf329d62" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_7b999b35-91b9-45e4-baae-a35402042c2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_7b999b35-91b9-45e4-baae-a35402042c2a" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_206b16f7-41d8-4a8c-9523-589dcc68dce3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_206b16f7-41d8-4a8c-9523-589dcc68dce3" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_58c19d70-dd29-47b2-b7ee-f70981ed27b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_InterestExpenseDebt_58c19d70-dd29-47b2-b7ee-f70981ed27b2" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InterestExpenseDebtContractualCouponRate_eb52bed7-65e6-4db6-b698-4a54df967bd1" xlink:href="jazz-20220930.xsd#jazz_InterestExpenseDebtContractualCouponRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_jazz_InterestExpenseDebtContractualCouponRate_eb52bed7-65e6-4db6-b698-4a54df967bd1" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_b858e384-98bc-4419-be8e-4f4a847a295c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_b858e384-98bc-4419-be8e-4f4a847a295c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_255df267-1abe-4088-bb09-0a07ffe66fde" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_afff7c39-9547-4d11-b5ce-756c9fa71164" xlink:to="loc_us-gaap_DebtInstrumentTable_255df267-1abe-4088-bb09-0a07ffe66fde" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_3be578e8-d3ce-4e56-8d91-3a07f17b64db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_255df267-1abe-4088-bb09-0a07ffe66fde" xlink:to="loc_us-gaap_DebtInstrumentAxis_3be578e8-d3ce-4e56-8d91-3a07f17b64db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3be578e8-d3ce-4e56-8d91-3a07f17b64db_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_3be578e8-d3ce-4e56-8d91-3a07f17b64db" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3be578e8-d3ce-4e56-8d91-3a07f17b64db_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_83763a3d-7e6e-4ecc-b4cb-5937e05f2842" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_3be578e8-d3ce-4e56-8d91-3a07f17b64db" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_83763a3d-7e6e-4ecc-b4cb-5937e05f2842" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_ff724da9-7d8c-44bb-be44-348ae8ef5aab" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_83763a3d-7e6e-4ecc-b4cb-5937e05f2842" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_ff724da9-7d8c-44bb-be44-348ae8ef5aab" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_e5f482cd-a907-44dc-8dec-dd43300ff3c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_255df267-1abe-4088-bb09-0a07ffe66fde" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_e5f482cd-a907-44dc-8dec-dd43300ff3c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_e5f482cd-a907-44dc-8dec-dd43300ff3c2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_e5f482cd-a907-44dc-8dec-dd43300ff3c2" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_e5f482cd-a907-44dc-8dec-dd43300ff3c2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_61cd8012-eff0-4781-a8ed-d605a94c2b56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_e5f482cd-a907-44dc-8dec-dd43300ff3c2" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_61cd8012-eff0-4781-a8ed-d605a94c2b56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_e997ad88-532d-4ff5-beb0-245ef42d9c59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_61cd8012-eff0-4781-a8ed-d605a94c2b56" xlink:to="loc_us-gaap_ConvertibleDebtMember_e997ad88-532d-4ff5-beb0-245ef42d9c59" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtExchangeableSeniorNotesDue2024NarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#DebtExchangeableSeniorNotesDue2024NarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtExchangeableSeniorNotesDue2024NarrativeDetails" xlink:type="extended" id="i28a64f021d6741d3a57c4eb08570e77d_DebtExchangeableSeniorNotesDue2024NarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_f9dcff75-9187-4403-87d8-835404b02fdb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_f9dcff75-9187-4403-87d8-835404b02fdb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_140e5bfb-e954-4eef-bdd3-2585a5686ef9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_140e5bfb-e954-4eef-bdd3-2585a5686ef9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_f95adbdb-43f2-4c38-8b7a-ed0f9d9b80f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_f95adbdb-43f2-4c38-8b7a-ed0f9d9b80f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_88e100bf-02db-49b9-8fc9-56bf52567805" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_88e100bf-02db-49b9-8fc9-56bf52567805" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_324bcfaa-16b0-4e67-88ce-6570316e3b85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_324bcfaa-16b0-4e67-88ce-6570316e3b85" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_856b7e58-e01c-4564-8d9a-7978a1a946b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_856b7e58-e01c-4564-8d9a-7978a1a946b2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_6467a5aa-9811-4d47-9a9e-432835591408" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_6467a5aa-9811-4d47-9a9e-432835591408" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_1a6d9b7f-ddb3-49d7-aea6-bf8d2236d624" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_1a6d9b7f-ddb3-49d7-aea6-bf8d2236d624" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_ef81d544-791d-4be7-893f-8082253bb90b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_ef81d544-791d-4be7-893f-8082253bb90b" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_b9494fcd-63a5-4af2-9334-0885fbf61af5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_InterestExpenseDebt_b9494fcd-63a5-4af2-9334-0885fbf61af5" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InterestExpenseDebtContractualCouponRate_554a74fe-63d8-485e-87de-72460c52e83f" xlink:href="jazz-20220930.xsd#jazz_InterestExpenseDebtContractualCouponRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_jazz_InterestExpenseDebtContractualCouponRate_554a74fe-63d8-485e-87de-72460c52e83f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_a6b1b15c-474d-4e7a-9c1a-47d2ba151fd0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_a6b1b15c-474d-4e7a-9c1a-47d2ba151fd0" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_4d86889a-07a7-4806-82ed-886664db41df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_4d86889a-07a7-4806-82ed-886664db41df" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_2aec7929-7fed-4742-9b5e-322aea7e5b91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_121789c4-86c6-4697-b877-c20f32bbecd5" xlink:to="loc_us-gaap_DebtInstrumentTable_2aec7929-7fed-4742-9b5e-322aea7e5b91" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_705af4ad-5ff8-44f1-952b-d83312c2d394" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_2aec7929-7fed-4742-9b5e-322aea7e5b91" xlink:to="loc_us-gaap_DebtInstrumentAxis_705af4ad-5ff8-44f1-952b-d83312c2d394" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_705af4ad-5ff8-44f1-952b-d83312c2d394_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_705af4ad-5ff8-44f1-952b-d83312c2d394" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_705af4ad-5ff8-44f1-952b-d83312c2d394_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_25d152ed-6bc8-4809-a680-271ba5cbc50a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_705af4ad-5ff8-44f1-952b-d83312c2d394" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_25d152ed-6bc8-4809-a680-271ba5cbc50a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_a52a5398-f0ce-47ce-a8ab-204c9b05d201" xlink:href="jazz-20220930.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_25d152ed-6bc8-4809-a680-271ba5cbc50a" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_a52a5398-f0ce-47ce-a8ab-204c9b05d201" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_f66e6c44-2436-43b6-bb17-998466e3520f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_2aec7929-7fed-4742-9b5e-322aea7e5b91" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_f66e6c44-2436-43b6-bb17-998466e3520f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f66e6c44-2436-43b6-bb17-998466e3520f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_f66e6c44-2436-43b6-bb17-998466e3520f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f66e6c44-2436-43b6-bb17-998466e3520f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1c5fc926-bfb7-41be-bd5d-b0a6946cd2e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_f66e6c44-2436-43b6-bb17-998466e3520f" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1c5fc926-bfb7-41be-bd5d-b0a6946cd2e9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_6f3c9b55-3fbb-4d9b-89eb-da87ca50df54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_1c5fc926-bfb7-41be-bd5d-b0a6946cd2e9" xlink:to="loc_us-gaap_ConvertibleDebtMember_6f3c9b55-3fbb-4d9b-89eb-da87ca50df54" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_2f7c93f7-23f0-4f14-a87c-6d81839b81df" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_2aec7929-7fed-4742-9b5e-322aea7e5b91" xlink:to="loc_srt_OwnershipAxis_2f7c93f7-23f0-4f14-a87c-6d81839b81df" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_2f7c93f7-23f0-4f14-a87c-6d81839b81df_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_2f7c93f7-23f0-4f14-a87c-6d81839b81df" xlink:to="loc_srt_OwnershipDomain_2f7c93f7-23f0-4f14-a87c-6d81839b81df_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_17da2728-db5d-417a-b92e-48873b18c29c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_2f7c93f7-23f0-4f14-a87c-6d81839b81df" xlink:to="loc_srt_OwnershipDomain_17da2728-db5d-417a-b92e-48873b18c29c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_JazzInvestmentsILimitedMember_1f660b13-c133-426b-a5e8-eb7486185fbb" xlink:href="jazz-20220930.xsd#jazz_JazzInvestmentsILimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_17da2728-db5d-417a-b92e-48873b18c29c" xlink:to="loc_jazz_JazzInvestmentsILimitedMember_1f660b13-c133-426b-a5e8-eb7486185fbb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended" id="i6e9d03b9dea04867837914283d06b54a_CommitmentsandContingenciesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseCommitmentRemainingMinimumAmountCommitted_06880c44-5038-44c8-92c6-d2f93d9c387e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PurchaseCommitmentRemainingMinimumAmountCommitted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_us-gaap_PurchaseCommitmentRemainingMinimumAmountCommitted_06880c44-5038-44c8-92c6-d2f93d9c387e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNewClaimsFiledNumber_9f1b1c64-d7f6-491d-9a9a-316e40ebc2b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingencyNewClaimsFiledNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_us-gaap_LossContingencyNewClaimsFiledNumber_9f1b1c64-d7f6-491d-9a9a-316e40ebc2b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InfringedPatentsSuitNumberOfPatents_229e1f16-7b03-453e-a511-cee1b6538533" xlink:href="jazz-20220930.xsd#jazz_InfringedPatentsSuitNumberOfPatents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_jazz_InfringedPatentsSuitNumberOfPatents_229e1f16-7b03-453e-a511-cee1b6538533" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted_0d6e6862-fd63-4e82-a0c4-bc62ecacdb9c" xlink:href="jazz-20220930.xsd#jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted_0d6e6862-fd63-4e82-a0c4-bc62ecacdb9c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FDAStayOfApprovalPeriod_c12497a6-70b7-41ec-ab47-84b167f5edc7" xlink:href="jazz-20220930.xsd#jazz_FDAStayOfApprovalPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_jazz_FDAStayOfApprovalPeriod_c12497a6-70b7-41ec-ab47-84b167f5edc7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FDARecognitionOfOrphanDrugExclusivityPeriod_1cabd11a-2408-4da1-b182-43f60856df79" xlink:href="jazz-20220930.xsd#jazz_FDARecognitionOfOrphanDrugExclusivityPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_jazz_FDARecognitionOfOrphanDrugExclusivityPeriod_1cabd11a-2408-4da1-b182-43f60856df79" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_678bf0f0-ae1e-41d4-b306-28aca1300f6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_2068ef25-6962-45ba-9cb7-ed331a8fde37" xlink:to="loc_us-gaap_LossContingenciesTable_678bf0f0-ae1e-41d4-b306-28aca1300f6a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_1658878a-a86a-4c03-a57e-badcdd34ec17" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_678bf0f0-ae1e-41d4-b306-28aca1300f6a" xlink:to="loc_srt_LitigationCaseAxis_1658878a-a86a-4c03-a57e-badcdd34ec17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_1658878a-a86a-4c03-a57e-badcdd34ec17_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_1658878a-a86a-4c03-a57e-badcdd34ec17" xlink:to="loc_srt_LitigationCaseTypeDomain_1658878a-a86a-4c03-a57e-badcdd34ec17_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_1658878a-a86a-4c03-a57e-badcdd34ec17" xlink:to="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TeamstersAndGEHALawsuitsMember_aafe1144-0840-4e24-aea2-f9080d290898" xlink:href="jazz-20220930.xsd#jazz_TeamstersAndGEHALawsuitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:to="loc_jazz_TeamstersAndGEHALawsuitsMember_aafe1144-0840-4e24-aea2-f9080d290898" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FarrellLawsuitAndLevyLawsuitMember_b6685425-6b31-461b-9088-b797f1c8e1bc" xlink:href="jazz-20220930.xsd#jazz_FarrellLawsuitAndLevyLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:to="loc_jazz_FarrellLawsuitAndLevyLawsuitMember_b6685425-6b31-461b-9088-b797f1c8e1bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWLitigationMember_11490f0c-5ba8-42de-9b51-6cb9d2abe89b" xlink:href="jazz-20220930.xsd#jazz_GWLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:to="loc_jazz_GWLitigationMember_11490f0c-5ba8-42de-9b51-6cb9d2abe89b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_AvadelPharmaceuticalsPlcLawsuitMember_b9e54e31-3bfa-421a-925c-b68cd3c00a8f" xlink:href="jazz-20220930.xsd#jazz_AvadelPharmaceuticalsPlcLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:to="loc_jazz_AvadelPharmaceuticalsPlcLawsuitMember_b9e54e31-3bfa-421a-925c-b68cd3c00a8f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_LupinLawsuitMember_04156069-ed71-4406-b69a-59201aca71b2" xlink:href="jazz-20220930.xsd#jazz_LupinLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_e2887469-14bb-4d3c-aa92-b11686eaed09" xlink:to="loc_jazz_LupinLawsuitMember_04156069-ed71-4406-b69a-59201aca71b2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_494f5e35-3db0-4241-b2de-e2b24e1f60e0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_678bf0f0-ae1e-41d4-b306-28aca1300f6a" xlink:to="loc_srt_ProductOrServiceAxis_494f5e35-3db0-4241-b2de-e2b24e1f60e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_494f5e35-3db0-4241-b2de-e2b24e1f60e0_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_494f5e35-3db0-4241-b2de-e2b24e1f60e0" xlink:to="loc_srt_ProductsAndServicesDomain_494f5e35-3db0-4241-b2de-e2b24e1f60e0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c96ea018-906c-40a7-bc14-00ae0426c1a1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_494f5e35-3db0-4241-b2de-e2b24e1f60e0" xlink:to="loc_srt_ProductsAndServicesDomain_c96ea018-906c-40a7-bc14-00ae0426c1a1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XywavMember_f4314eb4-61b7-4ee5-aa08-00e469892249" xlink:href="jazz-20220930.xsd#jazz_XywavMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_c96ea018-906c-40a7-bc14-00ae0426c1a1" xlink:to="loc_jazz_XywavMember_f4314eb4-61b7-4ee5-aa08-00e469892249" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails" xlink:type="extended" id="if848bd8b644144b8a80b618f96f3e860_ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_acd39d34-5009-4171-8d88-b2941405ec40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_2eaca886-ccd7-4f3c-ba91-be58964835a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_acd39d34-5009-4171-8d88-b2941405ec40" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_2eaca886-ccd7-4f3c-ba91-be58964835a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c0b568c3-6317-492c-8043-f6487b9dbd0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_2eaca886-ccd7-4f3c-ba91-be58964835a7" xlink:to="loc_us-gaap_StockholdersEquity_c0b568c3-6317-492c-8043-f6487b9dbd0c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_b3c69554-049f-4eb5-bbbf-e6ab9edeb0d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_2eaca886-ccd7-4f3c-ba91-be58964835a7" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_b3c69554-049f-4eb5-bbbf-e6ab9edeb0d8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_2043dcaa-5f6b-4db0-a064-767df40c24b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_2eaca886-ccd7-4f3c-ba91-be58964835a7" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_2043dcaa-5f6b-4db0-a064-767df40c24b0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_9e0791a7-e063-4873-8b95-a88f6383c0ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_2eaca886-ccd7-4f3c-ba91-be58964835a7" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_9e0791a7-e063-4873-8b95-a88f6383c0ff" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_46d1c7a6-be38-4926-a330-b418c581a44d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_6a29a94c-67d1-40d6-9864-a87fa145b8f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_acd39d34-5009-4171-8d88-b2941405ec40" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_6a29a94c-67d1-40d6-9864-a87fa145b8f4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_13317c50-b7f5-4cba-8e22-af5838f390f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_6a29a94c-67d1-40d6-9864-a87fa145b8f4" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_13317c50-b7f5-4cba-8e22-af5838f390f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_13317c50-b7f5-4cba-8e22-af5838f390f3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_13317c50-b7f5-4cba-8e22-af5838f390f3" xlink:to="loc_us-gaap_EquityComponentDomain_13317c50-b7f5-4cba-8e22-af5838f390f3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_0b335ee8-64cf-407e-a926-dbfdc9738671" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_13317c50-b7f5-4cba-8e22-af5838f390f3" xlink:to="loc_us-gaap_EquityComponentDomain_0b335ee8-64cf-407e-a926-dbfdc9738671" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d493887b-f731-4833-94f7-d422041b55a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_0b335ee8-64cf-407e-a926-dbfdc9738671" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d493887b-f731-4833-94f7-d422041b55a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_f6e98023-db24-4bc0-9541-58760614de4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d493887b-f731-4833-94f7-d422041b55a7" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_f6e98023-db24-4bc0-9541-58760614de4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_8f802979-ee69-4486-95a6-d92d71d16806" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_d493887b-f731-4833-94f7-d422041b55a7" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_8f802979-ee69-4486-95a6-d92d71d16806" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails" xlink:type="extended" id="i993c4c93ed364db48b91a1d22731001c_NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_013d95c8-b04c-445b-987d-bd9a8a755e33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_e3fc9129-eedc-496e-9a35-f1cfb85e7ea4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_013d95c8-b04c-445b-987d-bd9a8a755e33" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_e3fc9129-eedc-496e-9a35-f1cfb85e7ea4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_563726f8-8f5b-4c5d-8013-5f097d68f4a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_013d95c8-b04c-445b-987d-bd9a8a755e33" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_563726f8-8f5b-4c5d-8013-5f097d68f4a2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_f1d1e1b0-34f7-4272-b87a-294fd6938ee4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_563726f8-8f5b-4c5d-8013-5f097d68f4a2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_f1d1e1b0-34f7-4272-b87a-294fd6938ee4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_f1d1e1b0-34f7-4272-b87a-294fd6938ee4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_f1d1e1b0-34f7-4272-b87a-294fd6938ee4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_f1d1e1b0-34f7-4272-b87a-294fd6938ee4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e02e23a-9ea5-4caa-817a-d93c32caff3f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_f1d1e1b0-34f7-4272-b87a-294fd6938ee4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e02e23a-9ea5-4caa-817a-d93c32caff3f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_f1a361fd-a352-4eeb-ae86-f95017ac39c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertibleDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e02e23a-9ea5-4caa-817a-d93c32caff3f" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_f1a361fd-a352-4eeb-ae86-f95017ac39c7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityUnitPurchaseAgreementsMember_ba825efc-9b7b-448a-bb21-f1048549ff2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityUnitPurchaseAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0e02e23a-9ea5-4caa-817a-d93c32caff3f" xlink:to="loc_us-gaap_EquityUnitPurchaseAgreementsMember_ba825efc-9b7b-448a-bb21-f1048549ff2d" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#RevenuesSummaryofDisaggregationofRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofDisaggregationofRevenueDetails" xlink:type="extended" id="icc13ab5c277946a08512dc1a2b6e4be0_RevenuesSummaryofDisaggregationofRevenueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_70e5ccd1-376e-4cf6-aa8e-6e5642626ff0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_84182e7b-cf6c-415e-b837-40292e733125" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_70e5ccd1-376e-4cf6-aa8e-6e5642626ff0" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_84182e7b-cf6c-415e-b837-40292e733125" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_afb046d1-9bf2-41f0-85cc-7ab05443f4e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_70e5ccd1-376e-4cf6-aa8e-6e5642626ff0" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_afb046d1-9bf2-41f0-85cc-7ab05443f4e6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_7f2cc9d9-12b4-4451-ada1-60e6f55ea255" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_afb046d1-9bf2-41f0-85cc-7ab05443f4e6" xlink:to="loc_srt_ProductOrServiceAxis_7f2cc9d9-12b4-4451-ada1-60e6f55ea255" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7f2cc9d9-12b4-4451-ada1-60e6f55ea255_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_7f2cc9d9-12b4-4451-ada1-60e6f55ea255" xlink:to="loc_srt_ProductsAndServicesDomain_7f2cc9d9-12b4-4451-ada1-60e6f55ea255_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_2be17ea2-66dd-4748-9c83-25a37ca92d4c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_7f2cc9d9-12b4-4451-ada1-60e6f55ea255" xlink:to="loc_srt_ProductsAndServicesDomain_2be17ea2-66dd-4748-9c83-25a37ca92d4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_cab40a77-2fc6-49df-8ee6-b67bc119485d" xlink:href="jazz-20220930.xsd#jazz_ProductAndServicesProductSalesNetOfDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2be17ea2-66dd-4748-9c83-25a37ca92d4c" xlink:to="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_cab40a77-2fc6-49df-8ee6-b67bc119485d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:href="jazz-20220930.xsd#jazz_OncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_cab40a77-2fc6-49df-8ee6-b67bc119485d" xlink:to="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TotalOxybateMember_8c48ae5b-aa1b-46ab-9e31-51507e5b598d" xlink:href="jazz-20220930.xsd#jazz_TotalOxybateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_TotalOxybateMember_8c48ae5b-aa1b-46ab-9e31-51507e5b598d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XyremMember_dc762b38-5c70-4d35-bfed-37fd86ea454a" xlink:href="jazz-20220930.xsd#jazz_XyremMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOxybateMember_8c48ae5b-aa1b-46ab-9e31-51507e5b598d" xlink:to="loc_jazz_XyremMember_dc762b38-5c70-4d35-bfed-37fd86ea454a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XywavMember_5a6ffd16-f3fd-4eaf-988c-b2f305a77f0b" xlink:href="jazz-20220930.xsd#jazz_XywavMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOxybateMember_8c48ae5b-aa1b-46ab-9e31-51507e5b598d" xlink:to="loc_jazz_XywavMember_5a6ffd16-f3fd-4eaf-988c-b2f305a77f0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NeuroscienceMember_6a1b17c5-68d5-490b-84ef-924ca0429c13" xlink:href="jazz-20220930.xsd#jazz_NeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_NeuroscienceMember_6a1b17c5-68d5-490b-84ef-924ca0429c13" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_EpidiolexEpidyolexMember_7cee15d8-85bb-407b-8df8-22b7f68f3db3" xlink:href="jazz-20220930.xsd#jazz_EpidiolexEpidyolexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_NeuroscienceMember_6a1b17c5-68d5-490b-84ef-924ca0429c13" xlink:to="loc_jazz_EpidiolexEpidyolexMember_7cee15d8-85bb-407b-8df8-22b7f68f3db3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SativexMember_34be3663-21c5-4c5b-afd4-7760764a7ecb" xlink:href="jazz-20220930.xsd#jazz_SativexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_NeuroscienceMember_6a1b17c5-68d5-490b-84ef-924ca0429c13" xlink:to="loc_jazz_SativexMember_34be3663-21c5-4c5b-afd4-7760764a7ecb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SunosiMember_9ac62fb3-a444-4e08-a24a-25e8df0747bd" xlink:href="jazz-20220930.xsd#jazz_SunosiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_NeuroscienceMember_6a1b17c5-68d5-490b-84ef-924ca0429c13" xlink:to="loc_jazz_SunosiMember_9ac62fb3-a444-4e08-a24a-25e8df0747bd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ZepzelcaMember_2e36f76f-477f-4740-b31a-6a6d8663d829" xlink:href="jazz-20220930.xsd#jazz_ZepzelcaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_ZepzelcaMember_2e36f76f-477f-4740-b31a-6a6d8663d829" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RylazeMember_51c114bc-92cf-42f8-b343-d501003831cd" xlink:href="jazz-20220930.xsd#jazz_RylazeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_RylazeMember_51c114bc-92cf-42f8-b343-d501003831cd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_VyxeosMember_52f39f23-584e-448d-a9ee-dbc3c6e3ab73" xlink:href="jazz-20220930.xsd#jazz_VyxeosMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_VyxeosMember_52f39f23-584e-448d-a9ee-dbc3c6e3ab73" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_DefitelioDefibrotideMember_9694e6e2-aacb-4b98-83b7-3cf805a48f5e" xlink:href="jazz-20220930.xsd#jazz_DefitelioDefibrotideMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_DefitelioDefibrotideMember_9694e6e2-aacb-4b98-83b7-3cf805a48f5e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ErwinazeAndErwinaseMember_21de56e3-4b70-48a4-89d8-cb778d024098" xlink:href="jazz-20220930.xsd#jazz_ErwinazeAndErwinaseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_086bedc8-4bc3-4179-9ff5-110d175f75ff" xlink:to="loc_jazz_ErwinazeAndErwinaseMember_21de56e3-4b70-48a4-89d8-cb778d024098" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherProductsMember_cbd2c839-2dcf-44a0-b2eb-d5c3510a7e68" xlink:href="jazz-20220930.xsd#jazz_OtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_cab40a77-2fc6-49df-8ee6-b67bc119485d" xlink:to="loc_jazz_OtherProductsMember_cbd2c839-2dcf-44a0-b2eb-d5c3510a7e68" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_27c98bc4-e9fb-4b92-967d-8a967f1f02b0" xlink:href="jazz-20220930.xsd#jazz_ProductAndServicesRoyaltiesAndContractRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_2be17ea2-66dd-4748-9c83-25a37ca92d4c" xlink:to="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_27c98bc4-e9fb-4b92-967d-8a967f1f02b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_f51eae85-aa45-4227-a387-37dcac7361da" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_afb046d1-9bf2-41f0-85cc-7ab05443f4e6" xlink:to="loc_srt_StatementGeographicalAxis_f51eae85-aa45-4227-a387-37dcac7361da" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_f51eae85-aa45-4227-a387-37dcac7361da_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_f51eae85-aa45-4227-a387-37dcac7361da" xlink:to="loc_srt_SegmentGeographicalDomain_f51eae85-aa45-4227-a387-37dcac7361da_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2aa76912-ced6-4c68-8853-2d54d95c30a5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_f51eae85-aa45-4227-a387-37dcac7361da" xlink:to="loc_srt_SegmentGeographicalDomain_2aa76912-ced6-4c68-8853-2d54d95c30a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_62bbcafc-eb13-4b01-abba-cc78d28261dc" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2aa76912-ced6-4c68-8853-2d54d95c30a5" xlink:to="loc_country_US_62bbcafc-eb13-4b01-abba-cc78d28261dc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_d48ce934-619e-41ae-9d2f-4d03a38a702a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2aa76912-ced6-4c68-8853-2d54d95c30a5" xlink:to="loc_srt_EuropeMember_d48ce934-619e-41ae-9d2f-4d03a38a702a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherCountriesMember_c6361442-b3cb-4f44-9987-dc597695b9b9" xlink:href="jazz-20220930.xsd#jazz_OtherCountriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2aa76912-ced6-4c68-8853-2d54d95c30a5" xlink:to="loc_jazz_OtherCountriesMember_c6361442-b3cb-4f44-9987-dc597695b9b9" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails" xlink:type="extended" id="i96e499d8b0e74dd8aa62d45c954ab2a9_RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_87f33818-8a51-4fab-ad01-4a2c459f67f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_c0fcb70e-0425-4d32-9dce-fc1a1aaaaa52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_87f33818-8a51-4fab-ad01-4a2c459f67f2" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_c0fcb70e-0425-4d32-9dce-fc1a1aaaaa52" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_cef72265-05e6-47a2-a609-437dc4a97404" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_87f33818-8a51-4fab-ad01-4a2c459f67f2" xlink:to="loc_us-gaap_ConcentrationRiskTable_cef72265-05e6-47a2-a609-437dc4a97404" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_e304e5a7-5f2a-4604-a26d-786596285d3b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_cef72265-05e6-47a2-a609-437dc4a97404" xlink:to="loc_srt_MajorCustomersAxis_e304e5a7-5f2a-4604-a26d-786596285d3b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_e304e5a7-5f2a-4604-a26d-786596285d3b_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_e304e5a7-5f2a-4604-a26d-786596285d3b" xlink:to="loc_srt_NameOfMajorCustomerDomain_e304e5a7-5f2a-4604-a26d-786596285d3b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_28927c63-a90c-4012-a69d-ad9fd6146df6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_e304e5a7-5f2a-4604-a26d-786596285d3b" xlink:to="loc_srt_NameOfMajorCustomerDomain_28927c63-a90c-4012-a69d-ad9fd6146df6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExpressScriptsMember_6a241188-2ac4-45bc-a0aa-8a67bb0e3b67" xlink:href="jazz-20220930.xsd#jazz_ExpressScriptsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_28927c63-a90c-4012-a69d-ad9fd6146df6" xlink:to="loc_jazz_ExpressScriptsMember_6a241188-2ac4-45bc-a0aa-8a67bb0e3b67" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_McKessonCorporationMember_95b40dd4-ab28-4224-83e5-2ea7cc24d5f9" xlink:href="jazz-20220930.xsd#jazz_McKessonCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_28927c63-a90c-4012-a69d-ad9fd6146df6" xlink:to="loc_jazz_McKessonCorporationMember_95b40dd4-ab28-4224-83e5-2ea7cc24d5f9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_242087fe-6dd5-439e-ac24-f40ab8c6591b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_cef72265-05e6-47a2-a609-437dc4a97404" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_242087fe-6dd5-439e-ac24-f40ab8c6591b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_242087fe-6dd5-439e-ac24-f40ab8c6591b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_242087fe-6dd5-439e-ac24-f40ab8c6591b" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_242087fe-6dd5-439e-ac24-f40ab8c6591b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_21366129-6148-4c39-a73e-025c2ee84c0e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_242087fe-6dd5-439e-ac24-f40ab8c6591b" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_21366129-6148-4c39-a73e-025c2ee84c0e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerMember_c24bf68f-faf1-4c10-abf1-44ab85a6edc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_21366129-6148-4c39-a73e-025c2ee84c0e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerMember_c24bf68f-faf1-4c10-abf1-44ab85a6edc6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_efaaa3c4-ca00-4a2c-8e12-9ce735068196" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_cef72265-05e6-47a2-a609-437dc4a97404" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_efaaa3c4-ca00-4a2c-8e12-9ce735068196" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_efaaa3c4-ca00-4a2c-8e12-9ce735068196_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_efaaa3c4-ca00-4a2c-8e12-9ce735068196" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_efaaa3c4-ca00-4a2c-8e12-9ce735068196_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_d1af5284-b4cc-4e3e-b45d-3af3ba697b60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_efaaa3c4-ca00-4a2c-8e12-9ce735068196" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_d1af5284-b4cc-4e3e-b45d-3af3ba697b60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_f92e551c-0417-44a4-a14b-ea5d4d9d651a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_d1af5284-b4cc-4e3e-b45d-3af3ba697b60" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_f92e551c-0417-44a4-a14b-ea5d4d9d651a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#RevenuesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesNarrativeDetails" xlink:type="extended" id="i1dbc854ac5904685a0dfb69cc4940dd4_RevenuesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SummaryOfDeferredRevenueLineItems_860cb797-71ec-4573-8e22-2e80a82b90d7" xlink:href="jazz-20220930.xsd#jazz_SummaryOfDeferredRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RevenuePerformanceObligationPaymentTerms_a44c48e5-f041-40a7-9be2-3cc3ea91cb29" xlink:href="jazz-20220930.xsd#jazz_RevenuePerformanceObligationPaymentTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_860cb797-71ec-4573-8e22-2e80a82b90d7" xlink:to="loc_jazz_RevenuePerformanceObligationPaymentTerms_a44c48e5-f041-40a7-9be2-3cc3ea91cb29" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_LicensingAgreementNumberOfAgreements_615ed06b-33e5-4877-9256-c32fe245caff" xlink:href="jazz-20220930.xsd#jazz_LicensingAgreementNumberOfAgreements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_860cb797-71ec-4573-8e22-2e80a82b90d7" xlink:to="loc_jazz_LicensingAgreementNumberOfAgreements_615ed06b-33e5-4877-9256-c32fe245caff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_d28b361d-7af8-419c-9bb1-4f3f1cbec2ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_860cb797-71ec-4573-8e22-2e80a82b90d7" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_d28b361d-7af8-419c-9bb1-4f3f1cbec2ea" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuePerformanceObligationDescriptionOfTiming_fa981b1d-9057-4639-b93d-be82c9b07f16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuePerformanceObligationDescriptionOfTiming"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_860cb797-71ec-4573-8e22-2e80a82b90d7" xlink:to="loc_us-gaap_RevenuePerformanceObligationDescriptionOfTiming_fa981b1d-9057-4639-b93d-be82c9b07f16" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SummaryOfDeferredRevenueTable_9ce9ea65-1138-4a32-be25-efb1ffbb6c95" xlink:href="jazz-20220930.xsd#jazz_SummaryOfDeferredRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_860cb797-71ec-4573-8e22-2e80a82b90d7" xlink:to="loc_jazz_SummaryOfDeferredRevenueTable_9ce9ea65-1138-4a32-be25-efb1ffbb6c95" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_7785b595-389e-43e2-a973-f26871537741" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_SummaryOfDeferredRevenueTable_9ce9ea65-1138-4a32-be25-efb1ffbb6c95" xlink:to="loc_srt_RangeAxis_7785b595-389e-43e2-a973-f26871537741" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7785b595-389e-43e2-a973-f26871537741_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_7785b595-389e-43e2-a973-f26871537741" xlink:to="loc_srt_RangeMember_7785b595-389e-43e2-a973-f26871537741_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_4c5f994e-ddf8-4875-b263-e612972a2e50" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_7785b595-389e-43e2-a973-f26871537741" xlink:to="loc_srt_RangeMember_4c5f994e-ddf8-4875-b263-e612972a2e50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_71bdd7db-daca-4ff3-bd33-c3f137cf770b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_4c5f994e-ddf8-4875-b263-e612972a2e50" xlink:to="loc_srt_MinimumMember_71bdd7db-daca-4ff3-bd33-c3f137cf770b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_5c7c3edc-2477-4d72-8427-21ea20179285" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_4c5f994e-ddf8-4875-b263-e612972a2e50" xlink:to="loc_srt_MaximumMember_5c7c3edc-2477-4d72-8427-21ea20179285" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_1ef97aa5-bd7c-45f1-8338-38cec93467d7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_SummaryOfDeferredRevenueTable_9ce9ea65-1138-4a32-be25-efb1ffbb6c95" xlink:to="loc_srt_MajorCustomersAxis_1ef97aa5-bd7c-45f1-8338-38cec93467d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_1ef97aa5-bd7c-45f1-8338-38cec93467d7_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_1ef97aa5-bd7c-45f1-8338-38cec93467d7" xlink:to="loc_srt_NameOfMajorCustomerDomain_1ef97aa5-bd7c-45f1-8338-38cec93467d7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_1ba1f7f5-4cdf-48f7-990a-e5b8d913da25" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_1ef97aa5-bd7c-45f1-8338-38cec93467d7" xlink:to="loc_srt_NameOfMajorCustomerDomain_1ba1f7f5-4cdf-48f7-990a-e5b8d913da25" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NipponShinyakuCo.Ltd.Member_b7c59166-754e-46dc-a550-71c6c1d09525" xlink:href="jazz-20220930.xsd#jazz_NipponShinyakuCo.Ltd.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_1ba1f7f5-4cdf-48f7-990a-e5b8d913da25" xlink:to="loc_jazz_NipponShinyakuCo.Ltd.Member_b7c59166-754e-46dc-a550-71c6c1d09525" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationExpenseDetails" xlink:type="extended" id="i0e5efbac5b9a4149b1da0996cab315b8_ShareBasedCompensationExpenseDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5ef1e895-1e5a-4ae0-a764-5a6ebac76759" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_c3fc8b9c-d108-4b54-acdf-6f58ff09178d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5ef1e895-1e5a-4ae0-a764-5a6ebac76759" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_c3fc8b9c-d108-4b54-acdf-6f58ff09178d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_a3567564-4fb4-4a22-95d2-bff885a8e64d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5ef1e895-1e5a-4ae0-a764-5a6ebac76759" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_a3567564-4fb4-4a22-95d2-bff885a8e64d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_59ec21b1-89f3-49ee-8f74-f975f3de14ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5ef1e895-1e5a-4ae0-a764-5a6ebac76759" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_59ec21b1-89f3-49ee-8f74-f975f3de14ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_3fbfbd36-58f0-4c83-9384-e2124e65b731" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_5ef1e895-1e5a-4ae0-a764-5a6ebac76759" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_3fbfbd36-58f0-4c83-9384-e2124e65b731" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_6265c96f-9bc8-4dea-ae66-3418e4f0eb00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_3fbfbd36-58f0-4c83-9384-e2124e65b731" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_6265c96f-9bc8-4dea-ae66-3418e4f0eb00" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_6265c96f-9bc8-4dea-ae66-3418e4f0eb00_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_6265c96f-9bc8-4dea-ae66-3418e4f0eb00" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_6265c96f-9bc8-4dea-ae66-3418e4f0eb00_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_3c82d9e1-8fc0-4963-886b-f61ff8f22678" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_6265c96f-9bc8-4dea-ae66-3418e4f0eb00" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_3c82d9e1-8fc0-4963-886b-f61ff8f22678" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_33f4e5f6-c32d-4ed3-8424-b3907be2e48a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3c82d9e1-8fc0-4963-886b-f61ff8f22678" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_33f4e5f6-c32d-4ed3-8424-b3907be2e48a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_6fb19296-723f-4306-be05-c2457cffcc6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3c82d9e1-8fc0-4963-886b-f61ff8f22678" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_6fb19296-723f-4306-be05-c2457cffcc6d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_39417508-eec4-4b9b-88f4-b415c745d1e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_3c82d9e1-8fc0-4963-886b-f61ff8f22678" xlink:to="loc_us-gaap_CostOfSalesMember_39417508-eec4-4b9b-88f4-b415c745d1e7" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="extended" id="i995d809ef9f74f24af47b900cb9f7e7f_ShareBasedCompensationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c282ee9f-a64f-4c69-aff3-e6668617c205" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_c282ee9f-a64f-4c69-aff3-e6668617c205" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b207ea26-cfa4-400d-9607-18a60112e3ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b207ea26-cfa4-400d-9607-18a60112e3ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_720c247d-f3ad-4e59-a5dd-c846709850fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_720c247d-f3ad-4e59-a5dd-c846709850fa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted_981007e1-9777-4083-9911-c0f34c0c3aa5" xlink:href="jazz-20220930.xsd#jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted_981007e1-9777-4083-9911-c0f34c0c3aa5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_c7970f02-1a41-45c3-b3fe-c33f41394efc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_c7970f02-1a41-45c3-b3fe-c33f41394efc" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_c61d5c66-3b6c-4bec-92e2-a18a501d6b52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_c61d5c66-3b6c-4bec-92e2-a18a501d6b52" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f179f443-362d-4731-a1e3-412bfa051887" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d370d430-ce2c-4e97-8519-f718d862bdc6" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f179f443-362d-4731-a1e3-412bfa051887" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_5f3f4354-e88b-466c-b735-bba0ac35ab89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f179f443-362d-4731-a1e3-412bfa051887" xlink:to="loc_us-gaap_AwardTypeAxis_5f3f4354-e88b-466c-b735-bba0ac35ab89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5f3f4354-e88b-466c-b735-bba0ac35ab89_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_5f3f4354-e88b-466c-b735-bba0ac35ab89" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5f3f4354-e88b-466c-b735-bba0ac35ab89_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_515f63a9-27b5-4b97-800b-a95fb0b09d11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_5f3f4354-e88b-466c-b735-bba0ac35ab89" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_515f63a9-27b5-4b97-800b-a95fb0b09d11" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_17bd5bef-d168-45ba-b33f-151dbaf623ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_515f63a9-27b5-4b97-800b-a95fb0b09d11" xlink:to="loc_us-gaap_EmployeeStockOptionMember_17bd5bef-d168-45ba-b33f-151dbaf623ba" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NominalStrikePriceOptionsMember_17ba4aeb-2560-4d40-ab73-4ee0f8f3838d" xlink:href="jazz-20220930.xsd#jazz_NominalStrikePriceOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_515f63a9-27b5-4b97-800b-a95fb0b09d11" xlink:to="loc_jazz_NominalStrikePriceOptionsMember_17ba4aeb-2560-4d40-ab73-4ee0f8f3838d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_b0f8426d-e8f6-4e1a-a3d1-60f663531d23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_515f63a9-27b5-4b97-800b-a95fb0b09d11" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_b0f8426d-e8f6-4e1a-a3d1-60f663531d23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_13bda6d2-9a84-4252-852b-4ff9749f602d" xlink:href="jazz-20220930.xsd#jazz_PerformanceBasedRestrictedStockUnitsRSUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_515f63a9-27b5-4b97-800b-a95fb0b09d11" xlink:to="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_13bda6d2-9a84-4252-852b-4ff9749f602d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_7eaffdae-cba9-4fa6-9c99-9e3e1094e065" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f179f443-362d-4731-a1e3-412bfa051887" xlink:to="loc_srt_RangeAxis_7eaffdae-cba9-4fa6-9c99-9e3e1094e065" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7eaffdae-cba9-4fa6-9c99-9e3e1094e065_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_7eaffdae-cba9-4fa6-9c99-9e3e1094e065" xlink:to="loc_srt_RangeMember_7eaffdae-cba9-4fa6-9c99-9e3e1094e065_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0f682897-f9ec-4a4d-a28c-87ac47e65064" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_7eaffdae-cba9-4fa6-9c99-9e3e1094e065" xlink:to="loc_srt_RangeMember_0f682897-f9ec-4a4d-a28c-87ac47e65064" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_f981b6e3-69c8-44df-aa3b-6d52f25468e1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0f682897-f9ec-4a4d-a28c-87ac47e65064" xlink:to="loc_srt_MinimumMember_f981b6e3-69c8-44df-aa3b-6d52f25468e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_12985028-a9b0-4bac-b1ae-a2c0c8415e74" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0f682897-f9ec-4a4d-a28c-87ac47e65064" xlink:to="loc_srt_MaximumMember_12985028-a9b0-4bac-b1ae-a2c0c8415e74" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails" xlink:type="extended" id="i93d0f4e72eab49739e30c1c799def2c0_ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:href="jazz-20220930.xsd#jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_e420229b-ccbb-4297-8168-b4305652a2d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_e420229b-ccbb-4297-8168-b4305652a2d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_c3bae74b-2b35-4468-a686-aafb91bb6ec2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_c3bae74b-2b35-4468-a686-aafb91bb6ec2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_88b3764f-9557-4ed9-b1f4-d87a9ba9d9a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_88b3764f-9557-4ed9-b1f4-d87a9ba9d9a5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_9403e242-5ac3-4d29-9527-dbf39a4f0c72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_9403e242-5ac3-4d29-9527-dbf39a4f0c72" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_e5db0dec-b448-4331-8f30-bbb3c244c359" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_e5db0dec-b448-4331-8f30-bbb3c244c359" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_5c69d22f-e900-4c91-8f49-64c8d7c22e3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_5c69d22f-e900-4c91-8f49-64c8d7c22e3e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_9235e2af-9a50-433a-bea2-6fc6332f10d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_9235e2af-9a50-433a-bea2-6fc6332f10d1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable_205b65b5-eaa3-4ac5-a5d7-8f9cb563d1e6" xlink:href="jazz-20220930.xsd#jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_944552da-0f71-4c92-88c2-1f710efb3957" xlink:to="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable_205b65b5-eaa3-4ac5-a5d7-8f9cb563d1e6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_63456cb4-1a46-41f8-ac4a-a9de1d58aebb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable_205b65b5-eaa3-4ac5-a5d7-8f9cb563d1e6" xlink:to="loc_us-gaap_AwardTypeAxis_63456cb4-1a46-41f8-ac4a-a9de1d58aebb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_63456cb4-1a46-41f8-ac4a-a9de1d58aebb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_63456cb4-1a46-41f8-ac4a-a9de1d58aebb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_63456cb4-1a46-41f8-ac4a-a9de1d58aebb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c13216d3-0042-42b7-8eb7-5b880457b926" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_63456cb4-1a46-41f8-ac4a-a9de1d58aebb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c13216d3-0042-42b7-8eb7-5b880457b926" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_df383aa8-7454-4f6a-98ff-11f676c3141b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c13216d3-0042-42b7-8eb7-5b880457b926" xlink:to="loc_us-gaap_EmployeeStockOptionMember_df383aa8-7454-4f6a-98ff-11f676c3141b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationNominalStrikePriceOptionsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareBasedCompensationNominalStrikePriceOptionsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationNominalStrikePriceOptionsDetails" xlink:type="extended" id="ia8d0a17ad103485db94a8e8eba134dc3_ShareBasedCompensationNominalStrikePriceOptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b2936618-9faf-4b25-8ee6-3a794f9c2aa9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_f5ba4784-8a5e-4dea-a3de-b9c0dce24e39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b2936618-9faf-4b25-8ee6-3a794f9c2aa9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_f5ba4784-8a5e-4dea-a3de-b9c0dce24e39" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_e0ebbc32-b72e-4dd8-8be4-a1f60fa7f0e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b2936618-9faf-4b25-8ee6-3a794f9c2aa9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_e0ebbc32-b72e-4dd8-8be4-a1f60fa7f0e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_0ea39855-5d48-48cc-9863-539dbb1872b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b2936618-9faf-4b25-8ee6-3a794f9c2aa9" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_0ea39855-5d48-48cc-9863-539dbb1872b2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_c70cdacf-08cf-42c7-935e-d5f0cf0c9765" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_0ea39855-5d48-48cc-9863-539dbb1872b2" xlink:to="loc_us-gaap_AwardTypeAxis_c70cdacf-08cf-42c7-935e-d5f0cf0c9765" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c70cdacf-08cf-42c7-935e-d5f0cf0c9765_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_c70cdacf-08cf-42c7-935e-d5f0cf0c9765" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c70cdacf-08cf-42c7-935e-d5f0cf0c9765_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0cda8718-0c08-4013-9648-3622b4f526f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_c70cdacf-08cf-42c7-935e-d5f0cf0c9765" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0cda8718-0c08-4013-9648-3622b4f526f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NominalStrikePriceOptionsMember_aa94decd-f9b6-41f1-b990-97f279c3f270" xlink:href="jazz-20220930.xsd#jazz_NominalStrikePriceOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_0cda8718-0c08-4013-9648-3622b4f526f2" xlink:to="loc_jazz_NominalStrikePriceOptionsMember_aa94decd-f9b6-41f1-b990-97f279c3f270" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationRestrictedUnitsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareBasedCompensationRestrictedUnitsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationRestrictedUnitsDetails" xlink:type="extended" id="i2067fb7be21640808a59eba0fb95b837_ShareBasedCompensationRestrictedUnitsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_222b9355-9dc2-4f7f-aa5d-01a6df4ef8c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_9db670ff-7a8e-41cd-adce-fa77f1df5d12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_222b9355-9dc2-4f7f-aa5d-01a6df4ef8c8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_9db670ff-7a8e-41cd-adce-fa77f1df5d12" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8d03d69a-5b6f-4c45-8970-7821a1316663" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_222b9355-9dc2-4f7f-aa5d-01a6df4ef8c8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8d03d69a-5b6f-4c45-8970-7821a1316663" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2d571b8f-4898-418d-aaa7-728ac5db1c76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_222b9355-9dc2-4f7f-aa5d-01a6df4ef8c8" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2d571b8f-4898-418d-aaa7-728ac5db1c76" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_8c2f1cc7-6f5e-4b38-b373-a500dac6712a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2d571b8f-4898-418d-aaa7-728ac5db1c76" xlink:to="loc_us-gaap_AwardTypeAxis_8c2f1cc7-6f5e-4b38-b373-a500dac6712a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8c2f1cc7-6f5e-4b38-b373-a500dac6712a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_8c2f1cc7-6f5e-4b38-b373-a500dac6712a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8c2f1cc7-6f5e-4b38-b373-a500dac6712a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e9a4a2bb-833b-41d9-a7ef-aca75f3ab00e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_8c2f1cc7-6f5e-4b38-b373-a500dac6712a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e9a4a2bb-833b-41d9-a7ef-aca75f3ab00e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_4a946d5f-2398-4627-81ae-73291aa9af9c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_e9a4a2bb-833b-41d9-a7ef-aca75f3ab00e" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_4a946d5f-2398-4627-81ae-73291aa9af9c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleofPerformancebasedRSUsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#ShareBasedCompensationScheduleofPerformancebasedRSUsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleofPerformancebasedRSUsDetails" xlink:type="extended" id="ic0f05fc3e59b491e86327cf0530d8f19_ShareBasedCompensationScheduleofPerformancebasedRSUsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3f4f3453-834c-4430-868a-739090a881c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_60731453-379d-48ee-b61b-ad4586dd3587" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3f4f3453-834c-4430-868a-739090a881c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_60731453-379d-48ee-b61b-ad4586dd3587" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8d8730e8-38e6-4661-9ddf-48872308f0e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3f4f3453-834c-4430-868a-739090a881c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8d8730e8-38e6-4661-9ddf-48872308f0e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_dca38bd0-29c0-45fe-ac84-216a1fe2b180" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3f4f3453-834c-4430-868a-739090a881c5" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_dca38bd0-29c0-45fe-ac84-216a1fe2b180" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_317b1457-14ab-4506-8b29-502aca38410c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_dca38bd0-29c0-45fe-ac84-216a1fe2b180" xlink:to="loc_us-gaap_AwardTypeAxis_317b1457-14ab-4506-8b29-502aca38410c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_317b1457-14ab-4506-8b29-502aca38410c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_317b1457-14ab-4506-8b29-502aca38410c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_317b1457-14ab-4506-8b29-502aca38410c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_572fe6dd-4ed6-4e20-8e3e-b7758a5dff93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_317b1457-14ab-4506-8b29-502aca38410c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_572fe6dd-4ed6-4e20-8e3e-b7758a5dff93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_73add97f-277d-421b-94c4-e0a5064eeb7e" xlink:href="jazz-20220930.xsd#jazz_PerformanceBasedRestrictedStockUnitsRSUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_572fe6dd-4ed6-4e20-8e3e-b7758a5dff93" xlink:to="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_73add97f-277d-421b-94c4-e0a5064eeb7e" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended" id="i82101b1c82ec45f1a55d4a263da0705b_IncomeTaxesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_b21d91c1-92ce-47c0-bbd0-5abc87ec173a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxContingencyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4e881904-46a1-494e-9b9c-4ec1e35aa04a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_b21d91c1-92ce-47c0-bbd0-5abc87ec173a" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_4e881904-46a1-494e-9b9c-4ec1e35aa04a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_UKFinanceActChangeInTaxRateDeferredTaxLiabilityIncomeTaxExpenseBenefit_1e5746fc-90ff-4f93-a98a-48a3a6e2b0bc" xlink:href="jazz-20220930.xsd#jazz_UKFinanceActChangeInTaxRateDeferredTaxLiabilityIncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_b21d91c1-92ce-47c0-bbd0-5abc87ec173a" xlink:to="loc_jazz_UKFinanceActChangeInTaxRateDeferredTaxLiabilityIncomeTaxExpenseBenefit_1e5746fc-90ff-4f93-a98a-48a3a6e2b0bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_7209c071-0655-4cd2-aba7-e9f553921571" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxContingencyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_b21d91c1-92ce-47c0-bbd0-5abc87ec173a" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_7209c071-0655-4cd2-aba7-e9f553921571" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_2be79c54-813f-4c39-a142-d8d21c1329b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_7209c071-0655-4cd2-aba7-e9f553921571" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_2be79c54-813f-4c39-a142-d8d21c1329b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2be79c54-813f-4c39-a142-d8d21c1329b0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2be79c54-813f-4c39-a142-d8d21c1329b0" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2be79c54-813f-4c39-a142-d8d21c1329b0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_51095978-d270-4e13-b964-478c940f3337" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2be79c54-813f-4c39-a142-d8d21c1329b0" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_51095978-d270-4e13-b964-478c940f3337" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWPharmaceuticalsPlcMember_ce544aa6-abaf-479a-b3a9-d3947a02f9e3" xlink:href="jazz-20220930.xsd#jazz_GWPharmaceuticalsPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_51095978-d270-4e13-b964-478c940f3337" xlink:to="loc_jazz_GWPharmaceuticalsPlcMember_ce544aa6-abaf-479a-b3a9-d3947a02f9e3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="jazz-20220930.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/SubsequentEventsDetails" xlink:type="extended" id="ib602bee2f81843af872fd2a8a4a1bea2_SubsequentEventsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_8acbcd27-799b-4d60-940e-6ea7216c1aa4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_8acbcd27-799b-4d60-940e-6ea7216c1aa4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_UpfrontPaymentPendingContinuedCollaboration_b9317568-55f4-4a58-b321-102f920e6c6a" xlink:href="jazz-20220930.xsd#jazz_UpfrontPaymentPendingContinuedCollaboration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_jazz_UpfrontPaymentPendingContinuedCollaboration_b9317568-55f4-4a58-b321-102f920e6c6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_0d62ab50-718e-479e-8419-309223cf4225" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_0d62ab50-718e-479e-8419-309223cf4225" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TotalPotentialCollaborationPayments_64d94005-d00d-4222-941f-6d2a5d025d53" xlink:href="jazz-20220930.xsd#jazz_TotalPotentialCollaborationPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_jazz_TotalPotentialCollaborationPayments_64d94005-d00d-4222-941f-6d2a5d025d53" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TieredRoyaltyFeesPercentageMinimum_eaeb6e8e-4c7a-4ceb-afaf-324281553d5e" xlink:href="jazz-20220930.xsd#jazz_TieredRoyaltyFeesPercentageMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_jazz_TieredRoyaltyFeesPercentageMinimum_eaeb6e8e-4c7a-4ceb-afaf-324281553d5e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TieredRoyaltyFeesPercentageMaximum_b62936a5-571b-4519-9e19-e8b923897cd7" xlink:href="jazz-20220930.xsd#jazz_TieredRoyaltyFeesPercentageMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_jazz_TieredRoyaltyFeesPercentageMaximum_b62936a5-571b-4519-9e19-e8b923897cd7" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_c90912b2-8463-4767-9290-93e403e902d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_86d9b3e5-612a-4e27-a5ba-abeea251884b" xlink:to="loc_us-gaap_SubsequentEventTable_c90912b2-8463-4767-9290-93e403e902d8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_0ce9bca5-5a24-452d-89a5-6b744de265b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_c90912b2-8463-4767-9290-93e403e902d8" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_0ce9bca5-5a24-452d-89a5-6b744de265b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_0ce9bca5-5a24-452d-89a5-6b744de265b4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_0ce9bca5-5a24-452d-89a5-6b744de265b4" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_0ce9bca5-5a24-452d-89a5-6b744de265b4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_36b7e99e-6c36-4fff-b8d6-7b2416321ced" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_0ce9bca5-5a24-452d-89a5-6b744de265b4" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_36b7e99e-6c36-4fff-b8d6-7b2416321ced" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_UpfrontPaymentsMember_4bf7d3de-3a7d-4ac5-b8a7-c91ef34aec2b" xlink:href="jazz-20220930.xsd#jazz_UpfrontPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_36b7e99e-6c36-4fff-b8d6-7b2416321ced" xlink:to="loc_jazz_UpfrontPaymentsMember_4bf7d3de-3a7d-4ac5-b8a7-c91ef34aec2b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OneTimePaymentsMember_afb7375a-502c-4b45-bf9b-f0cbc4df2e0a" xlink:href="jazz-20220930.xsd#jazz_OneTimePaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_36b7e99e-6c36-4fff-b8d6-7b2416321ced" xlink:to="loc_jazz_OneTimePaymentsMember_afb7375a-502c-4b45-bf9b-f0cbc4df2e0a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_MilestonePaymentMember_37668597-13a5-4f05-a827-6b49ce3df207" xlink:href="jazz-20220930.xsd#jazz_MilestonePaymentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_36b7e99e-6c36-4fff-b8d6-7b2416321ced" xlink:to="loc_jazz_MilestonePaymentMember_37668597-13a5-4f05-a827-6b49ce3df207" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_bf9aef92-8de5-4406-bd9b-186fe6b48ea8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_c90912b2-8463-4767-9290-93e403e902d8" xlink:to="loc_srt_CounterpartyNameAxis_bf9aef92-8de5-4406-bd9b-186fe6b48ea8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bf9aef92-8de5-4406-bd9b-186fe6b48ea8_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_bf9aef92-8de5-4406-bd9b-186fe6b48ea8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bf9aef92-8de5-4406-bd9b-186fe6b48ea8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_91bd1492-f03f-4394-aa65-f744cd4cac59" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_bf9aef92-8de5-4406-bd9b-186fe6b48ea8" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_91bd1492-f03f-4394-aa65-f744cd4cac59" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ZymeworksMember_f3af34cc-f1f7-4235-b014-ebf59f0771cd" xlink:href="jazz-20220930.xsd#jazz_ZymeworksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_91bd1492-f03f-4394-aa65-f744cd4cac59" xlink:to="loc_jazz_ZymeworksMember_f3af34cc-f1f7-4235-b014-ebf59f0771cd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_cdd49af9-1944-4bc1-be0b-3f8fdafe8739" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_c90912b2-8463-4767-9290-93e403e902d8" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_cdd49af9-1944-4bc1-be0b-3f8fdafe8739" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_cdd49af9-1944-4bc1-be0b-3f8fdafe8739_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_cdd49af9-1944-4bc1-be0b-3f8fdafe8739" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_cdd49af9-1944-4bc1-be0b-3f8fdafe8739_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_8ab2451c-2a10-4302-82f9-edab1b383c81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_cdd49af9-1944-4bc1-be0b-3f8fdafe8739" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_8ab2451c-2a10-4302-82f9-edab1b383c81" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_cff752f1-8688-4c30-ac65-c88bd795bd76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_8ab2451c-2a10-4302-82f9-edab1b383c81" xlink:to="loc_us-gaap_SubsequentEventMember_cff752f1-8688-4c30-ac65-c88bd795bd76" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_ed54e7b2-0742-4618-b510-88110d8ee8c4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_c90912b2-8463-4767-9290-93e403e902d8" xlink:to="loc_srt_StatementScenarioAxis_ed54e7b2-0742-4618-b510-88110d8ee8c4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_ed54e7b2-0742-4618-b510-88110d8ee8c4_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_ed54e7b2-0742-4618-b510-88110d8ee8c4" xlink:to="loc_srt_ScenarioUnspecifiedDomain_ed54e7b2-0742-4618-b510-88110d8ee8c4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_18ae9458-556a-448b-9ce4-60d50745f23e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_ed54e7b2-0742-4618-b510-88110d8ee8c4" xlink:to="loc_srt_ScenarioUnspecifiedDomain_18ae9458-556a-448b-9ce4-60d50745f23e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_c0b4ff36-e52a-4e20-9148-12d21f81d8d4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_18ae9458-556a-448b-9ce4-60d50745f23e" xlink:to="loc_srt_ScenarioForecastMember_c0b4ff36-e52a-4e20-9148-12d21f81d8d4" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate202006Member" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingStandardsUpdate202006Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember" xlink:to="loc_us-gaap_AccountingStandardsUpdate202006Member" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
