0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 0000003 - Statement - CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 0000004 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0000005 - Statement - CONSOLIDATED STATEMENTS OF INCOME (LOSS) link:presentationLink link:calculationLink link:definitionLink 0000006 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) link:presentationLink link:calculationLink link:definitionLink 0000007 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0000008 - Statement - CONSOLIDATED STATEMENTS OF SHAREHOLDERS’ EQUITY link:presentationLink link:calculationLink link:definitionLink 0000009 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 0000010 - Disclosure - Organization and Description of Business link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Cash and Available-for-Sale Securities link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Fair Value Measurement link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Derivative Instruments and Hedging Activities link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Inventories link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Other Current Assets link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Property, Plant and Equipment link:presentationLink link:calculationLink link:definitionLink 0000019 - Disclosure - Goodwill and Intangible Assets link:presentationLink link:calculationLink link:definitionLink 0000020 - Disclosure - Accrued Liabilities link:presentationLink link:calculationLink link:definitionLink 0000021 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 0000022 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 0000023 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 0000024 - Disclosure - Shareholders' Equity link:presentationLink link:calculationLink link:definitionLink 0000025 - Disclosure - Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 0000026 - Disclosure - Net Income (Loss) per Ordinary Share link:presentationLink link:calculationLink link:definitionLink 0000027 - Disclosure - Segment and Other Information link:presentationLink link:calculationLink link:definitionLink 0000028 - Disclosure - Revenues link:presentationLink link:calculationLink link:definitionLink 0000029 - Disclosure - Share-Based Compensation link:presentationLink link:calculationLink link:definitionLink 0000030 - Disclosure - Employee Benefit Plans link:presentationLink link:calculationLink link:definitionLink 0000031 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0000032 - Disclosure - Schedule II Valuation and Qualifying Accounts link:presentationLink link:calculationLink link:definitionLink 0000033 - Disclosure - Summary of Significant Accounting Policies - (Policies) link:presentationLink link:calculationLink link:definitionLink 0000034 - Disclosure - Summary of Significant Accounting Policies - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000035 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations (Tables) link:presentationLink link:calculationLink link:definitionLink 0000036 - Disclosure - Cash and Available-for-Sale Securities - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000037 - Disclosure - Fair Value Measurement - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000038 - Disclosure - Derivative Instruments and Hedging Activities - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000039 - Disclosure - Inventories (Tables) link:presentationLink link:calculationLink link:definitionLink 0000040 - Disclosure - Other Current Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 0000041 - Disclosure - Property, Plant and Equipment - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000042 - Disclosure - Goodwill and Intangible Assets - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000043 - Disclosure - Accrued Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 0000044 - Disclosure - Debt - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000045 - Disclosure - Leases - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000046 - Disclosure - Shareholders' Equity - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000047 - Disclosure - Comprehensive Income (Loss) - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Net Income (Loss) per Ordinary Share - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Segment and Other Information - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Revenues - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Share-Based Compensation - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000052 - Disclosure - Income Taxes - (Tables) link:presentationLink link:calculationLink link:definitionLink 0000053 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000054 - Disclosure - Summary of Significant Accounting Policies - Adoption of New Accounting Standards (Details) link:presentationLink link:calculationLink link:definitionLink 0000055 - Disclosure - Summary of Significant Accounting Policies - Schedule of Property and Equipment Estimated Useful Lives (Details) link:presentationLink link:calculationLink link:definitionLink 0000056 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations - Schedule of Aggregate Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 0000057 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations - Business Combination Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000058 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations - Schedule of Assets and Liabilities Acquired (Details) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations -License Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Business Combination, Disposition, Asset Acquisitions and Collaborations - Asset Acquisition and Exclusive License Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Cash and Available-for-Sale Securities - Summary of Cash and Cash Equivalents (Details) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Fair Value Measurement - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - Disclosure - Derivative Instruments and Hedging Activities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000065 - Disclosure - Derivative Instruments and Hedging Activities - Cross-Currency Loss Derivative Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 0000066 - Disclosure - Derivative Instruments and Hedging Activities - Foreign Exchange Gain (Loss) Derivative Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 0000067 - Disclosure - Derivative Instruments and Hedging Activities - Gains and Losses on Derivative Instruments (Details) link:presentationLink link:calculationLink link:definitionLink 0000068 - Disclosure - Derivative Instruments and Hedging Activities - Fair Value of Outstanding Derivatives (Details) link:presentationLink link:calculationLink link:definitionLink 0000069 - Disclosure - Derivative Instruments and Hedging Activities - Offsetting Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000070 - Disclosure - Inventories (Details) link:presentationLink link:calculationLink link:definitionLink 0000071 - Disclosure - Other Current Assets (Details) link:presentationLink link:calculationLink link:definitionLink 0000072 - Disclosure - Property, Plant and Equipment - Schedule of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 0000073 - Disclosure - Goodwill and Intangible Assets - Schedule of Gross Carrying Amount of Goodwill (Details) link:presentationLink link:calculationLink link:definitionLink 0000074 - Disclosure - Goodwill and Intangible Assets - Schedule of Gross Carrying Amounts and Net Book Values of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 0000075 - Disclosure - Goodwill and Intangible Assets - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000076 - Disclosure - Goodwill and Intangible Assets - Schedule of Estimated Future Amortization Costs (Details) link:presentationLink link:calculationLink link:definitionLink 0000077 - Disclosure - Accrued Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000078 - Disclosure - Debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 0000078 - Disclosure - Debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 0000079 - Disclosure - Debt - Credit Agreement Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000080 - Disclosure - Debt - 2029 Senior Secured Notes Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000081 - Disclosure - Debt - Exchangeable Senior Notes Due 2026 Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000082 - Disclosure - Debt - Exchangeable Senior Notes Due 2024 Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000083 - Disclosure - Debt - Schedule of Debt Maturities (Details) link:presentationLink link:calculationLink link:definitionLink 0000084 - Disclosure - Leases - Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 0000085 - Disclosure - Leases - Supplemental Balance Sheet Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000086 - Disclosure - Leases - Weighted Average Terms and Discount Rates (Details) link:presentationLink link:calculationLink link:definitionLink 0000087 - Disclosure - Leases - Supplemental Cash Flow Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000088 - Disclosure - Leases - Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000088 - Disclosure - Leases - Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000089 - Disclosure - Commitment and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 0000090 - Disclosure - Shareholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000091 - Disclosure - Shareholders' Equity - Schedule of Authorized But Unissued Ordinary Shares (Details) link:presentationLink link:calculationLink link:definitionLink 0000092 - Disclosure - Comprehensive Income (Loss) - Components of Accumulated Other Comprehensive Loss (Details) link:presentationLink link:calculationLink link:definitionLink 0000093 - Disclosure - Net Income (Loss) per Ordinary Share - Basic and Diluted Net Income (Loss) per Common Share (Details) link:presentationLink link:calculationLink link:definitionLink 0000094 - Disclosure - Net Income (Loss) per Ordinary Share - Weighted-Average Ordinary Shares Excluded from Computation of Diluted Net Income per Share (Details) link:presentationLink link:calculationLink link:definitionLink 0000095 - Disclosure - Segment and Other Information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000096 - Disclosure - Segment and Other Information - Total Long-Lived Assets by Location (Details) link:presentationLink link:calculationLink link:definitionLink 0000097 - Disclosure - Revenues - Summary of Disaggregation of Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 0000098 - Disclosure - Revenues - Summary of the Percentage of Total Revenues from Customers (Details) link:presentationLink link:calculationLink link:definitionLink 0000099 - Disclosure - Revenues - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000100 - Disclosure - Revenues - Summary of Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 0000101 - Disclosure - Share-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000102 - Disclosure - Share-Based Compensation - Schedule of Weighted-Average Assumptions Used in Black-Scholes Option Pricing Model and Resulting Weighted-Average Grant Date Fair Value of Share Options Granted (Details) link:presentationLink link:calculationLink link:definitionLink 0000103 - Disclosure - Share-Based Compensation - Share-Based Compensation - Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000104 - Disclosure - Share-Based Compensation - Schedule of Share Option Plans Activity (Details) link:presentationLink link:calculationLink link:definitionLink 0000105 - Disclosure - Share-Based Compensation - Schedule of RSUs Activity (Details) link:presentationLink link:calculationLink link:definitionLink 0000106 - Disclosure - Share-Based Compensation - Performance-based RSU's Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000107 - Disclosure - Employee Benefit Plans (Details) link:presentationLink link:calculationLink link:definitionLink 0000108 - Disclosure - Income Taxes - Components of Income Before Income Tax Provision (Benefit) (Details) link:presentationLink link:calculationLink link:definitionLink 0000109 - Disclosure - Income Taxes - Details of Income Tax Provision (Details) link:presentationLink link:calculationLink link:definitionLink 0000110 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 0000111 - Disclosure - Income Taxes - Effective Income Tax Rate Reconciliation (Details) link:presentationLink link:calculationLink link:definitionLink 0000112 - Disclosure - Income Taxes - Schedule of Net Deferred Tax Assets/(Liabilities) (Details) link:presentationLink link:calculationLink link:definitionLink 0000113 - Disclosure - Income Taxes - Current and Non-current Deferred Assets/(Liabilities) (Details) link:presentationLink link:calculationLink link:definitionLink 0000114 - Disclosure - Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 0000115 - Disclosure - Schedule II Valuation and Qualifying Accounts - (Details) link:presentationLink link:calculationLink link:definitionLink