<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:d97d2b90-be7e-4ffc-8bc2-149f3f9a02eb,g:01c76103-d520-4a65-8637-10c9eb008e00-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS" xlink:type="simple" xlink:href="jazz-20240331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_d67db87b-0922-4eed-ad01-152268a95302" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_StatementTable_d67db87b-0922-4eed-ad01-152268a95302" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_efaf856f-b74f-4f1c-b398-bd1d80321190" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_d67db87b-0922-4eed-ad01-152268a95302" xlink:to="loc_srt_ProductOrServiceAxis_efaf856f-b74f-4f1c-b398-bd1d80321190" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_efaf856f-b74f-4f1c-b398-bd1d80321190_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_efaf856f-b74f-4f1c-b398-bd1d80321190" xlink:to="loc_srt_ProductsAndServicesDomain_efaf856f-b74f-4f1c-b398-bd1d80321190_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_50bf5adb-deeb-4db8-81c3-aa2580b113ac" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_efaf856f-b74f-4f1c-b398-bd1d80321190" xlink:to="loc_srt_ProductsAndServicesDomain_50bf5adb-deeb-4db8-81c3-aa2580b113ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_d276f027-4799-465c-ae4c-113239df1f1f" xlink:href="jazz-20240331.xsd#jazz_ProductAndServicesProductSalesNetOfDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_50bf5adb-deeb-4db8-81c3-aa2580b113ac" xlink:to="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_d276f027-4799-465c-ae4c-113239df1f1f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_ce8c9081-10cb-407a-8405-3a54420b653d" xlink:href="jazz-20240331.xsd#jazz_ProductAndServicesRoyaltiesAndContractRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_50bf5adb-deeb-4db8-81c3-aa2580b113ac" xlink:to="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_ce8c9081-10cb-407a-8405-3a54420b653d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_e4725fcb-8f1a-4f72-a565-3eb48eba1aca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_RevenuesAbstract_e4725fcb-8f1a-4f72-a565-3eb48eba1aca" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_02a90bc7-0773-4ba5-83ed-f61b6e6347eb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_e4725fcb-8f1a-4f72-a565-3eb48eba1aca" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_02a90bc7-0773-4ba5-83ed-f61b6e6347eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment_5e3bfcee-ccc0-4b76-bf8a-589221b9f585" xlink:href="jazz-20240331.xsd#jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:to="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment_5e3bfcee-ccc0-4b76-bf8a-589221b9f585" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_823e0e5a-0cee-432b-b70e-6c3b1a9bfea8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_823e0e5a-0cee-432b-b70e-6c3b1a9bfea8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_3242b97f-a394-4d9f-b109-34ac423b0dad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_3242b97f-a394-4d9f-b109-34ac423b0dad" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_5e7f3448-6deb-4836-bc6d-6e05c8d034c3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_5e7f3448-6deb-4836-bc6d-6e05c8d034c3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_55c0f9cb-8f96-4a31-bb51-b1d8a8e203a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_55c0f9cb-8f96-4a31-bb51-b1d8a8e203a5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_da2ad7ce-1831-4cdd-a782-17b552dd21f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_5b0f13fc-7c94-46bf-903d-6919f02ffa14" xlink:to="loc_us-gaap_CostsAndExpenses_da2ad7ce-1831-4cdd-a782-17b552dd21f4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ffa955b1-2e76-46f0-944f-98564e8e1967" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_OperatingIncomeLoss_ffa955b1-2e76-46f0-944f-98564e8e1967" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_ce912302-d4ab-4011-ac0e-d894df522385" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_ce912302-d4ab-4011-ac0e-d894df522385" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_1f376d6e-785f-408d-aeab-961b0e62b452" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_1f376d6e-785f-408d-aeab-961b0e62b452" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_0fc2cf51-46b2-47bf-b7fb-9522492f6914" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_0fc2cf51-46b2-47bf-b7fb-9522492f6914" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_88eb5be8-c0b0-4b43-84cb-4d0f7e7a8e93" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_88eb5be8-c0b0-4b43-84cb-4d0f7e7a8e93" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_a3780e93-a85c-4617-8ee0-545e0990646f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_a3780e93-a85c-4617-8ee0-545e0990646f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_19bea3e2-313b-4b4c-80a4-6c3e3183d703" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_NetIncomeLoss_19bea3e2-313b-4b4c-80a4-6c3e3183d703" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NetIncomeLossPerOrdinaryShareAbstract_452513d2-2942-4060-ba7f-305c97a73786" xlink:href="jazz-20240331.xsd#jazz_NetIncomeLossPerOrdinaryShareAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_jazz_NetIncomeLossPerOrdinaryShareAbstract_452513d2-2942-4060-ba7f-305c97a73786" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_3540a18c-0b49-4cf6-8f00-d88d0e5f5572" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_NetIncomeLossPerOrdinaryShareAbstract_452513d2-2942-4060-ba7f-305c97a73786" xlink:to="loc_us-gaap_EarningsPerShareBasic_3540a18c-0b49-4cf6-8f00-d88d0e5f5572" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_d0ec9a4d-f037-4b26-b38a-41c1da1edfee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_NetIncomeLossPerOrdinaryShareAbstract_452513d2-2942-4060-ba7f-305c97a73786" xlink:to="loc_us-gaap_EarningsPerShareDiluted_d0ec9a4d-f037-4b26-b38a-41c1da1edfee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_b763ae00-658f-4dee-883d-efb32098ab73" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_b763ae00-658f-4dee-883d-efb32098ab73" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_6946cdf8-e6a6-4713-a298-577199f8c990" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_3a5b4ff9-875d-4c4c-b7c5-8fe16d31c66d" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_6946cdf8-e6a6-4713-a298-577199f8c990" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="simple" xlink:href="jazz-20240331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_f8ba6629-68e2-41ea-9fd1-093a276497b1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_40f43afe-0e8f-463a-ac52-cb1bfa58e1a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_f8ba6629-68e2-41ea-9fd1-093a276497b1" xlink:to="loc_us-gaap_StatementTable_40f43afe-0e8f-463a-ac52-cb1bfa58e1a2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f3ef69e1-ff94-4bfd-b5c5-80783e6e9d7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_40f43afe-0e8f-463a-ac52-cb1bfa58e1a2" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f3ef69e1-ff94-4bfd-b5c5-80783e6e9d7e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f3ef69e1-ff94-4bfd-b5c5-80783e6e9d7e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f3ef69e1-ff94-4bfd-b5c5-80783e6e9d7e" xlink:to="loc_us-gaap_EquityComponentDomain_f3ef69e1-ff94-4bfd-b5c5-80783e6e9d7e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f3ef69e1-ff94-4bfd-b5c5-80783e6e9d7e" xlink:to="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_6be969b1-13ec-4a9e-a29a-4e017b9018c2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:to="loc_us-gaap_CommonStockMember_6be969b1-13ec-4a9e-a29a-4e017b9018c2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_EuroDeferredSharesMember_8e335e41-aaef-4fa9-b227-6e0e0f2d7f89" xlink:href="jazz-20240331.xsd#jazz_EuroDeferredSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:to="loc_jazz_EuroDeferredSharesMember_8e335e41-aaef-4fa9-b227-6e0e0f2d7f89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CapitalRedemptionReserveMember_c31fb6e9-b768-4e50-bc6e-3853b5845196" xlink:href="jazz-20240331.xsd#jazz_CapitalRedemptionReserveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:to="loc_jazz_CapitalRedemptionReserveMember_c31fb6e9-b768-4e50-bc6e-3853b5845196" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_1c6b75bd-db02-471a-ac3e-d087997e442b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_1c6b75bd-db02-471a-ac3e-d087997e442b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_55e91013-59ad-4dd0-a2bb-3580b549d465" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_55e91013-59ad-4dd0-a2bb-3580b549d465" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_7d029a49-4bcb-40e1-93c7-cc71939bfe57" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_2ec2d583-11f5-4a5e-979a-b87236774c8c" xlink:to="loc_us-gaap_RetainedEarningsMember_7d029a49-4bcb-40e1-93c7-cc71939bfe57" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_95f7578d-a0fe-491e-8324-229773ceffa8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_40f43afe-0e8f-463a-ac52-cb1bfa58e1a2" xlink:to="loc_us-gaap_AwardTypeAxis_95f7578d-a0fe-491e-8324-229773ceffa8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_95f7578d-a0fe-491e-8324-229773ceffa8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_95f7578d-a0fe-491e-8324-229773ceffa8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_95f7578d-a0fe-491e-8324-229773ceffa8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f86a9679-8821-4bf8-b8e7-7b1bf1daa905" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_95f7578d-a0fe-491e-8324-229773ceffa8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f86a9679-8821-4bf8-b8e7-7b1bf1daa905" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_58560ec9-177d-4d1a-8b3d-d94c85b6d4b5" xlink:href="jazz-20240331.xsd#jazz_PerformanceBasedRestrictedStockUnitsRSUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f86a9679-8821-4bf8-b8e7-7b1bf1daa905" xlink:to="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_58560ec9-177d-4d1a-8b3d-d94c85b6d4b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_f8ba6629-68e2-41ea-9fd1-093a276497b1" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_80d105c8-907b-47ad-8f28-e5c6f6abcae4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_80d105c8-907b-47ad-8f28-e5c6f6abcae4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d9fc545e-7849-43a0-a40c-690477d46c54" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_StockholdersEquity_d9fc545e-7849-43a0-a40c-690477d46c54" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_67806b05-6889-4ea2-b532-bdb34a2b053b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_67806b05-6889-4ea2-b532-bdb34a2b053b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_7b6fa535-25fa-42f6-b3a1-4fd6b9d32835" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_7b6fa535-25fa-42f6-b3a1-4fd6b9d32835" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_6af5b4e3-b6a9-42cf-8910-1b0f3bf613de" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_6af5b4e3-b6a9-42cf-8910-1b0f3bf613de" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_a7db0d9f-1088-4855-938a-b2fce25f0ac8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_a7db0d9f-1088-4855-938a-b2fce25f0ac8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_b50ab8d1-9015-45e7-8c8e-2591bc7e2254" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_b50ab8d1-9015-45e7-8c8e-2591bc7e2254" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_0518eb5d-dcf6-41a9-841a-de4373e07551" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_0518eb5d-dcf6-41a9-841a-de4373e07551" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1c324e0f-846d-4ae1-92c0-2d68b2bee9ab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1e4f76d0-f330-4c27-a2b7-f2eff3ecbca8" xlink:to="loc_us-gaap_NetIncomeLoss_1c324e0f-846d-4ae1-92c0-2d68b2bee9ab" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_43751eb3-43bc-439c-99f3-a90cbd4d8f8f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1ad798ff-faa1-4e7c-bc10-9cb166260d13" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_bfa2e873-8bbe-4839-a1a5-10baef88ebb7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_bfa2e873-8bbe-4839-a1a5-10baef88ebb7" xlink:to="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_8f78cc69-39fe-40c5-b2d5-45195e12c5a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_8f78cc69-39fe-40c5-b2d5-45195e12c5a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_8f78cc69-39fe-40c5-b2d5-45195e12c5a2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_8f78cc69-39fe-40c5-b2d5-45195e12c5a2" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_8f78cc69-39fe-40c5-b2d5-45195e12c5a2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_215287dc-8677-4bfb-910c-0c8a7d3e3f06" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_8f78cc69-39fe-40c5-b2d5-45195e12c5a2" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_215287dc-8677-4bfb-910c-0c8a7d3e3f06" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_f19dc8a0-37db-4919-8619-eff71b0467d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_215287dc-8677-4bfb-910c-0c8a7d3e3f06" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_f19dc8a0-37db-4919-8619-eff71b0467d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_19bf533a-79cd-4d22-aed8-730c20135842" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_215287dc-8677-4bfb-910c-0c8a7d3e3f06" xlink:to="loc_us-gaap_InterestRateSwapMember_19bf533a-79cd-4d22-aed8-730c20135842" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_886f14b1-0a35-46b4-a221-bdcd68dbf6be" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:to="loc_us-gaap_HedgingDesignationAxis_886f14b1-0a35-46b4-a221-bdcd68dbf6be" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_886f14b1-0a35-46b4-a221-bdcd68dbf6be_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_886f14b1-0a35-46b4-a221-bdcd68dbf6be" xlink:to="loc_us-gaap_HedgingDesignationDomain_886f14b1-0a35-46b4-a221-bdcd68dbf6be_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_a153d871-6d9f-4546-bcfb-fd59bdf38004" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_886f14b1-0a35-46b4-a221-bdcd68dbf6be" xlink:to="loc_us-gaap_HedgingDesignationDomain_a153d871-6d9f-4546-bcfb-fd59bdf38004" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_821c5548-9d66-4be0-b187-776377a87560" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_a153d871-6d9f-4546-bcfb-fd59bdf38004" xlink:to="loc_us-gaap_NondesignatedMember_821c5548-9d66-4be0-b187-776377a87560" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_e255a24e-0121-48f5-8700-d3fdbc1e1739" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_a153d871-6d9f-4546-bcfb-fd59bdf38004" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_e255a24e-0121-48f5-8700-d3fdbc1e1739" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_f8cb08e3-284c-424f-9607-4b5fc8ffc7be" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_f8cb08e3-284c-424f-9607-4b5fc8ffc7be" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_f8cb08e3-284c-424f-9607-4b5fc8ffc7be_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_f8cb08e3-284c-424f-9607-4b5fc8ffc7be" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_f8cb08e3-284c-424f-9607-4b5fc8ffc7be_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_1f4dab6e-70ad-43ef-a4f5-9217776104d9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_f8cb08e3-284c-424f-9607-4b5fc8ffc7be" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_1f4dab6e-70ad-43ef-a4f5-9217776104d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_459721d8-01a4-450a-a859-f76d5a9a3f49" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_1f4dab6e-70ad-43ef-a4f5-9217776104d9" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_459721d8-01a4-450a-a859-f76d5a9a3f49" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7ed033aa-4261-41c6-bfdf-83524f54dde6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7ed033aa-4261-41c6-bfdf-83524f54dde6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_7ed033aa-4261-41c6-bfdf-83524f54dde6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7ed033aa-4261-41c6-bfdf-83524f54dde6" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_7ed033aa-4261-41c6-bfdf-83524f54dde6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a3f92fbf-5875-4234-92c7-09e78d54a8b2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7ed033aa-4261-41c6-bfdf-83524f54dde6" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a3f92fbf-5875-4234-92c7-09e78d54a8b2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_594c262c-2c7a-4b0d-a98b-9381a500916c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a3f92fbf-5875-4234-92c7-09e78d54a8b2" xlink:to="loc_us-gaap_AccountsReceivableMember_594c262c-2c7a-4b0d-a98b-9381a500916c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_ad0a0849-5a69-487b-8088-61827b61fa03" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_9db30a03-fbaa-477b-97db-b1d4b4e42d0c" xlink:to="loc_srt_MajorCustomersAxis_ad0a0849-5a69-487b-8088-61827b61fa03" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_ad0a0849-5a69-487b-8088-61827b61fa03_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_ad0a0849-5a69-487b-8088-61827b61fa03" xlink:to="loc_srt_NameOfMajorCustomerDomain_ad0a0849-5a69-487b-8088-61827b61fa03_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_e5c2ac60-6609-4ca2-95ea-20ee901affd6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_ad0a0849-5a69-487b-8088-61827b61fa03" xlink:to="loc_srt_NameOfMajorCustomerDomain_e5c2ac60-6609-4ca2-95ea-20ee901affd6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FiveCustomersMember_ea777b6d-4f20-4603-868a-205a2a804271" xlink:href="jazz-20240331.xsd#jazz_FiveCustomersMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e5c2ac60-6609-4ca2-95ea-20ee901affd6" xlink:to="loc_jazz_FiveCustomersMember_ea777b6d-4f20-4603-868a-205a2a804271" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExpressScriptsMember_797d3022-e739-41ba-927d-6105d4c2e8c5" xlink:href="jazz-20240331.xsd#jazz_ExpressScriptsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e5c2ac60-6609-4ca2-95ea-20ee901affd6" xlink:to="loc_jazz_ExpressScriptsMember_797d3022-e739-41ba-927d-6105d4c2e8c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ASDSpecialtyHealthcareLLCMember_6acd5a07-584f-42f5-8f73-ed42338132e3" xlink:href="jazz-20240331.xsd#jazz_ASDSpecialtyHealthcareLLCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e5c2ac60-6609-4ca2-95ea-20ee901affd6" xlink:to="loc_jazz_ASDSpecialtyHealthcareLLCMember_6acd5a07-584f-42f5-8f73-ed42338132e3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_McKessonCorporationMember_0b65db9f-d0e8-45c6-8dcb-6f1509d7c698" xlink:href="jazz-20240331.xsd#jazz_McKessonCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e5c2ac60-6609-4ca2-95ea-20ee901affd6" xlink:to="loc_jazz_McKessonCorporationMember_0b65db9f-d0e8-45c6-8dcb-6f1509d7c698" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_1cc22fdd-a5a1-4e79-b81d-f88b9dee2eb8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_bfa2e873-8bbe-4839-a1a5-10baef88ebb7" xlink:to="loc_us-gaap_DerivativeNotionalAmount_1cc22fdd-a5a1-4e79-b81d-f88b9dee2eb8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_2a26fa2b-3973-4f63-a963-9f8bbcbc8e9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_bfa2e873-8bbe-4839-a1a5-10baef88ebb7" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_2a26fa2b-3973-4f63-a963-9f8bbcbc8e9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_64904f69-9b26-4c13-b741-75eff3e6dc9f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_bfa2e873-8bbe-4839-a1a5-10baef88ebb7" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_64904f69-9b26-4c13-b741-75eff3e6dc9f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_60bc653e-3127-4757-b922-8a4fe5595c27" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_60bc653e-3127-4757-b922-8a4fe5595c27" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0062324d-2c81-4838-9e89-4dd85a7f046c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_60bc653e-3127-4757-b922-8a4fe5595c27" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0062324d-2c81-4838-9e89-4dd85a7f046c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0062324d-2c81-4838-9e89-4dd85a7f046c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0062324d-2c81-4838-9e89-4dd85a7f046c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0062324d-2c81-4838-9e89-4dd85a7f046c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_16551998-1f71-449d-a99f-870427535d64" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0062324d-2c81-4838-9e89-4dd85a7f046c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_16551998-1f71-449d-a99f-870427535d64" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashMember_4a14dd1f-0427-4a4f-9a0f-09382f7be2e6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_16551998-1f71-449d-a99f-870427535d64" xlink:to="loc_us-gaap_CashMember_4a14dd1f-0427-4a4f-9a0f-09382f7be2e6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_27af49ec-1807-401c-82a9-33349ea7ba18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_16551998-1f71-449d-a99f-870427535d64" xlink:to="loc_us-gaap_BankTimeDepositsMember_27af49ec-1807-401c-82a9-33349ea7ba18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_0c2fd3e0-0412-44fb-8df2-6cc6d782f05a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_16551998-1f71-449d-a99f-870427535d64" xlink:to="loc_us-gaap_MoneyMarketFundsMember_0c2fd3e0-0412-44fb-8df2-6cc6d782f05a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_e1954542-5729-4be1-92fc-390bee3330f9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_e1954542-5729-4be1-92fc-390bee3330f9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_8defa4cd-5719-4e98-bdb2-ad55e9f8e2a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_8defa4cd-5719-4e98-bdb2-ad55e9f8e2a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_0a8481f2-0d59-4f52-b8d3-9794cc5fc660" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_0a8481f2-0d59-4f52-b8d3-9794cc5fc660" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f6c63ec7-2fca-49fe-aa54-e9cafb61dfc0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_f6c63ec7-2fca-49fe-aa54-e9cafb61dfc0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_17161027-739a-40e1-bfc3-a1336f85474f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_17161027-739a-40e1-bfc3-a1336f85474f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Investments_df75be57-b88a-4c60-9b22-9235322a2ff5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_Investments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_79985f88-c442-477e-87b4-723f6c05782b" xlink:to="loc_us-gaap_Investments_df75be57-b88a-4c60-9b22-9235322a2ff5" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_48b34258-3287-4db9-889f-dc37fc318f2f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3be7f512-793c-4aae-bcfc-f698f3c6b7f4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_48b34258-3287-4db9-889f-dc37fc318f2f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3be7f512-793c-4aae-bcfc-f698f3c6b7f4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_dfb96e74-fc48-4c50-ada9-fadc427ab40d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3be7f512-793c-4aae-bcfc-f698f3c6b7f4" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_dfb96e74-fc48-4c50-ada9-fadc427ab40d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_dfb96e74-fc48-4c50-ada9-fadc427ab40d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_dfb96e74-fc48-4c50-ada9-fadc427ab40d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_dfb96e74-fc48-4c50-ada9-fadc427ab40d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_20f9bcfc-ce24-4951-9605-c70081941468" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_dfb96e74-fc48-4c50-ada9-fadc427ab40d" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_20f9bcfc-ce24-4951-9605-c70081941468" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_194ccaff-a109-4d68-96a7-cc8804a9413c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_20f9bcfc-ce24-4951-9605-c70081941468" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_194ccaff-a109-4d68-96a7-cc8804a9413c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_38224dcb-ef67-4fc3-9a3e-ed7fab0dcf19" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3be7f512-793c-4aae-bcfc-f698f3c6b7f4" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_38224dcb-ef67-4fc3-9a3e-ed7fab0dcf19" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38224dcb-ef67-4fc3-9a3e-ed7fab0dcf19_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_38224dcb-ef67-4fc3-9a3e-ed7fab0dcf19" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_38224dcb-ef67-4fc3-9a3e-ed7fab0dcf19_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_70b06c2d-de79-473f-9e71-109f161b2990" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_38224dcb-ef67-4fc3-9a3e-ed7fab0dcf19" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_70b06c2d-de79-473f-9e71-109f161b2990" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_e665fe10-9ead-4ef3-913c-b54cba07214e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_70b06c2d-de79-473f-9e71-109f161b2990" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_e665fe10-9ead-4ef3-913c-b54cba07214e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_3916f1d3-2ae6-4702-9562-ce9b9c1eb0f6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_70b06c2d-de79-473f-9e71-109f161b2990" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_3916f1d3-2ae6-4702-9562-ce9b9c1eb0f6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_a882408b-7844-4fb4-868c-132557cd4ffa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3be7f512-793c-4aae-bcfc-f698f3c6b7f4" xlink:to="loc_us-gaap_FinancialInstrumentAxis_a882408b-7844-4fb4-868c-132557cd4ffa" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_a882408b-7844-4fb4-868c-132557cd4ffa_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_a882408b-7844-4fb4-868c-132557cd4ffa" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_a882408b-7844-4fb4-868c-132557cd4ffa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_42535ab2-3195-4882-9d63-380615f3cde0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_a882408b-7844-4fb4-868c-132557cd4ffa" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_42535ab2-3195-4882-9d63-380615f3cde0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_3ed9f8ed-d6a9-486f-a120-ff985b2877e1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_42535ab2-3195-4882-9d63-380615f3cde0" xlink:to="loc_us-gaap_MoneyMarketFundsMember_3ed9f8ed-d6a9-486f-a120-ff985b2877e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_b1f624fa-978e-4d86-8d1b-80376c72a94e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_42535ab2-3195-4882-9d63-380615f3cde0" xlink:to="loc_us-gaap_BankTimeDepositsMember_b1f624fa-978e-4d86-8d1b-80376c72a94e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_8c58485e-dabd-44d4-8a81-1acc16cfc7c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_42535ab2-3195-4882-9d63-380615f3cde0" xlink:to="loc_us-gaap_InterestRateContractMember_8c58485e-dabd-44d4-8a81-1acc16cfc7c5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_4a2e60a6-f894-49dc-a71d-0bef0b4b33a3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_42535ab2-3195-4882-9d63-380615f3cde0" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_4a2e60a6-f894-49dc-a71d-0bef0b4b33a3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_3a85f09a-84f3-436a-9365-65ed2c09856c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_48b34258-3287-4db9-889f-dc37fc318f2f" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_3a85f09a-84f3-436a-9365-65ed2c09856c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_e71ba8a1-922b-4bf5-b09a-10a1b8354b99" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_3a85f09a-84f3-436a-9365-65ed2c09856c" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_e71ba8a1-922b-4bf5-b09a-10a1b8354b99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_25199326-0c77-4a9f-a1ed-71057668963a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_e71ba8a1-922b-4bf5-b09a-10a1b8354b99" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_25199326-0c77-4a9f-a1ed-71057668963a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_23e9a08e-5fda-4165-90b2-db9e97ae26ed" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_e71ba8a1-922b-4bf5-b09a-10a1b8354b99" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_23e9a08e-5fda-4165-90b2-db9e97ae26ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_e25fa2a1-d459-40aa-942e-865c79de9397" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_e71ba8a1-922b-4bf5-b09a-10a1b8354b99" xlink:to="loc_us-gaap_DerivativeAssets_e25fa2a1-d459-40aa-942e-865c79de9397" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_835a4091-68aa-4006-ba30-adec43c0362c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_3a85f09a-84f3-436a-9365-65ed2c09856c" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_835a4091-68aa-4006-ba30-adec43c0362c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_d53baa78-b307-4022-968c-5ae19ba2fbcd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_48b34258-3287-4db9-889f-dc37fc318f2f" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_d53baa78-b307-4022-968c-5ae19ba2fbcd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_9f5113bc-927d-4156-b636-86f277f68d7b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_d53baa78-b307-4022-968c-5ae19ba2fbcd" xlink:to="loc_us-gaap_DerivativeLiabilities_9f5113bc-927d-4156-b636-86f277f68d7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_fa2870a8-d0cf-452e-bc58-6be1732cb624" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_d53baa78-b307-4022-968c-5ae19ba2fbcd" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_fa2870a8-d0cf-452e-bc58-6be1732cb624" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#FairValueMeasurementNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61e94329-cef1-4a56-8ef4-b6f03f621439" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61e94329-cef1-4a56-8ef4-b6f03f621439" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4533dc40-47ec-4d9f-b00a-60160f9b2225" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61e94329-cef1-4a56-8ef4-b6f03f621439" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4533dc40-47ec-4d9f-b00a-60160f9b2225" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4533dc40-47ec-4d9f-b00a-60160f9b2225_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4533dc40-47ec-4d9f-b00a-60160f9b2225" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_4533dc40-47ec-4d9f-b00a-60160f9b2225_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6366b6b6-6140-4597-b3c8-b7e90d618e8d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_4533dc40-47ec-4d9f-b00a-60160f9b2225" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6366b6b6-6140-4597-b3c8-b7e90d618e8d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_3b64b4a9-079b-4583-8346-160228b5197f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_6366b6b6-6140-4597-b3c8-b7e90d618e8d" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_3b64b4a9-079b-4583-8346-160228b5197f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_9b287719-c8ae-494e-b5e6-8152d14f7058" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61e94329-cef1-4a56-8ef4-b6f03f621439" xlink:to="loc_us-gaap_DebtInstrumentAxis_9b287719-c8ae-494e-b5e6-8152d14f7058" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_9b287719-c8ae-494e-b5e6-8152d14f7058_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_9b287719-c8ae-494e-b5e6-8152d14f7058" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_9b287719-c8ae-494e-b5e6-8152d14f7058_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_2a2f998a-d154-45f0-8691-b7de04e5c729" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_9b287719-c8ae-494e-b5e6-8152d14f7058" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_2a2f998a-d154-45f0-8691-b7de04e5c729" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_14d774be-c74b-491a-a8e8-a671e755e054" xlink:href="jazz-20240331.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2a2f998a-d154-45f0-8691-b7de04e5c729" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_14d774be-c74b-491a-a8e8-a671e755e054" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_a452d82d-ddc4-42bf-86bd-268123b09ddc" xlink:href="jazz-20240331.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2a2f998a-d154-45f0-8691-b7de04e5c729" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_a452d82d-ddc4-42bf-86bd-268123b09ddc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorNotesDue2029Member_1b092ecf-f842-4a9a-a7a3-4dfdf99006aa" xlink:href="jazz-20240331.xsd#jazz_SeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2a2f998a-d154-45f0-8691-b7de04e5c729" xlink:to="loc_jazz_SeniorNotesDue2029Member_1b092ecf-f842-4a9a-a7a3-4dfdf99006aa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember_b1425003-dddb-4046-8622-5c0c3a2b9d57" xlink:href="jazz-20240331.xsd#jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_2a2f998a-d154-45f0-8691-b7de04e5c729" xlink:to="loc_jazz_TwoThousandTwentyOneCreditAgreementDollarTermLoanMember_b1425003-dddb-4046-8622-5c0c3a2b9d57" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_ba597a02-7350-4e38-bd6e-4e81eb1d5e55" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61e94329-cef1-4a56-8ef4-b6f03f621439" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_ba597a02-7350-4e38-bd6e-4e81eb1d5e55" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ba597a02-7350-4e38-bd6e-4e81eb1d5e55_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ba597a02-7350-4e38-bd6e-4e81eb1d5e55" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ba597a02-7350-4e38-bd6e-4e81eb1d5e55_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_b3547f90-5cde-4c21-80b9-cf53e606f786" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ba597a02-7350-4e38-bd6e-4e81eb1d5e55" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_b3547f90-5cde-4c21-80b9-cf53e606f786" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_1acd8ee2-3ac9-4e9d-96b3-2b7d15b07a7c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_b3547f90-5cde-4c21-80b9-cf53e606f786" xlink:to="loc_us-gaap_ConvertibleDebtMember_1acd8ee2-3ac9-4e9d-96b3-2b7d15b07a7c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredDebtMember_97bd2b2b-8637-4592-ae08-1480d67da161" xlink:href="jazz-20240331.xsd#jazz_SeniorSecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_b3547f90-5cde-4c21-80b9-cf53e606f786" xlink:to="loc_jazz_SeniorSecuredDebtMember_97bd2b2b-8637-4592-ae08-1480d67da161" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_7367ddda-cf42-4710-8d0c-7285e025304c" xlink:href="jazz-20240331.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_b3547f90-5cde-4c21-80b9-cf53e606f786" xlink:to="loc_jazz_TermLoanMember_7367ddda-cf42-4710-8d0c-7285e025304c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_4b70021e-262e-4325-ab7c-9eb02487e036" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_61e94329-cef1-4a56-8ef4-b6f03f621439" xlink:to="loc_dei_LegalEntityAxis_4b70021e-262e-4325-ab7c-9eb02487e036" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_4b70021e-262e-4325-ab7c-9eb02487e036_default" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_4b70021e-262e-4325-ab7c-9eb02487e036" xlink:to="loc_dei_EntityDomain_4b70021e-262e-4325-ab7c-9eb02487e036_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_59429b09-5df8-4e76-a795-aed45fc801ea" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_4b70021e-262e-4325-ab7c-9eb02487e036" xlink:to="loc_dei_EntityDomain_59429b09-5df8-4e76-a795-aed45fc801ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_JazzSecuritiesDesignatedActivityCompanyMember_fe09dd45-ad95-4f13-b7a9-281b46da4651" xlink:href="jazz-20240331.xsd#jazz_JazzSecuritiesDesignatedActivityCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_59429b09-5df8-4e76-a795-aed45fc801ea" xlink:to="loc_jazz_JazzSecuritiesDesignatedActivityCompanyMember_fe09dd45-ad95-4f13-b7a9-281b46da4651" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_71a2a036-da44-4a7f-a9b5-8fc5d6e20267" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_71a2a036-da44-4a7f-a9b5-8fc5d6e20267" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_1a7c7eed-f40c-41f0-a7eb-4db5f6524d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_1a7c7eed-f40c-41f0-a7eb-4db5f6524d3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_0ada1c32-8330-45c1-b5ae-77577b618776" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_DebtInstrumentTerm_0ada1c32-8330-45c1-b5ae-77577b618776" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_cb9fe39c-0881-43e0-b553-679224f23b32" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_cb9fe39c-0881-43e0-b553-679224f23b32" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_a0906df7-d07f-49a0-acbb-df26e49cb0fe" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_a0906df7-d07f-49a0-acbb-df26e49cb0fe" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableFairValueDisclosure_8bf39e59-89eb-48d1-b1ab-e1da965c2617" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NotesPayableFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_NotesPayableFairValueDisclosure_8bf39e59-89eb-48d1-b1ab-e1da965c2617" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LinesOfCreditFairValueDisclosure_48ef53f8-03ac-4f43-849f-572a95c62811" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LinesOfCreditFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_b145306f-96d6-4d18-855f-6ecb58a9f434" xlink:to="loc_us-gaap_LinesOfCreditFairValueDisclosure_48ef53f8-03ac-4f43-849f-572a95c62811" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DerivativeInstrumentsandHedgingActivitiesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_c8c1589d-458e-4360-b3a2-5d0ee5d72b99" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_1477b9f1-a6da-429b-b59c-1774b184c6ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_c8c1589d-458e-4360-b3a2-5d0ee5d72b99" xlink:to="loc_us-gaap_DerivativeTable_1477b9f1-a6da-429b-b59c-1774b184c6ce" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_f55a82df-d65d-4f20-85a6-26d7db4b26a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_1477b9f1-a6da-429b-b59c-1774b184c6ce" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_f55a82df-d65d-4f20-85a6-26d7db4b26a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_f55a82df-d65d-4f20-85a6-26d7db4b26a5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_f55a82df-d65d-4f20-85a6-26d7db4b26a5" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_f55a82df-d65d-4f20-85a6-26d7db4b26a5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_78308aa7-2a66-4541-936f-dc983651dcf4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_f55a82df-d65d-4f20-85a6-26d7db4b26a5" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_78308aa7-2a66-4541-936f-dc983651dcf4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_3a4b066c-1e07-4676-ba8f-54847222a21e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_78308aa7-2a66-4541-936f-dc983651dcf4" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_3a4b066c-1e07-4676-ba8f-54847222a21e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_b87a1716-eff9-449f-858a-9459d84a3b33" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_78308aa7-2a66-4541-936f-dc983651dcf4" xlink:to="loc_us-gaap_InterestRateSwapMember_b87a1716-eff9-449f-858a-9459d84a3b33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_6cfe9f04-1e9f-4e2c-9688-ff7a4696a3d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_1477b9f1-a6da-429b-b59c-1774b184c6ce" xlink:to="loc_us-gaap_HedgingDesignationAxis_6cfe9f04-1e9f-4e2c-9688-ff7a4696a3d5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_6cfe9f04-1e9f-4e2c-9688-ff7a4696a3d5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_6cfe9f04-1e9f-4e2c-9688-ff7a4696a3d5" xlink:to="loc_us-gaap_HedgingDesignationDomain_6cfe9f04-1e9f-4e2c-9688-ff7a4696a3d5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_c1ffb6cc-7bd0-4b15-ad37-a6817148d711" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_6cfe9f04-1e9f-4e2c-9688-ff7a4696a3d5" xlink:to="loc_us-gaap_HedgingDesignationDomain_c1ffb6cc-7bd0-4b15-ad37-a6817148d711" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_cdea7114-a570-45ae-be83-a6807f0766e0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_c1ffb6cc-7bd0-4b15-ad37-a6817148d711" xlink:to="loc_us-gaap_NondesignatedMember_cdea7114-a570-45ae-be83-a6807f0766e0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_8422ed5c-8860-4f76-8f09-94992cde4c42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_c1ffb6cc-7bd0-4b15-ad37-a6817148d711" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_8422ed5c-8860-4f76-8f09-94992cde4c42" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_a97976ec-03dc-431f-97ab-c563d71ed83e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_1477b9f1-a6da-429b-b59c-1774b184c6ce" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_a97976ec-03dc-431f-97ab-c563d71ed83e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_a97976ec-03dc-431f-97ab-c563d71ed83e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_a97976ec-03dc-431f-97ab-c563d71ed83e" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_a97976ec-03dc-431f-97ab-c563d71ed83e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_2946256f-6953-45c3-999b-e001976b5cc1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_a97976ec-03dc-431f-97ab-c563d71ed83e" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_2946256f-6953-45c3-999b-e001976b5cc1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_89a015c2-7630-4c66-9544-220e9ff4f9ee" xlink:href="jazz-20240331.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_2946256f-6953-45c3-999b-e001976b5cc1" xlink:to="loc_jazz_TermLoanMember_89a015c2-7630-4c66-9544-220e9ff4f9ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_145688fb-8bac-4ca7-8173-1d4c6d535a76" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_c8c1589d-458e-4360-b3a2-5d0ee5d72b99" xlink:to="loc_us-gaap_DerivativeNotionalAmount_145688fb-8bac-4ca7-8173-1d4c6d535a76" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2859f0d8-7d46-4f32-b0b3-f94d62082041" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_c8c1589d-458e-4360-b3a2-5d0ee5d72b99" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2859f0d8-7d46-4f32-b0b3-f94d62082041" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths_189f5b84-86a3-41a8-b264-b5856d0eddf0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_c8c1589d-458e-4360-b3a2-5d0ee5d72b99" xlink:to="loc_us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths_189f5b84-86a3-41a8-b264-b5856d0eddf0" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_3c9e4365-6737-4616-bf96-aa626ec231da" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_1f594079-2333-4910-945f-bc9da954b2f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_3c9e4365-6737-4616-bf96-aa626ec231da" xlink:to="loc_us-gaap_DerivativeTable_1f594079-2333-4910-945f-bc9da954b2f8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_dd14adf7-6299-40e7-bb65-d3e22059afc4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_1f594079-2333-4910-945f-bc9da954b2f8" xlink:to="loc_us-gaap_HedgingDesignationAxis_dd14adf7-6299-40e7-bb65-d3e22059afc4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_dd14adf7-6299-40e7-bb65-d3e22059afc4_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_dd14adf7-6299-40e7-bb65-d3e22059afc4" xlink:to="loc_us-gaap_HedgingDesignationDomain_dd14adf7-6299-40e7-bb65-d3e22059afc4_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_592ed47d-7c06-495c-8063-17b86fd4bd1e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_dd14adf7-6299-40e7-bb65-d3e22059afc4" xlink:to="loc_us-gaap_HedgingDesignationDomain_592ed47d-7c06-495c-8063-17b86fd4bd1e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_98a5e6d5-1b54-4ea9-9219-336373d29e2c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_592ed47d-7c06-495c-8063-17b86fd4bd1e" xlink:to="loc_us-gaap_NondesignatedMember_98a5e6d5-1b54-4ea9-9219-336373d29e2c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_42c363e6-7a0b-481c-8c9d-aced35bfae53" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_1f594079-2333-4910-945f-bc9da954b2f8" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_42c363e6-7a0b-481c-8c9d-aced35bfae53" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_42c363e6-7a0b-481c-8c9d-aced35bfae53_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_42c363e6-7a0b-481c-8c9d-aced35bfae53" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_42c363e6-7a0b-481c-8c9d-aced35bfae53_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_845c94cf-997f-48e7-9ddb-05895dc428ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_42c363e6-7a0b-481c-8c9d-aced35bfae53" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_845c94cf-997f-48e7-9ddb-05895dc428ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_844e04ce-097e-4df2-ae03-d06b42b0864a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_845c94cf-997f-48e7-9ddb-05895dc428ee" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_844e04ce-097e-4df2-ae03-d06b42b0864a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_19864ff7-d001-45f6-9c5e-d3167610fcbb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_3c9e4365-6737-4616-bf96-aa626ec231da" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_19864ff7-d001-45f6-9c5e-d3167610fcbb" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesGainsandLossesonDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DerivativeInstrumentsandHedgingActivitiesGainsandLossesonDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesGainsandLossesonDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_03fe426b-7380-4dcd-a936-e74b0d44f361" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_b331ce78-64c5-4ede-90ad-9a41a6b53a39" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_03fe426b-7380-4dcd-a936-e74b0d44f361" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_b331ce78-64c5-4ede-90ad-9a41a6b53a39" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_35bbfa1e-5f94-49ac-b8fd-ab8de709d84b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_b331ce78-64c5-4ede-90ad-9a41a6b53a39" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_35bbfa1e-5f94-49ac-b8fd-ab8de709d84b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_35bbfa1e-5f94-49ac-b8fd-ab8de709d84b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_35bbfa1e-5f94-49ac-b8fd-ab8de709d84b" xlink:to="loc_us-gaap_HedgingRelationshipDomain_35bbfa1e-5f94-49ac-b8fd-ab8de709d84b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_38434e4b-ad92-4ac9-aecb-1afc6020d389" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_35bbfa1e-5f94-49ac-b8fd-ab8de709d84b" xlink:to="loc_us-gaap_HedgingRelationshipDomain_38434e4b-ad92-4ac9-aecb-1afc6020d389" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_7978e92a-1e37-43a5-8c0a-362a4aeb65ff" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_38434e4b-ad92-4ac9-aecb-1afc6020d389" xlink:to="loc_us-gaap_CashFlowHedgingMember_7978e92a-1e37-43a5-8c0a-362a4aeb65ff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_d40f70dd-c9fc-4eda-bb8a-bd260088b0bd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_b331ce78-64c5-4ede-90ad-9a41a6b53a39" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_d40f70dd-c9fc-4eda-bb8a-bd260088b0bd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_d40f70dd-c9fc-4eda-bb8a-bd260088b0bd_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_d40f70dd-c9fc-4eda-bb8a-bd260088b0bd" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_d40f70dd-c9fc-4eda-bb8a-bd260088b0bd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_db764548-97a4-405c-8d32-6bfa40c2b1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_d40f70dd-c9fc-4eda-bb8a-bd260088b0bd" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_db764548-97a4-405c-8d32-6bfa40c2b1b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_fd558ef4-515e-49bf-b54a-2cdbf7166d75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_db764548-97a4-405c-8d32-6bfa40c2b1b5" xlink:to="loc_us-gaap_InterestRateContractMember_fd558ef4-515e-49bf-b54a-2cdbf7166d75" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_c0fad78e-7f6d-4925-b44e-857ae5a9f054" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_03fe426b-7380-4dcd-a936-e74b0d44f361" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_c0fad78e-7f6d-4925-b44e-857ae5a9f054" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_2b10a758-429b-4b2d-b4e5-32ef87612b1e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_03fe426b-7380-4dcd-a936-e74b0d44f361" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_2b10a758-429b-4b2d-b4e5-32ef87612b1e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_f37d4d99-0015-4296-9cb8-0a81dd826dd3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_a9438e9f-9457-4625-aa9b-d2590141fff5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_f37d4d99-0015-4296-9cb8-0a81dd826dd3" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_a9438e9f-9457-4625-aa9b-d2590141fff5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_1596a2db-b380-4883-8e6b-8e5412286cb6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_a9438e9f-9457-4625-aa9b-d2590141fff5" xlink:to="loc_us-gaap_HedgingDesignationAxis_1596a2db-b380-4883-8e6b-8e5412286cb6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_1596a2db-b380-4883-8e6b-8e5412286cb6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_1596a2db-b380-4883-8e6b-8e5412286cb6" xlink:to="loc_us-gaap_HedgingDesignationDomain_1596a2db-b380-4883-8e6b-8e5412286cb6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_eb00bb20-8b55-454e-9f55-6dc9aeae312f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_1596a2db-b380-4883-8e6b-8e5412286cb6" xlink:to="loc_us-gaap_HedgingDesignationDomain_eb00bb20-8b55-454e-9f55-6dc9aeae312f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_51f4f423-09f1-49ea-8e97-0f98d99cf382" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_eb00bb20-8b55-454e-9f55-6dc9aeae312f" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_51f4f423-09f1-49ea-8e97-0f98d99cf382" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_9aafe304-2504-408a-a07d-98e1e19d9976" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_eb00bb20-8b55-454e-9f55-6dc9aeae312f" xlink:to="loc_us-gaap_NondesignatedMember_9aafe304-2504-408a-a07d-98e1e19d9976" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_7a73f9e6-f014-45ff-a40b-31119b09d9a0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_a9438e9f-9457-4625-aa9b-d2590141fff5" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_7a73f9e6-f014-45ff-a40b-31119b09d9a0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_7a73f9e6-f014-45ff-a40b-31119b09d9a0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_7a73f9e6-f014-45ff-a40b-31119b09d9a0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_7a73f9e6-f014-45ff-a40b-31119b09d9a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_4b59b240-6aa2-42b2-9501-35155b16361a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_7a73f9e6-f014-45ff-a40b-31119b09d9a0" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_4b59b240-6aa2-42b2-9501-35155b16361a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateSwapMember_d9b22e18-ec4a-4c25-852b-b163b2156c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateSwapMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4b59b240-6aa2-42b2-9501-35155b16361a" xlink:to="loc_us-gaap_InterestRateSwapMember_d9b22e18-ec4a-4c25-852b-b163b2156c6a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_8a4b7fdf-650a-4885-aa16-5c9ddfd8803a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4b59b240-6aa2-42b2-9501-35155b16361a" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_8a4b7fdf-650a-4885-aa16-5c9ddfd8803a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_4a2b0f00-509b-43c8-b569-a5879dcbc184" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_4b59b240-6aa2-42b2-9501-35155b16361a" xlink:to="loc_us-gaap_InterestRateContractMember_4a2b0f00-509b-43c8-b569-a5879dcbc184" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_49c79dce-53b4-4c2f-8179-94feba20a815" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_a9438e9f-9457-4625-aa9b-d2590141fff5" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_49c79dce-53b4-4c2f-8179-94feba20a815" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_49c79dce-53b4-4c2f-8179-94feba20a815_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_49c79dce-53b4-4c2f-8179-94feba20a815" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_49c79dce-53b4-4c2f-8179-94feba20a815_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_cc0adc09-4422-4648-a3e8-cb2a72d8ea95" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_49c79dce-53b4-4c2f-8179-94feba20a815" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_cc0adc09-4422-4648-a3e8-cb2a72d8ea95" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentAssetsMember_c0159ab1-8369-4508-aa1d-4c1302ade531" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_cc0adc09-4422-4648-a3e8-cb2a72d8ea95" xlink:to="loc_us-gaap_OtherCurrentAssetsMember_c0159ab1-8369-4508-aa1d-4c1302ade531" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentAssetsMember_42cfa8df-17fc-4503-a86f-3f052a9fda91" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_cc0adc09-4422-4648-a3e8-cb2a72d8ea95" xlink:to="loc_us-gaap_OtherNoncurrentAssetsMember_42cfa8df-17fc-4503-a86f-3f052a9fda91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncurrentLiabilitiesMember_c7180c06-09a3-4758-8e6f-c66290a1a967" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherNoncurrentLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_cc0adc09-4422-4648-a3e8-cb2a72d8ea95" xlink:to="loc_us-gaap_OtherNoncurrentLiabilitiesMember_c7180c06-09a3-4758-8e6f-c66290a1a967" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_a8237014-5ba8-4d94-99d7-065a2a0b3d47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccruedLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_cc0adc09-4422-4648-a3e8-cb2a72d8ea95" xlink:to="loc_us-gaap_AccruedLiabilitiesMember_a8237014-5ba8-4d94-99d7-065a2a0b3d47" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_910f1bc7-d6b0-4f9d-8e3e-68f0fb802ed4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_f37d4d99-0015-4296-9cb8-0a81dd826dd3" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_910f1bc7-d6b0-4f9d-8e3e-68f0fb802ed4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_064830cd-2e02-48fd-b083-fa35aa3ae523" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_f37d4d99-0015-4296-9cb8-0a81dd826dd3" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_064830cd-2e02-48fd-b083-fa35aa3ae523" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsLineItems_f6eccecc-f628-4aa6-868f-40c0c835592d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsTable_90918412-bdbe-4486-a129-f67bfdfceb35" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_f6eccecc-f628-4aa6-868f-40c0c835592d" xlink:to="loc_us-gaap_OffsettingAssetsTable_90918412-bdbe-4486-a129-f67bfdfceb35" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_91a29fd1-056f-4a55-8197-aa65281e5987" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingAssetsTable_90918412-bdbe-4486-a129-f67bfdfceb35" xlink:to="loc_srt_StatementScenarioAxis_91a29fd1-056f-4a55-8197-aa65281e5987" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_91a29fd1-056f-4a55-8197-aa65281e5987_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_91a29fd1-056f-4a55-8197-aa65281e5987" xlink:to="loc_srt_ScenarioUnspecifiedDomain_91a29fd1-056f-4a55-8197-aa65281e5987_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_c05f8889-4128-4a3e-a905-cb0968abd25f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_91a29fd1-056f-4a55-8197-aa65281e5987" xlink:to="loc_srt_ScenarioUnspecifiedDomain_c05f8889-4128-4a3e-a905-cb0968abd25f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProFormaMember_505542b4-8702-44b8-9ba5-ef54327fc5ee" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProFormaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_c05f8889-4128-4a3e-a905-cb0968abd25f" xlink:to="loc_srt_ProFormaMember_505542b4-8702-44b8-9ba5-ef54327fc5ee" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsAbstract_91f4923e-21ba-4676-8b3f-600eb3498c78" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_f6eccecc-f628-4aa6-868f-40c0c835592d" xlink:to="loc_us-gaap_DerivativeAssetsAbstract_91f4923e-21ba-4676-8b3f-600eb3498c78" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_58ab8130-2cd6-42cb-b4bb-511ea8298a30" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_91f4923e-21ba-4676-8b3f-600eb3498c78" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_58ab8130-2cd6-42cb-b4bb-511ea8298a30" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossLiability_f8677624-9b70-44e7-b264-f4310c4749dd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetFairValueGrossLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_91f4923e-21ba-4676-8b3f-600eb3498c78" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossLiability_f8677624-9b70-44e7-b264-f4310c4749dd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_292975ca-60ef-4eba-8639-71232acdf431" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_91f4923e-21ba-4676-8b3f-600eb3498c78" xlink:to="loc_us-gaap_DerivativeAssets_292975ca-60ef-4eba-8639-71232acdf431" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_2d565d16-f18f-40c6-98dc-62251396816a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_91f4923e-21ba-4676-8b3f-600eb3498c78" xlink:to="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_2d565d16-f18f-40c6-98dc-62251396816a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_1bf230fd-2f14-4cff-bde0-23f292adcc15" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeCollateralObligationToReturnSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_2d565d16-f18f-40c6-98dc-62251396816a" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_1bf230fd-2f14-4cff-bde0-23f292adcc15" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_e0b2829a-1e42-4420-8d8c-a85080189cbb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_2d565d16-f18f-40c6-98dc-62251396816a" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_e0b2829a-1e42-4420-8d8c-a85080189cbb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_3f31b1af-a482-4b86-b6e4-d8607a19c3c7" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_2d565d16-f18f-40c6-98dc-62251396816a" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_3f31b1af-a482-4b86-b6e4-d8607a19c3c7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_4095c043-d887-450d-8192-acd1b41c7644" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_f6eccecc-f628-4aa6-868f-40c0c835592d" xlink:to="loc_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_4095c043-d887-450d-8192-acd1b41c7644" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesLineItems_3231a177-8f89-4d9f-9e92-8db84af63f7e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingLiabilitiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesTable_01c5a573-cea3-48e2-a5d4-52fec13dbc94" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OffsettingLiabilitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_3231a177-8f89-4d9f-9e92-8db84af63f7e" xlink:to="loc_us-gaap_OffsettingLiabilitiesTable_01c5a573-cea3-48e2-a5d4-52fec13dbc94" xlink:type="arc" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_5c4ea909-c5be-4007-94e5-2b71c1429f11" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingLiabilitiesTable_01c5a573-cea3-48e2-a5d4-52fec13dbc94" xlink:to="loc_srt_StatementScenarioAxis_5c4ea909-c5be-4007-94e5-2b71c1429f11" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_5c4ea909-c5be-4007-94e5-2b71c1429f11_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_f1ca3a4d-952f-4336-a921-68eba79f79fa" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProFormaMember_6638894f-71b7-4426-84d9-b9e64ce65763" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProFormaMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesAbstract_e475032f-34e6-4b85-b24c-ddd446fb1d5a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_3231a177-8f89-4d9f-9e92-8db84af63f7e" xlink:to="loc_us-gaap_DerivativeLiabilitiesAbstract_e475032f-34e6-4b85-b24c-ddd446fb1d5a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_3418ff38-62e7-401a-8bcd-7286b0b261c3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_e475032f-34e6-4b85-b24c-ddd446fb1d5a" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_3418ff38-62e7-401a-8bcd-7286b0b261c3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_5f396193-7f89-40a1-ae55-bf5174d632d4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityFairValueGrossAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_e475032f-34e6-4b85-b24c-ddd446fb1d5a" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_5f396193-7f89-40a1-ae55-bf5174d632d4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_68bb2306-8f1f-4e36-86b5-0c943d2b21ee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_e475032f-34e6-4b85-b24c-ddd446fb1d5a" xlink:to="loc_us-gaap_DerivativeLiabilities_68bb2306-8f1f-4e36-86b5-0c943d2b21ee" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_cc2c20e1-067e-44a8-bdc2-dbd13dcd5ab6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_e475032f-34e6-4b85-b24c-ddd446fb1d5a" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_cc2c20e1-067e-44a8-bdc2-dbd13dcd5ab6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_8a24eeeb-744f-449c-9248-11fee3bf5604" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeCollateralRightToReclaimSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_cc2c20e1-067e-44a8-bdc2-dbd13dcd5ab6" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_8a24eeeb-744f-449c-9248-11fee3bf5604" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_1f58e2dd-ea6a-4ae5-a189-3dcc826135b3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_cc2c20e1-067e-44a8-bdc2-dbd13dcd5ab6" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_1f58e2dd-ea6a-4ae5-a189-3dcc826135b3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_b7364a0d-be57-42aa-9bfe-5412a3cbbb6a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_cc2c20e1-067e-44a8-bdc2-dbd13dcd5ab6" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_b7364a0d-be57-42aa-9bfe-5412a3cbbb6a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_f6097fe7-e908-49ee-9691-a4827c04a2a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_3231a177-8f89-4d9f-9e92-8db84af63f7e" xlink:to="loc_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_f6097fe7-e908-49ee-9691-a4827c04a2a8" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/InventoriesComponentsofInventoriesDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#InventoriesComponentsofInventoriesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/InventoriesComponentsofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryCurrentTable_3f549787-2e7d-47af-9ac4-6eff68e4e00f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryCurrentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:to="loc_us-gaap_InventoryCurrentTable_3f549787-2e7d-47af-9ac4-6eff68e4e00f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_5b5322e2-ee62-469f-bbee-f2b07f728720" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_InventoryCurrentTable_3f549787-2e7d-47af-9ac4-6eff68e4e00f" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_5b5322e2-ee62-469f-bbee-f2b07f728720" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5b5322e2-ee62-469f-bbee-f2b07f728720_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_5b5322e2-ee62-469f-bbee-f2b07f728720" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_5b5322e2-ee62-469f-bbee-f2b07f728720_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3012e94b-3d15-4e13-8676-6f39eeb42291" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_5b5322e2-ee62-469f-bbee-f2b07f728720" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3012e94b-3d15-4e13-8676-6f39eeb42291" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWPharmaceuticalsPlcMember_564a8658-22c8-4e95-b03e-a80eaccec2bc" xlink:href="jazz-20240331.xsd#jazz_GWPharmaceuticalsPlcMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_3012e94b-3d15-4e13-8676-6f39eeb42291" xlink:to="loc_jazz_GWPharmaceuticalsPlcMember_564a8658-22c8-4e95-b03e-a80eaccec2bc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_ce4ec40a-aafb-4719-a66a-26fe7cd7e1b0" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_ce4ec40a-aafb-4719-a66a-26fe7cd7e1b0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_e680b1ba-b472-4d8c-9711-fa91943c81e2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_e680b1ba-b472-4d8c-9711-fa91943c81e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_86bf1210-7bda-4e3c-997e-bf99cfccc5ae" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_86bf1210-7bda-4e3c-997e-bf99cfccc5ae" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_310ca726-8623-49cd-8ce0-4714bd77cc62" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InventoryNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:to="loc_us-gaap_InventoryNet_310ca726-8623-49cd-8ce0-4714bd77cc62" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InventoryStepUpValue_1ead82fc-97c1-4c5f-bdbb-81437447d57c" xlink:href="jazz-20240331.xsd#jazz_InventoryStepUpValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InventoryLineItems_32c16f89-0bc2-4321-95b0-5597fef846ae" xlink:to="loc_jazz_InventoryStepUpValue_1ead82fc-97c1-4c5f-bdbb-81437447d57c" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_c2e98048-2858-4d20-b76c-cb4b5f013610" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_1dba6616-9d9e-482d-ac27-5fa6544641ca" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_c2e98048-2858-4d20-b76c-cb4b5f013610" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_1dba6616-9d9e-482d-ac27-5fa6544641ca" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_6da2abcb-1c6f-479c-b743-368f59b7bf9a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_1dba6616-9d9e-482d-ac27-5fa6544641ca" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_6da2abcb-1c6f-479c-b743-368f59b7bf9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6da2abcb-1c6f-479c-b743-368f59b7bf9a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_6da2abcb-1c6f-479c-b743-368f59b7bf9a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6da2abcb-1c6f-479c-b743-368f59b7bf9a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ed365e2-4be4-4a9a-98ad-7b8a0e4f3347" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_6da2abcb-1c6f-479c-b743-368f59b7bf9a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ed365e2-4be4-4a9a-98ad-7b8a0e4f3347" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_9753d890-a20d-41db-9efa-f68ee590b205" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ed365e2-4be4-4a9a-98ad-7b8a0e4f3347" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_9753d890-a20d-41db-9efa-f68ee590b205" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ManufacturingContractsMember_e30df7ed-ff59-4786-8747-4f808f0aa3b9" xlink:href="jazz-20240331.xsd#jazz_ManufacturingContractsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ed365e2-4be4-4a9a-98ad-7b8a0e4f3347" xlink:to="loc_jazz_ManufacturingContractsMember_e30df7ed-ff59-4786-8747-4f808f0aa3b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_5cdab25c-3922-4e2b-bc80-a6abcf7632ce" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ed365e2-4be4-4a9a-98ad-7b8a0e4f3347" xlink:to="loc_us-gaap_TrademarksMember_5cdab25c-3922-4e2b-bc80-a6abcf7632ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_aa4da275-c4f6-4324-a1e7-741a6948d51e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_c2e98048-2858-4d20-b76c-cb4b5f013610" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_aa4da275-c4f6-4324-a1e7-741a6948d51e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4b04e5a3-741e-4891-b6e5-e4afb45594d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_c2e98048-2858-4d20-b76c-cb4b5f013610" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_4b04e5a3-741e-4891-b6e5-e4afb45594d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_a6b0d6f8-950f-494b-b371-fd390d3ed781" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_c2e98048-2858-4d20-b76c-cb4b5f013610" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_a6b0d6f8-950f-494b-b371-fd390d3ed781" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_07d25d60-5e9c-40d0-a597-6d831a974857" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_c2e98048-2858-4d20-b76c-cb4b5f013610" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_07d25d60-5e9c-40d0-a597-6d831a974857" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CertainBalanceSheetItemsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#CertainBalanceSheetItemsPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CertainBalanceSheetItemsPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_6493f7fe-f2fd-42a7-ae25-d1678ea25609" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_16bcde77-bf13-46e0-8e7b-df563dfd84d8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_6493f7fe-f2fd-42a7-ae25-d1678ea25609" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_16bcde77-bf13-46e0-8e7b-df563dfd84d8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3c862664-9a30-40dd-b85b-cecbff269d04" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_16bcde77-bf13-46e0-8e7b-df563dfd84d8" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3c862664-9a30-40dd-b85b-cecbff269d04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3c862664-9a30-40dd-b85b-cecbff269d04_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3c862664-9a30-40dd-b85b-cecbff269d04" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3c862664-9a30-40dd-b85b-cecbff269d04_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_3c862664-9a30-40dd-b85b-cecbff269d04" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_78f8df1f-a951-4b40-9980-dd82e2215577" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_78f8df1f-a951-4b40-9980-dd82e2215577" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandAndBuildingMember_fde21d19-1d30-451a-a775-cc583555aef4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LandAndBuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_LandAndBuildingMember_fde21d19-1d30-451a-a775-cc583555aef4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_8c5dc319-d073-4f39-bfdd-2d193d18ce54" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_8c5dc319-d073-4f39-bfdd-2d193d18ce54" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_e7ccb77d-992c-4a5f-b0ab-51dd9f28d469" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_e7ccb77d-992c-4a5f-b0ab-51dd9f28d469" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_1914f9b4-8e08-4392-beb9-5067473145e5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_ConstructionInProgressMember_1914f9b4-8e08-4392-beb9-5067473145e5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_76e1a1f4-3625-44d5-bfe3-53acaba89fab" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_ComputerEquipmentMember_76e1a1f4-3625-44d5-bfe3-53acaba89fab" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_44c83743-5c19-410a-8f9d-2ae4fd03df05" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_069be02e-42ef-44c9-81f7-3ba775a0ad63" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_44c83743-5c19-410a-8f9d-2ae4fd03df05" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_a3dec9ab-2c3f-45fc-8d3f-75b96f7f13a9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_6493f7fe-f2fd-42a7-ae25-d1678ea25609" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_a3dec9ab-2c3f-45fc-8d3f-75b96f7f13a9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_f20a42a4-9fa8-4cfb-8f08-b1a1dffe8747" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_6493f7fe-f2fd-42a7-ae25-d1678ea25609" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_f20a42a4-9fa8-4cfb-8f08-b1a1dffe8747" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_45d76a29-79de-4273-b321-1c487e86c65f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_6493f7fe-f2fd-42a7-ae25-d1678ea25609" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_45d76a29-79de-4273-b321-1c487e86c65f" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtScheduleofLongtermDebtDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DebtScheduleofLongtermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtScheduleofLongtermDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_52d1ce10-ef44-4448-82c8-58085a97a11a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:to="loc_us-gaap_DebtInstrumentTable_52d1ce10-ef44-4448-82c8-58085a97a11a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_ea3ef3fc-9dd9-4b7b-9812-ed23cb44fa10" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_52d1ce10-ef44-4448-82c8-58085a97a11a" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_ea3ef3fc-9dd9-4b7b-9812-ed23cb44fa10" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ea3ef3fc-9dd9-4b7b-9812-ed23cb44fa10_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ea3ef3fc-9dd9-4b7b-9812-ed23cb44fa10" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ea3ef3fc-9dd9-4b7b-9812-ed23cb44fa10_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f20330c9-2930-44f5-81a7-6ebd1de31583" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ea3ef3fc-9dd9-4b7b-9812-ed23cb44fa10" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f20330c9-2930-44f5-81a7-6ebd1de31583" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_c3e7754e-77ca-4659-b3ed-cd391e84bf18" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f20330c9-2930-44f5-81a7-6ebd1de31583" xlink:to="loc_us-gaap_ConvertibleDebtMember_c3e7754e-77ca-4659-b3ed-cd391e84bf18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_bfcf4d43-dd39-4e49-a95d-d52ae6dd566b" xlink:href="jazz-20240331.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f20330c9-2930-44f5-81a7-6ebd1de31583" xlink:to="loc_jazz_TermLoanMember_bfcf4d43-dd39-4e49-a95d-d52ae6dd566b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_14400b51-a25c-4320-a566-4d58c11135bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_52d1ce10-ef44-4448-82c8-58085a97a11a" xlink:to="loc_us-gaap_DebtInstrumentAxis_14400b51-a25c-4320-a566-4d58c11135bf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_14400b51-a25c-4320-a566-4d58c11135bf_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_14400b51-a25c-4320-a566-4d58c11135bf" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_14400b51-a25c-4320-a566-4d58c11135bf_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_8d9f6af3-0d06-47c1-a17b-f3a66905a579" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_14400b51-a25c-4320-a566-4d58c11135bf" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_8d9f6af3-0d06-47c1-a17b-f3a66905a579" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_29f82469-517b-440c-bdd3-f0cd4deee8fd" xlink:href="jazz-20240331.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8d9f6af3-0d06-47c1-a17b-f3a66905a579" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_29f82469-517b-440c-bdd3-f0cd4deee8fd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_3ff1bd55-1b56-49e4-a700-7a1d57e9da9e" xlink:href="jazz-20240331.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8d9f6af3-0d06-47c1-a17b-f3a66905a579" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_3ff1bd55-1b56-49e4-a700-7a1d57e9da9e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorNotesDue2029Member_18a4b1fe-7a2e-46de-a6a4-ed4098749a6c" xlink:href="jazz-20240331.xsd#jazz_SeniorNotesDue2029Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_8d9f6af3-0d06-47c1-a17b-f3a66905a579" xlink:to="loc_jazz_SeniorNotesDue2029Member_18a4b1fe-7a2e-46de-a6a4-ed4098749a6c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_56322215-ecb3-47c6-9c42-20a76763c592" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_56322215-ecb3-47c6-9c42-20a76763c592" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnamortizedDebtIssuanceExpense_dbb12ca0-2f83-425b-abdd-da4d7cd4db0a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_UnamortizedDebtIssuanceExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:to="loc_us-gaap_UnamortizedDebtIssuanceExpense_dbb12ca0-2f83-425b-abdd-da4d7cd4db0a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_3cd01e18-1ee5-4e53-b7cf-64efcc27d277" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:to="loc_us-gaap_LongTermDebt_3cd01e18-1ee5-4e53-b7cf-64efcc27d277" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_ffa4277e-a435-4d0f-9580-c0930b649f9b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:to="loc_us-gaap_LongTermDebtCurrent_ffa4277e-a435-4d0f-9580-c0930b649f9b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_975d1ebe-89cb-4428-827d-cc107c2c6e5f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_fca13088-2be5-4200-a148-a00c1f8e3b63" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_975d1ebe-89cb-4428-827d-cc107c2c6e5f" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtNarrativesDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#DebtNarrativesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtNarrativesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_1042ab1c-a1a3-40af-9465-9640a7a67377" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:to="loc_srt_OwnershipAxis_1042ab1c-a1a3-40af-9465-9640a7a67377" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_1042ab1c-a1a3-40af-9465-9640a7a67377_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_1042ab1c-a1a3-40af-9465-9640a7a67377" xlink:to="loc_srt_OwnershipDomain_1042ab1c-a1a3-40af-9465-9640a7a67377_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_81a49e61-5954-4bb0-9a30-9610734946fd" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_1042ab1c-a1a3-40af-9465-9640a7a67377" xlink:to="loc_srt_OwnershipDomain_81a49e61-5954-4bb0-9a30-9610734946fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_JazzInvestmentsILimitedMember_795b3d62-9794-4b03-8cba-c4fc0b23ee77" xlink:href="jazz-20240331.xsd#jazz_JazzInvestmentsILimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_81a49e61-5954-4bb0-9a30-9610734946fd" xlink:to="loc_jazz_JazzInvestmentsILimitedMember_795b3d62-9794-4b03-8cba-c4fc0b23ee77" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_f64a5ace-1547-4d8a-8809-9a7de17f9cfb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:to="loc_us-gaap_DebtInstrumentAxis_f64a5ace-1547-4d8a-8809-9a7de17f9cfb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f64a5ace-1547-4d8a-8809-9a7de17f9cfb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_f64a5ace-1547-4d8a-8809-9a7de17f9cfb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f64a5ace-1547-4d8a-8809-9a7de17f9cfb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7b7a75c7-88cc-4c18-ab41-1f27a28e9f5f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_f64a5ace-1547-4d8a-8809-9a7de17f9cfb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7b7a75c7-88cc-4c18-ab41-1f27a28e9f5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_5b220da4-dbd6-4aca-b5ff-5e8a6377d351" xlink:href="jazz-20240331.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7b7a75c7-88cc-4c18-ab41-1f27a28e9f5f" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_5b220da4-dbd6-4aca-b5ff-5e8a6377d351" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_15bddbe0-f696-4299-a073-2009d37c51cd" xlink:href="jazz-20240331.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7b7a75c7-88cc-4c18-ab41-1f27a28e9f5f" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_15bddbe0-f696-4299-a073-2009d37c51cd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TrancheB1DollarTermLoanMember_e5c6e4c4-fa35-442a-a593-5464d643352e" xlink:href="jazz-20240331.xsd#jazz_TrancheB1DollarTermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7b7a75c7-88cc-4c18-ab41-1f27a28e9f5f" xlink:to="loc_jazz_TrancheB1DollarTermLoanMember_e5c6e4c4-fa35-442a-a593-5464d643352e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TwoThousandTwentyOneCreditAgreementRevolvingCreditFacilityMember_d04ca8c4-0c75-4c63-8df4-47562c45a708" xlink:href="jazz-20240331.xsd#jazz_TwoThousandTwentyOneCreditAgreementRevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_7b7a75c7-88cc-4c18-ab41-1f27a28e9f5f" xlink:to="loc_jazz_TwoThousandTwentyOneCreditAgreementRevolvingCreditFacilityMember_d04ca8c4-0c75-4c63-8df4-47562c45a708" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_50982ef2-2a29-4482-bd11-34b6392d1d42" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_50982ef2-2a29-4482-bd11-34b6392d1d42" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_50982ef2-2a29-4482-bd11-34b6392d1d42_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_50982ef2-2a29-4482-bd11-34b6392d1d42" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_50982ef2-2a29-4482-bd11-34b6392d1d42_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_200fe500-82c4-4c82-b012-7a5ff967c0d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_50982ef2-2a29-4482-bd11-34b6392d1d42" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_200fe500-82c4-4c82-b012-7a5ff967c0d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_215c3a55-2018-4b89-aec2-9039bcaf3c4f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_200fe500-82c4-4c82-b012-7a5ff967c0d6" xlink:to="loc_us-gaap_ConvertibleDebtMember_215c3a55-2018-4b89-aec2-9039bcaf3c4f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_7897d28a-9af9-4012-a931-b2584d7a0982" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_200fe500-82c4-4c82-b012-7a5ff967c0d6" xlink:to="loc_us-gaap_LineOfCreditMember_7897d28a-9af9-4012-a931-b2584d7a0982" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_771e8cee-bddb-4248-9232-674472605fee" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:to="loc_us-gaap_VariableRateAxis_771e8cee-bddb-4248-9232-674472605fee" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_771e8cee-bddb-4248-9232-674472605fee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_771e8cee-bddb-4248-9232-674472605fee" xlink:to="loc_us-gaap_VariableRateDomain_771e8cee-bddb-4248-9232-674472605fee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_9e8e75c5-3ac0-4fd0-a6ce-7f71df3c78c5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_771e8cee-bddb-4248-9232-674472605fee" xlink:to="loc_us-gaap_VariableRateDomain_9e8e75c5-3ac0-4fd0-a6ce-7f71df3c78c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_58b1d916-c3af-4779-a252-5317b08de484" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_9e8e75c5-3ac0-4fd0-a6ce-7f71df3c78c5" xlink:to="loc_us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_58b1d916-c3af-4779-a252-5317b08de484" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrimeRateMember_bfcc2d59-f0a0-43aa-b946-9476a38d2fb2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_PrimeRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_9e8e75c5-3ac0-4fd0-a6ce-7f71df3c78c5" xlink:to="loc_us-gaap_PrimeRateMember_bfcc2d59-f0a0-43aa-b946-9476a38d2fb2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b8533c24-47bf-4b07-abb5-753542a01f8c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:to="loc_srt_RangeAxis_b8533c24-47bf-4b07-abb5-753542a01f8c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b8533c24-47bf-4b07-abb5-753542a01f8c_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_b8533c24-47bf-4b07-abb5-753542a01f8c" xlink:to="loc_srt_RangeMember_b8533c24-47bf-4b07-abb5-753542a01f8c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_d8c9e68a-2533-443e-ba58-43dea04beac0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_b8533c24-47bf-4b07-abb5-753542a01f8c" xlink:to="loc_srt_RangeMember_d8c9e68a-2533-443e-ba58-43dea04beac0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_3d141156-a0bd-40e7-8af5-a1280b892518" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_d8c9e68a-2533-443e-ba58-43dea04beac0" xlink:to="loc_srt_MinimumMember_3d141156-a0bd-40e7-8af5-a1280b892518" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_542f7c96-f153-4218-8085-4747c4d24d61" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_d8c9e68a-2533-443e-ba58-43dea04beac0" xlink:to="loc_srt_MaximumMember_542f7c96-f153-4218-8085-4747c4d24d61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_de87db23-413b-46a7-bc12-3c841f630ab8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fb622573-a804-4f1c-a730-54f7fc0b61d2" xlink:to="loc_us-gaap_CreditFacilityAxis_de87db23-413b-46a7-bc12-3c841f630ab8" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_de87db23-413b-46a7-bc12-3c841f630ab8_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_de87db23-413b-46a7-bc12-3c841f630ab8" xlink:to="loc_us-gaap_CreditFacilityDomain_de87db23-413b-46a7-bc12-3c841f630ab8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_ff387c4d-01f6-428c-b250-ff505572f0f5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_de87db23-413b-46a7-bc12-3c841f630ab8" xlink:to="loc_us-gaap_CreditFacilityDomain_ff387c4d-01f6-428c-b250-ff505572f0f5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_b239d9fa-89f5-4ce9-8300-2c618532382c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_ff387c4d-01f6-428c-b250-ff505572f0f5" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_b239d9fa-89f5-4ce9-8300-2c618532382c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_362a3dca-99fb-4c96-ade3-b3a8d29fc352" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_362a3dca-99fb-4c96-ade3-b3a8d29fc352" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_01ea56ae-17e9-4771-b66b-83281bcba272" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_LineOfCreditFacilityRemainingBorrowingCapacity_01ea56ae-17e9-4771-b66b-83281bcba272" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_3be101c5-6de3-4277-bc42-a45af8a59bd4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_3be101c5-6de3-4277-bc42-a45af8a59bd4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_DebtInstrumentDecreaseInBasisSpreadOnVariableRate_dd72d5d0-3aac-4e14-8754-78d53bc19ec9" xlink:href="jazz-20240331.xsd#jazz_DebtInstrumentDecreaseInBasisSpreadOnVariableRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_jazz_DebtInstrumentDecreaseInBasisSpreadOnVariableRate_dd72d5d0-3aac-4e14-8754-78d53bc19ec9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_bbb93aa8-3a80-48d3-aa7d-9edb32f9f899" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_bbb93aa8-3a80-48d3-aa7d-9edb32f9f899" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_716585fd-d0b1-4d58-b9e2-c5cdf45ace37" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_716585fd-d0b1-4d58-b9e2-c5cdf45ace37" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_528d0651-682a-475c-8949-716390447233" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_528d0651-682a-475c-8949-716390447233" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_7a229b36-72a6-4c8a-8eb5-562a3a9818fa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_7a229b36-72a6-4c8a-8eb5-562a3a9818fa" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_60776ebb-55fa-46d6-a1a8-5884bfda6998" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_60776ebb-55fa-46d6-a1a8-5884bfda6998" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_6c7e0007-baee-43c0-85fa-32edece34092" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_InterestExpenseDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_InterestExpenseDebt_6c7e0007-baee-43c0-85fa-32edece34092" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InterestExpenseDebtContractualCouponRate_5de7553f-f609-4464-9f52-6cccf25a7128" xlink:href="jazz-20240331.xsd#jazz_InterestExpenseDebtContractualCouponRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_jazz_InterestExpenseDebtContractualCouponRate_5de7553f-f609-4464-9f52-6cccf25a7128" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_8b47799d-db2e-4c4e-905d-7407c6eab89c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_bc573917-2436-4dd1-a8ca-db92d71092a2" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_8b47799d-db2e-4c4e-905d-7407c6eab89c" xlink:type="arc" order="11"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#CommitmentsandContingenciesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CommitmentsandContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_2e363c65-3b1b-44ad-aa93-0d4c556f0aad" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_us-gaap_LossContingenciesTable_2e363c65-3b1b-44ad-aa93-0d4c556f0aad" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_91b841bb-6f12-463d-a767-8142328509f0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_2e363c65-3b1b-44ad-aa93-0d4c556f0aad" xlink:to="loc_srt_LitigationCaseAxis_91b841bb-6f12-463d-a767-8142328509f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_91b841bb-6f12-463d-a767-8142328509f0_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_91b841bb-6f12-463d-a767-8142328509f0" xlink:to="loc_srt_LitigationCaseTypeDomain_91b841bb-6f12-463d-a767-8142328509f0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_91b841bb-6f12-463d-a767-8142328509f0" xlink:to="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TeamstersAndGEHALawsuitsMember_b08374c9-e993-45c1-a45b-65b453fdf955" xlink:href="jazz-20240331.xsd#jazz_TeamstersAndGEHALawsuitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_TeamstersAndGEHALawsuitsMember_b08374c9-e993-45c1-a45b-65b453fdf955" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FarrellLawsuitAndLevyLawsuitMember_229cce49-42d0-4570-9dea-226cdccc05d0" xlink:href="jazz-20240331.xsd#jazz_FarrellLawsuitAndLevyLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_FarrellLawsuitAndLevyLawsuitMember_229cce49-42d0-4570-9dea-226cdccc05d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWLitigationMember_5f7b3307-9791-4a5f-ad97-eb74f800f4df" xlink:href="jazz-20240331.xsd#jazz_GWLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_GWLitigationMember_5f7b3307-9791-4a5f-ad97-eb74f800f4df" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_AvadelPharmaceuticalsPlcLawsuitMember_9129053b-734b-4cb4-9919-1379696015c8" xlink:href="jazz-20240331.xsd#jazz_AvadelPharmaceuticalsPlcLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_AvadelPharmaceuticalsPlcLawsuitMember_9129053b-734b-4cb4-9919-1379696015c8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_LupinLawsuitMember_934f07db-db20-4d52-a017-c15c2c43d651" xlink:href="jazz-20240331.xsd#jazz_LupinLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_LupinLawsuitMember_934f07db-db20-4d52-a017-c15c2c43d651" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TevaLawsuitMember_f547a350-5359-4284-b45b-cbe7de99cc80" xlink:href="jazz-20240331.xsd#jazz_TevaLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_TevaLawsuitMember_f547a350-5359-4284-b45b-cbe7de99cc80" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_AlkemPatentLitigationMember_7f9c4d93-7c49-48e1-8bf2-92320f818c6f" xlink:href="jazz-20240331.xsd#jazz_AlkemPatentLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_0d87ad38-cbe3-4ff8-aede-1baf84c74712" xlink:to="loc_jazz_AlkemPatentLitigationMember_7f9c4d93-7c49-48e1-8bf2-92320f818c6f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_97ad0abe-5db9-4f0d-8735-d760b50eb42b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_2e363c65-3b1b-44ad-aa93-0d4c556f0aad" xlink:to="loc_srt_ProductOrServiceAxis_97ad0abe-5db9-4f0d-8735-d760b50eb42b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_97ad0abe-5db9-4f0d-8735-d760b50eb42b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_97ad0abe-5db9-4f0d-8735-d760b50eb42b" xlink:to="loc_srt_ProductsAndServicesDomain_97ad0abe-5db9-4f0d-8735-d760b50eb42b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_4fde4384-0ab6-453b-9f02-1b82d8a778e6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_97ad0abe-5db9-4f0d-8735-d760b50eb42b" xlink:to="loc_srt_ProductsAndServicesDomain_4fde4384-0ab6-453b-9f02-1b82d8a778e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XywavMember_3a79b360-b9ae-422b-8320-84834a4b3119" xlink:href="jazz-20240331.xsd#jazz_XywavMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_4fde4384-0ab6-453b-9f02-1b82d8a778e6" xlink:to="loc_jazz_XywavMember_3a79b360-b9ae-422b-8320-84834a4b3119" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNewClaimsFiledNumber_8b1b2751-8d16-4cd7-8318-dae67b5ec6a8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LossContingencyNewClaimsFiledNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_us-gaap_LossContingencyNewClaimsFiledNumber_8b1b2751-8d16-4cd7-8318-dae67b5ec6a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InfringedPatentsSuitNumberOfPatents_ba0164de-8de2-41be-9950-bb63022f5217" xlink:href="jazz-20240331.xsd#jazz_InfringedPatentsSuitNumberOfPatents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_jazz_InfringedPatentsSuitNumberOfPatents_ba0164de-8de2-41be-9950-bb63022f5217" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted_cce0da13-4f78-4140-ba39-d3c929497da7" xlink:href="jazz-20240331.xsd#jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted_cce0da13-4f78-4140-ba39-d3c929497da7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FDAStayOfApprovalPeriod_f309d233-ae29-40c4-9e69-8f127d36f7dd" xlink:href="jazz-20240331.xsd#jazz_FDAStayOfApprovalPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_jazz_FDAStayOfApprovalPeriod_f309d233-ae29-40c4-9e69-8f127d36f7dd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainContingencyPatentsAllegedlyInfringedUponNumber_5f49caad-34e2-4935-8458-0dc9407a8425" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_GainContingencyPatentsAllegedlyInfringedUponNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_us-gaap_GainContingencyPatentsAllegedlyInfringedUponNumber_5f49caad-34e2-4935-8458-0dc9407a8425" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FDARecognitionOfOrphanDrugExclusivityPeriod_9354fc8e-330e-4274-a8c2-b60496e2c92b" xlink:href="jazz-20240331.xsd#jazz_FDARecognitionOfOrphanDrugExclusivityPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_fca7e9c2-8606-4f59-a1b2-e0d8fa7ae340" xlink:to="loc_jazz_FDARecognitionOfOrphanDrugExclusivityPeriod_9354fc8e-330e-4274-a8c2-b60496e2c92b" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#ShareholdersEquityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeLineItems_71e9209c-cef4-459b-b512-0e3854914482" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSubsidiaryOrEquityMethodInvesteeTable_b375ff55-f335-42aa-86ca-6d36896a4d07" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfSubsidiaryOrEquityMethodInvesteeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeLineItems_71e9209c-cef4-459b-b512-0e3854914482" xlink:to="loc_us-gaap_ScheduleOfSubsidiaryOrEquityMethodInvesteeTable_b375ff55-f335-42aa-86ca-6d36896a4d07" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_49c2becb-f4ab-46cf-9215-4b943330179b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSubsidiaryOrEquityMethodInvesteeTable_b375ff55-f335-42aa-86ca-6d36896a4d07" xlink:to="loc_us-gaap_AwardTypeAxis_49c2becb-f4ab-46cf-9215-4b943330179b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_49c2becb-f4ab-46cf-9215-4b943330179b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_49c2becb-f4ab-46cf-9215-4b943330179b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_49c2becb-f4ab-46cf-9215-4b943330179b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c0785315-768a-4878-9580-8c5fc57d1314" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_49c2becb-f4ab-46cf-9215-4b943330179b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c0785315-768a-4878-9580-8c5fc57d1314" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OrdinarySharesMember_23dd6776-6de4-410b-878e-c37cea1695a3" xlink:href="jazz-20240331.xsd#jazz_OrdinarySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_c0785315-768a-4878-9580-8c5fc57d1314" xlink:to="loc_jazz_OrdinarySharesMember_23dd6776-6de4-410b-878e-c37cea1695a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_16530a13-e5f0-4914-a201-7a44cb9f805e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSubsidiaryOrEquityMethodInvesteeTable_b375ff55-f335-42aa-86ca-6d36896a4d07" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_16530a13-e5f0-4914-a201-7a44cb9f805e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_16530a13-e5f0-4914-a201-7a44cb9f805e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_16530a13-e5f0-4914-a201-7a44cb9f805e" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_16530a13-e5f0-4914-a201-7a44cb9f805e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_78b90ea9-bfaa-4ae6-b8ee-957b261d993c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_16530a13-e5f0-4914-a201-7a44cb9f805e" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_78b90ea9-bfaa-4ae6-b8ee-957b261d993c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_November2016ShareRepurchaseProgramMember_a50894bf-d6dc-4960-ab42-a90407d3dc29" xlink:href="jazz-20240331.xsd#jazz_November2016ShareRepurchaseProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_78b90ea9-bfaa-4ae6-b8ee-957b261d993c" xlink:to="loc_jazz_November2016ShareRepurchaseProgramMember_a50894bf-d6dc-4960-ab42-a90407d3dc29" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_719f7336-7874-4d56-aa35-d40f58359d7d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeLineItems_71e9209c-cef4-459b-b512-0e3854914482" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_719f7336-7874-4d56-aa35-d40f58359d7d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_6eab01bc-e279-40d4-8fea-ab236dcd2d14" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeLineItems_71e9209c-cef4-459b-b512-0e3854914482" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_6eab01bc-e279-40d4-8fea-ab236dcd2d14" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e1a92770-8191-49d7-8132-a60df009476a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_e18bea78-6ebe-4327-bb6a-4b65b75653be" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e1a92770-8191-49d7-8132-a60df009476a" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_e18bea78-6ebe-4327-bb6a-4b65b75653be" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_a06ed836-9818-4234-bf91-ebb21c6c34a5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_e18bea78-6ebe-4327-bb6a-4b65b75653be" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_a06ed836-9818-4234-bf91-ebb21c6c34a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_a06ed836-9818-4234-bf91-ebb21c6c34a5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_a06ed836-9818-4234-bf91-ebb21c6c34a5" xlink:to="loc_us-gaap_EquityComponentDomain_a06ed836-9818-4234-bf91-ebb21c6c34a5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_800f7a23-bddd-45bf-8b7d-0baf9ebc11d5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_a06ed836-9818-4234-bf91-ebb21c6c34a5" xlink:to="loc_us-gaap_EquityComponentDomain_800f7a23-bddd-45bf-8b7d-0baf9ebc11d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_94a9cc71-4f2e-4839-9c80-25de8de1a3f3" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_800f7a23-bddd-45bf-8b7d-0baf9ebc11d5" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_94a9cc71-4f2e-4839-9c80-25de8de1a3f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_f6a5417a-fb6d-4dc8-a73e-a8d16cb5084d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_94a9cc71-4f2e-4839-9c80-25de8de1a3f3" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_f6a5417a-fb6d-4dc8-a73e-a8d16cb5084d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_ef863f8c-7342-4f4b-af9e-6098dac754bf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_94a9cc71-4f2e-4839-9c80-25de8de1a3f3" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_ef863f8c-7342-4f4b-af9e-6098dac754bf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_ab972168-e659-449e-a62d-27351307bbde" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_e1a92770-8191-49d7-8132-a60df009476a" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_ab972168-e659-449e-a62d-27351307bbde" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_2ac119d9-b5ac-4c27-918f-170140f3ecf5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_ab972168-e659-449e-a62d-27351307bbde" xlink:to="loc_us-gaap_StockholdersEquity_2ac119d9-b5ac-4c27-918f-170140f3ecf5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_4fb0aead-3718-4fc5-be2b-ac3bd87d56f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_ab972168-e659-449e-a62d-27351307bbde" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_4fb0aead-3718-4fc5-be2b-ac3bd87d56f8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_eb18c196-1864-4e44-bee6-ed263a643615" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_ab972168-e659-449e-a62d-27351307bbde" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_eb18c196-1864-4e44-bee6-ed263a643615" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_e66d90ce-0cce-4354-a6fa-6b9de783676c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_ab972168-e659-449e-a62d-27351307bbde" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_e66d90ce-0cce-4354-a6fa-6b9de783676c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3e271492-a5c4-4449-b302-b3b165dab1f9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_StockholdersEquity"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeLossperShareDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeLossperShareDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeLossperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_b2798e3d-4b32-4cb1-9895-f74eda8d0edd" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_746aeda8-c39f-4fcc-bcde-2acb8e626cf6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_b2798e3d-4b32-4cb1-9895-f74eda8d0edd" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_746aeda8-c39f-4fcc-bcde-2acb8e626cf6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_fecfb5e8-a2cf-4ace-bf3f-89a5e516dfa6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_746aeda8-c39f-4fcc-bcde-2acb8e626cf6" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_fecfb5e8-a2cf-4ace-bf3f-89a5e516dfa6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_fecfb5e8-a2cf-4ace-bf3f-89a5e516dfa6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_fecfb5e8-a2cf-4ace-bf3f-89a5e516dfa6" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_fecfb5e8-a2cf-4ace-bf3f-89a5e516dfa6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_288edb2b-1fad-4461-9070-6223c0b135f8" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_fecfb5e8-a2cf-4ace-bf3f-89a5e516dfa6" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_288edb2b-1fad-4461-9070-6223c0b135f8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_0d254039-f14f-448b-9f82-e3be6c491483" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConvertibleDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_288edb2b-1fad-4461-9070-6223c0b135f8" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_0d254039-f14f-448b-9f82-e3be6c491483" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityUnitPurchaseAgreementsMember_64762423-a599-4315-babc-3b9bcef449aa" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EquityUnitPurchaseAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_288edb2b-1fad-4461-9070-6223c0b135f8" xlink:to="loc_us-gaap_EquityUnitPurchaseAgreementsMember_64762423-a599-4315-babc-3b9bcef449aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_0256d601-e09c-48f9-8211-af72d0c58d50" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_b2798e3d-4b32-4cb1-9895-f74eda8d0edd" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_0256d601-e09c-48f9-8211-af72d0c58d50" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#RevenuesSummaryofDisaggregationofRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofDisaggregationofRevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_361a0da0-2894-4b63-8825-75aeb5e2f080" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_6c6e2c01-0bf2-4b5f-ad34-ebea45330d5d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_361a0da0-2894-4b63-8825-75aeb5e2f080" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_6c6e2c01-0bf2-4b5f-ad34-ebea45330d5d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_e0441efa-d4a9-453a-8553-e637aa324772" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_6c6e2c01-0bf2-4b5f-ad34-ebea45330d5d" xlink:to="loc_srt_ProductOrServiceAxis_e0441efa-d4a9-453a-8553-e637aa324772" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_e0441efa-d4a9-453a-8553-e637aa324772_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_e0441efa-d4a9-453a-8553-e637aa324772" xlink:to="loc_srt_ProductsAndServicesDomain_e0441efa-d4a9-453a-8553-e637aa324772_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_65acc909-6980-4cfe-bfb3-2e21dbe4f690" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_e0441efa-d4a9-453a-8553-e637aa324772" xlink:to="loc_srt_ProductsAndServicesDomain_65acc909-6980-4cfe-bfb3-2e21dbe4f690" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_e48370de-e086-4745-84a2-4837c0317921" xlink:href="jazz-20240331.xsd#jazz_ProductAndServicesProductSalesNetOfDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_65acc909-6980-4cfe-bfb3-2e21dbe4f690" xlink:to="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_e48370de-e086-4745-84a2-4837c0317921" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TotalNeuroscienceMember_04bcfb72-1df6-439e-8381-fed8b141da44" xlink:href="jazz-20240331.xsd#jazz_TotalNeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_e48370de-e086-4745-84a2-4837c0317921" xlink:to="loc_jazz_TotalNeuroscienceMember_04bcfb72-1df6-439e-8381-fed8b141da44" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XywavMember_c915f262-a8bd-45ea-a9f0-4b222b9a79b4" xlink:href="jazz-20240331.xsd#jazz_XywavMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalNeuroscienceMember_04bcfb72-1df6-439e-8381-fed8b141da44" xlink:to="loc_jazz_XywavMember_c915f262-a8bd-45ea-a9f0-4b222b9a79b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XyremMember_02ebc612-de5a-42a1-b987-06e80604980f" xlink:href="jazz-20240331.xsd#jazz_XyremMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalNeuroscienceMember_04bcfb72-1df6-439e-8381-fed8b141da44" xlink:to="loc_jazz_XyremMember_02ebc612-de5a-42a1-b987-06e80604980f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_EpidiolexEpidyolexMember_ffaa3d2f-2db8-4cdf-ab5a-335bc2fb2d7f" xlink:href="jazz-20240331.xsd#jazz_EpidiolexEpidyolexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalNeuroscienceMember_04bcfb72-1df6-439e-8381-fed8b141da44" xlink:to="loc_jazz_EpidiolexEpidyolexMember_ffaa3d2f-2db8-4cdf-ab5a-335bc2fb2d7f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SativexMember_b442a8ed-3ff7-417f-9777-4c7134dcd652" xlink:href="jazz-20240331.xsd#jazz_SativexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalNeuroscienceMember_04bcfb72-1df6-439e-8381-fed8b141da44" xlink:to="loc_jazz_SativexMember_b442a8ed-3ff7-417f-9777-4c7134dcd652" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TotalOncologyMember_61a361b0-398e-4e4a-a43d-0d39dbc348d1" xlink:href="jazz-20240331.xsd#jazz_TotalOncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_e48370de-e086-4745-84a2-4837c0317921" xlink:to="loc_jazz_TotalOncologyMember_61a361b0-398e-4e4a-a43d-0d39dbc348d1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RylazeEnrylazeMember_ad4d19cf-34ca-4685-a698-ce7bec95edef" xlink:href="jazz-20240331.xsd#jazz_RylazeEnrylazeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOncologyMember_61a361b0-398e-4e4a-a43d-0d39dbc348d1" xlink:to="loc_jazz_RylazeEnrylazeMember_ad4d19cf-34ca-4685-a698-ce7bec95edef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ZepzelcaMember_cc10007b-402d-4928-9994-250cea95a836" xlink:href="jazz-20240331.xsd#jazz_ZepzelcaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOncologyMember_61a361b0-398e-4e4a-a43d-0d39dbc348d1" xlink:to="loc_jazz_ZepzelcaMember_cc10007b-402d-4928-9994-250cea95a836" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_DefitelioDefibrotideMember_62a42930-382e-4c26-bd90-8e45303c006e" xlink:href="jazz-20240331.xsd#jazz_DefitelioDefibrotideMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOncologyMember_61a361b0-398e-4e4a-a43d-0d39dbc348d1" xlink:to="loc_jazz_DefitelioDefibrotideMember_62a42930-382e-4c26-bd90-8e45303c006e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_VyxeosMember_339cf39e-2be7-40bf-8e3e-455ac751308e" xlink:href="jazz-20240331.xsd#jazz_VyxeosMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOncologyMember_61a361b0-398e-4e4a-a43d-0d39dbc348d1" xlink:to="loc_jazz_VyxeosMember_339cf39e-2be7-40bf-8e3e-455ac751308e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherProductsMember_69c3350b-51d6-4fab-b255-8b93790ed84f" xlink:href="jazz-20240331.xsd#jazz_OtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_e48370de-e086-4745-84a2-4837c0317921" xlink:to="loc_jazz_OtherProductsMember_69c3350b-51d6-4fab-b255-8b93790ed84f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_HighSodiumAGOxybateProductRoyaltyRevenueMember_38c13a02-7fef-45ec-a86e-78a99ca842aa" xlink:href="jazz-20240331.xsd#jazz_HighSodiumAGOxybateProductRoyaltyRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_65acc909-6980-4cfe-bfb3-2e21dbe4f690" xlink:to="loc_jazz_HighSodiumAGOxybateProductRoyaltyRevenueMember_38c13a02-7fef-45ec-a86e-78a99ca842aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherRoyaltyAndContractRevenuesMember_da0cdf0d-6fb1-426a-83e8-a53b6c489a71" xlink:href="jazz-20240331.xsd#jazz_OtherRoyaltyAndContractRevenuesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_65acc909-6980-4cfe-bfb3-2e21dbe4f690" xlink:to="loc_jazz_OtherRoyaltyAndContractRevenuesMember_da0cdf0d-6fb1-426a-83e8-a53b6c489a71" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_66b4a212-1d68-47cc-84bf-6b0a597ccf7f" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_6c6e2c01-0bf2-4b5f-ad34-ebea45330d5d" xlink:to="loc_srt_StatementGeographicalAxis_66b4a212-1d68-47cc-84bf-6b0a597ccf7f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_66b4a212-1d68-47cc-84bf-6b0a597ccf7f_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_66b4a212-1d68-47cc-84bf-6b0a597ccf7f" xlink:to="loc_srt_SegmentGeographicalDomain_66b4a212-1d68-47cc-84bf-6b0a597ccf7f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_2f162044-a8dd-48cf-90c7-a412dec201a6" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_66b4a212-1d68-47cc-84bf-6b0a597ccf7f" xlink:to="loc_srt_SegmentGeographicalDomain_2f162044-a8dd-48cf-90c7-a412dec201a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_7f181aa8-dcd5-4df6-9f8e-d21e6fea3ae6" xlink:href="https://xbrl.sec.gov/country/2023/country-2023.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2f162044-a8dd-48cf-90c7-a412dec201a6" xlink:to="loc_country_US_7f181aa8-dcd5-4df6-9f8e-d21e6fea3ae6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_685e5101-d0ce-456c-bf4a-409022f3005a" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2f162044-a8dd-48cf-90c7-a412dec201a6" xlink:to="loc_srt_EuropeMember_685e5101-d0ce-456c-bf4a-409022f3005a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherCountriesMember_a121e412-089d-49e3-82bb-717e9a56ee5f" xlink:href="jazz-20240331.xsd#jazz_OtherCountriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_2f162044-a8dd-48cf-90c7-a412dec201a6" xlink:to="loc_jazz_OtherCountriesMember_a121e412-089d-49e3-82bb-717e9a56ee5f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ae5fd8ed-a484-4bba-afa0-580cbefc392c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_361a0da0-2894-4b63-8825-75aeb5e2f080" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_ae5fd8ed-a484-4bba-afa0-580cbefc392c" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_075bdd9e-1a4a-4692-869f-9b9d5c724985" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_cc057087-e82d-448f-905d-a99c7afdfadc" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_075bdd9e-1a4a-4692-869f-9b9d5c724985" xlink:to="loc_us-gaap_ConcentrationRiskTable_cc057087-e82d-448f-905d-a99c7afdfadc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_f89162d9-c356-447a-bff9-b3240564f33b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_cc057087-e82d-448f-905d-a99c7afdfadc" xlink:to="loc_srt_MajorCustomersAxis_f89162d9-c356-447a-bff9-b3240564f33b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_f89162d9-c356-447a-bff9-b3240564f33b_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_f89162d9-c356-447a-bff9-b3240564f33b" xlink:to="loc_srt_NameOfMajorCustomerDomain_f89162d9-c356-447a-bff9-b3240564f33b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_3d76d215-75c2-4bda-8ab9-e3e60bf216be" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_f89162d9-c356-447a-bff9-b3240564f33b" xlink:to="loc_srt_NameOfMajorCustomerDomain_3d76d215-75c2-4bda-8ab9-e3e60bf216be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExpressScriptsMember_48b6dbae-d563-47cf-a5d6-e19ba13c44a7" xlink:href="jazz-20240331.xsd#jazz_ExpressScriptsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_3d76d215-75c2-4bda-8ab9-e3e60bf216be" xlink:to="loc_jazz_ExpressScriptsMember_48b6dbae-d563-47cf-a5d6-e19ba13c44a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_McKessonCorporationMember_21895c08-37b1-4478-bbe1-34b0dc645323" xlink:href="jazz-20240331.xsd#jazz_McKessonCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_3d76d215-75c2-4bda-8ab9-e3e60bf216be" xlink:to="loc_jazz_McKessonCorporationMember_21895c08-37b1-4478-bbe1-34b0dc645323" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CardinalHealthIncMember_41378b91-289c-4969-8ba5-d9312cd56ca9" xlink:href="jazz-20240331.xsd#jazz_CardinalHealthIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_3d76d215-75c2-4bda-8ab9-e3e60bf216be" xlink:to="loc_jazz_CardinalHealthIncMember_41378b91-289c-4969-8ba5-d9312cd56ca9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_bbbafa6c-fe51-42af-a8b8-a5ce5b46934c" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_cc057087-e82d-448f-905d-a99c7afdfadc" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_bbbafa6c-fe51-42af-a8b8-a5ce5b46934c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_bbbafa6c-fe51-42af-a8b8-a5ce5b46934c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_bbbafa6c-fe51-42af-a8b8-a5ce5b46934c" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_bbbafa6c-fe51-42af-a8b8-a5ce5b46934c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_f7de1a40-5ec0-4837-a4db-51de804e4a17" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_bbbafa6c-fe51-42af-a8b8-a5ce5b46934c" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_f7de1a40-5ec0-4837-a4db-51de804e4a17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerMember_368a4402-e4f1-4c90-bbc9-62e210e93855" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RevenueFromContractWithCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_f7de1a40-5ec0-4837-a4db-51de804e4a17" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerMember_368a4402-e4f1-4c90-bbc9-62e210e93855" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_11eedd53-6371-426a-9be1-88e181fe2ed9" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_cc057087-e82d-448f-905d-a99c7afdfadc" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_11eedd53-6371-426a-9be1-88e181fe2ed9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_11eedd53-6371-426a-9be1-88e181fe2ed9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_11eedd53-6371-426a-9be1-88e181fe2ed9" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_11eedd53-6371-426a-9be1-88e181fe2ed9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_97ea0f4c-379a-4627-b6b8-d7bf161a4f02" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_11eedd53-6371-426a-9be1-88e181fe2ed9" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_97ea0f4c-379a-4627-b6b8-d7bf161a4f02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_ac50b9a5-bf56-4ca6-b29a-a0e1779203c4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_97ea0f4c-379a-4627-b6b8-d7bf161a4f02" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_ac50b9a5-bf56-4ca6-b29a-a0e1779203c4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_7a624044-ed41-41fd-8375-03929079216f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_075bdd9e-1a4a-4692-869f-9b9d5c724985" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_7a624044-ed41-41fd-8375-03929079216f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#RevenuesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SummaryOfDeferredRevenueLineItems_06da77b5-b8bb-460e-a955-d72fea4b481c" xlink:href="jazz-20240331.xsd#jazz_SummaryOfDeferredRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SummaryOfDeferredRevenueTable_8b124eb7-07a5-42c1-a98e-e269790fd90a" xlink:href="jazz-20240331.xsd#jazz_SummaryOfDeferredRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_06da77b5-b8bb-460e-a955-d72fea4b481c" xlink:to="loc_jazz_SummaryOfDeferredRevenueTable_8b124eb7-07a5-42c1-a98e-e269790fd90a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e4803eb5-4ab9-49d2-a78f-adf0d7934cd0" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_SummaryOfDeferredRevenueTable_8b124eb7-07a5-42c1-a98e-e269790fd90a" xlink:to="loc_srt_RangeAxis_e4803eb5-4ab9-49d2-a78f-adf0d7934cd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e4803eb5-4ab9-49d2-a78f-adf0d7934cd0_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e4803eb5-4ab9-49d2-a78f-adf0d7934cd0" xlink:to="loc_srt_RangeMember_e4803eb5-4ab9-49d2-a78f-adf0d7934cd0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0a1d32cd-63b9-4890-b66a-ec7cb8c7a233" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e4803eb5-4ab9-49d2-a78f-adf0d7934cd0" xlink:to="loc_srt_RangeMember_0a1d32cd-63b9-4890-b66a-ec7cb8c7a233" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_c48d107a-af83-4d43-be84-5fbd4780e44c" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0a1d32cd-63b9-4890-b66a-ec7cb8c7a233" xlink:to="loc_srt_MinimumMember_c48d107a-af83-4d43-be84-5fbd4780e44c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_cd24e9d3-c317-43d5-a6c4-55441a893f4b" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0a1d32cd-63b9-4890-b66a-ec7cb8c7a233" xlink:to="loc_srt_MaximumMember_cd24e9d3-c317-43d5-a6c4-55441a893f4b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RevenuePerformanceObligationPaymentTerms_a2ab5083-3443-47ea-aee1-a0eea33d5459" xlink:href="jazz-20240331.xsd#jazz_RevenuePerformanceObligationPaymentTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_06da77b5-b8bb-460e-a955-d72fea4b481c" xlink:to="loc_jazz_RevenuePerformanceObligationPaymentTerms_a2ab5083-3443-47ea-aee1-a0eea33d5459" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#ShareBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7c01a22b-c4c4-44d7-a58e-0994766b323f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1b29d9bd-ffb2-4a9f-aa95-4e9055d0bd36" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7c01a22b-c4c4-44d7-a58e-0994766b323f" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1b29d9bd-ffb2-4a9f-aa95-4e9055d0bd36" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_0a1fa46d-eaf3-4c36-b115-5c732b5002d6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_1b29d9bd-ffb2-4a9f-aa95-4e9055d0bd36" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_0a1fa46d-eaf3-4c36-b115-5c732b5002d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_0a1fa46d-eaf3-4c36-b115-5c732b5002d6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_0a1fa46d-eaf3-4c36-b115-5c732b5002d6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_0a1fa46d-eaf3-4c36-b115-5c732b5002d6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_33163a65-40b1-482f-8aef-c19c68928eaf" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_0a1fa46d-eaf3-4c36-b115-5c732b5002d6" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_33163a65-40b1-482f-8aef-c19c68928eaf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_9b9a656d-82bf-40bb-ac97-dce56850754f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_33163a65-40b1-482f-8aef-c19c68928eaf" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_9b9a656d-82bf-40bb-ac97-dce56850754f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_32ad28b1-f15c-4e20-b1ec-ae6febde3c6e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_33163a65-40b1-482f-8aef-c19c68928eaf" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_32ad28b1-f15c-4e20-b1ec-ae6febde3c6e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_126f6f1b-8759-4e40-b05d-29e1dd00fad4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_33163a65-40b1-482f-8aef-c19c68928eaf" xlink:to="loc_us-gaap_CostOfSalesMember_126f6f1b-8759-4e40-b05d-29e1dd00fad4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_57c9ec94-c8bf-4ff7-a43a-723f8561163a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7c01a22b-c4c4-44d7-a58e-0994766b323f" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_57c9ec94-c8bf-4ff7-a43a-723f8561163a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_27e06dbb-98d4-476a-84db-ea47d9120a24" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7c01a22b-c4c4-44d7-a58e-0994766b323f" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_27e06dbb-98d4-476a-84db-ea47d9120a24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_eefb28f4-c148-4cae-8182-e94bd3f32b2d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_7c01a22b-c4c4-44d7-a58e-0994766b323f" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_eefb28f4-c148-4cae-8182-e94bd3f32b2d" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationRestrictedUnitsDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#ShareBasedCompensationRestrictedUnitsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationRestrictedUnitsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d4ebfe78-51f3-48d4-a335-4ba0fca3826b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_294beff8-fe05-4621-ae41-38630ad8a956" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d4ebfe78-51f3-48d4-a335-4ba0fca3826b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_294beff8-fe05-4621-ae41-38630ad8a956" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_dec1576f-3f35-4bed-bf85-81307f6f363b" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_294beff8-fe05-4621-ae41-38630ad8a956" xlink:to="loc_us-gaap_AwardTypeAxis_dec1576f-3f35-4bed-bf85-81307f6f363b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_dec1576f-3f35-4bed-bf85-81307f6f363b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_dec1576f-3f35-4bed-bf85-81307f6f363b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_dec1576f-3f35-4bed-bf85-81307f6f363b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d889e388-17c7-407b-8054-52ba87232fb1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_dec1576f-3f35-4bed-bf85-81307f6f363b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d889e388-17c7-407b-8054-52ba87232fb1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_dad1ab80-66d3-4ef3-af0a-5c1e2bd8a542" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_d889e388-17c7-407b-8054-52ba87232fb1" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_dad1ab80-66d3-4ef3-af0a-5c1e2bd8a542" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b8eaa4bb-b4d1-463b-bb14-c19f9c4594f1" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d4ebfe78-51f3-48d4-a335-4ba0fca3826b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_b8eaa4bb-b4d1-463b-bb14-c19f9c4594f1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_d50cf7de-05e4-4908-98bf-4922e0ca3e47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d4ebfe78-51f3-48d4-a335-4ba0fca3826b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_d50cf7de-05e4-4908-98bf-4922e0ca3e47" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#ShareBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8c2ba67e-d3ec-47d7-8ea7-32371be80e60" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_24a8655b-0cd1-4f20-ad00-3a5204464ef4" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8c2ba67e-d3ec-47d7-8ea7-32371be80e60" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_24a8655b-0cd1-4f20-ad00-3a5204464ef4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_aa19ca13-bdf0-4974-b06f-0578ed64509e" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_24a8655b-0cd1-4f20-ad00-3a5204464ef4" xlink:to="loc_us-gaap_AwardTypeAxis_aa19ca13-bdf0-4974-b06f-0578ed64509e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_aa19ca13-bdf0-4974-b06f-0578ed64509e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_aa19ca13-bdf0-4974-b06f-0578ed64509e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_aa19ca13-bdf0-4974-b06f-0578ed64509e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cf9c6f3c-502d-4352-a490-8d09df154126" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_aa19ca13-bdf0-4974-b06f-0578ed64509e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cf9c6f3c-502d-4352-a490-8d09df154126" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_0cd81ea4-11f9-4ca8-857c-74529c58d477" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cf9c6f3c-502d-4352-a490-8d09df154126" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_0cd81ea4-11f9-4ca8-857c-74529c58d477" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_75986c60-d9a5-4e6f-a9d9-dc2b8aadc096" xlink:href="jazz-20240331.xsd#jazz_PerformanceBasedRestrictedStockUnitsRSUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cf9c6f3c-502d-4352-a490-8d09df154126" xlink:to="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_75986c60-d9a5-4e6f-a9d9-dc2b8aadc096" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_571087b8-497a-4fbd-a84f-7c09723ab4fb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cf9c6f3c-502d-4352-a490-8d09df154126" xlink:to="loc_us-gaap_EmployeeStockMember_571087b8-497a-4fbd-a84f-7c09723ab4fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_c6d2874e-e34a-46d9-8382-bee356ce0799" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_cf9c6f3c-502d-4352-a490-8d09df154126" xlink:to="loc_us-gaap_EmployeeStockOptionMember_c6d2874e-e34a-46d9-8382-bee356ce0799" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_4ce5a032-c984-4529-83bf-ee4a734748b9" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_24a8655b-0cd1-4f20-ad00-3a5204464ef4" xlink:to="loc_srt_RangeAxis_4ce5a032-c984-4529-83bf-ee4a734748b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_4ce5a032-c984-4529-83bf-ee4a734748b9_default" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_4ce5a032-c984-4529-83bf-ee4a734748b9" xlink:to="loc_srt_RangeMember_4ce5a032-c984-4529-83bf-ee4a734748b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2892cd01-8eb7-424e-a498-ff7d73d602b8" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_4ce5a032-c984-4529-83bf-ee4a734748b9" xlink:to="loc_srt_RangeMember_2892cd01-8eb7-424e-a498-ff7d73d602b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_8f6a8dcd-ebb7-4a7c-ade2-d63fa4e7cf92" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2892cd01-8eb7-424e-a498-ff7d73d602b8" xlink:to="loc_srt_MinimumMember_8f6a8dcd-ebb7-4a7c-ade2-d63fa4e7cf92" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_b520333a-a05a-443f-9544-723c6f39b3d4" xlink:href="https://xbrl.fasb.org/srt/2023/elts/srt-2023.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_2892cd01-8eb7-424e-a498-ff7d73d602b8" xlink:to="loc_srt_MaximumMember_b520333a-a05a-443f-9544-723c6f39b3d4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_d2837a88-c613-413c-9097-6c28cfc8422d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8c2ba67e-d3ec-47d7-8ea7-32371be80e60" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_d2837a88-c613-413c-9097-6c28cfc8422d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted_5e0846d5-5230-43a3-9af9-03f3e89d0665" xlink:href="jazz-20240331.xsd#jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8c2ba67e-d3ec-47d7-8ea7-32371be80e60" xlink:to="loc_jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted_5e0846d5-5230-43a3-9af9-03f3e89d0665" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_b2a3aea0-ae53-4cc3-8afb-c7670ae50652" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8c2ba67e-d3ec-47d7-8ea7-32371be80e60" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_b2a3aea0-ae53-4cc3-8afb-c7670ae50652" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_40979a13-e00e-41fa-8121-188ca6cc7038" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_8c2ba67e-d3ec-47d7-8ea7-32371be80e60" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_40979a13-e00e-41fa-8121-188ca6cc7038" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleofPerformancebasedRSUsDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#ShareBasedCompensationScheduleofPerformancebasedRSUsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleofPerformancebasedRSUsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_55790cec-9d47-4d41-b824-ce5e59ea7efb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_46f4ad01-0636-4165-8d82-76408ab30420" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_55790cec-9d47-4d41-b824-ce5e59ea7efb" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_46f4ad01-0636-4165-8d82-76408ab30420" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_24686f47-59c0-4123-96a6-f04271808e3a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_46f4ad01-0636-4165-8d82-76408ab30420" xlink:to="loc_us-gaap_AwardTypeAxis_24686f47-59c0-4123-96a6-f04271808e3a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_24686f47-59c0-4123-96a6-f04271808e3a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_24686f47-59c0-4123-96a6-f04271808e3a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_24686f47-59c0-4123-96a6-f04271808e3a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a407fddd-9ef0-434c-94d0-551b2953cbc2" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_24686f47-59c0-4123-96a6-f04271808e3a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a407fddd-9ef0-434c-94d0-551b2953cbc2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_d9c15a69-f318-4b1b-9e8d-53061858ffa9" xlink:href="jazz-20240331.xsd#jazz_PerformanceBasedRestrictedStockUnitsRSUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a407fddd-9ef0-434c-94d0-551b2953cbc2" xlink:to="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_d9c15a69-f318-4b1b-9e8d-53061858ffa9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_fc344f2f-f3fa-42f1-9589-402ac97471b5" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_55790cec-9d47-4d41-b824-ce5e59ea7efb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_fc344f2f-f3fa-42f1-9589-402ac97471b5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8f6ecdfd-890f-4494-ba03-9cdaa7d37a0a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_55790cec-9d47-4d41-b824-ce5e59ea7efb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_8f6ecdfd-890f-4494-ba03-9cdaa7d37a0a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesDetails" xlink:type="simple" xlink:href="jazz-20240331.xsd#IncomeTaxesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_ef559da3-77e9-463a-a2ec-f4413ee9da7f" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxContingencyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_04f50cbc-fa5d-4f68-bd98-a1d8613cba75" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxContingencyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_ef559da3-77e9-463a-a2ec-f4413ee9da7f" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_04f50cbc-fa5d-4f68-bd98-a1d8613cba75" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_8b2de872-7359-44c3-a48f-d76d0f1eec03" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_04f50cbc-fa5d-4f68-bd98-a1d8613cba75" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_8b2de872-7359-44c3-a48f-d76d0f1eec03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_8b2de872-7359-44c3-a48f-d76d0f1eec03_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_8b2de872-7359-44c3-a48f-d76d0f1eec03" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_8b2de872-7359-44c3-a48f-d76d0f1eec03_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_750233ad-8154-47eb-8622-2ccb920cafeb" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_8b2de872-7359-44c3-a48f-d76d0f1eec03" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_750233ad-8154-47eb-8622-2ccb920cafeb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCountryMember_2df1cf18-89ea-4a6b-ab4d-8c6b51abce4d" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ForeignCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_750233ad-8154-47eb-8622-2ccb920cafeb" xlink:to="loc_us-gaap_ForeignCountryMember_2df1cf18-89ea-4a6b-ab4d-8c6b51abce4d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameAxis_46f47c5f-2e34-4b73-af3a-86603f750b47" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_04f50cbc-fa5d-4f68-bd98-a1d8613cba75" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameAxis_46f47c5f-2e34-4b73-af3a-86603f750b47" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_46f47c5f-2e34-4b73-af3a-86603f750b47_default" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_46f47c5f-2e34-4b73-af3a-86603f750b47" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_46f47c5f-2e34-4b73-af3a-86603f750b47_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityNameDomain_839da485-c5f9-480b-a392-d4987d1858a6" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxAuthorityNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameAxis_46f47c5f-2e34-4b73-af3a-86603f750b47" xlink:to="loc_us-gaap_IncomeTaxAuthorityNameDomain_839da485-c5f9-480b-a392-d4987d1858a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LuxembourgInlandRevenueMember_bde09b29-e270-49a3-8e29-83e09b638d65" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LuxembourgInlandRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityNameDomain_839da485-c5f9-480b-a392-d4987d1858a6" xlink:to="loc_us-gaap_LuxembourgInlandRevenueMember_bde09b29-e270-49a3-8e29-83e09b638d65" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_414ab815-f012-4e7d-9600-5fe41395d851" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_ef559da3-77e9-463a-a2ec-f4413ee9da7f" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_414ab815-f012-4e7d-9600-5fe41395d851" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_5c33347f-bf7d-4b04-9a21-16692bc4137a" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_ef559da3-77e9-463a-a2ec-f4413ee9da7f" xlink:to="loc_us-gaap_IncomeTaxExaminationEstimateOfPossibleLoss_5c33347f-bf7d-4b04-9a21-16692bc4137a" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-roles-2023.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_AssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_OtherAssetsNoncurrent" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesAbstract" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/TradingArrangementsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#TradingArrangmentsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/TradingArrangementsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllTradingArrangementsMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllTradingArrangementsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RobertIannoneMarch2024PlanMember_b51938f1-a6a5-48a6-b0d9-6b94f5b89a27" xlink:href="jazz-20240331.xsd#jazz_RobertIannoneMarch2024PlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="loc_jazz_RobertIannoneMarch2024PlanMember_b51938f1-a6a5-48a6-b0d9-6b94f5b89a27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RobertIannonePlanPriorToMarch2024Member_cc8cfb74-0728-4d33-b6b0-6729688100c8" xlink:href="jazz-20240331.xsd#jazz_RobertIannonePlanPriorToMarch2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllTradingArrangementsMember" xlink:to="loc_jazz_RobertIannonePlanPriorToMarch2024Member_cc8cfb74-0728-4d33-b6b0-6729688100c8" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/AwardTypeOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#AwardTypeOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/AwardTypeOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_67a94e8f-a624-4af5-a02d-e84dd6582b8a" xlink:href="jazz-20240331.xsd#jazz_PerformanceBasedRestrictedStockUnitsRSUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_jazz_PerformanceBasedRestrictedStockUnitsRSUsMember_67a94e8f-a624-4af5-a02d-e84dd6582b8a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OrdinarySharesMember_ed1f0ab9-887f-457e-9617-b8e4ce4dd970" xlink:href="jazz-20240331.xsd#jazz_OrdinarySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_jazz_OrdinarySharesMember_ed1f0ab9-887f-457e-9617-b8e4ce4dd970" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember" xlink:href="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="loc_us-gaap_EmployeeStockMember" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#IndividualsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllIndividualsMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RobertIannoneMember_2f99b6aa-440b-4662-b5f1-fc83427e615b" xlink:href="jazz-20240331.xsd#jazz_RobertIannoneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllIndividualsMember" xlink:to="loc_jazz_RobertIannoneMember_2f99b6aa-440b-4662-b5f1-fc83427e615b" xlink:type="arc" order="2"/>
  </link:definitionLink>
</link:linkbase>
