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    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_E06243080C4DE019BBD5B981AC84091F_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_E06243080C4DE019BBD5B981AC84091F" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Income tax benefit from share-based compensation expense</link:label>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_E06243080C4DE019BBD5B981AC84091F_label_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_E06243080C4DE019BBD5B981AC84091F" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share-based Payment Arrangement, Expense, Tax Benefit</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_E06243080C4DE019BBD5B981AC84091F" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_88A85103C9A38216E768B981AC84DAF6_totalLabel_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_88A85103C9A38216E768B981AC84DAF6" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total share-based compensation expense, net of tax</link:label>
    <link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_88A85103C9A38216E768B981AC84DAF6_label_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_88A85103C9A38216E768B981AC84DAF6" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Share-based Payment Arrangement, Expense, after Tax</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_88A85103C9A38216E768B981AC84DAF6" xlink:type="locator" />
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    <link:label id="lab_jazz_AccruedRebatesAndOtherSalesDeductions_B33D5CA430788A770080535C728CC34C_label_en-US" xlink:label="lab_jazz_AccruedRebatesAndOtherSalesDeductions_B33D5CA430788A770080535C728CC34C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Rebates And Other Sales Deductions</link:label>
    <link:label id="lab_jazz_AccruedRebatesAndOtherSalesDeductions_B33D5CA430788A770080535C728CC34C_documentation_en-US" xlink:label="lab_jazz_AccruedRebatesAndOtherSalesDeductions_B33D5CA430788A770080535C728CC34C" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Carrying value as of the balance sheet date of obligations incurred through that date and payable for rebates and other sales deductions. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</link:label>
    <link:loc xlink:href="jazz-20200630.xsd#jazz_AccruedRebatesAndOtherSalesDeductions" xlink:label="loc_jazz_AccruedRebatesAndOtherSalesDeductions_B33D5CA430788A770080535C728CC34C" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AccruedEmployeeBenefitsCurrent_7B8C88ED8D55FB567665535C728CFCED_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedEmployeeBenefitsCurrent_7B8C88ED8D55FB567665535C728CFCED" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Employee compensation and benefits</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_7B8C88ED8D55FB567665535C728CFCED" xlink:type="locator" />
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    <link:label id="lab_us-gaap_OperatingLeaseLiabilityCurrent_873D41F8EF4616BA1C2E535C728C97C7_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeaseLiabilityCurrent_873D41F8EF4616BA1C2E535C728C97C7" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Current portion of operating lease liabilities</link:label>
    <link:label id="lab_us-gaap_OperatingLeaseLiabilityCurrent_873D41F8EF4616BA1C2E535C728C97C7_label_en-US" xlink:label="lab_us-gaap_OperatingLeaseLiabilityCurrent_873D41F8EF4616BA1C2E535C728C97C7" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Operating Lease, Liability, Current</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_873D41F8EF4616BA1C2E535C728C97C7" xlink:type="locator" />
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    <link:label id="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36_terseLabel_en-US" xlink:label="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Inventory-related accruals</link:label>
    <link:label id="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36_label_en-US" xlink:label="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Inventory Related Liabilities</link:label>
    <link:label id="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36_documentation_en-US" xlink:label="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Accrued Inventory Related Liabilities</link:label>
    <link:loc xlink:href="jazz-20200630.xsd#jazz_AccruedInventoryRelatedLiabilities" xlink:label="loc_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36" xlink:to="lab_jazz_AccruedInventoryRelatedLiabilities_0A2A410BFEAA186AF1F8535C728CAE36" xlink:type="arc" />
    <link:label id="lab_jazz_SalesReturnReserve_DE981FB743600730C7FE535C728D86C4_terseLabel_en-US" xlink:label="lab_jazz_SalesReturnReserve_DE981FB743600730C7FE535C728D86C4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sales returns reserve</link:label>
    <link:label id="lab_jazz_SalesReturnReserve_DE981FB743600730C7FE535C728D86C4_label_en-US" xlink:label="lab_jazz_SalesReturnReserve_DE981FB743600730C7FE535C728D86C4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sales Return Reserve</link:label>
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    <link:loc xlink:href="jazz-20200630.xsd#jazz_SalesReturnReserve" xlink:label="loc_jazz_SalesReturnReserve_DE981FB743600730C7FE535C728D86C4" xlink:type="locator" />
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    <link:label id="lab_us-gaap_DerivativeLiabilitiesCurrent_035CEF96691D7D6D47A1535C728D768C_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilitiesCurrent_035CEF96691D7D6D47A1535C728D768C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative instrument liabilities</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilitiesCurrent_035CEF96691D7D6D47A1535C728D768C_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilitiesCurrent_035CEF96691D7D6D47A1535C728D768C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Liability, Current</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_035CEF96691D7D6D47A1535C728D768C" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_28ED34A2628E04DA216F535C728D6304_label_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent_28ED34A2628E04DA216F535C728D6304" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Professional Fees, Current</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_28ED34A2628E04DA216F535C728D6304" xlink:type="locator" />
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    <link:label id="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534_terseLabel_en-US" xlink:label="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued interest</link:label>
    <link:label id="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534_label_en-US" xlink:label="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Interest</link:label>
    <link:label id="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534_documentation_en-US" xlink:label="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Carrying value as of the balance sheet date of obligations incurred through that date and payable for interest. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</link:label>
    <link:loc xlink:href="jazz-20200630.xsd#jazz_AccruedInterest" xlink:label="loc_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534" xlink:to="lab_jazz_AccruedInterest_12169BE2A40ABC8FB703535C728D3534" xlink:type="arc" />
    <link:label id="lab_us-gaap_AccruedRoyaltiesCurrent_7F822CF402B95E4FB9BF535C728D0242_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedRoyaltiesCurrent_7F822CF402B95E4FB9BF535C728D0242" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Royalties</link:label>
    <link:label id="lab_us-gaap_AccruedRoyaltiesCurrent_7F822CF402B95E4FB9BF535C728D0242_label_en-US" xlink:label="lab_us-gaap_AccruedRoyaltiesCurrent_7F822CF402B95E4FB9BF535C728D0242" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Royalties, Current</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_7F822CF402B95E4FB9BF535C728D0242" xlink:type="locator" />
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    <link:label id="lab_us-gaap_AccruedMarketingCostsCurrent_C0795FD3DBAFF81F216C535C728DAF5B_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedMarketingCostsCurrent_C0795FD3DBAFF81F216C535C728DAF5B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Selling and marketing accruals</link:label>
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    <link:label id="lab_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669_terseLabel_en-US" xlink:label="lab_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued collaboration expenses</link:label>
    <link:label id="lab_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669_label_en-US" xlink:label="lab_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Collaboration Costs, Current</link:label>
    <link:label id="lab_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669_documentation_en-US" xlink:label="lab_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Accrued Collaboration Costs, Current</link:label>
    <link:loc xlink:href="jazz-20200630.xsd#jazz_AccruedCollaborationCostsCurrent" xlink:label="loc_jazz_AccruedCollaborationCostsCurrent_3C048265345265433541535C728EC669" xlink:type="locator" />
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