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  <xs:element id="jazz_ForeignTaxEffectsPercentAbstract" abstract="true" name="ForeignTaxEffectsPercentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_EffectiveIncomeTaxRateReconciliationNonDeductibleContingentConsiderationPaymentsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNonDeductibleContingentConsiderationPaymentsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="jazz_EffectiveIncomeTaxRateReconciliationPatentBoxIncentiveBenefitPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationPatentBoxIncentiveBenefitPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="jazz_EffectiveIncomeTaxRateReconciliationChangeInEstimateAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationChangeInEstimateAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseFacilityExpenseAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseFacilityExpenseAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_DeferredTaxAssetsDeductionsOnSubsidiaryEquityCarryforwards" abstract="false" name="DeferredTaxAssetsDeductionsOnSubsidiaryEquityCarryforwards" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_DeferredTaxAssetsIntangibleAssets" abstract="false" name="DeferredTaxAssetsIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_DeferredTaxAssetsIndirectEffectsOfUnrecognizedTaxBenefits" abstract="false" name="DeferredTaxAssetsIndirectEffectsOfUnrecognizedTaxBenefits" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_SaleOfProductiveAssetPercentOfPostTaxProceedsEntitled" abstract="false" name="SaleOfProductiveAssetPercentOfPostTaxProceedsEntitled" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="jazz_AllowanceForSalesDiscountsMember" abstract="true" name="AllowanceForSalesDiscountsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="jazz_AllowanceForChargebacksMember" abstract="true" name="AllowanceForChargebacksMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="jazz_BruceC.CozaadMember" abstract="true" name="BruceC.CozaadMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
