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  <xsd:element id="jazz_LesseeLeasingArrangementOperatingLeasesEarlyTerminationTermOfContractOptionOne" name="LesseeLeasingArrangementOperatingLeasesEarlyTerminationTermOfContractOptionOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LesseeLeasingArrangementOperatingLeasesEarlyTerminationTermOfContractOptionTwo" name="LesseeLeasingArrangementOperatingLeasesEarlyTerminationTermOfContractOptionTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LesseeLeasingArrangementOperatingLeasesNumberOfRenewalTerms" name="LesseeLeasingArrangementOperatingLeasesNumberOfRenewalTerms" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LesseeLeasingArrangementOperatingLeasesTerminationNoticePeriod" name="LesseeLeasingArrangementOperatingLeasesTerminationNoticePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LicenseAndOptionAgreementUpfrontPayment" name="LicenseAndOptionAgreementUpfrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_LicenseDevelopmentAndCommercializationAgreementsMember" name="LicenseDevelopmentAndCommercializationAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LicenseandOptionAgreementPotentialPayments" name="LicenseandOptionAgreementPotentialPayments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="jazz_LicensingAgreementAgreementTerm" name="LicensingAgreementAgreementTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LicensingAgreementNumberOfAgreements" name="LicensingAgreementNumberOfAgreements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="jazz_LicensingAgreementRoyaltyRateIncreaseSalesPeriodExtension" name="LicensingAgreementRoyaltyRateIncreaseSalesPeriodExtension" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_LossContingencyExclusivityGracePeriod" name="LossContingencyExclusivityGracePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_ManufacturingContractsMember" name="ManufacturingContractsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_May2013ShareRepurchaseProgramMember" name="May2013ShareRepurchaseProgramMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_McKessonCorporationMember" name="McKessonCorporationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_MilestonePaymentMember" name="MilestonePaymentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NonvotingEuroDeferredShares" name="NonvotingEuroDeferredShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="jazz_NonvotingEuroDeferredSharesParOrStatedValuePerShare" name="NonvotingEuroDeferredSharesParOrStatedValuePerShare" nillable="true" substitutionGroup="xbrli:item" type="num:perShareItemType" xbrli:periodType="instant" />
  <xsd:element id="jazz_NonvotingEuroDeferredSharesSharesIssued" name="NonvotingEuroDeferredSharesSharesIssued" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="jazz_NonvotingEuroDeferredSharesSharesOutstanding" name="NonvotingEuroDeferredSharesSharesOutstanding" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="jazz_NonvotingEuroPreferredSharesSharesAuthorized" name="NonvotingEuroPreferredSharesSharesAuthorized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="jazz_November2015ShareRepurchaseProgramMember" name="November2015ShareRepurchaseProgramMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_November2016ShareRepurchaseProgramMember" name="November2016ShareRepurchaseProgramMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfCustomersWithSignificantAccountsReceivableBalance" name="NumberOfCustomersWithSignificantAccountsReceivableBalance" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element id="jazz_NumberOfLitigationCasesAfterConsolidation" name="NumberOfLitigationCasesAfterConsolidation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfPatentsDeemedUnenforceable" name="NumberOfPatentsDeemedUnenforceable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfPatentsNamedInReviewPetitions" name="NumberOfPatentsNamedInReviewPetitions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfPetitionClaimsDeniedUnderPatent" name="NumberOfPetitionClaimsDeniedUnderPatent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfPetitionClaimsUnderPatentReview" name="NumberOfPetitionClaimsUnderPatentReview" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfPetitionClaimsUnderPatentReviewAwaitingDecision" name="NumberOfPetitionClaimsUnderPatentReviewAwaitingDecision" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_NumberOfPetitionClaimsUnderPatentReviewDeemedUnpatentable" name="NumberOfPetitionClaimsUnderPatentReviewDeemedUnpatentable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_NumeratorAbstract" name="NumeratorAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_OperatingLeaseExtendedTerm" name="OperatingLeaseExtendedTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_OperatingLossCarryforwardsAnnualLimitationOnUse" name="OperatingLossCarryforwardsAnnualLimitationOnUse" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="jazz_OperatingLossCarryforwardsByExpirationPeriodAxis" name="OperatingLossCarryforwardsByExpirationPeriodAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_OperatingLossCarryforwardsExpirationPeriodDomain" name="OperatingLossCarryforwardsExpirationPeriodDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_OrdinarySharesMember" name="OrdinarySharesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_OtherCountriesMember" name="OtherCountriesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_OtherLongTermLiabilitiesLineItems" name="OtherLongTermLiabilitiesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_OtherLongTermLiabilitiesTable" name="OtherLongTermLiabilitiesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_OtherProductsMember" name="OtherProductsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_PaloAltoAndDublinMember" name="PaloAltoAndDublinMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_PaloAltoMember" name="PaloAltoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_PaymentsForProceedsFromTenantAllowanceFinancingActivities" name="PaymentsForProceedsFromTenantAllowanceFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="jazz_PaymentstoAcquireInProcessResearchandDevelopmentOtherThanThroughBusinessCombination" name="PaymentstoAcquireInProcessResearchandDevelopmentOtherThanThroughBusinessCombination" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_PfenexMember" name="PfenexMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_PortionOfEUSAMember" name="PortionOfEUSAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_PrialtMember" name="PrialtMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_ProvisionForLossesOnAccountsReceivableAndInventory" name="ProvisionForLossesOnAccountsReceivableAndInventory" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_QuarterlyFinancialDataLineItems" name="QuarterlyFinancialDataLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
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  <xsd:element id="jazz_RoyaltiesAndContractRevenues" name="RoyaltiesAndContractRevenues" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="jazz_SalesReturnReserve" name="SalesReturnReserve" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualAutomaticAdditionalSharesAuthorizationPercentageOfOutstandingShares" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualAutomaticAdditionalSharesAuthorizationPercentageOfOutstandingShares" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriodsWithinEachOfferingPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPurchasePeriodsWithinEachOfferingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfferingPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_SignificantRisksAndUncertaintiesPolicyTextBlock" name="SignificantRisksAndUncertaintiesPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_StockIssuedDuringPeriodSharesStockOptionsExercisedNetOfTax" name="StockIssuedDuringPeriodSharesStockOptionsExercisedNetOfTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_StockholdersEquityNoteLineItems" name="StockholdersEquityNoteLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_StockholdersEquityNoteTable" name="StockholdersEquityNoteTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_TaxCutsAndJobsActIncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalIncomeTaxExpense" name="TaxCutsAndJobsActIncompleteAccountingTransitionTaxForAccumulatedForeignEarningsProvisionalIncomeTaxExpense" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TaxCutsAndJobsActOf2017ForeignTaxCreditsMember" name="TaxCutsAndJobsActOf2017ForeignTaxCreditsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateProvisionalIncomeTaxExpenseBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="jazz_TaxCutsAndJobsActOf2017IncompleteAccountingDeferredTaxAssetExecutiveCompensation" name="TaxCutsAndJobsActOf2017IncompleteAccountingDeferredTaxAssetExecutiveCompensation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="jazz_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TermLoanMember" name="TermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandElevenEquityIncentivePlanMember" name="TwoThousandElevenEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandElevenEquityIncentivePlanOptionOneMember" name="TwoThousandElevenEquityIncentivePlanOptionOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandElevenEquityIncentivePlanOptionTwoMember" name="TwoThousandElevenEquityIncentivePlanOptionTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandSevenEmployeeStockPurchasePlanMember" name="TwoThousandSevenEmployeeStockPurchasePlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandSevenEmployeeStockPurchasePlanOptionOneMember" name="TwoThousandSevenEmployeeStockPurchasePlanOptionOneMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandSevenEmployeeStockPurchasePlanOptionTwoMember" name="TwoThousandSevenEmployeeStockPurchasePlanOptionTwoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandSevenEquityIncentivePlanMember" name="TwoThousandSevenEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_TwoThousandSevenNonEmployeeDirectorsStockOptionPlanMember" name="TwoThousandSevenNonEmployeeDirectorsStockOptionPlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_UcbPharmaLimitedMember" name="UcbPharmaLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_UpfrontAndMilestonePaymentsMember" name="UpfrontAndMilestonePaymentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_UtilizationOfNetOperatingLossCarryforwardsWhichPreviouslyCarriedValuationAllowanceMember" name="UtilizationOfNetOperatingLossCarryforwardsWhichPreviouslyCarriedValuationAllowanceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_VyxeosMember" name="VyxeosMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="jazz_WriteOffOfUnamortizedDeferredFinancingCostsAndUnamortizedDiscount" name="WriteOffOfUnamortizedDeferredFinancingCostsAndUnamortizedDiscount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_XyremANDAMattersMember" name="XyremANDAMattersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="jazz_XyremMember" name="XyremMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
</xsd:schema>
