<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with WebFilings-->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.jazzpharma.com/role/AccruedLiabilities" xlink:href="jazz-20121231.xsd#AccruedLiabilities" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/AccruedLiabilitiesDetails" xlink:href="jazz-20121231.xsd#AccruedLiabilitiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/AccruedLiabilitiesTables" xlink:href="jazz-20121231.xsd#AccruedLiabilitiesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinations" xlink:href="jazz-20121231.xsd#BusinessCombinations" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsAdditionalInformationDetails" xlink:href="jazz-20121231.xsd#BusinessCombinationsAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsAssetsAcquiredAndLiabilitiesAssumedAtAcquisitionDateBasedUponRespectiveEstimatedFairValuesDetails" xlink:href="jazz-20121231.xsd#BusinessCombinationsAssetsAcquiredAndLiabilitiesAssumedAtAcquisitionDateBasedUponRespectiveEstimatedFairValuesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsCombinedResultsOfOperationsDetails" xlink:href="jazz-20121231.xsd#BusinessCombinationsCombinedResultsOfOperationsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsIntangibleAssetsAsOfClosingDateOfAcquisitionDetails" xlink:href="jazz-20121231.xsd#BusinessCombinationsIntangibleAssetsAsOfClosingDateOfAcquisitionDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsSummaryOfCashPaidToFormerSecurityHoldersOfEusaPharmaDetails" xlink:href="jazz-20121231.xsd#BusinessCombinationsSummaryOfCashPaidToFormerSecurityHoldersOfEusaPharmaDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsSummaryOfCashPaidToFormerSecurityHoldersOfEusaPharmaDetailsCalc2" xlink:href="jazz-20121231.xsd#BusinessCombinationsSummaryOfCashPaidToFormerSecurityHoldersOfEusaPharmaDetailsCalc2" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/BusinessCombinationsTables" xlink:href="jazz-20121231.xsd#BusinessCombinationsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsAndContingencies" xlink:href="jazz-20121231.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsAndContingenciesNarrativeDetails" xlink:href="jazz-20121231.xsd#CommitmentsAndContingenciesNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsAndContingenciesScheduleOfFutureMinimumLeasePaymentsUnderNoncancelableOperatingLeasesDetails" xlink:href="jazz-20121231.xsd#CommitmentsAndContingenciesScheduleOfFutureMinimumLeasePaymentsUnderNoncancelableOperatingLeasesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsAndContingenciesScheduleOfRentExpenseUnderOperatingLeasesDetails" xlink:href="jazz-20121231.xsd#CommitmentsAndContingenciesScheduleOfRentExpenseUnderOperatingLeasesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsAndContingenciesTables" xlink:href="jazz-20121231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ComprehensiveIncomeLossDetails" xlink:href="jazz-20121231.xsd#ComprehensiveIncomeLossDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ComprehensiveIncomeloss" xlink:href="jazz-20121231.xsd#ComprehensiveIncomeloss" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ComprehensiveIncomelossTables" xlink:href="jazz-20121231.xsd#ComprehensiveIncomelossTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedBalanceSheets" xlink:href="jazz-20121231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="jazz-20121231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="jazz-20121231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedStatementsOfCashFlowsParenthetical" xlink:href="jazz-20121231.xsd#ConsolidatedStatementsOfCashFlowsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:href="jazz-20121231.xsd#ConsolidatedStatementsOfComprehensiveIncome" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedStatementsOfIncome" xlink:href="jazz-20121231.xsd#ConsolidatedStatementsOfIncome" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedStatementsOfIncomeParenthetical" xlink:href="jazz-20121231.xsd#ConsolidatedStatementsOfIncomeParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:href="jazz-20121231.xsd#ConsolidatedStatementsOfStockholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/DiscontinuedOperations" xlink:href="jazz-20121231.xsd#DiscontinuedOperations" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/DiscontinuedOperationsDetails" xlink:href="jazz-20121231.xsd#DiscontinuedOperationsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/DiscontinuedOperationsTables" xlink:href="jazz-20121231.xsd#DiscontinuedOperationsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/DocumentAndEntityInformation" xlink:href="jazz-20121231.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/EmployeeBenefitPlans" xlink:href="jazz-20121231.xsd#EmployeeBenefitPlans" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/EmployeeBenefitPlansDetails" xlink:href="jazz-20121231.xsd#EmployeeBenefitPlansDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurement" xlink:href="jazz-20121231.xsd#FairValueMeasurement" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementContingentConsiderationPayableDetails" xlink:href="jazz-20121231.xsd#FairValueMeasurementContingentConsiderationPayableDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:href="jazz-20121231.xsd#FairValueMeasurementNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementScheduleOfAvailableForSaleInvestmentsMeasuredAtFairValueOnRecurringBasisDetails" xlink:href="jazz-20121231.xsd#FairValueMeasurementScheduleOfAvailableForSaleInvestmentsMeasuredAtFairValueOnRecurringBasisDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementScheduleOfAvailableForSaleSecuritiesDetails" xlink:href="jazz-20121231.xsd#FairValueMeasurementScheduleOfAvailableForSaleSecuritiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementsTables" xlink:href="jazz-20121231.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssets" xlink:href="jazz-20121231.xsd#GoodwillAndIntangibleAssets" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsAdditionalInformationDetails" xlink:href="jazz-20121231.xsd#GoodwillAndIntangibleAssetsAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsScheduleOfEstimatedFutureAmortizationCostsDetails" xlink:href="jazz-20121231.xsd#GoodwillAndIntangibleAssetsScheduleOfEstimatedFutureAmortizationCostsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsScheduleOfGrossCarryingAmountOfGoodwillDetails" xlink:href="jazz-20121231.xsd#GoodwillAndIntangibleAssetsScheduleOfGrossCarryingAmountOfGoodwillDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsScheduleOfGrossCarryingAmountsAndNetBookValuesOfIntangibleAssetsDetails" xlink:href="jazz-20121231.xsd#GoodwillAndIntangibleAssetsScheduleOfGrossCarryingAmountsAndNetBookValuesOfIntangibleAssetsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsTables" xlink:href="jazz-20121231.xsd#GoodwillAndIntangibleAssetsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxes" xlink:href="jazz-20121231.xsd#IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesComponentsOfIncomeFromContinuingOperationsBeforeIncomeTaxProvisionBenefitDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesComponentsOfIncomeFromContinuingOperationsBeforeIncomeTaxProvisionBenefitDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesCurrentAndNonCurrentDeferredAssetsLiabilitiesDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesCurrentAndNonCurrentDeferredAssetsLiabilitiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesDetailsOfIncomeTaxProvisionBenefitDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesDetailsOfIncomeTaxProvisionBenefitDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesNarrativeDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesReconciliationOfGrossUnrecognizedTaxBenefitsDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesReconciliationOfGrossUnrecognizedTaxBenefitsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesReconciliationOfIncomeTaxAtUnitedStatesStatutoryIncomeTaxRateAndOurProvisionForIncomeTaxesDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesReconciliationOfIncomeTaxAtUnitedStatesStatutoryIncomeTaxRateAndOurProvisionForIncomeTaxesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesScheduleOfNetDeferredTaxAssetsLiabilitiesDetails" xlink:href="jazz-20121231.xsd#IncomeTaxesScheduleOfNetDeferredTaxAssetsLiabilitiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesScheduleOfNetDeferredTaxAssetsLiabilitiesDetailsCalc2" xlink:href="jazz-20121231.xsd#IncomeTaxesScheduleOfNetDeferredTaxAssetsLiabilitiesDetailsCalc2" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesTables" xlink:href="jazz-20121231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/Inventories" xlink:href="jazz-20121231.xsd#Inventories" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/InventoriesDetails" xlink:href="jazz-20121231.xsd#InventoriesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/InventoriesTables" xlink:href="jazz-20121231.xsd#InventoriesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/LongTermDebt" xlink:href="jazz-20121231.xsd#LongTermDebt" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/LongTermDebtAdditionalInformationDetails" xlink:href="jazz-20121231.xsd#LongTermDebtAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/LongTermDebtDebtMaturitiesDetails" xlink:href="jazz-20121231.xsd#LongTermDebtDebtMaturitiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/LongTermDebtTables" xlink:href="jazz-20121231.xsd#LongTermDebtTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/OrganizationAndDescriptionOfBusiness" xlink:href="jazz-20121231.xsd#OrganizationAndDescriptionOfBusiness" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/OtherLiabilitiesDetails" xlink:href="jazz-20121231.xsd#OtherLiabilitiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/OtherLiabilitiesNotes" xlink:href="jazz-20121231.xsd#OtherLiabilitiesNotes" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/PropertyAndEquipment" xlink:href="jazz-20121231.xsd#PropertyAndEquipment" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/PropertyAndEquipmentDetails" xlink:href="jazz-20121231.xsd#PropertyAndEquipmentDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/PropertyAndEquipmentTables" xlink:href="jazz-20121231.xsd#PropertyAndEquipmentTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/QuarterlyFinancialDataUnaudited" xlink:href="jazz-20121231.xsd#QuarterlyFinancialDataUnaudited" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/QuarterlyFinancialDataUnauditedScheduleOfInterimFinancialInformationPresentsResultsOfOperationsOnQuarterlyBasisDetails" xlink:href="jazz-20121231.xsd#QuarterlyFinancialDataUnauditedScheduleOfInterimFinancialInformationPresentsResultsOfOperationsOnQuarterlyBasisDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/QuarterlyFinancialDataUnauditedTables" xlink:href="jazz-20121231.xsd#QuarterlyFinancialDataUnauditedTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/RelatedPartyTransactions" xlink:href="jazz-20121231.xsd#RelatedPartyTransactions" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/RelatedPartyTransactionsDetails" xlink:href="jazz-20121231.xsd#RelatedPartyTransactionsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/Restructuring" xlink:href="jazz-20121231.xsd#Restructuring" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/RestructuringDetails" xlink:href="jazz-20121231.xsd#RestructuringDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/RestructuringTables" xlink:href="jazz-20121231.xsd#RestructuringTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformation" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformationAdditionalInformationDetails" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformationAdditionalInformationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformationSegmentAndOtherInformationTables" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformationSegmentAndOtherInformationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformationSummaryOfRevenuesFromCustomersRepresentingAtLeast10OfTotalRevenuesDetails" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformationSummaryOfRevenuesFromCustomersRepresentingAtLeast10OfTotalRevenuesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformationSummaryOfTotalRevenuesAttributedToGeographicSourcesDetails" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformationSummaryOfTotalRevenuesAttributedToGeographicSourcesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformationSummaryOfTotalRevenuesDetails" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformationSummaryOfTotalRevenuesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SegmentAndOtherInformationTotalLongLivedAssetsByLocationDetails" xlink:href="jazz-20121231.xsd#SegmentAndOtherInformationTotalLongLivedAssetsByLocationDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensation" xlink:href="jazz-20121231.xsd#ShareBasedCompensation" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:href="jazz-20121231.xsd#ShareBasedCompensationNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfRsusActivityDetails" xlink:href="jazz-20121231.xsd#ShareBasedCompensationScheduleOfRsusActivityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfStockBasedCompensationExpenseRelatedToStockOptionsRsusOrdinarySharesCreditedToDirectorsPhantomShareAccountsAndGrantsUnderEsppDetails" xlink:href="jazz-20121231.xsd#ShareBasedCompensationScheduleOfStockBasedCompensationExpenseRelatedToStockOptionsRsusOrdinarySharesCreditedToDirectorsPhantomShareAccountsAndGrantsUnderEsppDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfStockOptionPlansActivityDetails" xlink:href="jazz-20121231.xsd#ShareBasedCompensationScheduleOfStockOptionPlansActivityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfWeightedAverageAssumptionsUsedInBlackScholesOptionPricingModelAndResultingWeightedAverageGrantDateFairValueOfStockOptionsGrantedDetails" xlink:href="jazz-20121231.xsd#ShareBasedCompensationScheduleOfWeightedAverageAssumptionsUsedInBlackScholesOptionPricingModelAndResultingWeightedAverageGrantDateFairValueOfStockOptionsGrantedDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationTables" xlink:href="jazz-20121231.xsd#ShareBasedCompensationTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquity" xlink:href="jazz-20121231.xsd#ShareholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityNarrativeDetails" xlink:href="jazz-20121231.xsd#ShareholdersEquityNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityScheduleOfAuthorizedButUnissuedOrdinarySharesDetails" xlink:href="jazz-20121231.xsd#ShareholdersEquityScheduleOfAuthorizedButUnissuedOrdinarySharesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityScheduleOfCommonStockIssuableUnderWarrantsDetails" xlink:href="jazz-20121231.xsd#ShareholdersEquityScheduleOfCommonStockIssuableUnderWarrantsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityTables" xlink:href="jazz-20121231.xsd#ShareholdersEquityTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPolicies" xlink:href="jazz-20121231.xsd#SummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:href="jazz-20121231.xsd#SummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:href="jazz-20121231.xsd#SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfComputationOfDilutedNetIncomeLossPerShareHavingAntiDilutiveEffectDetails" xlink:href="jazz-20121231.xsd#SummaryOfSignificantAccountingPoliciesScheduleOfComputationOfDilutedNetIncomeLossPerShareHavingAntiDilutiveEffectDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfNetIncomeLossPerOrdinaryShareDetails" xlink:href="jazz-20121231.xsd#SummaryOfSignificantAccountingPoliciesScheduleOfNetIncomeLossPerOrdinaryShareDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:href="jazz-20121231.xsd#SummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ValuationAndQualifyingAccounts" xlink:href="jazz-20121231.xsd#ValuationAndQualifyingAccounts" xlink:type="simple" />
  <roleRef roleURI="http://www.jazzpharma.com/role/ValuationAndQualifyingAccountsScheduleOfValuationAndQualifyingAccountsDetails" xlink:href="jazz-20121231.xsd#ValuationAndQualifyingAccountsScheduleOfValuationAndQualifyingAccountsDetails" xlink:type="simple" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/AccruedLiabilities" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/AccruedLiabilitiesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedEmployeeBenefitsCurrent" xlink:label="loc_us-gaap_AccruedEmployeeBenefitsCurrent_2998d70a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccruedEmployeeBenefitsCurrent_2998d70a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_AccruedRebatesAndOtherSalesDeductions" xlink:label="loc_jazz_AccruedRebatesAndOtherSalesDeductions_92777b9e-5451-2c10-87c1-e3db9c4643e5" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_AccruedRebatesAndOtherSalesDeductions_92777b9e-5451-2c10-87c1-e3db9c4643e5" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_SalesReturnReserve" xlink:label="loc_jazz_SalesReturnReserve_ea40e5d6-a592-3798-a06e-e3db9c4648aa" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_SalesReturnReserve_ea40e5d6-a592-3798-a06e-e3db9c4648aa" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_293a2110-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_293a2110-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedRoyaltiesCurrent" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_29a0bace-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_29a0bace-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_643d0570-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_643d0570-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/AccruedLiabilitiesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinations" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsAdditionalInformationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsAssetsAcquiredAndLiabilitiesAssumedAtAcquisitionDateBasedUponRespectiveEstimatedFairValuesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents_2e21b9ea-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents_2e21b9ea-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables_2ec28fe6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsReceivables_2ec28fe6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory_2e45423e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsInventory_2e45423e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets_2de83ef4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsPrepaidExpenseAndOtherAssets_2de83ef4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment_2edb902c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationPropertyPlantAndEquipment_2edb902c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill_2e57fe7e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill_2e57fe7e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount_2dfad1d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationGoodwillAmount_2dfad1d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets_2e110e60-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherAssets_2e110e60-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiabilities" xlink:label="loc_jazz_BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiabilities_031c9c62-3758-c8eb-52cb-e3db9c467d5a" xlink:type="locator" />
    <calculationArc order="9" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_BusinessAcquisitionPurchasePriceAllocationAccountsPayableAndAccruedLiabilities_031c9c62-3758-c8eb-52cb-e3db9c467d5a" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredTaxLiabilitiesNoncurrent_2de7398c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="10" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationDeferredTaxLiabilitiesNoncurrent_2de7398c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherLiabilities" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherLiabilities_2e10a7c2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="11" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationOtherLiabilities_2e10a7c2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesOtherLiabilities" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesOtherLiabilities_2e46d194-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="12" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentLiabilitiesOtherLiabilities_2e46d194-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCapitalLeaseObligationAccrual" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCapitalLeaseObligationAccrual_2de5cbc4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="13" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCapitalLeaseObligationAccrual_2de5cbc4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsCombinedResultsOfOperationsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsIntangibleAssetsAsOfClosingDateOfAcquisitionDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill_2e57fe7e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AcquiredIndefiniteLivedIntangibleAssetAmount" xlink:label="loc_us-gaap_AcquiredIndefiniteLivedIntangibleAssetAmount_29c2fcba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill_2e57fe7e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AcquiredIndefiniteLivedIntangibleAssetAmount_29c2fcba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetAmount" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetAmount_29c5ce40-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationIntangibleAssetsOtherThanGoodwill_2e57fe7e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetAmount_29c5ce40-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsSummaryOfCashPaidToFormerSecurityHoldersOfEusaPharmaDetails" xlink:type="extended">
    <loc xlink:href="jazz-20121231.xsd#jazz_BusinessAcquisitionUpfrontPayment" xlink:label="loc_jazz_BusinessAcquisitionUpfrontPayment_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:type="locator" />
    <loc xlink:href="jazz-20121231.xsd#jazz_BusinessAcquisitionCostOfAcquiredEntityAgreementBasePrice" xlink:label="loc_jazz_BusinessAcquisitionCostOfAcquiredEntityAgreementBasePrice_a9da353b-13b4-d3a3-6cc0-e3db9c460850" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_BusinessAcquisitionUpfrontPayment_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:to="loc_jazz_BusinessAcquisitionCostOfAcquiredEntityAgreementBasePrice_a9da353b-13b4-d3a3-6cc0-e3db9c460850" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents" xlink:label="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents_2e21b9ea-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_BusinessAcquisitionUpfrontPayment_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:to="loc_us-gaap_BusinessAcquisitionPurchasePriceAllocationCurrentAssetsCashAndCashEquivalents_2e21b9ea-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_BusinessAcquisitionCostOfAcquiredEntityWorkingCapitalAndOtherAdjustments" xlink:label="loc_jazz_BusinessAcquisitionCostOfAcquiredEntityWorkingCapitalAndOtherAdjustments_584fd96a-fa60-d0f7-870c-e3db9c46fda8" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_BusinessAcquisitionUpfrontPayment_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:to="loc_jazz_BusinessAcquisitionCostOfAcquiredEntityWorkingCapitalAndOtherAdjustments_584fd96a-fa60-d0f7-870c-e3db9c46fda8" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsSummaryOfCashPaidToFormerSecurityHoldersOfEusaPharmaDetailsCalc2" xlink:type="extended">
    <loc xlink:href="jazz-20121231.xsd#jazz_BusinessAcquisitionUpfrontPayment" xlink:label="loc_jazz_BusinessAcquisitionUpfrontPayment_3E0288F1635B64469C28F4275344815D_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue_3E0288F1635B64469C28F4275344815D_2df9aa5e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_BusinessAcquisitionUpfrontPayment_3E0288F1635B64469C28F4275344815D_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:to="loc_us-gaap_BusinessAcquisitionContingentConsiderationAtFairValue_3E0288F1635B64469C28F4275344815D_2df9aa5e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice" xlink:label="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_3E0288F1635B64469C28F4275344815D_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_BusinessAcquisitionUpfrontPayment_3E0288F1635B64469C28F4275344815D_09688807-47c5-8c63-6d8e-e3db9c4638ca" xlink:to="loc_us-gaap_BusinessAcquisitionCostOfAcquiredEntityPurchasePrice_3E0288F1635B64469C28F4275344815D_2ec8c76c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/BusinessCombinationsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/CommitmentsAndContingencies" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/CommitmentsAndContingenciesNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/CommitmentsAndContingenciesScheduleOfFutureMinimumLeasePaymentsUnderNoncancelableOperatingLeasesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_6262eea4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_624ef566-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_6262eea4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_624ef566-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_624fc05e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_6262eea4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_624fc05e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_6246695a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_6262eea4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_6246695a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_62597bee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_6262eea4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_62597bee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_6260ce6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_6262eea4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_6260ce6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/CommitmentsAndContingenciesScheduleOfRentExpenseUnderOperatingLeasesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/CommitmentsAndContingenciesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ComprehensiveIncomeLossDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ComprehensiveIncomeloss" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ComprehensiveIncomelossTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_30cfd000-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_30cfd000-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesCurrent" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesCurrent_2cb61bfa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesCurrent_2cb61bfa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_28c3463a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_28c3463a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_5b10f3ee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_InventoryNet_5b10f3ee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="loc_us-gaap_PrepaidExpenseCurrent_66bb4ae6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PrepaidExpenseCurrent_66bb4ae6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_47298288-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetCurrent_47298288-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherAssetsCurrent" xlink:label="loc_us-gaap_OtherAssetsCurrent_62bc2ffa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_2c23c494-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherAssetsCurrent_62bc2ffa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_683dcad8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_683dcad8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5a1fdbbc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5a1fdbbc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Goodwill" xlink:label="loc_us-gaap_Goodwill_567ea9de-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_Goodwill_567ea9de-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsNetNoncurrent" xlink:label="loc_us-gaap_DeferredTaxAssetsNetNoncurrent_475df306-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsNetNoncurrent_475df306-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredFinanceCostsNet" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_46ea9fbe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_46ea9fbe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_62df8554-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_2c254058-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_62df8554-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_4737a390-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredRevenueNoncurrent_4737a390-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_5ea4bd74-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_5ea4bd74-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessAcquisitionContingentConsiderationAtFairValueNoncurrent" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationAtFairValueNoncurrent_2e0f5408-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessAcquisitionContingentConsiderationAtFairValueNoncurrent_2e0f5408-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxLiabilitiesNoncurrent" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_476c4866-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesNoncurrent_476c4866-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_63d8f7d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_63d8f7d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_34116ef4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CommitmentsAndContingencies_34116ef4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_664b7ebe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PreferredStockValue_664b7ebe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_34ddf442-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CommonStockValue_34ddf442-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_NonvotingEuroDeferredShares" xlink:label="loc_jazz_NonvotingEuroDeferredShares_f90a3100-2dff-7a87-963d-e3db9c467e19" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_NonvotingEuroDeferredShares_f90a3100-2dff-7a87-963d-e3db9c467e19" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_CapitalRedemptionReserve" xlink:label="loc_jazz_CapitalRedemptionReserve_2db45e8b-8bea-c026-434b-e3db9c464a31" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_CapitalRedemptionReserve_2db45e8b-8bea-c026-434b-e3db9c464a31" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AdditionalPaidInCapitalCommonStock" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_29c8cba4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_29c8cba4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_29c0ce5e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_29c0ce5e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_6b785646-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_70895bd0-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_6b785646-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_5c4fc6ae-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_28d58084-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccountsPayableCurrent_28d58084-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_299992da-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtCurrent" xlink:label="loc_us-gaap_LongTermDebtCurrent_5ea447fe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtCurrent_5ea447fe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_716f9f3c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_TaxesPayableCurrent_716f9f3c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxLiabilitiesCurrent" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesCurrent_47827f46-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesCurrent_47827f46-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_PurchasedProductRightsLiabilityCurrent" xlink:label="loc_jazz_PurchasedProductRightsLiabilityCurrent_31ac7c52-d9b8-1f6a-770b-e3db9c461f1c" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_PurchasedProductRightsLiabilityCurrent_31ac7c52-d9b8-1f6a-770b-e3db9c461f1c" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_LiabilityUnderGovernmentSettlementCurrent" xlink:label="loc_jazz_LiabilityUnderGovernmentSettlementCurrent_2a8c4859-75b0-facd-ab0e-e3db9c466beb" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_LiabilityUnderGovernmentSettlementCurrent_2a8c4859-75b0-facd-ab0e-e3db9c466beb" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_473bd082-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_5c188d92-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredRevenueCurrent_473bd082-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_31a4213e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_31a4213e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_2b3ffbc4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_2b3ffbc4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Depreciation" xlink:label="loc_us-gaap_Depreciation_48aefde0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_Depreciation_48aefde0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_559e3eee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_559e3eee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_6ec09264-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ShareBasedCompensation_6ec09264-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities" xlink:label="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities_4f6c0772-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationOperatingActivities_4f6c0772-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_FairValueInventoryStepUpAdjustment" xlink:label="loc_jazz_FairValueInventoryStepUpAdjustment_0ef8c452-39cc-583e-9461-e3db9c468c17" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_FairValueInventoryStepUpAdjustment_0ef8c452-39cc-583e-9461-e3db9c468c17" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability_2f2fa662-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability_2f2fa662-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_472866e6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="9" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_472866e6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_555c97b4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="10" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_555c97b4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_ProvisionForLossesOnAccountsReceivableAndInventory" xlink:label="loc_jazz_ProvisionForLossesOnAccountsReceivableAndInventory_3c585044-2514-11e2-b3ab-22000a1cf22c" xlink:type="locator" />
    <calculationArc order="11" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_ProvisionForLossesOnAccountsReceivableAndInventory_3c585044-2514-11e2-b3ab-22000a1cf22c" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_2b764dd2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="12" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_2b764dd2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_55dec02c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="13" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_55dec02c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_58ea018c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="14" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_58ea018c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_5962f3b2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="15" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_5962f3b2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_595df15a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="16" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_595df15a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_595e31f6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="17" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherOperatingAssets_595e31f6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_58a5226a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="18" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_58a5226a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_58c61cea-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="19" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_58c61cea-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_58e15870-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="20" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_58e15870-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_58e591d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="21" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_58e591d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_58e51460-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="22" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentLiabilities_58e51460-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_DecreaseInLiabilityUnderGovernmentSettlement" xlink:label="loc_jazz_DecreaseInLiabilityUnderGovernmentSettlement_6c50e3e6-53a7-b6b4-65de-e3db9c465992" xlink:type="locator" />
    <calculationArc order="23" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_611fd732-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_DecreaseInLiabilityUnderGovernmentSettlement_6c50e3e6-53a7-b6b4-65de-e3db9c465992" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_31a4213e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_6544a1b2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_6544a1b2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_654796ce-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecurities_654796ce-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_67542a54-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecurities_67542a54-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_6752d8de-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_6752d8de-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_6546d400-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_6546d400-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsToAcquireIntangibleAssets" xlink:label="loc_us-gaap_PaymentsToAcquireIntangibleAssets_6546184e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PaymentsToAcquireIntangibleAssets_6546184e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncreaseDecreaseInRestrictedCash" xlink:label="loc_us-gaap_IncreaseDecreaseInRestrictedCash_59912bba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncreaseDecreaseInRestrictedCash_59912bba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_676ee9de-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_60ef698a-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_676ee9de-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_31a4213e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSecuredDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_672e6008-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_672e6008-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_ProceedsFromEmployeeStockPurchasesAndExerciseOfStockOptionsAndWarrants" xlink:label="loc_jazz_ProceedsFromEmployeeStockPurchasesAndExerciseOfStockOptionsAndWarrants_c096082f-1870-9790-3cb8-e3db9c462ca8" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_ProceedsFromEmployeeStockPurchasesAndExerciseOfStockOptionsAndWarrants_c096082f-1870-9790-3cb8-e3db9c462ca8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_64c9d4d2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_64c9d4d2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities" xlink:label="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities_4f6b30fe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities_4f6b30fe-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_RepaymentsOfSecuredDebt" xlink:label="loc_us-gaap_RepaymentsOfSecuredDebt_6ad7d2e8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_RepaymentsOfSecuredDebt_6ad7d2e8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_64ca7130-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_64ca7130-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_67480440-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_67480440-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfLinesOfCredit" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfLinesOfCredit_672b5f16-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_60f52a96-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfLinesOfCredit_672b5f16-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalentsContinuingOperations" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalentsContinuingOperations_4e1209e4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_31a4213e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalentsContinuingOperations_4e1209e4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedStatementsOfCashFlowsParenthetical" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedStatementsOfComprehensiveIncome" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_38f2d2fa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_629be1be-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_38f2d2fa-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_629be1be-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_633cc110-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_629be1be-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_633cc110-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_63bfc6aa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_629be1be-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_63bfc6aa-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax_631e0ec8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_629be1be-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentForSaleOfSecuritiesIncludedInNetIncomeNetOfTax_631e0ec8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_38f2d2fa-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedStatementsOfIncome" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_57e107d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_624609ec-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_57e107d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingIncomeLoss_624609ec-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_6bd78760-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_624609ec-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_Revenues_6bd78760-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_6c240414-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_6bd78760-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_6c240414-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_RoyaltiesAndContractRevenues" xlink:label="loc_jazz_RoyaltiesAndContractRevenues_6e6a7fd7-5a4e-09cf-ca8f-e3db9c461bc5" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Revenues_6bd78760-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_RoyaltiesAndContractRevenues_6e6a7fd7-5a4e-09cf-ca8f-e3db9c461bc5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OperatingExpenses" xlink:label="loc_us-gaap_OperatingExpenses_623a80b8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_624609ec-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OperatingExpenses_623a80b8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnology" xlink:label="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnology_f9aa7a32-b9c5-9db9-33e7-e3db9c4624ae" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_623a80b8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnology_f9aa7a32-b9c5-9db9-33e7-e3db9c4624ae" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_6e581cc0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_623a80b8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_6e581cc0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_6aef6d04-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_623a80b8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_6aef6d04-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_IntangibleAssetAmortizationFromContinuingOperations" xlink:label="loc_jazz_IntangibleAssetAmortizationFromContinuingOperations_4cb74e06-275b-11e2-b3ab-22000a1cf22c" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_623a80b8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_IntangibleAssetAmortizationFromContinuingOperations_4cb74e06-275b-11e2-b3ab-22000a1cf22c" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_5a70278e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_57e107d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_5a70278e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_OtherNonoperatingExpense" xlink:label="loc_us-gaap_OtherNonoperatingExpense_63c80e14-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_57e107d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_OtherNonoperatingExpense_63c80e14-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_55dec02c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_57e107d6-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_55dec02c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_4d22f55c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_58429c12-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_4d22f55c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_58429c12-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_58132d10-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_4d22f55c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_58132d10-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperations" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperations_58096fb4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperations_58096fb4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_58828f8e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_611bec6c-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_58828f8e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_4dae81bc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_5842593c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_4dae81bc-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_5842593c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_57f4b52e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_4dae81bc-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_57f4b52e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedStatementsOfIncomeParenthetical" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/DiscontinuedOperations" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/DiscontinuedOperationsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_58828f8e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_4abcdf26-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_58828f8e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_4abcdf26-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_4abd1bda-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_4abcdf26-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_4abd1bda-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_4ad20ee6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_4abcdf26-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_4ad20ee6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_DiscontinuedOperationsExpectedNonRecurringGainOnSale" xlink:label="loc_jazz_DiscontinuedOperationsExpectedNonRecurringGainOnSale_88a830f4-283e-11e2-b3ab-22000a1cf22c" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxAttributableToReportingEntity_58828f8e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_DiscontinuedOperationsExpectedNonRecurringGainOnSale_88a830f4-283e-11e2-b3ab-22000a1cf22c" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/DiscontinuedOperationsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/DocumentAndEntityInformation" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/EmployeeBenefitPlans" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/EmployeeBenefitPlansDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurement" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementContingentConsiderationPayableDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementScheduleOfAvailableForSaleInvestmentsMeasuredAtFairValueOnRecurringBasisDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementScheduleOfAvailableForSaleSecuritiesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesFairValueDisclosure" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_2ca70372-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1_2cc11636-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_2ca70372-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossUnrealizedLosses1_2cc11636-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain" xlink:label="loc_us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain_28857b48-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_2ca70372-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AvailableforsaleSecuritiesGrossUnrealizedGain_28857b48-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_2ce4a1c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesFairValueDisclosure_2ca70372-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_2ce4a1c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssets" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsAdditionalInformationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsScheduleOfEstimatedFutureAmortizationCostsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_5441d830-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_5441d830-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_5447a6a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_5447a6a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_54352b8a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_54352b8a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_54474748-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_54474748-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_5432149a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_5432149a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_543dc34e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseAfterYearFive_543dc34e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsScheduleOfGrossCarryingAmountOfGoodwillDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsScheduleOfGrossCarryingAmountsAndNetBookValuesOfIntangibleAssetsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5a1fdbbc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="jazz-20121231.xsd#jazz_IntangibleAssetsGrossExcludingGoodwill" xlink:label="loc_jazz_IntangibleAssetsGrossExcludingGoodwill_3d9e56a3-2ee1-6fa8-1698-e3db9c460ae0" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5a1fdbbc-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_IntangibleAssetsGrossExcludingGoodwill_3d9e56a3-2ee1-6fa8-1698-e3db9c460ae0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_54334af4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_IntangibleAssetsGrossExcludingGoodwill_3d9e56a3-2ee1-6fa8-1698-e3db9c460ae0" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_54334af4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AcquiredIndefiniteLivedIntangibleAssetAmount" xlink:label="loc_us-gaap_AcquiredIndefiniteLivedIntangibleAssetAmount_29c2fcba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_jazz_IntangibleAssetsGrossExcludingGoodwill_3d9e56a3-2ee1-6fa8-1698-e3db9c460ae0" xlink:to="loc_us-gaap_AcquiredIndefiniteLivedIntangibleAssetAmount_29c2fcba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_543933d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5a1fdbbc-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_543933d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_54334af4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_544b59c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_543933d8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/GoodwillAndIntangibleAssetsTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesComponentsOfIncomeFromContinuingOperationsBeforeIncomeTaxProvisionBenefitDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5817da40-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_58427a66-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5817da40-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_58427a66-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_57f8c5ec-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_5817da40-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_57f8c5ec-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesCurrentAndNonCurrentDeferredAssetsLiabilitiesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesDetailsOfIncomeTaxProvisionBenefitDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperations" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_472866e6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_472866e6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_46e95794-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_472866e6-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_46e95794-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_470a2b68-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_472866e6-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_470a2b68-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_446dc392-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_446dc392-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_446e35f2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_446dc392-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_446e35f2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_446dfd76-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_446dc392-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_446dfd76-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesReconciliationOfGrossUnrecognizedTaxBenefitsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesReconciliationOfIncomeTaxAtUnitedStatesStatutoryIncomeTaxRateAndOurProvisionForIncomeTaxesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperations" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_58552bde-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_58552bde-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="jazz-20121231.xsd#jazz_IncomeTaxReconciliationNondeductibleExpenseAcquisitionRelatedCosts" xlink:label="loc_jazz_IncomeTaxReconciliationNondeductibleExpenseAcquisitionRelatedCosts_582922e7-ef20-7363-fd94-0b2ff5829f84" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_jazz_IncomeTaxReconciliationNondeductibleExpenseAcquisitionRelatedCosts_582922e7-ef20-7363-fd94-0b2ff5829f84" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_58602782-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_58602782-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_58613140-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_58613140-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential" xlink:label="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_58590d94-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_58590d94-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxContingencies" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_5879b8c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_5879b8c8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes" xlink:label="loc_us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes_587779dc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="7" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationPriorYearIncomeTaxes_587779dc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_587a13c2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="8" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_587a13c2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_5857a2f6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="9" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperations_584d47a2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_5857a2f6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesScheduleOfNetDeferredTaxAssetsLiabilitiesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_472b9258-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_47290db2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_472b9258-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_47290db2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_47290db2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_473dc93c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_473dc93c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_47489d30-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_47489d30-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets" xlink:label="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_46c83136-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets_46c83136-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_474efad6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_474efad6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_47474926-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals_47474926-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpense" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpense_47428b66-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_473698e2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpense_47428b66-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_476b24e0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_47290db2-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_476b24e0-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_4776711a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_472b9258-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesGoodwillAndIntangibleAssetsIntangibleAssets_4776711a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_476b8660-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_472b9258-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_476b8660-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesScheduleOfNetDeferredTaxAssetsLiabilitiesDetailsCalc2" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_C10DEBE7F139B1BACABF13AF3CFF7332_472b9258-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/Inventories" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/InventoriesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_5b10f3ee-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_5b016a00-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_5b10f3ee-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_5b016a00-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_5b172430-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_5b10f3ee-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_5b172430-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_5afe7bba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_5b10f3ee-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_5afe7bba-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/InventoriesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/LongTermDebt" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/LongTermDebtAdditionalInformationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/LongTermDebtDebtMaturitiesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebt" xlink:label="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_5e9d9c60-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_5e9d9c60-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_5e997928-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_5e997928-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5e988f2c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5e988f2c-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_5e9adc5a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_5e9adc5a-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_5e9e1294-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_5e9e1294-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_5ea82036-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_5e43607e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_5ea82036-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/LongTermDebtTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/OrganizationAndDescriptionOfBusiness" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/OtherLiabilitiesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/OtherLiabilitiesNotes" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/PropertyAndEquipment" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/PropertyAndEquipmentDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_683dcad8-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_683dcad8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_LeaseholdImprovementsGross" xlink:label="loc_us-gaap_LeaseholdImprovementsGross_5bf2ed12-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_LeaseholdImprovementsGross_5bf2ed12-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_PropertyPlantAndEquipmentOther" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentOther_682dc638-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentOther_682dc638-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_CapitalizedComputerSoftwareGross" xlink:label="loc_us-gaap_CapitalizedComputerSoftwareGross_306ffb94-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_CapitalizedComputerSoftwareGross_306ffb94-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_FurnitureAndFixturesGross" xlink:label="loc_us-gaap_FurnitureAndFixturesGross_550c1f50-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="4" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_FurnitureAndFixturesGross_550c1f50-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_MachineryAndEquipmentGross" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_5f1f8f18-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="5" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_5f1f8f18-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_ConstructionInProgressGross" xlink:label="loc_us-gaap_ConstructionInProgressGross_3c607fdc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="6" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_683f0542-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_ConstructionInProgressGross_3c607fdc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_29bfb410-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_683dcad8-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_29bfb410-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/PropertyAndEquipmentTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/QuarterlyFinancialDataUnaudited" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/QuarterlyFinancialDataUnauditedScheduleOfInterimFinancialInformationPresentsResultsOfOperationsOnQuarterlyBasisDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/QuarterlyFinancialDataUnauditedTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/RelatedPartyTransactions" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/RelatedPartyTransactionsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/Restructuring" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/RestructuringDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/RestructuringTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformation" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformationAdditionalInformationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformationSegmentAndOtherInformationTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformationSummaryOfRevenuesFromCustomersRepresentingAtLeast10OfTotalRevenuesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformationSummaryOfTotalRevenuesAttributedToGeographicSourcesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformationSummaryOfTotalRevenuesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SegmentAndOtherInformationTotalLongLivedAssetsByLocationDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensation" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfRsusActivityDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfStockBasedCompensationExpenseRelatedToStockOptionsRsusOrdinarySharesCreditedToDirectorsPhantomShareAccountsAndGrantsUnderEsppDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_2acd138e-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_2acd53bc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_2acd138e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_2acd53bc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_4ea4cacc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="-1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_2acd138e-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_4ea4cacc-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfStockOptionPlansActivityDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationScheduleOfWeightedAverageAssumptionsUsedInBlackScholesOptionPricingModelAndResultingWeightedAverageGrantDateFairValueOfStockOptionsGrantedDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquity" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityScheduleOfAuthorizedButUnissuedOrdinarySharesDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityScheduleOfCommonStockIssuableUnderWarrantsDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPolicies" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesPolicy" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfComputationOfDilutedNetIncomeLossPerShareHavingAntiDilutiveEffectDetails" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesScheduleOfNetIncomeLossPerOrdinaryShareDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_741fe8a4-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7416e4b6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="1" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_741fe8a4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7416e4b6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_59a8dc24-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="2" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_741fe8a4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_59a8dc24-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2012/elts/us-gaap-2012-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_59aec1b6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="locator" />
    <calculationArc order="3" weight="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_741fe8a4-78f6-11e1-94fe-25ba39ebf1f4" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_59aec1b6-78f6-11e1-94fe-25ba39ebf1f4" xlink:type="arc" />
  </calculationLink>
  <calculationLink xlink:role="http://www.jazzpharma.com/role/SummaryOfSignificantAccountingPoliciesTables" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ValuationAndQualifyingAccounts" xlink:type="extended" />
  <calculationLink xlink:role="http://www.jazzpharma.com/role/ValuationAndQualifyingAccountsScheduleOfValuationAndQualifyingAccountsDetails" xlink:type="extended" />
</linkbase>
