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  <xs:element id="jazz_EpidiolexPatentLitigationMember" abstract="true" name="EpidiolexPatentLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="jazz_XywavMember" abstract="true" name="XywavMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_InfringedPatentsSuitNumberOfPatents" abstract="false" name="InfringedPatentsSuitNumberOfPatents" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="jazz_InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted" abstract="false" name="InfringedPatentsSuitOtherPartyCounterclaimNumberOfPatentsRequestedToBeDelisted" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="jazz_NumberOfDaysProvidedToDelistPatent" abstract="false" name="NumberOfDaysProvidedToDelistPatent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="jazz_NumberOfPatentsParagraphIVCertificationNoticeFiled" abstract="false" name="NumberOfPatentsParagraphIVCertificationNoticeFiled" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="jazz_RoyaltyRateForFutureSalePercentage" abstract="false" name="RoyaltyRateForFutureSalePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="jazz_PlaintiffNumberOfDaysRequestedForFDAToTakeAction" abstract="false" name="PlaintiffNumberOfDaysRequestedForFDAToTakeAction" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="jazz_FDAStayOfApprovalPeriod" abstract="false" name="FDAStayOfApprovalPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="jazz_FDARecognitionOfOrphanDrugExclusivityPeriod" abstract="false" name="FDARecognitionOfOrphanDrugExclusivityPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="jazz_NumberOfLawsuitsOngoing" abstract="false" name="NumberOfLawsuitsOngoing" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="jazz_OrdinarySharesMember" abstract="true" name="OrdinarySharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="jazz_July2024ShareRepurchaseProgramMember" abstract="true" name="July2024ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="jazz_November2016ShareRepurchaseProgramMember" abstract="true" name="November2016ShareRepurchaseProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
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  <xs:element id="jazz_DenominatorAbstract" abstract="true" name="DenominatorAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_DebtInstrumentIrrevocableElectionForSettlementMethodFixMaximumCashPer1000PrincipalAmount" abstract="false" name="DebtInstrumentIrrevocableElectionForSettlementMethodFixMaximumCashPer1000PrincipalAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_TotalNeuroscienceMember" abstract="true" name="TotalNeuroscienceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_XyremMember" abstract="true" name="XyremMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_EpidiolexEpidyolexMember" abstract="true" name="EpidiolexEpidyolexMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_SativexMember" abstract="true" name="SativexMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_TotalOncologyMember" abstract="true" name="TotalOncologyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_RylazeEnrylazeMember" abstract="true" name="RylazeEnrylazeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="jazz_ZepzelcaMember" abstract="true" name="ZepzelcaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_DefitelioDefibrotideMember" abstract="true" name="DefitelioDefibrotideMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_VyxeosMember" abstract="true" name="VyxeosMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_OtherProductsMember" abstract="true" name="OtherProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_HighSodiumAGOxybateProductRoyaltyRevenueMember" abstract="true" name="HighSodiumAGOxybateProductRoyaltyRevenueMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_OtherRoyaltyAndContractRevenuesMember" abstract="true" name="OtherRoyaltyAndContractRevenuesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_OtherCountriesMember" abstract="true" name="OtherCountriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="jazz_SummaryOfDeferredRevenueTable" abstract="true" name="SummaryOfDeferredRevenueTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="jazz_SummaryOfDeferredRevenueLineItems" abstract="true" name="SummaryOfDeferredRevenueLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_RevenuePerformanceObligationPaymentTerms" abstract="false" name="RevenuePerformanceObligationPaymentTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="jazz_ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAchievementTargetPercentageOfAwardsGranted" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
</xs:schema>
