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  <xs:element id="jazz_TenderOfferPaymentToAcquireBusinessGross" abstract="false" name="TenderOfferPaymentToAcquireBusinessGross" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_NoncashoperatingactivitiesAbstract" abstract="true" name="NoncashoperatingactivitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems" abstract="true" name="ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_TenderOfferPerShareAmountStock" abstract="false" name="TenderOfferPerShareAmountStock" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
  <xs:element id="jazz_FarrellLawsuitAndLevyLawsuitMember" abstract="true" name="FarrellLawsuitAndLevyLawsuitMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_ExchangeableSeniorNotesDue2021Member" abstract="true" name="ExchangeableSeniorNotesDue2021Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_ExchangeRatioLowerThreshold" abstract="false" name="ExchangeRatioLowerThreshold" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="jazz_PharmaMarS.A.Member" abstract="true" name="PharmaMarS.A.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_SummaryOfDeferredRevenueLineItems" abstract="true" name="SummaryOfDeferredRevenueLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_TenderOfferPerShareAmountCash" abstract="false" name="TenderOfferPerShareAmountCash" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
  <xs:element id="jazz_TeamstersAndGEHALawsuitsMember" abstract="true" name="TeamstersAndGEHALawsuitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_SeniorSecuredBridgeLoanFacilityMember" abstract="true" name="SeniorSecuredBridgeLoanFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_IncreaseDecreaseInOperatingLeaseAssets" abstract="false" name="IncreaseDecreaseInOperatingLeaseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_SummaryOfDeferredRevenueTable" abstract="true" name="SummaryOfDeferredRevenueTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="jazz_NonvotingEuroDeferredShares" abstract="false" name="NonvotingEuroDeferredShares" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsTableTextBlock" abstract="false" name="ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="jazz_LicensingAgreementNumberOfAgreements" abstract="false" name="LicensingAgreementNumberOfAgreements" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="jazz_ExchangeableSeniorNotesDue2026Member" abstract="true" name="ExchangeableSeniorNotesDue2026Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_SunosiMember" abstract="true" name="SunosiMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" abstract="true" name="CashPaidForAmountsIncludedInTheMeasurementOfLeaseLiabilitiesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_RevenuePerformanceObligationPaymentTerms" abstract="false" name="RevenuePerformanceObligationPaymentTerms" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="jazz_CapitalRedemptionReserveMember" abstract="true" name="CapitalRedemptionReserveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_IncreaseDecreaseInOperatingLeaseLiabilitiesNoncurrent" abstract="false" name="IncreaseDecreaseInOperatingLeaseLiabilitiesNoncurrent" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_GWLitigationMember" abstract="true" name="GWLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_NumeratorAbstract" abstract="true" name="NumeratorAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="jazz_AccruedConstructionInProgress" abstract="false" name="AccruedConstructionInProgress" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_PricePerShareToBePaidToFormerShareholdersCash" abstract="false" name="PricePerShareToBePaidToFormerShareholdersCash" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
  <xs:element id="jazz_AccruedClinicalTrialLiability" abstract="false" name="AccruedClinicalTrialLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_ProceedsMultiplierForCashAndShareAmounts" abstract="false" name="ProceedsMultiplierForCashAndShareAmounts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="jazz_CapitalRedemptionReserve" abstract="false" name="CapitalRedemptionReserve" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_JazzSecuritiesDesignatedActivityCompanyMember" abstract="true" name="JazzSecuritiesDesignatedActivityCompanyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_AccruedRebatesAndOtherSalesDeductions" abstract="false" name="AccruedRebatesAndOtherSalesDeductions" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_JazzInvestmentsILimitedMember" abstract="true" name="JazzInvestmentsILimitedMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_PaymentstoAcquireInProcessResearchandDevelopmentOtherThanThroughBusinessCombination" abstract="false" name="PaymentstoAcquireInProcessResearchandDevelopmentOtherThanThroughBusinessCombination" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" abstract="false" name="FiniteLivedIntangibleAssetExpectedAmortizationAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_TotalOxybateMember" abstract="true" name="TotalOxybateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_SalesReturnReserve" abstract="false" name="SalesReturnReserve" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="jazz_OtherProductsMember" abstract="true" name="OtherProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="jazz_ProvisionForLossesOnAccountsReceivableAndInventory" abstract="false" name="ProvisionForLossesOnAccountsReceivableAndInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
