<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:1427a48e-8baf-4fdb-a501-17bd635182b6,g:f8d0c33c-a93b-4375-bb95-5b19c871d595-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/Cover" xlink:type="simple" xlink:href="jazz-20210331.xsd#Cover"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/Cover" xlink:type="extended" id="ifcbd74e3cba0433da062e305363d4518_Cover"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSENEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="jazz-20210331.xsd#CONDENSENEDCONSOLIDATEDBALANCESHEETS"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSENEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended" id="i8ac012c8ff0f46d697fbe812d982723d_CONDENSENEDCONSOLIDATEDBALANCESHEETS"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS" xlink:type="simple" xlink:href="jazz-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS" xlink:type="extended" id="iac93990b92894f068178cae8bdc95795_CONDENSEDCONSOLIDATEDSTATEMENTSOFINCOMELOSS">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_f74908be-ae35-4652-b998-8c9cbb97ad66" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_RevenuesAbstract_f74908be-ae35-4652-b998-8c9cbb97ad66" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9c8c5063-f3df-43ee-9e13-9a3a9a4665c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_f74908be-ae35-4652-b998-8c9cbb97ad66" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9c8c5063-f3df-43ee-9e13-9a3a9a4665c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment_47696757-0fe7-4afc-bc90-a79d9dee6e2d" xlink:href="jazz-20210331.xsd#jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_jazz_CostOfProductSalesExcludingAmortizationOfAcquiredDevelopedTechnologyAndIntangibleAssetImpairment_47696757-0fe7-4afc-bc90-a79d9dee6e2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_aad0dd60-71dc-4c44-8418-66d969bceb4c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_aad0dd60-71dc-4c44-8418-66d969bceb4c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_7aad0f09-15b5-49e7-bd30-ab75259dae88" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseExcludingAcquiredInProcessCost_7aad0f09-15b5-49e7-bd30-ab75259dae88" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_e26a89c3-b4ae-4ab3-8ab8-dbc58475195d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_e26a89c3-b4ae-4ab3-8ab8-dbc58475195d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_bab635e1-ee88-4d6e-a742-a7c26dda800f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_bab635e1-ee88-4d6e-a742-a7c26dda800f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_5a39e62f-e87c-4341-8500-0a655dc9f4e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_us-gaap_AssetImpairmentCharges_5a39e62f-e87c-4341-8500-0a655dc9f4e7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_e916da4b-975a-403f-a85c-aab7413f4ada" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingExpensesAbstract_796cf670-81cd-4399-b555-5625e6b9e5b9" xlink:to="loc_us-gaap_CostsAndExpenses_e916da4b-975a-403f-a85c-aab7413f4ada" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_f7fecea9-e319-4245-a304-e3974da4464b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_OperatingIncomeLoss_f7fecea9-e319-4245-a304-e3974da4464b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_ad8f6c00-d99a-4a7c-bc3e-3bfd5b5f7e82" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_ad8f6c00-d99a-4a7c-bc3e-3bfd5b5f7e82" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_2ca5c2ac-aae6-495f-87a2-922b54758ac7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_2ca5c2ac-aae6-495f-87a2-922b54758ac7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_35b2901f-2145-484e-b106-0b30d3ef158d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_35b2901f-2145-484e-b106-0b30d3ef158d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_9e26af77-996c-4748-9fad-dff22ee49d02" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_9e26af77-996c-4748-9fad-dff22ee49d02" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_4a2f58c5-52de-4633-b7c8-dbea6189d18e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_4a2f58c5-52de-4633-b7c8-dbea6189d18e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_fb40ca06-1d74-4f88-a8ca-73ed93c828d4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_NetIncomeLoss_fb40ca06-1d74-4f88-a8ca-73ed93c828d4" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_fdd335d6-8d63-405f-8595-18d15fd16c52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_fdd335d6-8d63-405f-8595-18d15fd16c52" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e2538f4a-ae56-4911-a0d1-15f1c3a91c62" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_fdd335d6-8d63-405f-8595-18d15fd16c52" xlink:to="loc_us-gaap_EarningsPerShareBasic_e2538f4a-ae56-4911-a0d1-15f1c3a91c62" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_616f016c-fd14-4d66-9f03-c661b2273e00" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_fdd335d6-8d63-405f-8595-18d15fd16c52" xlink:to="loc_us-gaap_EarningsPerShareDiluted_616f016c-fd14-4d66-9f03-c661b2273e00" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ef949125-a8e5-44fc-8d15-5c5f8dae4c0e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ef949125-a8e5-44fc-8d15-5c5f8dae4c0e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7da05c81-fdb9-4c8f-ac14-9583b61525e7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7da05c81-fdb9-4c8f-ac14-9583b61525e7" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_8f41c196-79bf-499c-a1ae-80c0a731e72a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_49c6b6a9-9080-445a-bd42-e78a62e630d4" xlink:to="loc_us-gaap_StatementTable_8f41c196-79bf-499c-a1ae-80c0a731e72a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_37e8fe78-d61c-40e9-9832-154270762361" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_8f41c196-79bf-499c-a1ae-80c0a731e72a" xlink:to="loc_srt_ProductOrServiceAxis_37e8fe78-d61c-40e9-9832-154270762361" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_37e8fe78-d61c-40e9-9832-154270762361_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_37e8fe78-d61c-40e9-9832-154270762361" xlink:to="loc_srt_ProductsAndServicesDomain_37e8fe78-d61c-40e9-9832-154270762361_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_0511189b-480e-45f0-9da5-92d9367b3b99" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_37e8fe78-d61c-40e9-9832-154270762361" xlink:to="loc_srt_ProductsAndServicesDomain_0511189b-480e-45f0-9da5-92d9367b3b99" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_81eb6aa7-9a72-4f8f-a02b-7fe035c09370" xlink:href="jazz-20210331.xsd#jazz_ProductAndServicesProductSalesNetOfDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_0511189b-480e-45f0-9da5-92d9367b3b99" xlink:to="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_81eb6aa7-9a72-4f8f-a02b-7fe035c09370" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_3dca2564-782e-41f4-8d5b-fdb2e5114ec0" xlink:href="jazz-20210331.xsd#jazz_ProductAndServicesRoyaltiesAndContractRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_0511189b-480e-45f0-9da5-92d9367b3b99" xlink:to="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_3dca2564-782e-41f4-8d5b-fdb2e5114ec0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="jazz-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended" id="ief39ab4341ea476fa02ae4fa7a8529e7_CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSParenthetical" xlink:type="simple" xlink:href="jazz-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSParenthetical"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSParenthetical" xlink:type="extended" id="i3a160311f227435cba410a3761195911_CONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSSParenthetical"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="simple" xlink:href="jazz-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY" xlink:type="extended" id="i777d333b4ac341a2bb7acb9978c932fd_CONDENSEDCONSOLIDATEDSTATEMENTSOFSHAREHOLDERSEQUITY">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_1fe7d48d-5435-4829-89b1-faa5e33ff214" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_1fe7d48d-5435-4829-89b1-faa5e33ff214" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_1d5de695-d9a7-41e5-83ea-f7bf38327573" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_SharesOutstanding_1d5de695-d9a7-41e5-83ea-f7bf38327573" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_42e124ac-f381-4955-9fc4-ace6c113d61b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_StockholdersEquity_42e124ac-f381-4955-9fc4-ace6c113d61b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a9bc11bc-4d6b-47cc-aa32-2b2fa6add38e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_a9bc11bc-4d6b-47cc-aa32-2b2fa6add38e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_e0386195-abdc-4cc4-92cf-fc4e68215d6f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_e0386195-abdc-4cc4-92cf-fc4e68215d6f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_98ec262a-e4b9-483e-b425-c0f2a890da01" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_98ec262a-e4b9-483e-b425-c0f2a890da01" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_9a3ae85e-064b-4c3c-aa2c-a7486930eb72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_9a3ae85e-064b-4c3c-aa2c-a7486930eb72" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_7b289dd6-b940-459f-ae4a-1375e322163e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_7b289dd6-b940-459f-ae4a-1375e322163e" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_8ac2f089-9c14-4547-b77c-1e4a07cb339e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodShares_8ac2f089-9c14-4547-b77c-1e4a07cb339e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_964d161d-50b7-45d6-a6a8-c2d244382542" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_964d161d-50b7-45d6-a6a8-c2d244382542" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_7fe67729-6912-4c9a-8a6e-e0568eb8314f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_7fe67729-6912-4c9a-8a6e-e0568eb8314f" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c86524f3-eb61-4da6-98ad-c4d793bd3f80" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_65c2c9f7-f421-4fb6-8122-390226cab1d0" xlink:to="loc_us-gaap_NetIncomeLoss_c86524f3-eb61-4da6-98ad-c4d793bd3f80" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_8e8c2c53-173c-428c-9421-c2f2e19b68f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_528ffc4d-920c-46c7-8769-19e480e82c56" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_ecd8dca2-2d90-48af-af45-fbcfc9f85388" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_1fe7d48d-5435-4829-89b1-faa5e33ff214" xlink:to="loc_us-gaap_StatementTable_ecd8dca2-2d90-48af-af45-fbcfc9f85388" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_8a83e773-f6af-44d6-befd-507aa6f8bf4c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_ecd8dca2-2d90-48af-af45-fbcfc9f85388" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_8a83e773-f6af-44d6-befd-507aa6f8bf4c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_8a83e773-f6af-44d6-befd-507aa6f8bf4c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8a83e773-f6af-44d6-befd-507aa6f8bf4c" xlink:to="loc_us-gaap_EquityComponentDomain_8a83e773-f6af-44d6-befd-507aa6f8bf4c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8a83e773-f6af-44d6-befd-507aa6f8bf4c" xlink:to="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_210f077d-06b2-4806-8dcc-ed4954d63588" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:to="loc_us-gaap_CommonStockMember_210f077d-06b2-4806-8dcc-ed4954d63588" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_EuroDeferredSharesMember_1f1c29d4-7d62-437b-9768-8275fb389add" xlink:href="jazz-20210331.xsd#jazz_EuroDeferredSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:to="loc_jazz_EuroDeferredSharesMember_1f1c29d4-7d62-437b-9768-8275fb389add" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_CapitalRedemptionReserveMember_9f70687b-2a3f-4383-bacb-44ec52087616" xlink:href="jazz-20210331.xsd#jazz_CapitalRedemptionReserveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:to="loc_jazz_CapitalRedemptionReserveMember_9f70687b-2a3f-4383-bacb-44ec52087616" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_e726ceb1-c2bf-45f2-afb0-ac445919f0f7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_e726ceb1-c2bf-45f2-afb0-ac445919f0f7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_6bd1dd8c-e411-4547-a3a7-eac590246467" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_6bd1dd8c-e411-4547-a3a7-eac590246467" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_44397b7c-b4b9-4cd8-8baf-ce63cf9da2c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_e99457b6-1720-45e3-9fa7-ae245818f05e" xlink:to="loc_us-gaap_RetainedEarningsMember_44397b7c-b4b9-4cd8-8baf-ce63cf9da2c1" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="jazz-20210331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended" id="ifd2e87f53cc9485a8dc83c06903fbf9b_CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="jazz-20210331.xsd#TheCompanyandSummaryofSignificantAccountingPolicies"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPolicies" xlink:type="extended" id="id786dacab3c941f59c644cee71874fdb_TheCompanyandSummaryofSignificantAccountingPolicies"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="jazz-20210331.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended" id="id4181344b07f41d193d54830a1b9c321_TheCompanyandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails" xlink:type="extended" id="i2122efae84424a7188a54ee0c358f76a_TheCompanyandSummaryofSignificantAccountingPoliciesBasisofPresentationNarrativeDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails" xlink:type="extended" id="ib709aad1cc1449e0b54b5b7cbf0b933a_TheCompanyandSummaryofSignificantAccountingPoliciesConcentrationsofRiskNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_073840d9-acfc-44b8-913d-939fd17eb0f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_f7f44fa3-9464-4ff0-b6c5-284c7f298c8e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_073840d9-acfc-44b8-913d-939fd17eb0f3" xlink:to="loc_us-gaap_DerivativeNotionalAmount_f7f44fa3-9464-4ff0-b6c5-284c7f298c8e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeNet_12e1c3e7-0bc9-4342-9a7e-17a1ed13f8b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_073840d9-acfc-44b8-913d-939fd17eb0f3" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeNet_12e1c3e7-0bc9-4342-9a7e-17a1ed13f8b3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_d0b1fff3-a02c-4969-92a1-1bd13ea0aa2d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_073840d9-acfc-44b8-913d-939fd17eb0f3" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_d0b1fff3-a02c-4969-92a1-1bd13ea0aa2d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_073840d9-acfc-44b8-913d-939fd17eb0f3" xlink:to="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_2a09c8f8-784f-44a6-bc88-1c0f6c061c61" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_2a09c8f8-784f-44a6-bc88-1c0f6c061c61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_2a09c8f8-784f-44a6-bc88-1c0f6c061c61_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_2a09c8f8-784f-44a6-bc88-1c0f6c061c61" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_2a09c8f8-784f-44a6-bc88-1c0f6c061c61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_36f43da0-8fe4-477c-b7da-40d357fb0444" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_2a09c8f8-784f-44a6-bc88-1c0f6c061c61" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_36f43da0-8fe4-477c-b7da-40d357fb0444" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_20e802ba-6ca8-40a5-9d52-09d6085afdaa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_36f43da0-8fe4-477c-b7da-40d357fb0444" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_20e802ba-6ca8-40a5-9d52-09d6085afdaa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_75996734-f6ae-4715-9a5e-35d177ac92e4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_36f43da0-8fe4-477c-b7da-40d357fb0444" xlink:to="loc_us-gaap_InterestRateContractMember_75996734-f6ae-4715-9a5e-35d177ac92e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_235265c5-582c-45cc-9ebd-59545cf01403" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:to="loc_us-gaap_HedgingDesignationAxis_235265c5-582c-45cc-9ebd-59545cf01403" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_235265c5-582c-45cc-9ebd-59545cf01403_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_235265c5-582c-45cc-9ebd-59545cf01403" xlink:to="loc_us-gaap_HedgingDesignationDomain_235265c5-582c-45cc-9ebd-59545cf01403_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_185685c3-4ea6-4173-b5d2-81c4cbb89008" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_235265c5-582c-45cc-9ebd-59545cf01403" xlink:to="loc_us-gaap_HedgingDesignationDomain_185685c3-4ea6-4173-b5d2-81c4cbb89008" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_b1d83b0d-5fb1-4c39-af22-94a70efe2217" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_185685c3-4ea6-4173-b5d2-81c4cbb89008" xlink:to="loc_us-gaap_NondesignatedMember_b1d83b0d-5fb1-4c39-af22-94a70efe2217" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_e582461b-9ba9-4b07-8962-c2990b3e5ba4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_185685c3-4ea6-4173-b5d2-81c4cbb89008" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_e582461b-9ba9-4b07-8962-c2990b3e5ba4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_a487e3d5-10c9-41d3-aed1-8cd458678d7d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_a487e3d5-10c9-41d3-aed1-8cd458678d7d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_a487e3d5-10c9-41d3-aed1-8cd458678d7d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_a487e3d5-10c9-41d3-aed1-8cd458678d7d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_a487e3d5-10c9-41d3-aed1-8cd458678d7d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_a2cff614-6530-4ee1-a7d4-b8aae478b5fb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_a487e3d5-10c9-41d3-aed1-8cd458678d7d" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_a2cff614-6530-4ee1-a7d4-b8aae478b5fb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_1f21f0e0-679f-4247-862b-147399776783" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_a2cff614-6530-4ee1-a7d4-b8aae478b5fb" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_1f21f0e0-679f-4247-862b-147399776783" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_81e4aed5-6aa5-438b-8ed9-b6dfd4a97a14" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_81e4aed5-6aa5-438b-8ed9-b6dfd4a97a14" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_81e4aed5-6aa5-438b-8ed9-b6dfd4a97a14_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_81e4aed5-6aa5-438b-8ed9-b6dfd4a97a14" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_81e4aed5-6aa5-438b-8ed9-b6dfd4a97a14_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_d6c56d90-812b-47e4-af6a-f30c10011936" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_81e4aed5-6aa5-438b-8ed9-b6dfd4a97a14" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_d6c56d90-812b-47e4-af6a-f30c10011936" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_6b183ae8-aed2-4d53-8681-5d4e8a45d738" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_d6c56d90-812b-47e4-af6a-f30c10011936" xlink:to="loc_us-gaap_AccountsReceivableMember_6b183ae8-aed2-4d53-8681-5d4e8a45d738" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_52743f0f-1660-48f9-b3c3-110e5961f0cb" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_640b006a-677b-4cd7-a9e1-d708ea57784a" xlink:to="loc_srt_MajorCustomersAxis_52743f0f-1660-48f9-b3c3-110e5961f0cb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_52743f0f-1660-48f9-b3c3-110e5961f0cb_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_52743f0f-1660-48f9-b3c3-110e5961f0cb" xlink:to="loc_srt_NameOfMajorCustomerDomain_52743f0f-1660-48f9-b3c3-110e5961f0cb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_2bcf55c3-9487-4a83-a3ca-62ca4e43523f" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_52743f0f-1660-48f9-b3c3-110e5961f0cb" xlink:to="loc_srt_NameOfMajorCustomerDomain_2bcf55c3-9487-4a83-a3ca-62ca4e43523f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExpressScriptsMember_b67a98e5-f2b3-4a53-ad15-26b57080c22f" xlink:href="jazz-20210331.xsd#jazz_ExpressScriptsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_2bcf55c3-9487-4a83-a3ca-62ca4e43523f" xlink:to="loc_jazz_ExpressScriptsMember_b67a98e5-f2b3-4a53-ad15-26b57080c22f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_McKessonCorporationMember_f442e8af-e872-4a99-b884-d0797533f0f7" xlink:href="jazz-20210331.xsd#jazz_McKessonCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_2bcf55c3-9487-4a83-a3ca-62ca4e43523f" xlink:to="loc_jazz_McKessonCorporationMember_f442e8af-e872-4a99-b884-d0797533f0f7" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/AcquisitionAgreement" xlink:type="simple" xlink:href="jazz-20210331.xsd#AcquisitionAgreement"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/AcquisitionAgreement" xlink:type="extended" id="i4dfbe87456d44450a1176cfbb8541986_AcquisitionAgreement"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/AcquisitionAgreementNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#AcquisitionAgreementNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/AcquisitionAgreementNarrativeDetails" xlink:type="extended" id="iebeea1b61b714cf4b557ee2a41be8f4e_AcquisitionAgreementNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PricePerShareToBePaidToFormerShareholdersCash_bad3584e-7845-4370-8657-45bed76e0e2e" xlink:href="jazz-20210331.xsd#jazz_PricePerShareToBePaidToFormerShareholdersCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_PricePerShareToBePaidToFormerShareholdersCash_bad3584e-7845-4370-8657-45bed76e0e2e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_VolumeWeightedAverageSalesPriceOrdinarySharesUsedToDetermineExchangeRatio_62b11de0-6b8b-47c1-ae02-5dc4ff6b353a" xlink:href="jazz-20210331.xsd#jazz_VolumeWeightedAverageSalesPriceOrdinarySharesUsedToDetermineExchangeRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_VolumeWeightedAverageSalesPriceOrdinarySharesUsedToDetermineExchangeRatio_62b11de0-6b8b-47c1-ae02-5dc4ff6b353a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeRatioMiddleThresholdNumerator_32e1d289-a1e6-4e9d-adcc-c11be613b2a4" xlink:href="jazz-20210331.xsd#jazz_ExchangeRatioMiddleThresholdNumerator"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_ExchangeRatioMiddleThresholdNumerator_32e1d289-a1e6-4e9d-adcc-c11be613b2a4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeRatioLowerThreshold_ec8537bf-8746-4a83-8cce-9a8f5d0ff463" xlink:href="jazz-20210331.xsd#jazz_ExchangeRatioLowerThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_ExchangeRatioLowerThreshold_ec8537bf-8746-4a83-8cce-9a8f5d0ff463" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeRatioUpperThreshold_d73ed57f-902a-41c2-9131-977e1d5e98f3" xlink:href="jazz-20210331.xsd#jazz_ExchangeRatioUpperThreshold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_ExchangeRatioUpperThreshold_d73ed57f-902a-41c2-9131-977e1d5e98f3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NumberOfSharesPerGWAmericanDepositoryShare_e94baf3d-4ff3-47ff-9a43-07b4281bc42e" xlink:href="jazz-20210331.xsd#jazz_NumberOfSharesPerGWAmericanDepositoryShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_NumberOfSharesPerGWAmericanDepositoryShare_e94baf3d-4ff3-47ff-9a43-07b4281bc42e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProceedsMultiplierForCashAndShareAmounts_d9a52e90-9576-418f-aad1-889faf246661" xlink:href="jazz-20210331.xsd#jazz_ProceedsMultiplierForCashAndShareAmounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_ProceedsMultiplierForCashAndShareAmounts_d9a52e90-9576-418f-aad1-889faf246661" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TenderOfferPerShareAmountCash_15923a87-dba4-4a42-b71a-8979ad7c60ae" xlink:href="jazz-20210331.xsd#jazz_TenderOfferPerShareAmountCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_TenderOfferPerShareAmountCash_15923a87-dba4-4a42-b71a-8979ad7c60ae" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TenderOfferPerShareAmountStock_01475ac7-6be5-4ad5-827f-af0379101615" xlink:href="jazz-20210331.xsd#jazz_TenderOfferPerShareAmountStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_TenderOfferPerShareAmountStock_01475ac7-6be5-4ad5-827f-af0379101615" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TenderOfferPaymentToAcquireBusinessGross_17fc225a-f419-48de-90be-1effc895b56e" xlink:href="jazz-20210331.xsd#jazz_TenderOfferPaymentToAcquireBusinessGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_jazz_TenderOfferPaymentToAcquireBusinessGross_17fc225a-f419-48de-90be-1effc895b56e" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8e28ded5-82d4-4c0b-a3cb-ac9900621ed1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_33c12d4a-638e-48da-b905-b32819f4b1af" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8e28ded5-82d4-4c0b-a3cb-ac9900621ed1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_7bfbd629-bab9-4494-8519-0cb63c3815e2" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8e28ded5-82d4-4c0b-a3cb-ac9900621ed1" xlink:to="loc_srt_RangeAxis_7bfbd629-bab9-4494-8519-0cb63c3815e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_7bfbd629-bab9-4494-8519-0cb63c3815e2_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_7bfbd629-bab9-4494-8519-0cb63c3815e2" xlink:to="loc_srt_RangeMember_7bfbd629-bab9-4494-8519-0cb63c3815e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_4031cecd-41fd-4d4b-a632-b7239b451b01" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_7bfbd629-bab9-4494-8519-0cb63c3815e2" xlink:to="loc_srt_RangeMember_4031cecd-41fd-4d4b-a632-b7239b451b01" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_3916ff1b-f3f0-4639-af59-d6d0e8385ee9" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_4031cecd-41fd-4d4b-a632-b7239b451b01" xlink:to="loc_srt_MinimumMember_3916ff1b-f3f0-4639-af59-d6d0e8385ee9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_cb5944fa-1d6b-4770-8779-d44a4d060e70" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_4031cecd-41fd-4d4b-a632-b7239b451b01" xlink:to="loc_srt_MaximumMember_cb5944fa-1d6b-4770-8779-d44a4d060e70" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CashandAvailableforSaleSecurities" xlink:type="simple" xlink:href="jazz-20210331.xsd#CashandAvailableforSaleSecurities"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CashandAvailableforSaleSecurities" xlink:type="extended" id="i4e244d8511164197af8c189cfef29ebe_CashandAvailableforSaleSecurities"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#CashandAvailableforSaleSecuritiesTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesTables" xlink:type="extended" id="icdfc6b6068394bd094ff40ebf9fbdf7d_CashandAvailableforSaleSecuritiesTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails" xlink:type="extended" id="i6da2fa8ad834459083247c634dcb75ca_CashandAvailableforSaleSecuritiesSummaryofCashandCashEquivalentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_c4d97014-7902-4038-bc02-47987a2610fb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_c4d97014-7902-4038-bc02-47987a2610fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_5cda8cf5-8507-47df-8271-6e5e6162987d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_5cda8cf5-8507-47df-8271-6e5e6162987d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1b48412f-60e5-4c8c-9e17-ccb12e8366d7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1b48412f-60e5-4c8c-9e17-ccb12e8366d7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0cd7b05e-0da0-4ea4-802a-4671d829217d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0cd7b05e-0da0-4ea4-802a-4671d829217d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e10d2c6e-cb3a-4b1f-84b5-604643f2ebbe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e10d2c6e-cb3a-4b1f-84b5-604643f2ebbe" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Investments_0dc1b18b-e840-4896-9f33-0914834b8e0f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_Investments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_Investments_0dc1b18b-e840-4896-9f33-0914834b8e0f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_88e7b7ee-0b7b-4533-b9ed-f9ab5df0249a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_17ba1b3b-5b6d-41b6-bf89-79cd59f996a9" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_88e7b7ee-0b7b-4533-b9ed-f9ab5df0249a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_47211432-1db0-4f97-a0cb-76e2fa3eae2b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_88e7b7ee-0b7b-4533-b9ed-f9ab5df0249a" xlink:to="loc_us-gaap_FinancialInstrumentAxis_47211432-1db0-4f97-a0cb-76e2fa3eae2b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_47211432-1db0-4f97-a0cb-76e2fa3eae2b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_47211432-1db0-4f97-a0cb-76e2fa3eae2b" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_47211432-1db0-4f97-a0cb-76e2fa3eae2b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_048c1d51-d61d-46c4-b7c5-735ce3981ad5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_47211432-1db0-4f97-a0cb-76e2fa3eae2b" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_048c1d51-d61d-46c4-b7c5-735ce3981ad5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashMember_b7e78ecf-47a2-493d-882b-395be4d77950" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_048c1d51-d61d-46c4-b7c5-735ce3981ad5" xlink:to="loc_us-gaap_CashMember_b7e78ecf-47a2-493d-882b-395be4d77950" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_e0166f53-1ce2-4465-9e0b-72a50414bf58" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_048c1d51-d61d-46c4-b7c5-735ce3981ad5" xlink:to="loc_us-gaap_BankTimeDepositsMember_e0166f53-1ce2-4465-9e0b-72a50414bf58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_aecfa2f6-f4b1-4f47-b66e-430d2152c9d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_048c1d51-d61d-46c4-b7c5-735ce3981ad5" xlink:to="loc_us-gaap_MoneyMarketFundsMember_aecfa2f6-f4b1-4f47-b66e-430d2152c9d1" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#CashandAvailableforSaleSecuritiesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CashandAvailableforSaleSecuritiesNarrativeDetails" xlink:type="extended" id="i61a4cac151bd4b3e94c724fc16a27194_CashandAvailableforSaleSecuritiesNarrativeDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="jazz-20210331.xsd#FairValueMeasurement"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurement" xlink:type="extended" id="i132521ec44284fb88a274d76a63f460d_FairValueMeasurement"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#FairValueMeasurementTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementTables" xlink:type="extended" id="i6aa245ba013b44329b7a6ed2cd302378_FairValueMeasurementTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended" id="i2df65e84f7824188a8a4adbcd422701a_FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_604e51d4-1ca2-4d69-a934-b5831c4be0f6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_36ea78fa-bb00-428e-9698-098e70f88066" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_604e51d4-1ca2-4d69-a934-b5831c4be0f6" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_36ea78fa-bb00-428e-9698-098e70f88066" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_79ff320b-41a5-4f1b-a614-70da23b29822" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_36ea78fa-bb00-428e-9698-098e70f88066" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_79ff320b-41a5-4f1b-a614-70da23b29822" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_edc5ace9-b9c2-4cb4-8e27-733a47d15077" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_79ff320b-41a5-4f1b-a614-70da23b29822" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_edc5ace9-b9c2-4cb4-8e27-733a47d15077" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_6406b178-9d61-4e10-8807-ff89e4911224" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_36ea78fa-bb00-428e-9698-098e70f88066" xlink:to="loc_us-gaap_DerivativeAssets_6406b178-9d61-4e10-8807-ff89e4911224" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_99af8f7b-3417-45e4-ae72-7d9da99c83e8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_36ea78fa-bb00-428e-9698-098e70f88066" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_99af8f7b-3417-45e4-ae72-7d9da99c83e8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_e1f8f5d0-d9e6-4321-bf31-6179460ffea7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_604e51d4-1ca2-4d69-a934-b5831c4be0f6" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_e1f8f5d0-d9e6-4321-bf31-6179460ffea7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_b898982b-008c-4a2c-ab0b-c6ebb5803a2f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_e1f8f5d0-d9e6-4321-bf31-6179460ffea7" xlink:to="loc_us-gaap_DerivativeLiabilities_b898982b-008c-4a2c-ab0b-c6ebb5803a2f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_cfe64c91-6655-4eed-9cec-dada3f2ace15" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_e1f8f5d0-d9e6-4321-bf31-6179460ffea7" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_cfe64c91-6655-4eed-9cec-dada3f2ace15" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_da41320a-c838-4d3a-b703-df1de61b0899" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_604e51d4-1ca2-4d69-a934-b5831c4be0f6" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_da41320a-c838-4d3a-b703-df1de61b0899" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_fb7198a9-d133-4b9a-9926-6a4dcceccf53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_da41320a-c838-4d3a-b703-df1de61b0899" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_fb7198a9-d133-4b9a-9926-6a4dcceccf53" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_fb7198a9-d133-4b9a-9926-6a4dcceccf53_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_fb7198a9-d133-4b9a-9926-6a4dcceccf53" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_fb7198a9-d133-4b9a-9926-6a4dcceccf53_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_d644d7de-38cb-418b-98f4-ab8366495142" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_fb7198a9-d133-4b9a-9926-6a4dcceccf53" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_d644d7de-38cb-418b-98f4-ab8366495142" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_2758f859-518b-43c1-9ab1-e30e92e8adc4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_d644d7de-38cb-418b-98f4-ab8366495142" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_2758f859-518b-43c1-9ab1-e30e92e8adc4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c745b9f6-3b9e-4c0f-a824-df833c1daf0d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_da41320a-c838-4d3a-b703-df1de61b0899" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c745b9f6-3b9e-4c0f-a824-df833c1daf0d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c745b9f6-3b9e-4c0f-a824-df833c1daf0d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c745b9f6-3b9e-4c0f-a824-df833c1daf0d" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_c745b9f6-3b9e-4c0f-a824-df833c1daf0d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8ff07060-9d80-45a4-b7ef-0142bb246d28" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_c745b9f6-3b9e-4c0f-a824-df833c1daf0d" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8ff07060-9d80-45a4-b7ef-0142bb246d28" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_58f45804-05cb-4cf1-80d7-061d1fde1113" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8ff07060-9d80-45a4-b7ef-0142bb246d28" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_58f45804-05cb-4cf1-80d7-061d1fde1113" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_696a0100-1de0-4677-b5da-5109cf27cf63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_8ff07060-9d80-45a4-b7ef-0142bb246d28" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_696a0100-1de0-4677-b5da-5109cf27cf63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_870cf9b9-377f-44de-af50-57948da3c9a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_da41320a-c838-4d3a-b703-df1de61b0899" xlink:to="loc_us-gaap_FinancialInstrumentAxis_870cf9b9-377f-44de-af50-57948da3c9a6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_870cf9b9-377f-44de-af50-57948da3c9a6_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_870cf9b9-377f-44de-af50-57948da3c9a6" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_870cf9b9-377f-44de-af50-57948da3c9a6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f30296a-976e-4897-ac66-0cb9010afc61" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_870cf9b9-377f-44de-af50-57948da3c9a6" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f30296a-976e-4897-ac66-0cb9010afc61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BankTimeDepositsMember_500e584e-0c41-46c3-b532-fab23edd1ba4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BankTimeDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f30296a-976e-4897-ac66-0cb9010afc61" xlink:to="loc_us-gaap_BankTimeDepositsMember_500e584e-0c41-46c3-b532-fab23edd1ba4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_0e3609cf-72f7-43f5-89d1-95e8799242a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f30296a-976e-4897-ac66-0cb9010afc61" xlink:to="loc_us-gaap_MoneyMarketFundsMember_0e3609cf-72f7-43f5-89d1-95e8799242a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_69a65372-f8fb-4263-8f5f-fff709089ea0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f30296a-976e-4897-ac66-0cb9010afc61" xlink:to="loc_us-gaap_InterestRateContractMember_69a65372-f8fb-4263-8f5f-fff709089ea0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_da3a1ce6-3f6e-44e7-bc5e-03bb89593f7d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3f30296a-976e-4897-ac66-0cb9010afc61" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_da3a1ce6-3f6e-44e7-bc5e-03bb89593f7d" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#FairValueMeasurementNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/FairValueMeasurementNarrativeDetails" xlink:type="extended" id="i5bd642a8ab0b4618a9f0825f83922a5f_FairValueMeasurementNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_90e3b165-e38e-434f-8261-49384030d08f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_680594f5-4e87-4bcd-bad7-2b97604b2791" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_90e3b165-e38e-434f-8261-49384030d08f" xlink:to="loc_us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount_680594f5-4e87-4bcd-bad7-2b97604b2791" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_92cee510-4bc6-4b3a-aa0f-8b5795966a3e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_90e3b165-e38e-434f-8261-49384030d08f" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_92cee510-4bc6-4b3a-aa0f-8b5795966a3e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_37e4bb2a-234f-48aa-86c1-ddc24a7f6d93" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_90e3b165-e38e-434f-8261-49384030d08f" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_37e4bb2a-234f-48aa-86c1-ddc24a7f6d93" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByBalanceSheetGroupingTable_15329128-5c62-4bcf-be41-a419472ec45b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByBalanceSheetGroupingTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_90e3b165-e38e-434f-8261-49384030d08f" xlink:to="loc_us-gaap_FairValueByBalanceSheetGroupingTable_15329128-5c62-4bcf-be41-a419472ec45b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_55e72ee8-387f-4d0e-a0d3-b013fd0b3a5e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_15329128-5c62-4bcf-be41-a419472ec45b" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_55e72ee8-387f-4d0e-a0d3-b013fd0b3a5e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_55e72ee8-387f-4d0e-a0d3-b013fd0b3a5e_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_55e72ee8-387f-4d0e-a0d3-b013fd0b3a5e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_55e72ee8-387f-4d0e-a0d3-b013fd0b3a5e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_75a6a6dd-8b85-4581-bab9-8f93c35f0990" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_55e72ee8-387f-4d0e-a0d3-b013fd0b3a5e" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_75a6a6dd-8b85-4581-bab9-8f93c35f0990" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_d9d796ab-13f2-4a18-ad7f-030de86e3c32" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_75a6a6dd-8b85-4581-bab9-8f93c35f0990" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_d9d796ab-13f2-4a18-ad7f-030de86e3c32" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_d6da5ad0-6792-453d-8fe4-015da64770ad" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_15329128-5c62-4bcf-be41-a419472ec45b" xlink:to="loc_us-gaap_DebtInstrumentAxis_d6da5ad0-6792-453d-8fe4-015da64770ad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_d6da5ad0-6792-453d-8fe4-015da64770ad_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_d6da5ad0-6792-453d-8fe4-015da64770ad" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_d6da5ad0-6792-453d-8fe4-015da64770ad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6df983f9-d9c6-479d-b4f9-499a1e05a888" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_d6da5ad0-6792-453d-8fe4-015da64770ad" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6df983f9-d9c6-479d-b4f9-499a1e05a888" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2021Member_1cf8564d-d43c-42a6-b64e-17874174cea2" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2021Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6df983f9-d9c6-479d-b4f9-499a1e05a888" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2021Member_1cf8564d-d43c-42a6-b64e-17874174cea2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_28a7a2df-4406-498b-bdac-7fe6fb73181d" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6df983f9-d9c6-479d-b4f9-499a1e05a888" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_28a7a2df-4406-498b-bdac-7fe6fb73181d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_250767fa-a291-45f6-9f8a-2ea6955204bf" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6df983f9-d9c6-479d-b4f9-499a1e05a888" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_250767fa-a291-45f6-9f8a-2ea6955204bf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_dd5a7b84-339a-404a-ab87-b9ff3f2fcd75" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueByBalanceSheetGroupingTable_15329128-5c62-4bcf-be41-a419472ec45b" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_dd5a7b84-339a-404a-ab87-b9ff3f2fcd75" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_dd5a7b84-339a-404a-ab87-b9ff3f2fcd75_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_dd5a7b84-339a-404a-ab87-b9ff3f2fcd75" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_dd5a7b84-339a-404a-ab87-b9ff3f2fcd75_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_fc0d143d-166c-4702-b289-10df2d88cdfe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_dd5a7b84-339a-404a-ab87-b9ff3f2fcd75" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_fc0d143d-166c-4702-b289-10df2d88cdfe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_cbfbd5bb-10fb-4a07-be92-6a9c6bee3161" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_fc0d143d-166c-4702-b289-10df2d88cdfe" xlink:to="loc_us-gaap_ConvertibleDebtMember_cbfbd5bb-10fb-4a07-be92-6a9c6bee3161" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivities" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivities"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivities" xlink:type="extended" id="ifc45c21041ea42309ea3e5247432f307_DerivativeInstrumentsandHedgingActivities"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivitiesTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesTables" xlink:type="extended" id="i5673dcecfbf24035b5f9b7c027999bcb_DerivativeInstrumentsandHedgingActivitiesTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivitiesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesNarrativeDetails" xlink:type="extended" id="i26a7eeca8df14902ac29fbe8e7231ee9_DerivativeInstrumentsandHedgingActivitiesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_a87ab408-46ca-4c03-8500-e264a437e9a6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeNotionalAmount_9bd4becf-2372-418e-a727-a67758f3033b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeNotionalAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a87ab408-46ca-4c03-8500-e264a437e9a6" xlink:to="loc_us-gaap_DerivativeNotionalAmount_9bd4becf-2372-418e-a727-a67758f3033b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFixedInterestRate_2a0231d2-5657-4171-8aa5-0f213485d8d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFixedInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a87ab408-46ca-4c03-8500-e264a437e9a6" xlink:to="loc_us-gaap_DerivativeFixedInterestRate_2a0231d2-5657-4171-8aa5-0f213485d8d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths_656fb129-eb3f-43f3-b373-f8e7e3661782" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a87ab408-46ca-4c03-8500-e264a437e9a6" xlink:to="loc_us-gaap_CashFlowHedgeGainLossToBeReclassifiedWithinTwelveMonths_656fb129-eb3f-43f3-b373-f8e7e3661782" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTermOfContract_2221e469-00ef-41e4-8eef-b65f25d3ad46" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeTermOfContract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_a87ab408-46ca-4c03-8500-e264a437e9a6" xlink:to="loc_us-gaap_DerivativeTermOfContract_2221e469-00ef-41e4-8eef-b65f25d3ad46" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_fb6664c3-f309-49ab-8aa4-be0240f6f6b0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_a87ab408-46ca-4c03-8500-e264a437e9a6" xlink:to="loc_us-gaap_DerivativeTable_fb6664c3-f309-49ab-8aa4-be0240f6f6b0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_ed455eb6-ffdc-4655-9a39-50a39ce269e2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_fb6664c3-f309-49ab-8aa4-be0240f6f6b0" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_ed455eb6-ffdc-4655-9a39-50a39ce269e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_ed455eb6-ffdc-4655-9a39-50a39ce269e2_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ed455eb6-ffdc-4655-9a39-50a39ce269e2" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_ed455eb6-ffdc-4655-9a39-50a39ce269e2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_f6c4380a-12cc-4799-b323-879c084b660c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ed455eb6-ffdc-4655-9a39-50a39ce269e2" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_f6c4380a-12cc-4799-b323-879c084b660c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_eec617c3-b3bc-4850-95ea-77b4c26f1549" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f6c4380a-12cc-4799-b323-879c084b660c" xlink:to="loc_us-gaap_InterestRateContractMember_eec617c3-b3bc-4850-95ea-77b4c26f1549" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_b447234a-ce41-4b4b-8748-68d22f6ce163" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_f6c4380a-12cc-4799-b323-879c084b660c" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_b447234a-ce41-4b4b-8748-68d22f6ce163" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_9217637a-90c6-4280-b1d1-bf1f7300e358" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_fb6664c3-f309-49ab-8aa4-be0240f6f6b0" xlink:to="loc_us-gaap_HedgingDesignationAxis_9217637a-90c6-4280-b1d1-bf1f7300e358" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_9217637a-90c6-4280-b1d1-bf1f7300e358_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_9217637a-90c6-4280-b1d1-bf1f7300e358" xlink:to="loc_us-gaap_HedgingDesignationDomain_9217637a-90c6-4280-b1d1-bf1f7300e358_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_1ce0d7e9-418d-4f38-b110-4b02911e368a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_9217637a-90c6-4280-b1d1-bf1f7300e358" xlink:to="loc_us-gaap_HedgingDesignationDomain_1ce0d7e9-418d-4f38-b110-4b02911e368a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2d454ab1-5ec3-48ba-8e8f-6540d3ccb702" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_1ce0d7e9-418d-4f38-b110-4b02911e368a" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_2d454ab1-5ec3-48ba-8e8f-6540d3ccb702" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_1b5854be-e288-4d7b-b88f-7c4fab033615" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_1ce0d7e9-418d-4f38-b110-4b02911e368a" xlink:to="loc_us-gaap_NondesignatedMember_1b5854be-e288-4d7b-b88f-7c4fab033615" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_923f30d0-847d-4e46-8558-5b6ed3ed2bcd" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_fb6664c3-f309-49ab-8aa4-be0240f6f6b0" xlink:to="loc_srt_RangeAxis_923f30d0-847d-4e46-8558-5b6ed3ed2bcd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_923f30d0-847d-4e46-8558-5b6ed3ed2bcd_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_923f30d0-847d-4e46-8558-5b6ed3ed2bcd" xlink:to="loc_srt_RangeMember_923f30d0-847d-4e46-8558-5b6ed3ed2bcd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b96f70ba-9636-4216-bc50-121100b0bb41" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_923f30d0-847d-4e46-8558-5b6ed3ed2bcd" xlink:to="loc_srt_RangeMember_b96f70ba-9636-4216-bc50-121100b0bb41" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_4d25f3ce-7102-46bd-be61-0429838ad5aa" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_b96f70ba-9636-4216-bc50-121100b0bb41" xlink:to="loc_srt_MaximumMember_4d25f3ce-7102-46bd-be61-0429838ad5aa" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesLossonDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivitiesLossonDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesLossonDerivativeInstrumentsDetails" xlink:type="extended" id="i8ddd84acc218454d86202c708f7dc1e3_DerivativeInstrumentsandHedgingActivitiesLossonDerivativeInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_fd33a471-e36d-4cb4-9c20-7dc20dd05969" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_5663b69b-2d39-4df5-aa18-02d30c109100" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_fd33a471-e36d-4cb4-9c20-7dc20dd05969" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax_5663b69b-2d39-4df5-aa18-02d30c109100" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_135b3b5c-d37c-42c1-bbcd-0885d74cc843" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_fd33a471-e36d-4cb4-9c20-7dc20dd05969" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax_135b3b5c-d37c-42c1-bbcd-0885d74cc843" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_761a3005-1959-4b7d-89a5-ecbea9dc427c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossLineItems_fd33a471-e36d-4cb4-9c20-7dc20dd05969" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_761a3005-1959-4b7d-89a5-ecbea9dc427c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_5f1ecfb4-94e2-462a-b236-b7df57d9cb72" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_761a3005-1959-4b7d-89a5-ecbea9dc427c" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_5f1ecfb4-94e2-462a-b236-b7df57d9cb72" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_5f1ecfb4-94e2-462a-b236-b7df57d9cb72_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_5f1ecfb4-94e2-462a-b236-b7df57d9cb72" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_5f1ecfb4-94e2-462a-b236-b7df57d9cb72_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_9510439c-0fbb-42a2-88dd-c020a68d7dca" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_5f1ecfb4-94e2-462a-b236-b7df57d9cb72" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_9510439c-0fbb-42a2-88dd-c020a68d7dca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_32b0e7cd-38a6-4032-b90c-322956833a47" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_9510439c-0fbb-42a2-88dd-c020a68d7dca" xlink:to="loc_us-gaap_InterestRateContractMember_32b0e7cd-38a6-4032-b90c-322956833a47" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_c377653a-3bdf-48b4-b9ab-8dbeec450619" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipByIncomeStatementLocationByDerivativeInstrumentRiskTable_761a3005-1959-4b7d-89a5-ecbea9dc427c" xlink:to="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_c377653a-3bdf-48b4-b9ab-8dbeec450619" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_c377653a-3bdf-48b4-b9ab-8dbeec450619_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_c377653a-3bdf-48b4-b9ab-8dbeec450619" xlink:to="loc_us-gaap_HedgingRelationshipDomain_c377653a-3bdf-48b4-b9ab-8dbeec450619_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingRelationshipDomain_ae47ab0c-9678-45e9-a288-a4534c3b45d8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingRelationshipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentsGainLossByHedgingRelationshipAxis_c377653a-3bdf-48b4-b9ab-8dbeec450619" xlink:to="loc_us-gaap_HedgingRelationshipDomain_ae47ab0c-9678-45e9-a288-a4534c3b45d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowHedgingMember_11e3f242-e63e-4e43-9b3d-09b6271958b3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CashFlowHedgingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingRelationshipDomain_ae47ab0c-9678-45e9-a288-a4534c3b45d8" xlink:to="loc_us-gaap_CashFlowHedgingMember_11e3f242-e63e-4e43-9b3d-09b6271958b3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails" xlink:type="extended" id="ib4955066b3e14332b4df2a8603d9eba8_DerivativeInstrumentsandHedgingActivitiesForeignExchangeGainLossDerivativeInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLineItems_14cc1216-e307-4da1-ad1d-b25633cf92bc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_56acb165-f48b-4e34-b7d0-ca3c3e55852a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLineItems_14cc1216-e307-4da1-ad1d-b25633cf92bc" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_56acb165-f48b-4e34-b7d0-ca3c3e55852a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeTable_755f5199-4e80-4db8-9ea8-430b9f54250c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeLineItems_14cc1216-e307-4da1-ad1d-b25633cf92bc" xlink:to="loc_us-gaap_DerivativeTable_755f5199-4e80-4db8-9ea8-430b9f54250c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_60525cae-34ae-4aeb-8db1-cc06694a2730" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_755f5199-4e80-4db8-9ea8-430b9f54250c" xlink:to="loc_us-gaap_HedgingDesignationAxis_60525cae-34ae-4aeb-8db1-cc06694a2730" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_60525cae-34ae-4aeb-8db1-cc06694a2730_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_60525cae-34ae-4aeb-8db1-cc06694a2730" xlink:to="loc_us-gaap_HedgingDesignationDomain_60525cae-34ae-4aeb-8db1-cc06694a2730_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_0f91cff5-43a0-483d-8677-711c3847593c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_60525cae-34ae-4aeb-8db1-cc06694a2730" xlink:to="loc_us-gaap_HedgingDesignationDomain_0f91cff5-43a0-483d-8677-711c3847593c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_7fafd82d-6804-43ff-bc1f-6fbd287bd44d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_0f91cff5-43a0-483d-8677-711c3847593c" xlink:to="loc_us-gaap_NondesignatedMember_7fafd82d-6804-43ff-bc1f-6fbd287bd44d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_93b4e56a-6f8a-4388-b080-07cec17de494" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeTable_755f5199-4e80-4db8-9ea8-430b9f54250c" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_93b4e56a-6f8a-4388-b080-07cec17de494" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_93b4e56a-6f8a-4388-b080-07cec17de494_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_93b4e56a-6f8a-4388-b080-07cec17de494" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_93b4e56a-6f8a-4388-b080-07cec17de494_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_de638538-21f2-4a74-ac99-189140224d22" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_93b4e56a-6f8a-4388-b080-07cec17de494" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_de638538-21f2-4a74-ac99-189140224d22" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_a3809fd9-b4d8-4ed3-96f3-ed7dee2e5c7b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_de638538-21f2-4a74-ac99-189140224d22" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_a3809fd9-b4d8-4ed3-96f3-ed7dee2e5c7b" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails" xlink:type="extended" id="ic35f88d5f1fc4593af09a6213590a87e_DerivativeInstrumentsandHedgingActivitiesFairValueofOutstandingDerivativesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativesFairValueLineItems_6dd001db-69e7-4e6b-a6b5-f29a3c21ff97" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativesFairValueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_8ee7947c-ec76-478c-b64b-d0203b92d58a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_6dd001db-69e7-4e6b-a6b5-f29a3c21ff97" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossAssetIncludingNotSubjectToMasterNettingArrangement_8ee7947c-ec76-478c-b64b-d0203b92d58a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_565eb6d9-45d3-4ddf-ab39-2ff66e0f8e3d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_6dd001db-69e7-4e6b-a6b5-f29a3c21ff97" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossLiabilityIncludingNotSubjectToMasterNettingArrangement_565eb6d9-45d3-4ddf-ab39-2ff66e0f8e3d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_75251655-bb55-4dea-8ecc-6826b3ee349b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativesFairValueLineItems_6dd001db-69e7-4e6b-a6b5-f29a3c21ff97" xlink:to="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_75251655-bb55-4dea-8ecc-6826b3ee349b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationAxis_f7fa14fe-536c-4f7c-9f3c-6633509e0441" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_75251655-bb55-4dea-8ecc-6826b3ee349b" xlink:to="loc_us-gaap_HedgingDesignationAxis_f7fa14fe-536c-4f7c-9f3c-6633509e0441" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_f7fa14fe-536c-4f7c-9f3c-6633509e0441_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_HedgingDesignationAxis_f7fa14fe-536c-4f7c-9f3c-6633509e0441" xlink:to="loc_us-gaap_HedgingDesignationDomain_f7fa14fe-536c-4f7c-9f3c-6633509e0441_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HedgingDesignationDomain_06a4ffde-bf62-462e-af6b-b4abbcae80b5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_HedgingDesignationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_HedgingDesignationAxis_f7fa14fe-536c-4f7c-9f3c-6633509e0441" xlink:to="loc_us-gaap_HedgingDesignationDomain_06a4ffde-bf62-462e-af6b-b4abbcae80b5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DesignatedAsHedgingInstrumentMember_cfd0c24a-851c-44eb-ab7c-d6ea1cee749e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DesignatedAsHedgingInstrumentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_06a4ffde-bf62-462e-af6b-b4abbcae80b5" xlink:to="loc_us-gaap_DesignatedAsHedgingInstrumentMember_cfd0c24a-851c-44eb-ab7c-d6ea1cee749e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NondesignatedMember_831aec92-ec9d-41c1-ad3b-4ec91d3f9f50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_NondesignatedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_HedgingDesignationDomain_06a4ffde-bf62-462e-af6b-b4abbcae80b5" xlink:to="loc_us-gaap_NondesignatedMember_831aec92-ec9d-41c1-ad3b-4ec91d3f9f50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_31e51bae-91d1-4a78-a5c7-0b19e75b908b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_75251655-bb55-4dea-8ecc-6826b3ee349b" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_31e51bae-91d1-4a78-a5c7-0b19e75b908b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_31e51bae-91d1-4a78-a5c7-0b19e75b908b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_31e51bae-91d1-4a78-a5c7-0b19e75b908b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_31e51bae-91d1-4a78-a5c7-0b19e75b908b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_17b59d48-95af-4ac3-a682-396abc756e56" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_31e51bae-91d1-4a78-a5c7-0b19e75b908b" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_17b59d48-95af-4ac3-a682-396abc756e56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestRateContractMember_1ded9223-e418-4506-98e5-24601ea2f746" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_InterestRateContractMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_17b59d48-95af-4ac3-a682-396abc756e56" xlink:to="loc_us-gaap_InterestRateContractMember_1ded9223-e418-4506-98e5-24601ea2f746" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignExchangeForwardMember_f7bd5cfd-9bad-407d-ba66-3bb7efc6eb33" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ForeignExchangeForwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_17b59d48-95af-4ac3-a682-396abc756e56" xlink:to="loc_us-gaap_ForeignExchangeForwardMember_f7bd5cfd-9bad-407d-ba66-3bb7efc6eb33" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_3d6f1bca-9da0-434b-9e19-98a1ede6f737" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_75251655-bb55-4dea-8ecc-6826b3ee349b" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_3d6f1bca-9da0-434b-9e19-98a1ede6f737" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_3d6f1bca-9da0-434b-9e19-98a1ede6f737_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3d6f1bca-9da0-434b-9e19-98a1ede6f737" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_3d6f1bca-9da0-434b-9e19-98a1ede6f737_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_e0393342-e22d-4088-b48e-8bc48f200a42" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3d6f1bca-9da0-434b-9e19-98a1ede6f737" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_e0393342-e22d-4088-b48e-8bc48f200a42" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCurrentAssetsMember_2091944b-501a-44a2-b61b-f3e517737202" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherCurrentAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_e0393342-e22d-4088-b48e-8bc48f200a42" xlink:to="loc_us-gaap_OtherCurrentAssetsMember_2091944b-501a-44a2-b61b-f3e517737202" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_ee4cd679-aa18-4dfa-a1af-acfef10eff03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccruedLiabilitiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_e0393342-e22d-4088-b48e-8bc48f200a42" xlink:to="loc_us-gaap_AccruedLiabilitiesMember_ee4cd679-aa18-4dfa-a1af-acfef10eff03" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails" xlink:type="extended" id="i8cb14ab5f5b6486f81bf660b06103814_DerivativeInstrumentsandHedgingActivitiesOffsettingAssetsandLiabilitiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsLineItems_bb737bc2-d7e4-4788-91af-a612e8f1a5f3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OffsettingAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsAbstract_58d8eae1-2e96-495f-a2e4-34e44c9ad1d2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_bb737bc2-d7e4-4788-91af-a612e8f1a5f3" xlink:to="loc_us-gaap_DerivativeAssetsAbstract_58d8eae1-2e96-495f-a2e4-34e44c9ad1d2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_d505ecfe-523d-4922-9120-1894bc759257" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_58d8eae1-2e96-495f-a2e4-34e44c9ad1d2" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAsset_d505ecfe-523d-4922-9120-1894bc759257" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueGrossLiability_004ddd5a-c5d7-45da-ab20-378123d6c741" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueGrossLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_58d8eae1-2e96-495f-a2e4-34e44c9ad1d2" xlink:to="loc_us-gaap_DerivativeAssetFairValueGrossLiability_004ddd5a-c5d7-45da-ab20-378123d6c741" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssets_ba33a6bb-f663-421d-9e12-08cf52cfed24" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetsAbstract_58d8eae1-2e96-495f-a2e4-34e44c9ad1d2" xlink:to="loc_us-gaap_DerivativeAssets_ba33a6bb-f663-421d-9e12-08cf52cfed24" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_80eb7f13-1a63-43ef-964c-ddb7b9e90c32" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_bb737bc2-d7e4-4788-91af-a612e8f1a5f3" xlink:to="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_80eb7f13-1a63-43ef-964c-ddb7b9e90c32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_f4a7ceeb-b784-4a70-8377-12fcd3a3ae63" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeCollateralObligationToReturnSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_80eb7f13-1a63-43ef-964c-ddb7b9e90c32" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnSecurities_f4a7ceeb-b784-4a70-8377-12fcd3a3ae63" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralObligationToReturnCash_77abfd1f-96bd-4de9-8aea-67cb0393baa9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeCollateralObligationToReturnCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_80eb7f13-1a63-43ef-964c-ddb7b9e90c32" xlink:to="loc_us-gaap_DerivativeCollateralObligationToReturnCash_77abfd1f-96bd-4de9-8aea-67cb0393baa9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_31d6b6c3-5606-4e81-b2f6-1cc556ed6418" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeAssetFairValueAmountOffsetAgainstCollateralAbstract_80eb7f13-1a63-43ef-964c-ddb7b9e90c32" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeAssetAmountOffsetAgainstCollateral_31d6b6c3-5606-4e81-b2f6-1cc556ed6418" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingAssetsTable_e73039ae-6d40-4f8b-8232-e3dae2058b83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OffsettingAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingAssetsLineItems_bb737bc2-d7e4-4788-91af-a612e8f1a5f3" xlink:to="loc_us-gaap_OffsettingAssetsTable_e73039ae-6d40-4f8b-8232-e3dae2058b83" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_9d23d16c-c745-4a7b-8551-b39973c3d52e" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingAssetsTable_e73039ae-6d40-4f8b-8232-e3dae2058b83" xlink:to="loc_srt_StatementScenarioAxis_9d23d16c-c745-4a7b-8551-b39973c3d52e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_9d23d16c-c745-4a7b-8551-b39973c3d52e_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_9d23d16c-c745-4a7b-8551-b39973c3d52e" xlink:to="loc_srt_ScenarioUnspecifiedDomain_9d23d16c-c745-4a7b-8551-b39973c3d52e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_412b1669-bbbb-48cf-ad85-63c0d97dfbc7" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_9d23d16c-c745-4a7b-8551-b39973c3d52e" xlink:to="loc_srt_ScenarioUnspecifiedDomain_412b1669-bbbb-48cf-ad85-63c0d97dfbc7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProFormaMember_328d07c1-267d-4e18-8f88-fc0e68b74c30" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProFormaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_412b1669-bbbb-48cf-ad85-63c0d97dfbc7" xlink:to="loc_srt_ProFormaMember_328d07c1-267d-4e18-8f88-fc0e68b74c30" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesLineItems_379180fb-6b69-4465-a2f7-e78566ec1416" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OffsettingLiabilitiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesAbstract_c863cbed-48f8-4348-acc5-e61e1b6946a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_379180fb-6b69-4465-a2f7-e78566ec1416" xlink:to="loc_us-gaap_DerivativeLiabilitiesAbstract_c863cbed-48f8-4348-acc5-e61e1b6946a3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_063db4d3-eed2-4662-a9ea-d2145877fb8b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_c863cbed-48f8-4348-acc5-e61e1b6946a3" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiability_063db4d3-eed2-4662-a9ea-d2145877fb8b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_17583f94-f843-442f-a5c4-daaa68ee0926" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueGrossAsset"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_c863cbed-48f8-4348-acc5-e61e1b6946a3" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueGrossAsset_17583f94-f843-442f-a5c4-daaa68ee0926" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilities_517d83e3-0f88-4baa-8143-839d548a4ded" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilitiesAbstract_c863cbed-48f8-4348-acc5-e61e1b6946a3" xlink:to="loc_us-gaap_DerivativeLiabilities_517d83e3-0f88-4baa-8143-839d548a4ded" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_28a5c935-1de8-41aa-9e60-65bc355e6cfd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_379180fb-6b69-4465-a2f7-e78566ec1416" xlink:to="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_28a5c935-1de8-41aa-9e60-65bc355e6cfd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_a86f728f-b7e7-4f99-8e0e-3e96accaaffe" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeCollateralRightToReclaimSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_28a5c935-1de8-41aa-9e60-65bc355e6cfd" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimSecurities_a86f728f-b7e7-4f99-8e0e-3e96accaaffe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeCollateralRightToReclaimCash_5427d2f2-5d70-4f22-9b61-abd0785c9680" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeCollateralRightToReclaimCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_28a5c935-1de8-41aa-9e60-65bc355e6cfd" xlink:to="loc_us-gaap_DerivativeCollateralRightToReclaimCash_5427d2f2-5d70-4f22-9b61-abd0785c9680" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_4010113a-068d-42f7-a61a-f6a758b6ecc3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeLiabilityFairValueAmountOffsetAgainstCollateralAbstract_28a5c935-1de8-41aa-9e60-65bc355e6cfd" xlink:to="loc_us-gaap_DerivativeFairValueOfDerivativeLiabilityAmountOffsetAgainstCollateral_4010113a-068d-42f7-a61a-f6a758b6ecc3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OffsettingLiabilitiesTable_296a47f0-d58f-4a1e-9a1a-739184f5a921" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OffsettingLiabilitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OffsettingLiabilitiesLineItems_379180fb-6b69-4465-a2f7-e78566ec1416" xlink:to="loc_us-gaap_OffsettingLiabilitiesTable_296a47f0-d58f-4a1e-9a1a-739184f5a921" xlink:type="arc" order="2" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_26738641-76ac-454f-84d6-e6575ad9e9e7" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OffsettingLiabilitiesTable_296a47f0-d58f-4a1e-9a1a-739184f5a921" xlink:to="loc_srt_StatementScenarioAxis_26738641-76ac-454f-84d6-e6575ad9e9e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_26738641-76ac-454f-84d6-e6575ad9e9e7_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_21b629bd-0fae-4598-9f84-e805ce731b48" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProFormaMember_d12b02d1-66a7-4a61-b0c7-1abeaa66f5ca" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProFormaMember"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/Inventories" xlink:type="simple" xlink:href="jazz-20210331.xsd#Inventories"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/Inventories" xlink:type="extended" id="ib392b904286048aa8ca8fc217d3ea65e_Inventories"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/InventoriesTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#InventoriesTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/InventoriesTables" xlink:type="extended" id="i6f9345d802174ad6b7234fd93e407c90_InventoriesTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/InventoriesComponentsofInventoriesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#InventoriesComponentsofInventoriesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/InventoriesComponentsofInventoriesDetails" xlink:type="extended" id="ic5909539851e489885d2914585278a55_InventoriesComponentsofInventoriesDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssets" xlink:type="simple" xlink:href="jazz-20210331.xsd#GoodwillandIntangibleAssets"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssets" xlink:type="extended" id="id3b5153c265045a2ae830a5e38b296dc_GoodwillandIntangibleAssets"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#GoodwillandIntangibleAssetsTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsTables" xlink:type="extended" id="i2a4664df23854537992b0bae15948392_GoodwillandIntangibleAssetsTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGoodwillActivityDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#GoodwillandIntangibleAssetsGoodwillActivityDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGoodwillActivityDetails" xlink:type="extended" id="i3b50bda4f95f45d9add7e8857a3dee84_GoodwillandIntangibleAssetsGoodwillActivityDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails" xlink:type="extended" id="i7ab2fbac93984e769f5cb4397d803664_GoodwillandIntangibleAssetsGrossCarryingAmountsandNetBookValuesofIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_905808db-8bc8-4c62-9003-9361387c7703" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_8daeae95-1ff7-435e-8344-3e304c42352d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_905808db-8bc8-4c62-9003-9361387c7703" xlink:to="loc_us-gaap_AcquiredFiniteLivedIntangibleAssetsWeightedAverageUsefulLife_8daeae95-1ff7-435e-8344-3e304c42352d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_9b9804a6-7404-40ea-ab7a-594acbac502b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_905808db-8bc8-4c62-9003-9361387c7703" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_9b9804a6-7404-40ea-ab7a-594acbac502b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_b9769e19-9fa6-448c-86a1-5dad3ebd8e9d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_905808db-8bc8-4c62-9003-9361387c7703" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_b9769e19-9fa6-448c-86a1-5dad3ebd8e9d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_50c0e77f-ff29-4a3d-9bf8-8d1ee7d174a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_905808db-8bc8-4c62-9003-9361387c7703" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_50c0e77f-ff29-4a3d-9bf8-8d1ee7d174a4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4a0979ce-bf11-4ccc-a258-738560531f35" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_905808db-8bc8-4c62-9003-9361387c7703" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4a0979ce-bf11-4ccc-a258-738560531f35" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2a74b848-bb30-4135-973c-f98164d012e1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_4a0979ce-bf11-4ccc-a258-738560531f35" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2a74b848-bb30-4135-973c-f98164d012e1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2a74b848-bb30-4135-973c-f98164d012e1_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2a74b848-bb30-4135-973c-f98164d012e1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2a74b848-bb30-4135-973c-f98164d012e1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_906d0902-b04e-4334-8a20-fcfb0f3d44a3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2a74b848-bb30-4135-973c-f98164d012e1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_906d0902-b04e-4334-8a20-fcfb0f3d44a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_2f5df76c-9cfb-4706-a9fd-eecc6981215d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_906d0902-b04e-4334-8a20-fcfb0f3d44a3" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_2f5df76c-9cfb-4706-a9fd-eecc6981215d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ManufacturingContractsMember_de576950-d984-4783-b639-3cd677ae139c" xlink:href="jazz-20210331.xsd#jazz_ManufacturingContractsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_906d0902-b04e-4334-8a20-fcfb0f3d44a3" xlink:to="loc_jazz_ManufacturingContractsMember_de576950-d984-4783-b639-3cd677ae139c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_56944f3d-fea1-4837-a5ad-06404bd1cd7d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_906d0902-b04e-4334-8a20-fcfb0f3d44a3" xlink:to="loc_us-gaap_TrademarksMember_56944f3d-fea1-4837-a5ad-06404bd1cd7d" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsEstimatedFutureAmortizationCostsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#GoodwillandIntangibleAssetsEstimatedFutureAmortizationCostsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/GoodwillandIntangibleAssetsEstimatedFutureAmortizationCostsDetails" xlink:type="extended" id="ic2bc0e4f131d49b89a8d55b829ab442a_GoodwillandIntangibleAssetsEstimatedFutureAmortizationCostsDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CertainBalanceSheetItems" xlink:type="simple" xlink:href="jazz-20210331.xsd#CertainBalanceSheetItems"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CertainBalanceSheetItems" xlink:type="extended" id="i76266ebb015345e2932eb41d2dd98597_CertainBalanceSheetItems"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CertainBalanceSheetItemsTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#CertainBalanceSheetItemsTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CertainBalanceSheetItemsTables" xlink:type="extended" id="i8a6548078a354aba9510e1f1a41bc754_CertainBalanceSheetItemsTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CertainBalanceSheetItemsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#CertainBalanceSheetItemsPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CertainBalanceSheetItemsPropertyandEquipmentDetails" xlink:type="extended" id="id253474b41424749a9247806451ae5f9_CertainBalanceSheetItemsPropertyandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_7b70da2a-cd55-40e4-ad36-1483f9b047af" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_2964097e-e14b-43bd-baa2-15df5e5df2d6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_7b70da2a-cd55-40e4-ad36-1483f9b047af" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_2964097e-e14b-43bd-baa2-15df5e5df2d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_84091451-5214-4ab4-a699-041b33d53f49" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_7b70da2a-cd55-40e4-ad36-1483f9b047af" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_84091451-5214-4ab4-a699-041b33d53f49" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_5f26c890-e448-4da2-ac7e-214f3ab65f90" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_7b70da2a-cd55-40e4-ad36-1483f9b047af" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_5f26c890-e448-4da2-ac7e-214f3ab65f90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_64539dc1-7dd9-4e27-b7ad-37dd8d43f0c6" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_7b70da2a-cd55-40e4-ad36-1483f9b047af" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_64539dc1-7dd9-4e27-b7ad-37dd8d43f0c6" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_440903b4-4fc4-452b-acd8-1f5c629ad1fd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_64539dc1-7dd9-4e27-b7ad-37dd8d43f0c6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_440903b4-4fc4-452b-acd8-1f5c629ad1fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_440903b4-4fc4-452b-acd8-1f5c629ad1fd_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_440903b4-4fc4-452b-acd8-1f5c629ad1fd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_440903b4-4fc4-452b-acd8-1f5c629ad1fd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_440903b4-4fc4-452b-acd8-1f5c629ad1fd" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_b0ef8b42-8d05-4286-b4cf-a53e54469c9d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_b0ef8b42-8d05-4286-b4cf-a53e54469c9d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandAndBuildingMember_006cf562-c9f4-404d-b42a-655284385a52" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LandAndBuildingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_LandAndBuildingMember_006cf562-c9f4-404d-b42a-655284385a52" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_ba804989-3fd0-4fec-a4e0-951a75f6179b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_ba804989-3fd0-4fec-a4e0-951a75f6179b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0580fba7-9083-4ef6-8cae-f1f02ef0d0a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SoftwareAndSoftwareDevelopmentCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_SoftwareAndSoftwareDevelopmentCostsMember_0580fba7-9083-4ef6-8cae-f1f02ef0d0a5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_f2e953ee-7db1-41a1-8c43-e17d13dc9522" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_ComputerEquipmentMember_f2e953ee-7db1-41a1-8c43-e17d13dc9522" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_a0917278-f518-4cd8-a4c0-c9107e708d2a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_a0917278-f518-4cd8-a4c0-c9107e708d2a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_aaa18090-4838-491b-b4a4-cf434274046e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b44d4ebb-e8c1-496a-9705-b00765137003" xlink:to="loc_us-gaap_ConstructionInProgressMember_aaa18090-4838-491b-b4a4-cf434274046e" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CertainBalanceSheetItemsAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#CertainBalanceSheetItemsAccruedLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CertainBalanceSheetItemsAccruedLiabilitiesDetails" xlink:type="extended" id="i53bc236505fd4ae987ed7052e9467703_CertainBalanceSheetItemsAccruedLiabilitiesDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/Debt" xlink:type="simple" xlink:href="jazz-20210331.xsd#Debt"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/Debt" xlink:type="extended" id="i237a579f136e4e9bb741d603e37142b9_Debt"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#DebtTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtTables" xlink:type="extended" id="i9aedd71f7856467992bf5e3ef2b679be_DebtTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtScheduleofLongtermDebtDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DebtScheduleofLongtermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtScheduleofLongtermDebtDetails" xlink:type="extended" id="ic789b3b1485f45c2a22022c11ac7b927_DebtScheduleofLongtermDebtDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_c4714897-46fc-4cb6-a4c3-1354aa1ebda2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_c4714897-46fc-4cb6-a4c3-1354aa1ebda2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_64196f92-e476-42ff-ae64-5767534052bb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_64196f92-e476-42ff-ae64-5767534052bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_b5434d80-5e3e-4f08-907e-6b682fa2c40f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:to="loc_us-gaap_LongTermDebt_b5434d80-5e3e-4f08-907e-6b682fa2c40f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_6daf720f-2bfc-4ec9-a56f-cc57620c7595" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:to="loc_us-gaap_LongTermDebtCurrent_6daf720f-2bfc-4ec9-a56f-cc57620c7595" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_b620ef5a-674e-4d3d-abe0-c910a3f6a6c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_b620ef5a-674e-4d3d-abe0-c910a3f6a6c7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_15dda8df-48e5-44a5-8148-75d8c79e6ec9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0870f2e1-6f4e-4bef-a5c2-5ed144f26c0b" xlink:to="loc_us-gaap_DebtInstrumentTable_15dda8df-48e5-44a5-8148-75d8c79e6ec9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_58f825a0-2994-4d50-b090-4b6ae47d8b50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_15dda8df-48e5-44a5-8148-75d8c79e6ec9" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_58f825a0-2994-4d50-b090-4b6ae47d8b50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_58f825a0-2994-4d50-b090-4b6ae47d8b50_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_58f825a0-2994-4d50-b090-4b6ae47d8b50" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_58f825a0-2994-4d50-b090-4b6ae47d8b50_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_7b9300f2-3182-4836-88d1-88ecaf2253ba" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_58f825a0-2994-4d50-b090-4b6ae47d8b50" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_7b9300f2-3182-4836-88d1-88ecaf2253ba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_9658572c-ab36-4bf7-9e5b-f93eba8d7fd8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_7b9300f2-3182-4836-88d1-88ecaf2253ba" xlink:to="loc_us-gaap_ConvertibleDebtMember_9658572c-ab36-4bf7-9e5b-f93eba8d7fd8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_137cd3ad-060c-4077-a339-969d3226144e" xlink:href="jazz-20210331.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_7b9300f2-3182-4836-88d1-88ecaf2253ba" xlink:to="loc_jazz_TermLoanMember_137cd3ad-060c-4077-a339-969d3226144e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_e71119d0-ef7b-42e6-875e-31492866c37d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_15dda8df-48e5-44a5-8148-75d8c79e6ec9" xlink:to="loc_us-gaap_DebtInstrumentAxis_e71119d0-ef7b-42e6-875e-31492866c37d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e71119d0-ef7b-42e6-875e-31492866c37d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_e71119d0-ef7b-42e6-875e-31492866c37d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e71119d0-ef7b-42e6-875e-31492866c37d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_0ab5f125-4270-40e0-b934-b167e1895cfa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_e71119d0-ef7b-42e6-875e-31492866c37d" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_0ab5f125-4270-40e0-b934-b167e1895cfa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2021Member_241e7268-45d0-43b5-9e04-beeebe8df5e6" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2021Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0ab5f125-4270-40e0-b934-b167e1895cfa" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2021Member_241e7268-45d0-43b5-9e04-beeebe8df5e6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_7a165cb5-4867-479c-a941-8ce64c2663fd" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0ab5f125-4270-40e0-b934-b167e1895cfa" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_7a165cb5-4867-479c-a941-8ce64c2663fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_15bc911b-0c41-474f-aa39-675e9f993e30" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_0ab5f125-4270-40e0-b934-b167e1895cfa" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_15bc911b-0c41-474f-aa39-675e9f993e30" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DebtNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtNarrativeDetails" xlink:type="extended" id="id445a122dbe7471e91737066d3b2e253_DebtNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_d4583659-1330-4bf8-967c-5bd2d584309f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_212c4686-5904-4d02-be55-b0ae295e6ee7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d4583659-1330-4bf8-967c-5bd2d584309f" xlink:to="loc_us-gaap_MinorityInterestOwnershipPercentageByParent_212c4686-5904-4d02-be55-b0ae295e6ee7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_2e6d513e-d7fb-4909-88b3-976144866c32" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d4583659-1330-4bf8-967c-5bd2d584309f" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_2e6d513e-d7fb-4909-88b3-976144866c32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_f4a4c6fe-0483-4e50-b420-153ce616a0c7" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_d4583659-1330-4bf8-967c-5bd2d584309f" xlink:to="loc_us-gaap_DebtInstrumentTable_f4a4c6fe-0483-4e50-b420-153ce616a0c7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_ca846439-1b84-4484-9543-fa6d45417670" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_f4a4c6fe-0483-4e50-b420-153ce616a0c7" xlink:to="loc_srt_OwnershipAxis_ca846439-1b84-4484-9543-fa6d45417670" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_ca846439-1b84-4484-9543-fa6d45417670_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_ca846439-1b84-4484-9543-fa6d45417670" xlink:to="loc_srt_OwnershipDomain_ca846439-1b84-4484-9543-fa6d45417670_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_15d5ac55-4ba2-41e2-9a9c-7a1609fa24b0" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_ca846439-1b84-4484-9543-fa6d45417670" xlink:to="loc_srt_OwnershipDomain_15d5ac55-4ba2-41e2-9a9c-7a1609fa24b0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_JazzInvestmentsILimitedMember_cdc1d4a5-51cc-4404-a940-33c6c331480b" xlink:href="jazz-20210331.xsd#jazz_JazzInvestmentsILimitedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_15d5ac55-4ba2-41e2-9a9c-7a1609fa24b0" xlink:to="loc_jazz_JazzInvestmentsILimitedMember_cdc1d4a5-51cc-4404-a940-33c6c331480b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_1c5391d1-a736-43a6-aed0-03f6f4c00236" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_f4a4c6fe-0483-4e50-b420-153ce616a0c7" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_1c5391d1-a736-43a6-aed0-03f6f4c00236" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_1c5391d1-a736-43a6-aed0-03f6f4c00236_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1c5391d1-a736-43a6-aed0-03f6f4c00236" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_1c5391d1-a736-43a6-aed0-03f6f4c00236_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_a8c7d833-e256-4283-b0f0-d4cc5debee7c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_1c5391d1-a736-43a6-aed0-03f6f4c00236" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_a8c7d833-e256-4283-b0f0-d4cc5debee7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtMember_25a4aad8-0106-4d68-bf0e-5ad3616f074d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_a8c7d833-e256-4283-b0f0-d4cc5debee7c" xlink:to="loc_us-gaap_ConvertibleDebtMember_25a4aad8-0106-4d68-bf0e-5ad3616f074d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_7a8fcb0d-9998-4fee-b504-985c7271514c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_f4a4c6fe-0483-4e50-b420-153ce616a0c7" xlink:to="loc_us-gaap_DebtInstrumentAxis_7a8fcb0d-9998-4fee-b504-985c7271514c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_7a8fcb0d-9998-4fee-b504-985c7271514c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_7a8fcb0d-9998-4fee-b504-985c7271514c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_7a8fcb0d-9998-4fee-b504-985c7271514c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3eb703ed-1ecd-46db-a2ba-f1df0163b392" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_7a8fcb0d-9998-4fee-b504-985c7271514c" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3eb703ed-1ecd-46db-a2ba-f1df0163b392" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2021Member_12693c26-17bf-4e72-a74b-0dced7b70dbe" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2021Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3eb703ed-1ecd-46db-a2ba-f1df0163b392" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2021Member_12693c26-17bf-4e72-a74b-0dced7b70dbe" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2024Member_18678556-1277-4411-bd7f-dbed516e7fe6" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2024Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3eb703ed-1ecd-46db-a2ba-f1df0163b392" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2024Member_18678556-1277-4411-bd7f-dbed516e7fe6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExchangeableSeniorNotesDue2026Member_d5e5fd13-08f0-4150-83e4-e33f8098eb38" xlink:href="jazz-20210331.xsd#jazz_ExchangeableSeniorNotesDue2026Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3eb703ed-1ecd-46db-a2ba-f1df0163b392" xlink:to="loc_jazz_ExchangeableSeniorNotesDue2026Member_d5e5fd13-08f0-4150-83e4-e33f8098eb38" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/DebtScheduleofMaturitiesofLongtermDebtDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#DebtScheduleofMaturitiesofLongtermDebtDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/DebtScheduleofMaturitiesofLongtermDebtDetails" xlink:type="extended" id="i0a051290fd524e73bdc473974814f8eb_DebtScheduleofMaturitiesofLongtermDebtDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/Leases" xlink:type="simple" xlink:href="jazz-20210331.xsd#Leases"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/Leases" xlink:type="extended" id="i14ebf143263144f7a9b11b434ef56c34_Leases"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/LeasesTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#LeasesTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/LeasesTables" xlink:type="extended" id="i27e39fd9a7714a82b003c6a1018136cf_LeasesTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/LeasesLeaseCostDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#LeasesLeaseCostDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/LeasesLeaseCostDetails" xlink:type="extended" id="i9fc279a94e2b4fafbc9cd4ccd58c5177_LeasesLeaseCostDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#LeasesSupplementalBalanceSheetInformationDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/LeasesSupplementalBalanceSheetInformationDetails" xlink:type="extended" id="i2b0e6b809a7f4be8ae95b26ab57d923f_LeasesSupplementalBalanceSheetInformationDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/LeasesWeightedAverageTermsandDiscountRatesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#LeasesWeightedAverageTermsandDiscountRatesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/LeasesWeightedAverageTermsandDiscountRatesDetails" xlink:type="extended" id="i1da51c90d7d04f84b28ef7767c4afd7d_LeasesWeightedAverageTermsandDiscountRatesDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/LeasesSupplementalCashFlowInformationDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#LeasesSupplementalCashFlowInformationDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/LeasesSupplementalCashFlowInformationDetails" xlink:type="extended" id="i5ca3634cb99f40c882946a531572f6a0_LeasesSupplementalCashFlowInformationDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/LeasesMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#LeasesMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/LeasesMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="extended" id="i53585ade80884600b91c30327380fa83_LeasesMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="jazz-20210331.xsd#CommitmentsandContingencies"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CommitmentsandContingencies" xlink:type="extended" id="i3822873567d546f3934a6493726f94ca_CommitmentsandContingencies"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended" id="if17ba11ad0284e49901f1bbc6940e8c5_CommitmentsandContingenciesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_2f16c932-7ebc-48da-bab4-fab6784e58e3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationDueInNextRollingTwelveMonths_8aee469a-5912-4fc5-ba0c-ba6d672446da" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_UnrecordedUnconditionalPurchaseObligationDueInNextRollingTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2f16c932-7ebc-48da-bab4-fab6784e58e3" xlink:to="loc_us-gaap_UnrecordedUnconditionalPurchaseObligationDueInNextRollingTwelveMonths_8aee469a-5912-4fc5-ba0c-ba6d672446da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyNewClaimsFiledNumber_6295eb82-e613-4bd9-9af3-9cb336e758bd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingencyNewClaimsFiledNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_2f16c932-7ebc-48da-bab4-fab6784e58e3" xlink:to="loc_us-gaap_LossContingencyNewClaimsFiledNumber_6295eb82-e613-4bd9-9af3-9cb336e758bd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_025b49f4-e08d-4594-84ec-070cfc526002" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_2f16c932-7ebc-48da-bab4-fab6784e58e3" xlink:to="loc_us-gaap_LossContingenciesTable_025b49f4-e08d-4594-84ec-070cfc526002" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_3ba8f239-0228-442e-aa8d-287c3a74c625" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_025b49f4-e08d-4594-84ec-070cfc526002" xlink:to="loc_srt_LitigationCaseAxis_3ba8f239-0228-442e-aa8d-287c3a74c625" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_3ba8f239-0228-442e-aa8d-287c3a74c625_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_3ba8f239-0228-442e-aa8d-287c3a74c625" xlink:to="loc_srt_LitigationCaseTypeDomain_3ba8f239-0228-442e-aa8d-287c3a74c625_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_f9056b7a-5050-40cc-8d02-71a495f95cf5" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_3ba8f239-0228-442e-aa8d-287c3a74c625" xlink:to="loc_srt_LitigationCaseTypeDomain_f9056b7a-5050-40cc-8d02-71a495f95cf5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TeamstersAndGEHALawsuitsMember_4f4dbc6e-4c8f-4f54-81ee-6bfc946584e5" xlink:href="jazz-20210331.xsd#jazz_TeamstersAndGEHALawsuitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_f9056b7a-5050-40cc-8d02-71a495f95cf5" xlink:to="loc_jazz_TeamstersAndGEHALawsuitsMember_4f4dbc6e-4c8f-4f54-81ee-6bfc946584e5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_FarrellLawsuitAndLevyLawsuitMember_856530db-82e9-4d46-af3e-783a9cfb58ab" xlink:href="jazz-20210331.xsd#jazz_FarrellLawsuitAndLevyLawsuitMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_f9056b7a-5050-40cc-8d02-71a495f95cf5" xlink:to="loc_jazz_FarrellLawsuitAndLevyLawsuitMember_856530db-82e9-4d46-af3e-783a9cfb58ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_GWLitigationMember_be85cc46-b4cd-43c1-a790-bbdf2dc54978" xlink:href="jazz-20210331.xsd#jazz_GWLitigationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_f9056b7a-5050-40cc-8d02-71a495f95cf5" xlink:to="loc_jazz_GWLitigationMember_be85cc46-b4cd-43c1-a790-bbdf2dc54978" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquity" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareholdersEquity"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquity" xlink:type="extended" id="i642cc849c56d4998af951ef12dc07d54_ShareholdersEquity"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareholdersEquityTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityTables" xlink:type="extended" id="i6be1dd3c4b504cae9ab8b2990d022581_ShareholdersEquityTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityShareRepurchaseProgramsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareholdersEquityShareRepurchaseProgramsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityShareRepurchaseProgramsDetails" xlink:type="extended" id="i89aed123c4ec441abb69f7d6a589f4d1_ShareholdersEquityShareRepurchaseProgramsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_1a57ac39-2b85-4150-956a-23aa89eafae4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_e98ca890-4b5f-4a3e-bd71-e112770569b2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1a57ac39-2b85-4150-956a-23aa89eafae4" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_e98ca890-4b5f-4a3e-bd71-e112770569b2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_b8f8ee88-1590-450f-8e80-ab7850cfd466" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1a57ac39-2b85-4150-956a-23aa89eafae4" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_b8f8ee88-1590-450f-8e80-ab7850cfd466" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_5b52b938-0f61-4893-877d-d9e1961c398a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_1a57ac39-2b85-4150-956a-23aa89eafae4" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_5b52b938-0f61-4893-877d-d9e1961c398a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_9a64bf9b-0928-4adb-8428-bd3dfb018b03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_1a57ac39-2b85-4150-956a-23aa89eafae4" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_9a64bf9b-0928-4adb-8428-bd3dfb018b03" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_90c9503f-b53f-4d88-81a8-7d2a2214eaab" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_9a64bf9b-0928-4adb-8428-bd3dfb018b03" xlink:to="loc_us-gaap_AwardTypeAxis_90c9503f-b53f-4d88-81a8-7d2a2214eaab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_90c9503f-b53f-4d88-81a8-7d2a2214eaab_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_90c9503f-b53f-4d88-81a8-7d2a2214eaab" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_90c9503f-b53f-4d88-81a8-7d2a2214eaab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6ec97c87-63ca-4c6f-8dbb-0f9c8f467d2c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_90c9503f-b53f-4d88-81a8-7d2a2214eaab" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6ec97c87-63ca-4c6f-8dbb-0f9c8f467d2c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OrdinarySharesMember_ba9957a5-e725-4324-8861-c8095a0abd88" xlink:href="jazz-20210331.xsd#jazz_OrdinarySharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6ec97c87-63ca-4c6f-8dbb-0f9c8f467d2c" xlink:to="loc_jazz_OrdinarySharesMember_ba9957a5-e725-4324-8861-c8095a0abd88" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramAxis_c4448dc6-fcdf-45f9-aedb-4a869fa02f41" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareRepurchaseProgramAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_9a64bf9b-0928-4adb-8428-bd3dfb018b03" xlink:to="loc_us-gaap_ShareRepurchaseProgramAxis_c4448dc6-fcdf-45f9-aedb-4a869fa02f41" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_c4448dc6-fcdf-45f9-aedb-4a869fa02f41_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_c4448dc6-fcdf-45f9-aedb-4a869fa02f41" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_c4448dc6-fcdf-45f9-aedb-4a869fa02f41_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareRepurchaseProgramDomain_0b3e67d2-0d3f-45b3-9135-5ff739993d53" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareRepurchaseProgramDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareRepurchaseProgramAxis_c4448dc6-fcdf-45f9-aedb-4a869fa02f41" xlink:to="loc_us-gaap_ShareRepurchaseProgramDomain_0b3e67d2-0d3f-45b3-9135-5ff739993d53" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_November2016ShareRepurchaseProgramMember_264f157d-d0ea-4ec0-bd60-b6e28b2eaa20" xlink:href="jazz-20210331.xsd#jazz_November2016ShareRepurchaseProgramMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareRepurchaseProgramDomain_0b3e67d2-0d3f-45b3-9135-5ff739993d53" xlink:to="loc_jazz_November2016ShareRepurchaseProgramMember_264f157d-d0ea-4ec0-bd60-b6e28b2eaa20" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails" xlink:type="extended" id="ifad41ad2107e443dbaaa901cefd1cd47_ShareholdersEquityComponentofAccumulatedOtherComprehensiveLossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fbe65879-3695-47ef-b2bc-5490a96d81d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_bd279803-0c1d-43c1-bb77-791906c67592" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fbe65879-3695-47ef-b2bc-5490a96d81d1" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_bd279803-0c1d-43c1-bb77-791906c67592" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3f4b26c8-71b2-4e9a-b468-fa7aab737f50" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_bd279803-0c1d-43c1-bb77-791906c67592" xlink:to="loc_us-gaap_StockholdersEquity_3f4b26c8-71b2-4e9a-b468-fa7aab737f50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_57956562-d6a7-44e2-b60e-967221fcf315" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_bd279803-0c1d-43c1-bb77-791906c67592" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_57956562-d6a7-44e2-b60e-967221fcf315" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_04b5cda2-e41e-42c1-b2f1-08ff01a83fb0" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_bd279803-0c1d-43c1-bb77-791906c67592" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_04b5cda2-e41e-42c1-b2f1-08ff01a83fb0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_22847132-90a5-4b94-a073-bd7dbe35db0c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTaxAbstract_bd279803-0c1d-43c1-bb77-791906c67592" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_22847132-90a5-4b94-a073-bd7dbe35db0c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_edf467b9-ea50-47be-8a6e-d846b521bb16" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_6e7c505a-6978-40d6-981e-ed0575ed6989" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_fbe65879-3695-47ef-b2bc-5490a96d81d1" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_6e7c505a-6978-40d6-981e-ed0575ed6989" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_d53d7786-6114-4dd2-b6ac-690eefef0438" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_6e7c505a-6978-40d6-981e-ed0575ed6989" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_d53d7786-6114-4dd2-b6ac-690eefef0438" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_d53d7786-6114-4dd2-b6ac-690eefef0438_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_d53d7786-6114-4dd2-b6ac-690eefef0438" xlink:to="loc_us-gaap_EquityComponentDomain_d53d7786-6114-4dd2-b6ac-690eefef0438_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_885e40a0-e772-492a-bf69-859b53dd350f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_d53d7786-6114-4dd2-b6ac-690eefef0438" xlink:to="loc_us-gaap_EquityComponentDomain_885e40a0-e772-492a-bf69-859b53dd350f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_b3c8699d-2e75-4767-9fc0-0f1e71812713" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_885e40a0-e772-492a-bf69-859b53dd350f" xlink:to="loc_us-gaap_AccumulatedGainLossNetCashFlowHedgeParentMember_b3c8699d-2e75-4767-9fc0-0f1e71812713" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_65871d13-52be-4950-a058-fcd045e203b4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_885e40a0-e772-492a-bf69-859b53dd350f" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_65871d13-52be-4950-a058-fcd045e203b4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_8842deb4-ee44-4146-8493-9ecaf921adbf" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_885e40a0-e772-492a-bf69-859b53dd350f" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_8842deb4-ee44-4146-8493-9ecaf921adbf" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShare" xlink:type="simple" xlink:href="jazz-20210331.xsd#NetIncomeLossperOrdinaryShare"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShare" xlink:type="extended" id="i010be6d741994d89bb9bfdf53fe5afa4_NetIncomeLossperOrdinaryShare"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#NetIncomeLossperOrdinaryShareTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareTables" xlink:type="extended" id="idc66018844f04a3b8842967eaec643ce_NetIncomeLossperOrdinaryShareTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareBasicandDilutedNetIncomeperCommonShareDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#NetIncomeLossperOrdinaryShareBasicandDilutedNetIncomeperCommonShareDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareBasicandDilutedNetIncomeperCommonShareDetails" xlink:type="extended" id="i9c88758e347a40438fceb11287c3be4d_NetIncomeLossperOrdinaryShareBasicandDilutedNetIncomeperCommonShareDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails" xlink:type="extended" id="i3e527f6c34bc4e3f9be3580af935b864_NetIncomeLossperOrdinaryShareWeightedAverageOrdinarySharesExcludedfromComputationofDilutedNetIncomeperShareDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_21f4d269-c783-4f3d-be42-4f44e8249278" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6d47dbab-5660-4add-9c0f-2584ddcc55c2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_21f4d269-c783-4f3d-be42-4f44e8249278" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_6d47dbab-5660-4add-9c0f-2584ddcc55c2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_e8e22bd8-4387-40dc-ad0e-7b33841fb187" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_21f4d269-c783-4f3d-be42-4f44e8249278" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_e8e22bd8-4387-40dc-ad0e-7b33841fb187" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0c33529c-29d3-4b19-950a-0de841b6a197" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_e8e22bd8-4387-40dc-ad0e-7b33841fb187" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0c33529c-29d3-4b19-950a-0de841b6a197" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0c33529c-29d3-4b19-950a-0de841b6a197_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0c33529c-29d3-4b19-950a-0de841b6a197" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_0c33529c-29d3-4b19-950a-0de841b6a197_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_885eaa42-22e5-41a4-b233-e708d11a482b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_0c33529c-29d3-4b19-950a-0de841b6a197" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_885eaa42-22e5-41a4-b233-e708d11a482b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_06bdb4ab-a50d-400e-8e47-5deb00b71008" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_885eaa42-22e5-41a4-b233-e708d11a482b" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_06bdb4ab-a50d-400e-8e47-5deb00b71008" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityUnitPurchaseAgreementsMember_465d60bf-191e-4934-9193-df57335922cb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EquityUnitPurchaseAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_885eaa42-22e5-41a4-b233-e708d11a482b" xlink:to="loc_us-gaap_EquityUnitPurchaseAgreementsMember_465d60bf-191e-4934-9193-df57335922cb" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/Revenues" xlink:type="simple" xlink:href="jazz-20210331.xsd#Revenues"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/Revenues" xlink:type="extended" id="ifb6cb3cb799644b39522d2ce79fc3d9f_Revenues"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#RevenuesTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesTables" xlink:type="extended" id="i932b3c36acf7450eb70d5dabdf49d324_RevenuesTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#RevenuesSummaryofDisaggregationofRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofDisaggregationofRevenueDetails" xlink:type="extended" id="i55a2b39aef3c4b4aaeff12901186864e_RevenuesSummaryofDisaggregationofRevenueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_7d897cd5-ff87-4599-9d51-7b06f7018be1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_50b40919-8b9d-46d6-bf9f-ab60ea2c37ce" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7d897cd5-ff87-4599-9d51-7b06f7018be1" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_50b40919-8b9d-46d6-bf9f-ab60ea2c37ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_ec3041f6-2ec8-48b8-a8c6-a1abfa6cd89e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_7d897cd5-ff87-4599-9d51-7b06f7018be1" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_ec3041f6-2ec8-48b8-a8c6-a1abfa6cd89e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_ac5c65e3-9e46-47e1-aee3-e7f71bc4cf21" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_ec3041f6-2ec8-48b8-a8c6-a1abfa6cd89e" xlink:to="loc_srt_ProductOrServiceAxis_ac5c65e3-9e46-47e1-aee3-e7f71bc4cf21" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_ac5c65e3-9e46-47e1-aee3-e7f71bc4cf21_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_ac5c65e3-9e46-47e1-aee3-e7f71bc4cf21" xlink:to="loc_srt_ProductsAndServicesDomain_ac5c65e3-9e46-47e1-aee3-e7f71bc4cf21_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c996a0f0-62ef-451f-851c-1692f2b63083" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_ac5c65e3-9e46-47e1-aee3-e7f71bc4cf21" xlink:to="loc_srt_ProductsAndServicesDomain_c996a0f0-62ef-451f-851c-1692f2b63083" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_1ede2dd6-3ebe-48a4-9722-e31b2451f000" xlink:href="jazz-20210331.xsd#jazz_ProductAndServicesProductSalesNetOfDeductionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_c996a0f0-62ef-451f-851c-1692f2b63083" xlink:to="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_1ede2dd6-3ebe-48a4-9722-e31b2451f000" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:href="jazz-20210331.xsd#jazz_OncologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_1ede2dd6-3ebe-48a4-9722-e31b2451f000" xlink:to="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TotalOxybateMember_5206bf31-e9af-4c4e-b448-b8420121cfa6" xlink:href="jazz-20210331.xsd#jazz_TotalOxybateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:to="loc_jazz_TotalOxybateMember_5206bf31-e9af-4c4e-b448-b8420121cfa6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XyremMember_8df1ff2a-2e37-4288-a535-3ae5a824066d" xlink:href="jazz-20210331.xsd#jazz_XyremMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOxybateMember_5206bf31-e9af-4c4e-b448-b8420121cfa6" xlink:to="loc_jazz_XyremMember_8df1ff2a-2e37-4288-a535-3ae5a824066d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_XywavMember_fbe1e56f-64db-4f7a-8166-c52fa0dea70a" xlink:href="jazz-20210331.xsd#jazz_XywavMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_TotalOxybateMember_5206bf31-e9af-4c4e-b448-b8420121cfa6" xlink:to="loc_jazz_XywavMember_fbe1e56f-64db-4f7a-8166-c52fa0dea70a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NeuroscienceMember_faf12e3d-9758-47bb-9ab6-08d55da8f02c" xlink:href="jazz-20210331.xsd#jazz_NeuroscienceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:to="loc_jazz_NeuroscienceMember_faf12e3d-9758-47bb-9ab6-08d55da8f02c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SunosiMember_27aedf0c-8f4a-4cee-a6fe-f1ef9ffb5e14" xlink:href="jazz-20210331.xsd#jazz_SunosiMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_NeuroscienceMember_faf12e3d-9758-47bb-9ab6-08d55da8f02c" xlink:to="loc_jazz_SunosiMember_27aedf0c-8f4a-4cee-a6fe-f1ef9ffb5e14" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ZepzelcaMember_bfef89e4-3c33-4721-b9d6-b92efca3abc0" xlink:href="jazz-20210331.xsd#jazz_ZepzelcaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:to="loc_jazz_ZepzelcaMember_bfef89e4-3c33-4721-b9d6-b92efca3abc0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_VyxeosMember_6d83ea9f-f7c8-40bc-b7ab-10004da5e4d6" xlink:href="jazz-20210331.xsd#jazz_VyxeosMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:to="loc_jazz_VyxeosMember_6d83ea9f-f7c8-40bc-b7ab-10004da5e4d6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_DefitelioDefibrotideMember_13fc851c-bc48-4d3c-b6cd-e0a550dedfd5" xlink:href="jazz-20210331.xsd#jazz_DefitelioDefibrotideMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:to="loc_jazz_DefitelioDefibrotideMember_13fc851c-bc48-4d3c-b6cd-e0a550dedfd5" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ErwinazeAndErwinaseMember_ea8f7acc-e763-41cd-9fab-e123b38ca9bc" xlink:href="jazz-20210331.xsd#jazz_ErwinazeAndErwinaseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_OncologyMember_c76047d0-af2d-4061-804e-917b79c0c253" xlink:to="loc_jazz_ErwinazeAndErwinaseMember_ea8f7acc-e763-41cd-9fab-e123b38ca9bc" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherProductsMember_50b01298-a1c8-409e-a710-992168acecef" xlink:href="jazz-20210331.xsd#jazz_OtherProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ProductAndServicesProductSalesNetOfDeductionsMember_1ede2dd6-3ebe-48a4-9722-e31b2451f000" xlink:to="loc_jazz_OtherProductsMember_50b01298-a1c8-409e-a710-992168acecef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_8d09fa63-c3d7-433d-857f-3d3c077e7546" xlink:href="jazz-20210331.xsd#jazz_ProductAndServicesRoyaltiesAndContractRevenueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_c996a0f0-62ef-451f-851c-1692f2b63083" xlink:to="loc_jazz_ProductAndServicesRoyaltiesAndContractRevenueMember_8d09fa63-c3d7-433d-857f-3d3c077e7546" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_36b1e296-0f79-4978-86fe-702a5e237f1c" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_ec3041f6-2ec8-48b8-a8c6-a1abfa6cd89e" xlink:to="loc_srt_StatementGeographicalAxis_36b1e296-0f79-4978-86fe-702a5e237f1c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_36b1e296-0f79-4978-86fe-702a5e237f1c_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_36b1e296-0f79-4978-86fe-702a5e237f1c" xlink:to="loc_srt_SegmentGeographicalDomain_36b1e296-0f79-4978-86fe-702a5e237f1c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_da25fbf1-82d3-40fe-94ff-61b601a3bea9" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_36b1e296-0f79-4978-86fe-702a5e237f1c" xlink:to="loc_srt_SegmentGeographicalDomain_da25fbf1-82d3-40fe-94ff-61b601a3bea9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_97a3adea-8500-4ff7-97e8-3b6377894627" xlink:href="https://xbrl.sec.gov/country/2020/country-2020-01-31.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_da25fbf1-82d3-40fe-94ff-61b601a3bea9" xlink:to="loc_country_US_97a3adea-8500-4ff7-97e8-3b6377894627" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_99dce0d8-babe-4f62-b6be-54ed461bf083" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_da25fbf1-82d3-40fe-94ff-61b601a3bea9" xlink:to="loc_srt_EuropeMember_99dce0d8-babe-4f62-b6be-54ed461bf083" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_OtherCountriesMember_38f1eb39-c5f8-4c6d-bf34-fdacfa39ecdd" xlink:href="jazz-20210331.xsd#jazz_OtherCountriesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_da25fbf1-82d3-40fe-94ff-61b601a3bea9" xlink:to="loc_jazz_OtherCountriesMember_38f1eb39-c5f8-4c6d-bf34-fdacfa39ecdd" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails" xlink:type="extended" id="i04910e25ae504dea869fd95f3fd84965_RevenuesSummaryofthePercentageofTotalRevenuesfromCustomersDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_043b585f-c7c5-4eae-97c3-fbd99d3d634d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_0a2f4854-a917-4e3a-a1e1-4e0dff873849" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_043b585f-c7c5-4eae-97c3-fbd99d3d634d" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_0a2f4854-a917-4e3a-a1e1-4e0dff873849" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_6472dfcc-8b87-4440-85c4-e916957152aa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_043b585f-c7c5-4eae-97c3-fbd99d3d634d" xlink:to="loc_us-gaap_ConcentrationRiskTable_6472dfcc-8b87-4440-85c4-e916957152aa" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_04095f93-6516-415e-903b-04b4e2dbd60b" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_6472dfcc-8b87-4440-85c4-e916957152aa" xlink:to="loc_srt_MajorCustomersAxis_04095f93-6516-415e-903b-04b4e2dbd60b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_04095f93-6516-415e-903b-04b4e2dbd60b_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_04095f93-6516-415e-903b-04b4e2dbd60b" xlink:to="loc_srt_NameOfMajorCustomerDomain_04095f93-6516-415e-903b-04b4e2dbd60b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_0543e06c-fe51-4de5-8a17-24237239d2a6" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_04095f93-6516-415e-903b-04b4e2dbd60b" xlink:to="loc_srt_NameOfMajorCustomerDomain_0543e06c-fe51-4de5-8a17-24237239d2a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ExpressScriptsMember_b8c1ad8a-dcad-42de-96fa-1a1952d387b8" xlink:href="jazz-20210331.xsd#jazz_ExpressScriptsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_0543e06c-fe51-4de5-8a17-24237239d2a6" xlink:to="loc_jazz_ExpressScriptsMember_b8c1ad8a-dcad-42de-96fa-1a1952d387b8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_McKessonCorporationMember_b6a92d27-c08b-4eb9-8557-96ee96523cae" xlink:href="jazz-20210331.xsd#jazz_McKessonCorporationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_0543e06c-fe51-4de5-8a17-24237239d2a6" xlink:to="loc_jazz_McKessonCorporationMember_b6a92d27-c08b-4eb9-8557-96ee96523cae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_e9ef90b0-57f7-4499-94aa-14a1a1a7f619" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_6472dfcc-8b87-4440-85c4-e916957152aa" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_e9ef90b0-57f7-4499-94aa-14a1a1a7f619" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_e9ef90b0-57f7-4499-94aa-14a1a1a7f619_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_e9ef90b0-57f7-4499-94aa-14a1a1a7f619" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_e9ef90b0-57f7-4499-94aa-14a1a1a7f619_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_799bc538-4ca1-4c3e-9c4e-8c48d34023e2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_e9ef90b0-57f7-4499-94aa-14a1a1a7f619" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_799bc538-4ca1-4c3e-9c4e-8c48d34023e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerMember_50f6dbd4-94c7-4735-bad0-017b405c84a2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenueFromContractWithCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_799bc538-4ca1-4c3e-9c4e-8c48d34023e2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerMember_50f6dbd4-94c7-4735-bad0-017b405c84a2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_7ba7bd09-9899-4e1e-bf10-1efca98e6e68" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_6472dfcc-8b87-4440-85c4-e916957152aa" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_7ba7bd09-9899-4e1e-bf10-1efca98e6e68" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_7ba7bd09-9899-4e1e-bf10-1efca98e6e68_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_7ba7bd09-9899-4e1e-bf10-1efca98e6e68" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_7ba7bd09-9899-4e1e-bf10-1efca98e6e68_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_a1ea8a25-8e21-4c7b-9451-4de19b01c4d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_7ba7bd09-9899-4e1e-bf10-1efca98e6e68" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_a1ea8a25-8e21-4c7b-9451-4de19b01c4d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_8cb48799-8108-4836-82e4-b7c1355960fa" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_a1ea8a25-8e21-4c7b-9451-4de19b01c4d1" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_8cb48799-8108-4836-82e4-b7c1355960fa" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#RevenuesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesNarrativeDetails" xlink:type="extended" id="i27a8074a99bb48fe887c1a987868c4df_RevenuesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SummaryOfDeferredRevenueLineItems_493a7fd2-b51f-4a8e-9929-6c0898844d59" xlink:href="jazz-20210331.xsd#jazz_SummaryOfDeferredRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_RevenuePerformanceObligationPaymentTerms_95712f0a-76a5-4e27-9f10-27a00d709dc1" xlink:href="jazz-20210331.xsd#jazz_RevenuePerformanceObligationPaymentTerms"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_493a7fd2-b51f-4a8e-9929-6c0898844d59" xlink:to="loc_jazz_RevenuePerformanceObligationPaymentTerms_95712f0a-76a5-4e27-9f10-27a00d709dc1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_LicensingAgreementNumberOfAgreements_2b47e8b2-d7dc-497e-8cd5-99d4720ebc93" xlink:href="jazz-20210331.xsd#jazz_LicensingAgreementNumberOfAgreements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_493a7fd2-b51f-4a8e-9929-6c0898844d59" xlink:to="loc_jazz_LicensingAgreementNumberOfAgreements_2b47e8b2-d7dc-497e-8cd5-99d4720ebc93" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_6c5615f1-db5f-425d-ae7e-898d84bf63ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_493a7fd2-b51f-4a8e-9929-6c0898844d59" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_6c5615f1-db5f-425d-ae7e-898d84bf63ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuePerformanceObligationDescriptionOfTiming_218badc4-17ff-4ca3-960e-9d883a5b0259" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevenuePerformanceObligationDescriptionOfTiming"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_493a7fd2-b51f-4a8e-9929-6c0898844d59" xlink:to="loc_us-gaap_RevenuePerformanceObligationDescriptionOfTiming_218badc4-17ff-4ca3-960e-9d883a5b0259" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SummaryOfDeferredRevenueTable_e60d6522-76c8-4671-9a06-9a6b2e16aca0" xlink:href="jazz-20210331.xsd#jazz_SummaryOfDeferredRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_jazz_SummaryOfDeferredRevenueLineItems_493a7fd2-b51f-4a8e-9929-6c0898844d59" xlink:to="loc_jazz_SummaryOfDeferredRevenueTable_e60d6522-76c8-4671-9a06-9a6b2e16aca0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_ea794a1b-d159-4548-a305-b10d4b59815d" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_SummaryOfDeferredRevenueTable_e60d6522-76c8-4671-9a06-9a6b2e16aca0" xlink:to="loc_srt_RangeAxis_ea794a1b-d159-4548-a305-b10d4b59815d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ea794a1b-d159-4548-a305-b10d4b59815d_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_ea794a1b-d159-4548-a305-b10d4b59815d" xlink:to="loc_srt_RangeMember_ea794a1b-d159-4548-a305-b10d4b59815d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c980e093-3604-4757-b488-507b905b6764" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_ea794a1b-d159-4548-a305-b10d4b59815d" xlink:to="loc_srt_RangeMember_c980e093-3604-4757-b488-507b905b6764" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_e8deb9ef-e024-4bbe-8195-cb441e0536e3" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c980e093-3604-4757-b488-507b905b6764" xlink:to="loc_srt_MinimumMember_e8deb9ef-e024-4bbe-8195-cb441e0536e3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a9eb79fb-4c42-499a-addd-44a9d7d0a8e4" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c980e093-3604-4757-b488-507b905b6764" xlink:to="loc_srt_MaximumMember_a9eb79fb-4c42-499a-addd-44a9d7d0a8e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_e47658ec-a1ab-4615-8ee1-a38ed769eafe" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_SummaryOfDeferredRevenueTable_e60d6522-76c8-4671-9a06-9a6b2e16aca0" xlink:to="loc_srt_MajorCustomersAxis_e47658ec-a1ab-4615-8ee1-a38ed769eafe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_e47658ec-a1ab-4615-8ee1-a38ed769eafe_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_e47658ec-a1ab-4615-8ee1-a38ed769eafe" xlink:to="loc_srt_NameOfMajorCustomerDomain_e47658ec-a1ab-4615-8ee1-a38ed769eafe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_02c19b5d-d425-4d69-810f-78ef440848ec" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_e47658ec-a1ab-4615-8ee1-a38ed769eafe" xlink:to="loc_srt_NameOfMajorCustomerDomain_02c19b5d-d425-4d69-810f-78ef440848ec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NipponShinyakuCo.Ltd.Member_dc36f472-e68c-4aef-8015-084e16bcd1de" xlink:href="jazz-20210331.xsd#jazz_NipponShinyakuCo.Ltd.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_02c19b5d-d425-4d69-810f-78ef440848ec" xlink:to="loc_jazz_NipponShinyakuCo.Ltd.Member_dc36f472-e68c-4aef-8015-084e16bcd1de" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/RevenuesSummaryofContractLiabilitiesDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#RevenuesSummaryofContractLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/RevenuesSummaryofContractLiabilitiesDetails" xlink:type="extended" id="i6ecc3897d1e74e4ba54e03b353919eee_RevenuesSummaryofContractLiabilitiesDetails"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensation" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareBasedCompensation"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensation" xlink:type="extended" id="i1de0c57098c54f0f999ac291415975b3_ShareBasedCompensation"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationTables" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareBasedCompensationTables"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationTables" xlink:type="extended" id="if1e7dc726b5c461f83d2b6f407fdfa6b_ShareBasedCompensationTables"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationExpenseDetails" xlink:type="extended" id="i3ceab925173b490784ad635cab7be7b2_ShareBasedCompensationExpenseDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_023a0216-ec63-4bfb-9b0a-dc002583a5e8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_57404dde-736c-47bc-b5d3-0bbd4484c3a4" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_023a0216-ec63-4bfb-9b0a-dc002583a5e8" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_57404dde-736c-47bc-b5d3-0bbd4484c3a4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_2fd2d65c-4678-4bfb-aea6-83917ebd7eb8" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_023a0216-ec63-4bfb-9b0a-dc002583a5e8" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_2fd2d65c-4678-4bfb-aea6-83917ebd7eb8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_4a119c88-cc6b-4c6a-83e9-583f152d6a8d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_023a0216-ec63-4bfb-9b0a-dc002583a5e8" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_4a119c88-cc6b-4c6a-83e9-583f152d6a8d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_2f58385d-834f-494c-9946-b8df214ae433" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_023a0216-ec63-4bfb-9b0a-dc002583a5e8" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_2f58385d-834f-494c-9946-b8df214ae433" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_119251ef-1463-4bae-9ddb-2c29c85f66f2" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_2f58385d-834f-494c-9946-b8df214ae433" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_119251ef-1463-4bae-9ddb-2c29c85f66f2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_119251ef-1463-4bae-9ddb-2c29c85f66f2_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_119251ef-1463-4bae-9ddb-2c29c85f66f2" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_119251ef-1463-4bae-9ddb-2c29c85f66f2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_fd5d3f5f-d19c-4120-a75f-533e5dcab717" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_119251ef-1463-4bae-9ddb-2c29c85f66f2" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_fd5d3f5f-d19c-4120-a75f-533e5dcab717" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5e6238f2-0eff-4b90-b9fd-3ec6552fe1c5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_fd5d3f5f-d19c-4120-a75f-533e5dcab717" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesMember_5e6238f2-0eff-4b90-b9fd-3ec6552fe1c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_338c8080-9afd-49b4-a66e-cf1c4b20ee5a" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_fd5d3f5f-d19c-4120-a75f-533e5dcab717" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_338c8080-9afd-49b4-a66e-cf1c4b20ee5a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_b234cf5d-afca-4476-b4e5-92124a9a4f9d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_fd5d3f5f-d19c-4120-a75f-533e5dcab717" xlink:to="loc_us-gaap_CostOfSalesMember_b234cf5d-afca-4476-b4e5-92124a9a4f9d" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails" xlink:type="extended" id="i0ddad28ee4c344c6abfec1ac9f2bd269_ShareBasedCompensationWeightedAverageAssumptionsandResultingGrantDateFairValueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:href="jazz-20210331.xsd#jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_47ddff73-2c0c-409c-ad3e-762c770711d1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_47ddff73-2c0c-409c-ad3e-762c770711d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_65aac650-fb35-4a97-982b-db310b94f6c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_65aac650-fb35-4a97-982b-db310b94f6c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_79be2cb5-b798-4e7b-89cf-a1d14cb588ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_79be2cb5-b798-4e7b-89cf-a1d14cb588ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_3e68bf03-d4fd-486b-a9b4-04c72dc4ca00" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_3e68bf03-d4fd-486b-a9b4-04c72dc4ca00" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_18771a61-c7b2-4ffb-a59d-a5b4db3bc3e3" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_18771a61-c7b2-4ffb-a59d-a5b4db3bc3e3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_326ecf3b-9db9-4ba9-b2a5-465fcf349722" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_326ecf3b-9db9-4ba9-b2a5-465fcf349722" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_18fcb155-0454-439d-b675-7e7c57712028" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_18fcb155-0454-439d-b675-7e7c57712028" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable_cf6fa209-8a38-4ff1-b95b-0842891090f0" xlink:href="jazz-20210331.xsd#jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsLineItems_8d5b83b4-d669-4881-bec7-ddd4247eb4e7" xlink:to="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable_cf6fa209-8a38-4ff1-b95b-0842891090f0" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_83801204-4f59-4294-9b88-a56384aad569" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_jazz_ScheduleOfWeightedAverageAssumptionsForFairValuesOfStockOptionsTable_cf6fa209-8a38-4ff1-b95b-0842891090f0" xlink:to="loc_us-gaap_AwardTypeAxis_83801204-4f59-4294-9b88-a56384aad569" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_83801204-4f59-4294-9b88-a56384aad569_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_83801204-4f59-4294-9b88-a56384aad569" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_83801204-4f59-4294-9b88-a56384aad569_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_008cb181-cc86-464e-9074-4b2479886062" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_83801204-4f59-4294-9b88-a56384aad569" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_008cb181-cc86-464e-9074-4b2479886062" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_44839193-d711-46e0-b6ce-92c08de5d5c1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_008cb181-cc86-464e-9074-4b2479886062" xlink:to="loc_us-gaap_EmployeeStockOptionMember_44839193-d711-46e0-b6ce-92c08de5d5c1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationRestrictedUnitsDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareBasedCompensationRestrictedUnitsDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationRestrictedUnitsDetails" xlink:type="extended" id="icd1823cd57784fe68107d51369e33b5e_ShareBasedCompensationRestrictedUnitsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9961920a-5d8c-48dc-ac3d-016b7a735683" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5b1b07db-88d9-40ce-9f93-337e9967ac37" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9961920a-5d8c-48dc-ac3d-016b7a735683" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_5b1b07db-88d9-40ce-9f93-337e9967ac37" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7311ef3e-9ef6-46da-af47-16edd1545621" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9961920a-5d8c-48dc-ac3d-016b7a735683" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7311ef3e-9ef6-46da-af47-16edd1545621" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14e9fce0-4bb6-4443-b28f-bae4780eee03" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_9961920a-5d8c-48dc-ac3d-016b7a735683" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14e9fce0-4bb6-4443-b28f-bae4780eee03" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_39ac7a6e-5d0e-4276-8c25-ef5e8833d385" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_14e9fce0-4bb6-4443-b28f-bae4780eee03" xlink:to="loc_us-gaap_AwardTypeAxis_39ac7a6e-5d0e-4276-8c25-ef5e8833d385" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_39ac7a6e-5d0e-4276-8c25-ef5e8833d385_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_39ac7a6e-5d0e-4276-8c25-ef5e8833d385" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_39ac7a6e-5d0e-4276-8c25-ef5e8833d385_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ea480160-cbfe-4dcf-862b-3b97be3de513" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_39ac7a6e-5d0e-4276-8c25-ef5e8833d385" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ea480160-cbfe-4dcf-862b-3b97be3de513" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_f8d1cac3-6d39-463b-abc6-ae4de9213654" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ea480160-cbfe-4dcf-862b-3b97be3de513" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_f8d1cac3-6d39-463b-abc6-ae4de9213654" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#ShareBasedCompensationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/ShareBasedCompensationNarrativeDetails" xlink:type="extended" id="id574436129684589b12871cf21465f9e_ShareBasedCompensationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fd73610f-b220-40e8-a093-5388a920622c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_b8299a70-e132-4c13-8e47-2ba581107333" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fd73610f-b220-40e8-a093-5388a920622c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_b8299a70-e132-4c13-8e47-2ba581107333" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_4f740994-8c6a-47e8-9556-ece642607e83" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fd73610f-b220-40e8-a093-5388a920622c" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_4f740994-8c6a-47e8-9556-ece642607e83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_c2dd6ed8-2ca6-43d2-9d64-aab328cd45de" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fd73610f-b220-40e8-a093-5388a920622c" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_c2dd6ed8-2ca6-43d2-9d64-aab328cd45de" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f2b94c12-a4f8-4e2f-9c85-656151db6f4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_fd73610f-b220-40e8-a093-5388a920622c" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f2b94c12-a4f8-4e2f-9c85-656151db6f4d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_151e1230-009c-4caa-a034-5b7fda5aa86d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f2b94c12-a4f8-4e2f-9c85-656151db6f4d" xlink:to="loc_us-gaap_AwardTypeAxis_151e1230-009c-4caa-a034-5b7fda5aa86d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_151e1230-009c-4caa-a034-5b7fda5aa86d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_151e1230-009c-4caa-a034-5b7fda5aa86d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_151e1230-009c-4caa-a034-5b7fda5aa86d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b6fa01c9-215d-4ec1-af56-38d7a2bffc18" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_151e1230-009c-4caa-a034-5b7fda5aa86d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b6fa01c9-215d-4ec1-af56-38d7a2bffc18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_ef98904c-f773-4212-9021-19b78df9a54f" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b6fa01c9-215d-4ec1-af56-38d7a2bffc18" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_ef98904c-f773-4212-9021-19b78df9a54f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_d5eb2f12-ac80-4eb1-9b5d-42666959520e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b6fa01c9-215d-4ec1-af56-38d7a2bffc18" xlink:to="loc_us-gaap_EmployeeStockOptionMember_d5eb2f12-ac80-4eb1-9b5d-42666959520e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxes" xlink:type="simple" xlink:href="jazz-20210331.xsd#IncomeTaxes"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxes" xlink:type="extended" id="i50dbad59fdc24935b486eee6aa4e7710_IncomeTaxes"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended" id="id64e54f9aab84435bd3c4091717164c8_IncomeTaxesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxContingencyLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_87611133-d662-4346-b2d9-6ab188249857" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_87611133-d662-4346-b2d9-6ab188249857" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_283bb1b1-eb9e-47f3-abb5-0cdbb2a287db" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_283bb1b1-eb9e-47f3-abb5-0cdbb2a287db" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_d5d081c9-a1e4-4af1-a97c-c57f9d988812" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_d5d081c9-a1e4-4af1-a97c-c57f9d988812" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_f0a718c1-8ccb-44d3-b6d4-b57342b7a286" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_f0a718c1-8ccb-44d3-b6d4-b57342b7a286" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationPenaltiesAndInterestAccrued_8a47ff38-2cc3-4e06-9d46-b607368965cd" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxExaminationPenaltiesAndInterestAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_us-gaap_IncomeTaxExaminationPenaltiesAndInterestAccrued_8a47ff38-2cc3-4e06-9d46-b607368965cd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_IncomeTaxExaminationPenaltiesAndInterestPaid_9acfac9d-cfd0-425a-aaa8-edbdf77e6f04" xlink:href="jazz-20210331.xsd#jazz_IncomeTaxExaminationPenaltiesAndInterestPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_jazz_IncomeTaxExaminationPenaltiesAndInterestPaid_9acfac9d-cfd0-425a-aaa8-edbdf77e6f04" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxContingencyTable_f412b6ae-a43c-4a72-9efc-f749c2b138ec" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxContingencyTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeTaxContingencyLineItems_2abf6b52-fd89-4259-89db-b00ac88af26b" xlink:to="loc_us-gaap_IncomeTaxContingencyTable_f412b6ae-a43c-4a72-9efc-f749c2b138ec" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_48943f0b-3a2d-4954-94ad-b85ec9bbfe6b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_f412b6ae-a43c-4a72-9efc-f749c2b138ec" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_48943f0b-3a2d-4954-94ad-b85ec9bbfe6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_48943f0b-3a2d-4954-94ad-b85ec9bbfe6b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_48943f0b-3a2d-4954-94ad-b85ec9bbfe6b" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_48943f0b-3a2d-4954-94ad-b85ec9bbfe6b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_35aaf90a-133d-4045-b21d-4e7b367ad564" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_48943f0b-3a2d-4954-94ad-b85ec9bbfe6b" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_35aaf90a-133d-4045-b21d-4e7b367ad564" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_cfaa6cee-ea0b-40e8-aa73-13be4c885ebc" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_35aaf90a-133d-4045-b21d-4e7b367ad564" xlink:to="loc_us-gaap_DomesticCountryMember_cfaa6cee-ea0b-40e8-aa73-13be4c885ebc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_9b56b000-e949-4bb5-84f4-82db76846afa" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_f412b6ae-a43c-4a72-9efc-f749c2b138ec" xlink:to="loc_srt_CounterpartyNameAxis_9b56b000-e949-4bb5-84f4-82db76846afa" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_9b56b000-e949-4bb5-84f4-82db76846afa_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_9b56b000-e949-4bb5-84f4-82db76846afa" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_9b56b000-e949-4bb5-84f4-82db76846afa_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_f273ddf3-6a37-48c8-be25-23613cf3bf52" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_9b56b000-e949-4bb5-84f4-82db76846afa" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_f273ddf3-6a37-48c8-be25-23613cf3bf52" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_PharmaMarS.A.Member_37d28779-1f5f-4b20-90eb-61fff40ba8c5" xlink:href="jazz-20210331.xsd#jazz_PharmaMarS.A.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_f273ddf3-6a37-48c8-be25-23613cf3bf52" xlink:to="loc_jazz_PharmaMarS.A.Member_37d28779-1f5f-4b20-90eb-61fff40ba8c5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_94593cbc-8bba-46fe-8a1e-1812da2de618" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxContingencyTable_f412b6ae-a43c-4a72-9efc-f749c2b138ec" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_94593cbc-8bba-46fe-8a1e-1812da2de618" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_94593cbc-8bba-46fe-8a1e-1812da2de618_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_94593cbc-8bba-46fe-8a1e-1812da2de618" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_94593cbc-8bba-46fe-8a1e-1812da2de618_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_67bd0458-a2e8-4a4c-b39b-1c01d43dec4d" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_94593cbc-8bba-46fe-8a1e-1812da2de618" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_67bd0458-a2e8-4a4c-b39b-1c01d43dec4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_UpfrontPaymentsMember_708433c7-efff-4444-a503-e61f21cb1dd2" xlink:href="jazz-20210331.xsd#jazz_UpfrontPaymentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_67bd0458-a2e8-4a4c-b39b-1c01d43dec4d" xlink:to="loc_jazz_UpfrontPaymentsMember_708433c7-efff-4444-a503-e61f21cb1dd2" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/SubsequentEvent" xlink:type="simple" xlink:href="jazz-20210331.xsd#SubsequentEvent"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/SubsequentEvent" xlink:type="extended" id="i137f19012cd0413499df5ae0a428659b_SubsequentEvent"/>
  <link:roleRef roleURI="http://www.jazzpharma.com/role/SubsequentEventNarrativeDetails" xlink:type="simple" xlink:href="jazz-20210331.xsd#SubsequentEventNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.jazzpharma.com/role/SubsequentEventNarrativeDetails" xlink:type="extended" id="ic1a5921cfd8c4eef8abd1bc34a5a3c2b_SubsequentEventNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_951bf0a2-8acb-4552-92d5-41a6688a2545" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_332fa8c1-001b-4b18-9d1a-bffa99d1ce06" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_951bf0a2-8acb-4552-92d5-41a6688a2545" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_332fa8c1-001b-4b18-9d1a-bffa99d1ce06" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_eff7ac16-4238-433e-a060-ea065e89a6d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_951bf0a2-8acb-4552-92d5-41a6688a2545" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_eff7ac16-4238-433e-a060-ea065e89a6d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_64373166-05d6-473e-9020-a0fbc965ac9c" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_951bf0a2-8acb-4552-92d5-41a6688a2545" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_64373166-05d6-473e-9020-a0fbc965ac9c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_951bf0a2-8acb-4552-92d5-41a6688a2545" xlink:to="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_52c1439e-7c62-4e3c-acdc-18ca895f0871" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_52c1439e-7c62-4e3c-acdc-18ca895f0871" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_52c1439e-7c62-4e3c-acdc-18ca895f0871_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_52c1439e-7c62-4e3c-acdc-18ca895f0871" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_52c1439e-7c62-4e3c-acdc-18ca895f0871_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_67892ac1-30fa-453e-b919-5845613f9841" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_52c1439e-7c62-4e3c-acdc-18ca895f0871" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_67892ac1-30fa-453e-b919-5845613f9841" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_df147702-878a-484e-9104-d528b89625f9" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_67892ac1-30fa-453e-b919-5845613f9841" xlink:to="loc_us-gaap_SubsequentEventMember_df147702-878a-484e-9104-d528b89625f9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_ffa67947-c15e-4d14-9204-a0d525b4df19" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_ffa67947-c15e-4d14-9204-a0d525b4df19" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ffa67947-c15e-4d14-9204-a0d525b4df19_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ffa67947-c15e-4d14-9204-a0d525b4df19" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ffa67947-c15e-4d14-9204-a0d525b4df19_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_064dcb59-50b5-4f2a-82e1-02c4f797836b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_ffa67947-c15e-4d14-9204-a0d525b4df19" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_064dcb59-50b5-4f2a-82e1-02c4f797836b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_0841510f-6be8-4b0b-a7f6-9e0af34ef9d5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_064dcb59-50b5-4f2a-82e1-02c4f797836b" xlink:to="loc_us-gaap_LineOfCreditMember_0841510f-6be8-4b0b-a7f6-9e0af34ef9d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanMember_a1048685-2efb-4d69-b27f-06fa1dae1675" xlink:href="jazz-20210331.xsd#jazz_TermLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_064dcb59-50b5-4f2a-82e1-02c4f797836b" xlink:to="loc_jazz_TermLoanMember_a1048685-2efb-4d69-b27f-06fa1dae1675" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BridgeLoanMember_93e9d7f2-e332-400a-98b5-c5c533df564b" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_BridgeLoanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_064dcb59-50b5-4f2a-82e1-02c4f797836b" xlink:to="loc_us-gaap_BridgeLoanMember_93e9d7f2-e332-400a-98b5-c5c533df564b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredDebtMember_41298342-620d-4b35-a91d-8c77d5e53c96" xlink:href="jazz-20210331.xsd#jazz_SeniorSecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_064dcb59-50b5-4f2a-82e1-02c4f797836b" xlink:to="loc_jazz_SeniorSecuredDebtMember_41298342-620d-4b35-a91d-8c77d5e53c96" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_e1b61527-ab45-4423-92e0-2bdf0a78dccb" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:to="loc_us-gaap_DebtInstrumentAxis_e1b61527-ab45-4423-92e0-2bdf0a78dccb" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_e1b61527-ab45-4423-92e0-2bdf0a78dccb_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_e1b61527-ab45-4423-92e0-2bdf0a78dccb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_e1b61527-ab45-4423-92e0-2bdf0a78dccb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_e1b61527-ab45-4423-92e0-2bdf0a78dccb" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_NewRevolvingCreditFacilityMember_d87966ce-cc22-4099-9ad1-34e4e07110f5" xlink:href="jazz-20210331.xsd#jazz_NewRevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:to="loc_jazz_NewRevolvingCreditFacilityMember_d87966ce-cc22-4099-9ad1-34e4e07110f5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredTermLoanBFacilityMember_911358f4-19af-49dd-94e6-42f5ff7fd044" xlink:href="jazz-20210331.xsd#jazz_SeniorSecuredTermLoanBFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:to="loc_jazz_SeniorSecuredTermLoanBFacilityMember_911358f4-19af-49dd-94e6-42f5ff7fd044" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredBridgeLoanFacilityMember_c8cc1cb4-55c2-4fd0-bfd6-fb20692abb47" xlink:href="jazz-20210331.xsd#jazz_SeniorSecuredBridgeLoanFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:to="loc_jazz_SeniorSecuredBridgeLoanFacilityMember_c8cc1cb4-55c2-4fd0-bfd6-fb20692abb47" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredNotesDueTwoThousandTwentyNineMember_6903d542-7364-41a3-9aaf-77a78214936e" xlink:href="jazz-20210331.xsd#jazz_SeniorSecuredNotesDueTwoThousandTwentyNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:to="loc_jazz_SeniorSecuredNotesDueTwoThousandTwentyNineMember_6903d542-7364-41a3-9aaf-77a78214936e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_TermLoanBSeniorSecuredCreditFacilityMember_336f486b-8a38-4b51-96e4-728b59ec4cf2" xlink:href="jazz-20210331.xsd#jazz_TermLoanBSeniorSecuredCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_da730d30-0881-4465-809f-14019da591a5" xlink:to="loc_jazz_TermLoanBSeniorSecuredCreditFacilityMember_336f486b-8a38-4b51-96e4-728b59ec4cf2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_fb181f57-64a9-494b-ac59-99f2bae987a1" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:to="loc_us-gaap_CreditFacilityAxis_fb181f57-64a9-494b-ac59-99f2bae987a1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_fb181f57-64a9-494b-ac59-99f2bae987a1_default" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_fb181f57-64a9-494b-ac59-99f2bae987a1" xlink:to="loc_us-gaap_CreditFacilityDomain_fb181f57-64a9-494b-ac59-99f2bae987a1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_895974f9-1978-4142-b505-d0dbb92f6641" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_fb181f57-64a9-494b-ac59-99f2bae987a1" xlink:to="loc_us-gaap_CreditFacilityDomain_895974f9-1978-4142-b505-d0dbb92f6641" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_5966f8cf-066b-4210-8182-cae398fd001e" xlink:href="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_895974f9-1978-4142-b505-d0dbb92f6641" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_5966f8cf-066b-4210-8182-cae398fd001e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_SeniorSecuredFacilityMember_a857fab5-3146-4fc6-b325-360641d46a19" xlink:href="jazz-20210331.xsd#jazz_SeniorSecuredFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_895974f9-1978-4142-b505-d0dbb92f6641" xlink:to="loc_jazz_SeniorSecuredFacilityMember_a857fab5-3146-4fc6-b325-360641d46a19" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_7df71028-c5fc-4c45-a008-96186f4bcc98" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:to="loc_dei_LegalEntityAxis_7df71028-c5fc-4c45-a008-96186f4bcc98" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_7df71028-c5fc-4c45-a008-96186f4bcc98_default" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_7df71028-c5fc-4c45-a008-96186f4bcc98" xlink:to="loc_dei_EntityDomain_7df71028-c5fc-4c45-a008-96186f4bcc98_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_58f3d2a8-73d5-497c-870f-74509779062b" xlink:href="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_7df71028-c5fc-4c45-a008-96186f4bcc98" xlink:to="loc_dei_EntityDomain_58f3d2a8-73d5-497c-870f-74509779062b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_jazz_JazzSecuritiesDesignatedActivityCompanyMember_3ddc91c6-1f6a-432c-97ca-5cb57952d103" xlink:href="jazz-20210331.xsd#jazz_JazzSecuritiesDesignatedActivityCompanyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_58f3d2a8-73d5-497c-870f-74509779062b" xlink:to="loc_jazz_JazzSecuritiesDesignatedActivityCompanyMember_3ddc91c6-1f6a-432c-97ca-5cb57952d103" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementScenarioAxis_5148b462-579d-4ab2-9750-634fbe823bf1" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_StatementScenarioAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_dcf25d06-a45d-43ee-90fa-bda8863ff709" xlink:to="loc_srt_StatementScenarioAxis_5148b462-579d-4ab2-9750-634fbe823bf1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_5148b462-579d-4ab2-9750-634fbe823bf1_default" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementScenarioAxis_5148b462-579d-4ab2-9750-634fbe823bf1" xlink:to="loc_srt_ScenarioUnspecifiedDomain_5148b462-579d-4ab2-9750-634fbe823bf1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioUnspecifiedDomain_412b7810-b90e-4952-b213-eefc3c79a929" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioUnspecifiedDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementScenarioAxis_5148b462-579d-4ab2-9750-634fbe823bf1" xlink:to="loc_srt_ScenarioUnspecifiedDomain_412b7810-b90e-4952-b213-eefc3c79a929" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScenarioForecastMember_9c7a2c1b-25aa-4c21-9890-48bdb5cf1e47" xlink:href="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd#srt_ScenarioForecastMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ScenarioUnspecifiedDomain_412b7810-b90e-4952-b213-eefc3c79a929" xlink:to="loc_srt_ScenarioForecastMember_9c7a2c1b-25aa-4c21-9890-48bdb5cf1e47" xlink:type="arc" order="0"/>
  </link:definitionLink>
</link:linkbase>
