Acceleration Request

May 31, 2007


Re:    Jazz Pharmaceuticals, Inc.
     Common Stock
     Registration Statement on Form S-1 No. 333-141164


Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549


Dear Sir/Madam:


In connection with the proposed offering of the above-captioned securities, we, as representatives of the several underwriters, hereby join with the request of Jazz Pharmaceuticals, Inc. (“the Company”) that the effective date of the above-captioned Registration Statement be accelerated so that the same will become effective on May 31, 2007, at 4:00 p.m. Eastern Daylight Time, or as soon as practicable thereafter.


The following is supplemental information supplied under Rule 418(a)(7) under the Securities Act of 1933:


  (i)   Date of preliminary prospectus: May 17, 2007


  (ii)   Dates of Distribution: May 17, 2007, through the date hereof


  (iii)   Number of prospective underwriters to whom the preliminary prospectus was furnished: 4


  (iv)   Number of prospectuses so distributed: approximately 8,194


  (v)   Number of prospectuses distributed to others, including the Company, the Company’s counsel and independent accountants, and underwriters’ counsel: approximately 205


  (vi)   We have been informed by the participating underwriters that they will comply with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934.


Very truly yours,

Acting severally on behalf of themselves and the several Underwriters



/s/ Bryan W. Andrzejewski

Name:   Bryan W. Andrzejewski
Title:   Executive Director


[Underwriters Acceleration Request]

Acceleration Request

May 31, 2007


Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, DC 20549


Re:    Jazz Pharmaceuticals, Inc.
   Form S-1 Registration Statement
   Registration File No. 333-141164


Ladies and Gentlemen:


The undersigned registrant hereby requests that the Securities and Exchange Commission (the “Commission”) take appropriate action to cause the above-referenced Registration Statement on Form S-1 (the “Filing”) to become effective at 4:00 p.m. Eastern Time on May 31, 2007 or as soon thereafter as is practicable.


In connection with this request, the undersigned registrant hereby acknowledges that:


(i) should the Commission or the staff of the Commission (the “Staff”), acting pursuant to delegated authority, declare the Filing effective, it does not foreclose the Commission from taking any action with respect to the Filing;


(ii) the action of the Commission or the Staff, acting pursuant to delegated authority, in declaring the Filing effective, does not relieve the undersigned registrant from its full responsibility for the adequacy and the accuracy of the disclosure in the Filing; and


(iii) the undersigned registrant may not assert the action of the Commission or the Staff in declaring the Filing effective as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.


Very truly yours,



/s/ Carol A. Gamble

  Carol A. Gamble
  Senior Vice President, General Counsel and Corporate Secretary
cc:   Bruce K. Dallas, Esq., Davis Polk & Wardwell
  John M. Geschke, Esq., Cooley Godward Kronish LLP
  Suzanne Sawochka Hooper, Esq., Cooley Godward Kronish LLP